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The map label for this gene is benD [H]

Identifier: 189354031

GI number: 189354031

Start: 2359778

End: 2360554

Strand: Reverse

Name: benD [H]

Synonym: BMULJ_05284

Alternate gene names: 189354031

Gene position: 2360554-2359778 (Counterclockwise)

Preceding gene: 189354032

Following gene: 189354030

Centisome position: 95.45

GC content: 70.4

Gene sequence:

>777_bases
ATGACCATGCAACGATTCGCTGGCAAGACCCTCGTCGTCACCGGCGCCGCGCAGGGGATCGGCCGCGGCGTCGCGCTGCG
CGCCGCGGCCGAAGGCGGTCAAGTGCTGTTCGTCGATCGCGCCGAGTTCGTCGCCGACGTGGCGGCCGAAGCGGGCACCG
ATCGCGCGGCCGGCTTCGTCGCCGATCTCGAAACCTACGAAGGCGCGCGCGCGACGATGGCGTTCGCCGCCAGCCGGTTC
GGCGCGATCGACGTGCTGATCAACGGCGTCGGCGGTGCGATCCGGATGCGCCCGTTCGCCGAATTCGAGCCAGCGCAGAT
CGACGCCGAGATTCGCCGTTCGCTGATGCCGACGCTCTACGCGTGCCACGCGGTGCTGCCGTATCTGCTCGAACGCGGGC
GCGGCACGATCGTCAACGTGTCGTCGAACGCGACGCGCGGCATTCGCCGCGTGCCGTACTCGGCCGCGAAGGGCGGCGTC
AATGCGCTGACGCAGGCGCTTGCGATGGAATACGGCGAGCACAACATCCGCGTCGTCGCGACGGCGCCGGGCGGCACGAC
CGCGCCGCCGCGCCGTGTGCCGCGCAATGCGGCCGGCGACAGCGCGCAGGAACAGGCGTGGATGAGCGAGGCGGTGAAGC
AGGTCACCGAATCGACGTTCTTCAAGCGCTACGGCACGCTCGACGAGCAGATCGCGCCGATCCTGTTCCTCGCGTCGGAC
GAGGCGAGCTACATCACCGGCACCGTGCTGCCCGTCGCGGGCGGCGACAACGGCTGA

Upstream 100 bases:

>100_bases
CGATGGTCGATGCGGTGCGCAAGCATTTCGACGATACGGGCGTGAAGCCGAACAGCTTCCACTACGAGAAGTTCACGCCG
AACGTGACGGCAAAGGCGGC

Downstream 100 bases:

>100_bases
CGCGCACGCGTCATGCACGTACGCGCGCCGTCGAGCGACGGCGCGCATTCCATCATCGCAGCCGGCACATACGCCGGACG
AGGAGACATCGATGCAGCAG

Product: 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase

Products: NA

Alternate protein names: 2-hydro-1,2-dihydroxybenzoate dehydrogenase; DHB dehydrogenase; Cis-1,2-dihydroxy-3,4-cyclohexadiene-1-carboxylate dehydrogenase; Cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase [H]

Number of amino acids: Translated: 258; Mature: 257

Protein sequence:

>258_residues
MTMQRFAGKTLVVTGAAQGIGRGVALRAAAEGGQVLFVDRAEFVADVAAEAGTDRAAGFVADLETYEGARATMAFAASRF
GAIDVLINGVGGAIRMRPFAEFEPAQIDAEIRRSLMPTLYACHAVLPYLLERGRGTIVNVSSNATRGIRRVPYSAAKGGV
NALTQALAMEYGEHNIRVVATAPGGTTAPPRRVPRNAAGDSAQEQAWMSEAVKQVTESTFFKRYGTLDEQIAPILFLASD
EASYITGTVLPVAGGDNG

Sequences:

>Translated_258_residues
MTMQRFAGKTLVVTGAAQGIGRGVALRAAAEGGQVLFVDRAEFVADVAAEAGTDRAAGFVADLETYEGARATMAFAASRF
GAIDVLINGVGGAIRMRPFAEFEPAQIDAEIRRSLMPTLYACHAVLPYLLERGRGTIVNVSSNATRGIRRVPYSAAKGGV
NALTQALAMEYGEHNIRVVATAPGGTTAPPRRVPRNAAGDSAQEQAWMSEAVKQVTESTFFKRYGTLDEQIAPILFLASD
EASYITGTVLPVAGGDNG
>Mature_257_residues
TMQRFAGKTLVVTGAAQGIGRGVALRAAAEGGQVLFVDRAEFVADVAAEAGTDRAAGFVADLETYEGARATMAFAASRFG
AIDVLINGVGGAIRMRPFAEFEPAQIDAEIRRSLMPTLYACHAVLPYLLERGRGTIVNVSSNATRGIRRVPYSAAKGGVN
ALTQALAMEYGEHNIRVVATAPGGTTAPPRRVPRNAAGDSAQEQAWMSEAVKQVTESTFFKRYGTLDEQIAPILFLASDE
ASYITGTVLPVAGGDNG

Specific function: Degradation of 2-hydro-1,2-dihydroxy benzoate (DHB) to catechol [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]

Homologues:

Organism=Homo sapiens, GI7705925, Length=256, Percent_Identity=28.90625, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI15277342, Length=258, Percent_Identity=29.0697674418605, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI32483357, Length=263, Percent_Identity=30.0380228136882, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI19923817, Length=259, Percent_Identity=26.6409266409266, Blast_Score=71, Evalue=9e-13,
Organism=Homo sapiens, GI66933014, Length=265, Percent_Identity=28.3018867924528, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI40254992, Length=254, Percent_Identity=27.1653543307087, Blast_Score=68, Evalue=8e-12,
Organism=Homo sapiens, GI4504505, Length=192, Percent_Identity=30.7291666666667, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789208, Length=263, Percent_Identity=30.7984790874525, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082100, Length=259, Percent_Identity=29.7297297297297, Blast_Score=92, Evalue=3e-20,
Organism=Escherichia coli, GI1790717, Length=256, Percent_Identity=28.90625, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1787905, Length=257, Percent_Identity=27.2373540856031, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI87082160, Length=266, Percent_Identity=27.0676691729323, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1787335, Length=254, Percent_Identity=28.3464566929134, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1789378, Length=261, Percent_Identity=26.4367816091954, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI2367175, Length=263, Percent_Identity=28.1368821292776, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1789057, Length=254, Percent_Identity=28.740157480315, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788459, Length=259, Percent_Identity=29.7297297297297, Blast_Score=61, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17561402, Length=261, Percent_Identity=27.9693486590038, Blast_Score=91, Evalue=6e-19,
Organism=Caenorhabditis elegans, GI71994600, Length=253, Percent_Identity=29.2490118577075, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17560676, Length=249, Percent_Identity=26.9076305220884, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI71994604, Length=255, Percent_Identity=29.0196078431373, Blast_Score=81, Evalue=5e-16,
Organism=Caenorhabditis elegans, GI115534694, Length=258, Percent_Identity=29.8449612403101, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17559104, Length=195, Percent_Identity=30.7692307692308, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562910, Length=274, Percent_Identity=28.8321167883212, Blast_Score=77, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=266, Percent_Identity=26.6917293233083, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=192, Percent_Identity=29.1666666666667, Blast_Score=73, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=25, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17562904, Length=196, Percent_Identity=31.1224489795918, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17560150, Length=194, Percent_Identity=27.8350515463918, Blast_Score=71, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI17531453, Length=200, Percent_Identity=29.5, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17562990, Length=193, Percent_Identity=27.979274611399, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI17538480, Length=268, Percent_Identity=28.3582089552239, Blast_Score=68, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI17560220, Length=278, Percent_Identity=24.4604316546763, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI72000259, Length=272, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI193204405, Length=198, Percent_Identity=27.7777777777778, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17551412, Length=193, Percent_Identity=28.4974093264249, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17538486, Length=271, Percent_Identity=26.5682656826568, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322861, Length=265, Percent_Identity=24.9056603773585, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6324126, Length=263, Percent_Identity=28.5171102661597, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21357041, Length=266, Percent_Identity=31.9548872180451, Blast_Score=97, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24644339, Length=263, Percent_Identity=30.0380228136882, Blast_Score=88, Evalue=5e-18,
Organism=Drosophila melanogaster, GI28571526, Length=265, Percent_Identity=31.3207547169811, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI23397609, Length=263, Percent_Identity=30.7984790874525, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24639444, Length=264, Percent_Identity=28.7878787878788, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24643142, Length=252, Percent_Identity=25.7936507936508, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21357673, Length=193, Percent_Identity=25.9067357512953, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24644337, Length=185, Percent_Identity=32.4324324324324, Blast_Score=66, Evalue=3e-11,
Organism=Drosophila melanogaster, GI21355319, Length=265, Percent_Identity=27.1698113207547, Blast_Score=65, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904 [H]

Pfam domain/function: PF00106 adh_short [H]

EC number: =1.3.1.25 [H]

Molecular weight: Translated: 27127; Mature: 26996

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00061 ADH_SHORT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTMQRFAGKTLVVTGAAQGIGRGVALRAAAEGGQVLFVDRAEFVADVAAEAGTDRAAGFV
CCCHHHCCCEEEEEECCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCHHHHH
ADLETYEGARATMAFAASRFGAIDVLINGVGGAIRMRPFAEFEPAQIDAEIRRSLMPTLY
HHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHH
ACHAVLPYLLERGRGTIVNVSSNATRGIRRVPYSAAKGGVNALTQALAMEYGEHNIRVVA
HHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCHHHCCCHHHHHHHHHHHCCCCCEEEEE
TAPGGTTAPPRRVPRNAAGDSAQEQAWMSEAVKQVTESTFFKRYGTLDEQIAPILFLASD
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECC
EASYITGTVLPVAGGDNG
CCCEEEEEEEEECCCCCC
>Mature Secondary Structure 
TMQRFAGKTLVVTGAAQGIGRGVALRAAAEGGQVLFVDRAEFVADVAAEAGTDRAAGFV
CCHHHCCCEEEEEECCCCCCCCEEEEEECCCCEEEEEEHHHHHHHHHHHCCCCCHHHHH
ADLETYEGARATMAFAASRFGAIDVLINGVGGAIRMRPFAEFEPAQIDAEIRRSLMPTLY
HHHHHHCCHHHHHHHHHHHCCEEEEEEECCCCEEEECCCCCCCCCCCCHHHHHHHHHHHH
ACHAVLPYLLERGRGTIVNVSSNATRGIRRVPYSAAKGGVNALTQALAMEYGEHNIRVVA
HHHHHHHHHHHCCCCCEEEECCCCCCHHHHCCCHHHCCCHHHHHHHHHHHCCCCCEEEEE
TAPGGTTAPPRRVPRNAAGDSAQEQAWMSEAVKQVTESTFFKRYGTLDEQIAPILFLASD
ECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCCEEEEECC
EASYITGTVLPVAGGDNG
CCCEEEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1740120 [H]