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The map label for this gene is icfA [H]

Identifier: 189423626

GI number: 189423626

Start: 524458

End: 525090

Strand: Reverse

Name: icfA [H]

Synonym: Glov_0555

Alternate gene names: 189423626

Gene position: 525090-524458 (Counterclockwise)

Preceding gene: 189423627

Following gene: 189423625

Centisome position: 13.4

GC content: 54.98

Gene sequence:

>633_bases
ATGCAGGAGATCCAGAAATTTATCCACGGCTTCCGTAACTTCCAGGAGGAGTACTTCCACGAAGACCGGGAACTGTTTGA
TTGCCTGAAGCAGGGGCAGCGCCCCAAAGTGGTCCTGATCGGCTGCAGTGATTCACGGGTTGACCCGTCCATGATGGTCC
GCTCCGAGCCGGGTGATCTGTTTATTGTCCGCAACGTAGCCAACCTGGTTCCCCCCTGCGAACATGACCAGGCCTATCAC
GGCGTCAGTGCCGCCCTTGAATATGCGGTCTGCCACCTTGAGGTGGAACATGTCATTGTGCTGGGGCATTCCAACTGTGG
CGGTATCCGTTCTCTGATGGAAGGTATCCCGTCTGACAAGAACGGTGAATATATCAGCAAGTGGGTCAGTATTGCTGAAC
GGGCCAAGCAGCAGGTGCTGGAAACATTTTCAGATGCCTCAGCGGAGCGTCAGGCCAAGGCCTGCGAACATGCCTCGATT
CTGGTGTCGCTGGAAAACCTGCTGACCTTTCCCTGGATCAAGGAGCGGGTTGATGCCGGAAAACTTGACCTGCACGGCTG
GTACTTTGACATTGAGTCCGGTAACCTGTACAGCTACCACCCGGCCAGTGGTGAATTTACCCTGCTTGTGTAA

Upstream 100 bases:

>100_bases
GACAGGCTGGAGCAGTTCCGTGCTGCCACCCGGCAGGAGCTGGAGGAAAAATCCAGCGAGCTGCAGACCCGCCTGAAGCA
GGCTTGAGGGAGAAGCAGCA

Downstream 100 bases:

>100_bases
AACCTGTTGAAATAACGTAACAACAACATCTATTGAATCCCCTTGACAAGCATAGCAAGGCTGATTATGATTTCACTACG
TAAAGGGGAGTAGCTACCGA

Product: carbonate dehydratase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 210; Mature: 210

Protein sequence:

>210_residues
MQEIQKFIHGFRNFQEEYFHEDRELFDCLKQGQRPKVVLIGCSDSRVDPSMMVRSEPGDLFIVRNVANLVPPCEHDQAYH
GVSAALEYAVCHLEVEHVIVLGHSNCGGIRSLMEGIPSDKNGEYISKWVSIAERAKQQVLETFSDASAERQAKACEHASI
LVSLENLLTFPWIKERVDAGKLDLHGWYFDIESGNLYSYHPASGEFTLLV

Sequences:

>Translated_210_residues
MQEIQKFIHGFRNFQEEYFHEDRELFDCLKQGQRPKVVLIGCSDSRVDPSMMVRSEPGDLFIVRNVANLVPPCEHDQAYH
GVSAALEYAVCHLEVEHVIVLGHSNCGGIRSLMEGIPSDKNGEYISKWVSIAERAKQQVLETFSDASAERQAKACEHASI
LVSLENLLTFPWIKERVDAGKLDLHGWYFDIESGNLYSYHPASGEFTLLV
>Mature_210_residues
MQEIQKFIHGFRNFQEEYFHEDRELFDCLKQGQRPKVVLIGCSDSRVDPSMMVRSEPGDLFIVRNVANLVPPCEHDQAYH
GVSAALEYAVCHLEVEHVIVLGHSNCGGIRSLMEGIPSDKNGEYISKWVSIAERAKQQVLETFSDASAERQAKACEHASI
LVSLENLLTFPWIKERVDAGKLDLHGWYFDIESGNLYSYHPASGEFTLLV

Specific function: Reversible hydration of carbon dioxide. Essential to photosynthetic carbon dioxide fixation [H]

COG id: COG0288

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-class carbonic anhydrase family [H]

Homologues:

Organism=Escherichia coli, GI1786534, Length=211, Percent_Identity=35.0710900473934, Blast_Score=140, Evalue=6e-35,
Organism=Escherichia coli, GI1786318, Length=204, Percent_Identity=30.3921568627451, Blast_Score=92, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI25147564, Length=238, Percent_Identity=25.6302521008403, Blast_Score=87, Evalue=7e-18,
Organism=Caenorhabditis elegans, GI115532990, Length=242, Percent_Identity=24.3801652892562, Blast_Score=83, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6324292, Length=169, Percent_Identity=26.6272189349112, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24645213, Length=238, Percent_Identity=24.3697478991597, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001765
- InterPro:   IPR015892 [H]

Pfam domain/function: PF00484 Pro_CA [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 23769; Mature: 23769

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: PS00704 PROK_CO2_ANHYDRASE_1 ; PS00705 PROK_CO2_ANHYDRASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQEIQKFIHGFRNFQEEYFHEDRELFDCLKQGQRPKVVLIGCSDSRVDPSMMVRSEPGDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHEEECCCCCE
FIVRNVANLVPPCEHDQAYHGVSAALEYAVCHLEVEHVIVLGHSNCGGIRSLMEGIPSDK
EEEECHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHCCCCCC
NGEYISKWVSIAERAKQQVLETFSDASAERQAKACEHASILVSLENLLTFPWIKERVDAG
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
KLDLHGWYFDIESGNLYSYHPASGEFTLLV
CEEECEEEEEECCCCEEEECCCCCCEEEEC
>Mature Secondary Structure
MQEIQKFIHGFRNFQEEYFHEDRELFDCLKQGQRPKVVLIGCSDSRVDPSMMVRSEPGDL
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHEEECCCCCE
FIVRNVANLVPPCEHDQAYHGVSAALEYAVCHLEVEHVIVLGHSNCGGIRSLMEGIPSDK
EEEECHHHHCCCCCCCHHHHHHHHHHHHHHHEEEEEEEEEEECCCCCHHHHHHHCCCCCC
NGEYISKWVSIAERAKQQVLETFSDASAERQAKACEHASILVSLENLLTFPWIKERVDAG
CCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCC
KLDLHGWYFDIESGNLYSYHPASGEFTLLV
CEEECEEEEEECCCCEEEECCCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1584776 [H]