Click here to switch to the map view.

The map label for this gene is gyaR [H]

Identifier: 189353147

GI number: 189353147

Start: 1345260

End: 1346264

Strand: Direct

Name: gyaR [H]

Synonym: BMULJ_04383

Alternate gene names: 189353147

Gene position: 1345260-1346264 (Clockwise)

Preceding gene: 189353145

Following gene: 189353148

Centisome position: 54.39

GC content: 71.54

Gene sequence:

>1005_bases
ATGCGATTCCTATACTCGGTTGCACCCGATGCGCGGCCCGCGCCGCGCACGCCGACCGAGACTCTGATGACCATCGATAT
CCTGCTTACCCAGCCGCTTCCCGACGCGATCGACGCCGAACTGTCCGCCCGCTACGCCGTGCATCGGCTAAATGCGACCG
ATGAGCCCGACGCATTGCTCGCGCGCGTCGCGCCGCGCATCCGCGGCGTCGTGACGGGCGGCGCGAACGGCTTGTCCGCC
GCGCTGATGGAGCGGCTCGGCGCGCTCGAAATCGTCGCGATCAACGGCATCGGCACCGACGCCGTCGATCTCGAACGCGC
ACGCGCACGCGGCATCCACGTCACGACGACGCCCGACGTGCTGACCGACGACGTAGCCGACATGGCGATGGGGCTGATCC
TGATGACCTTGCGCGATCTCGGCCTCGGCGAACGCATCGTGCGCGCCGGCCGCTGGGGCACGTTCGCGCAGCCGCTCGCG
ACGCAGGTGACGGGCAAGCGGCTCGGCATCGTCGGCCTCGGCCGCGTCGGGCGCGCGATCGCGCAGCGCGCGCAGGCGTT
CCGGATGCCGGTCAGCTACTTCGGCCCGCGCGAGCATCGCGACAGCGGCTACCGGTTCGTGCCCGACCTGATCGCGCTCG
CGCGCGACAGCGACGTGCTGGTCGTCGCCGCGTCGGCCGATCACGGCAAGGTGCTGATCACGGCCGAGGTCCTCGCCGCG
CTCGGCCGCGACGGCTTCCTGATCAATGTCGCGCGCGGCAAGCTCGTCGACGAAACCGCGCTCGTGCGCGCGCTGGCGGA
CGGCACGATCGCAGGCGCAGGCCTCGACGTGTTCGCGAACGAACCGCAGGTGCCGTCCGCGCTGCTCGAACTCGACCGCG
TCGTCGTGCAGCCGCACCGCGCGAGCGCCACGCGCGAGACGCGCGAGGAAATGGGCCGCATCGTGCTCGCCAACCTCGCC
GCGTGCTTCGCGGGCCAGCGGCCGCCGACCAGCGTCACGACCTGA

Upstream 100 bases:

>100_bases
TGCAGTTCCTCGGCGACCGCGACGAAGCAGCGAAGCTGGTGCAGTTCGATCATTCAATAGTTGAATCAATCAATAGGCGT
TTGATGTTAGACCAACATCG

Downstream 100 bases:

>100_bases
ACGGGTCGCGCCGCGCAATCGGCGCGCGCCCCTCGCCACGACACACACAACATGCCTCCGCACGACGGAGGCCAGGAGAC
ACGCATGCCCGATCGATCCT

Product: glyoxylate reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 334

Protein sequence:

>334_residues
MRFLYSVAPDARPAPRTPTETLMTIDILLTQPLPDAIDAELSARYAVHRLNATDEPDALLARVAPRIRGVVTGGANGLSA
ALMERLGALEIVAINGIGTDAVDLERARARGIHVTTTPDVLTDDVADMAMGLILMTLRDLGLGERIVRAGRWGTFAQPLA
TQVTGKRLGIVGLGRVGRAIAQRAQAFRMPVSYFGPREHRDSGYRFVPDLIALARDSDVLVVAASADHGKVLITAEVLAA
LGRDGFLINVARGKLVDETALVRALADGTIAGAGLDVFANEPQVPSALLELDRVVVQPHRASATRETREEMGRIVLANLA
ACFAGQRPPTSVTT

Sequences:

>Translated_334_residues
MRFLYSVAPDARPAPRTPTETLMTIDILLTQPLPDAIDAELSARYAVHRLNATDEPDALLARVAPRIRGVVTGGANGLSA
ALMERLGALEIVAINGIGTDAVDLERARARGIHVTTTPDVLTDDVADMAMGLILMTLRDLGLGERIVRAGRWGTFAQPLA
TQVTGKRLGIVGLGRVGRAIAQRAQAFRMPVSYFGPREHRDSGYRFVPDLIALARDSDVLVVAASADHGKVLITAEVLAA
LGRDGFLINVARGKLVDETALVRALADGTIAGAGLDVFANEPQVPSALLELDRVVVQPHRASATRETREEMGRIVLANLA
ACFAGQRPPTSVTT
>Mature_334_residues
MRFLYSVAPDARPAPRTPTETLMTIDILLTQPLPDAIDAELSARYAVHRLNATDEPDALLARVAPRIRGVVTGGANGLSA
ALMERLGALEIVAINGIGTDAVDLERARARGIHVTTTPDVLTDDVADMAMGLILMTLRDLGLGERIVRAGRWGTFAQPLA
TQVTGKRLGIVGLGRVGRAIAQRAQAFRMPVSYFGPREHRDSGYRFVPDLIALARDSDVLVVAASADHGKVLITAEVLAA
LGRDGFLINVARGKLVDETALVRALADGTIAGAGLDVFANEPQVPSALLELDRVVVQPHRASATRETREEMGRIVLANLA
ACFAGQRPPTSVTT

Specific function: Unknown

COG id: COG1052

COG function: function code CHR; Lactate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. GyaR subfamily [H]

Homologues:

Organism=Homo sapiens, GI6912396, Length=286, Percent_Identity=34.6153846153846, Blast_Score=130, Evalue=2e-30,
Organism=Homo sapiens, GI23308577, Length=253, Percent_Identity=31.6205533596838, Blast_Score=116, Evalue=3e-26,
Organism=Homo sapiens, GI61743967, Length=251, Percent_Identity=34.2629482071713, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI4557497, Length=251, Percent_Identity=34.2629482071713, Blast_Score=105, Evalue=6e-23,
Organism=Homo sapiens, GI145580578, Length=247, Percent_Identity=32.3886639676113, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI4557499, Length=247, Percent_Identity=32.3886639676113, Blast_Score=103, Evalue=2e-22,
Organism=Homo sapiens, GI145580575, Length=247, Percent_Identity=32.3886639676113, Blast_Score=103, Evalue=3e-22,
Organism=Escherichia coli, GI87082289, Length=321, Percent_Identity=36.7601246105919, Blast_Score=165, Evalue=5e-42,
Organism=Escherichia coli, GI1789279, Length=227, Percent_Identity=32.5991189427313, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1787645, Length=267, Percent_Identity=26.2172284644195, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI87081824, Length=155, Percent_Identity=32.9032258064516, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=253, Percent_Identity=31.2252964426877, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25147481, Length=248, Percent_Identity=27.4193548387097, Blast_Score=88, Evalue=5e-18,
Organism=Saccharomyces cerevisiae, GI6324055, Length=237, Percent_Identity=34.5991561181435, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320925, Length=251, Percent_Identity=30.2788844621514, Blast_Score=96, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6322116, Length=251, Percent_Identity=30.2788844621514, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6321253, Length=278, Percent_Identity=24.4604316546763, Blast_Score=70, Evalue=3e-13,
Organism=Drosophila melanogaster, GI28571528, Length=275, Percent_Identity=36, Blast_Score=130, Evalue=1e-30,
Organism=Drosophila melanogaster, GI28574286, Length=291, Percent_Identity=31.6151202749141, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24585514, Length=270, Percent_Identity=31.4814814814815, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI28574282, Length=270, Percent_Identity=31.4814814814815, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45551003, Length=270, Percent_Identity=31.4814814814815, Blast_Score=114, Evalue=6e-26,
Organism=Drosophila melanogaster, GI45552429, Length=270, Percent_Identity=31.4814814814815, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI28574284, Length=270, Percent_Identity=31.4814814814815, Blast_Score=114, Evalue=8e-26,
Organism=Drosophila melanogaster, GI24585516, Length=278, Percent_Identity=29.136690647482, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI62472511, Length=264, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=8e-23,
Organism=Drosophila melanogaster, GI24646446, Length=264, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646448, Length=264, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646452, Length=264, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI24646450, Length=264, Percent_Identity=33.3333333333333, Blast_Score=104, Evalue=9e-23,
Organism=Drosophila melanogaster, GI19921140, Length=233, Percent_Identity=30.4721030042918, Blast_Score=89, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR016040 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C [H]

EC number: =1.1.1.26 [H]

Molecular weight: Translated: 35525; Mature: 35525

Theoretical pI: Translated: 7.08; Mature: 7.08

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFLYSVAPDARPAPRTPTETLMTIDILLTQPLPDAIDAELSARYAVHRLNATDEPDALL
CCEEEECCCCCCCCCCCCHHHHEEEEEEEECCCCHHHHHHHHHHHHHEECCCCCCHHHHH
ARVAPRIRGVVTGGANGLSAALMERLGALEIVAINGIGTDAVDLERARARGIHVTTTPDV
HHHHHHHHEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCEEEECCCCH
LTDDVADMAMGLILMTLRDLGLGERIVRAGRWGTFAQPLATQVTGKRLGIVGLGRVGRAI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCEECEEECHHHHHHH
AQRAQAFRMPVSYFGPREHRDSGYRFVPDLIALARDSDVLVVAASADHGKVLITAEVLAA
HHHHHHHCCCHHHCCCCCCCCCCCEEHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHH
LGRDGFLINVARGKLVDETALVRALADGTIAGAGLDVFANEPQVPSALLELDRVVVQPHR
HCCCCEEEEECCCCHHHHHHHHHHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHHCCCC
ASATRETREEMGRIVLANLAACFAGQRPPTSVTT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MRFLYSVAPDARPAPRTPTETLMTIDILLTQPLPDAIDAELSARYAVHRLNATDEPDALL
CCEEEECCCCCCCCCCCCHHHHEEEEEEEECCCCHHHHHHHHHHHHHEECCCCCCHHHHH
ARVAPRIRGVVTGGANGLSAALMERLGALEIVAINGIGTDAVDLERARARGIHVTTTPDV
HHHHHHHHEEEECCCCHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHCCEEEECCCCH
LTDDVADMAMGLILMTLRDLGLGERIVRAGRWGTFAQPLATQVTGKRLGIVGLGRVGRAI
HHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCEECEEECHHHHHHH
AQRAQAFRMPVSYFGPREHRDSGYRFVPDLIALARDSDVLVVAASADHGKVLITAEVLAA
HHHHHHHCCCHHHCCCCCCCCCCCEEHHHHHHHHCCCCEEEEEECCCCCEEEEHHHHHHH
LGRDGFLINVARGKLVDETALVRALADGTIAGAGLDVFANEPQVPSALLELDRVVVQPHR
HCCCCEEEEECCCCHHHHHHHHHHHHCCCEECCCCEEECCCCCCHHHHHHHHHHHHCCCC
ASATRETREEMGRIVLANLAACFAGQRPPTSVTT
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA