Click here to switch to the map view.

The map label for this gene is slc1 [H]

Identifier: 189353148

GI number: 189353148

Start: 1346349

End: 1347716

Strand: Direct

Name: slc1 [H]

Synonym: BMULJ_04384

Alternate gene names: 189353148

Gene position: 1346349-1347716 (Clockwise)

Preceding gene: 189353147

Following gene: 189353150

Centisome position: 54.44

GC content: 69.59

Gene sequence:

>1368_bases
ATGCCCGATCGATCCTCCGGCGCCGCCGTCGCCGCGCCCGCAGCCGCCGCTTCGCGTACGATCGGCCGCGTCCGTTACGC
GGTCCTCGCCCTGATCTTCGCCGTCACCGTCGTCAACTATGCGGACCGCGCGACGATGTCGATCGCCGGCACCGGCGTCG
CGCGCGACCTCGGGCTCACGCCCGTGCAGCTCGGCATCGTTTTTTCCGCGTTCGCGTGGGCCTATGCGATCGGGCAGATT
CCCGGCGGCTGGCTGCTCGACCGTTACGGCGCACGGCGCGTCTACGGCCTGAGCCTTCTGCTGTGGTCGGTGTTCACGAT
GCTGCAGGGCACGGTCGGATGGCTTGGCGTGCAGGCCGGTGCCGCGACACTCGCGCTGTTCGCGATGCGCTTCATGCTCG
GCCTCGTCGAATCGCCGGCCTTCCCGGCCAACTCGCGAATCGTCGCGTGCTGGTTCCCGACCGCCGAACGCGGCACCGCG
TCGGCGCTGTTCAATTCCGCGCAATACATGGCCGTCGTGCTGTTCACGCCGGCGATGGCGTGGCTCACGCATGCGCTGGG
CTGGACGCACGTATTCCTGTGGATGGGGATGCTCGGCATCGCGCTCGCCGCGCTATGGTTCGCGTGGTATCGCGAACCGC
ACAGCCACCCGCGCGTGAGCGACGCCGAGCGCGACTATCTGCGCGCGCACGGCGCGCTGGTCGATCTCGAGGCGAACCGC
GTCCGGCATCGCGCGCGCGTCTCGTGGCGCGCCGCCTCACAGCTGTTCCGCCACCGCAACCTGTGGGCGATCTACATCGG
CCAGTACTGCATCACGGCGCTCACCTACTTCTTCATCACCTGGTTTCCGATCTACCTGATCAAGGGACGCGGCATGACGA
TCATGGAAGCCGGCTGGGTCGCCGCGCTGCCGGCGATCTGCGGCTTCACGGGCGGCGTGCTCGGCGGCGTGCTGTCGGAC
TGGCTGATCCGGCGCGGCGTGCATCCGTCGCGCGCACGCAAGACGCCCTTCGTCGCGGGGATGGCGATGGCGACGCTGCT
GGTGCTCGCGAACGGCGCATCGTCGAACACGGTCGTGATCGCGCTGATGACGATCGCGTTCTTCGGCAAGGGGCTGGCGG
CCGTCGGCTGGGCCGTGCTCGCCGACACCGCGCCGGCAGGCATGGTCGGCCTGAGCGGCGGCGTGTTCAACGGCCTCGGC
AATATCGCGGGCATCGTCACGCCGCTCGTGATCGGCTACTTCGTCGCGCACACCGGCTCGTTTGCCGGCGCGCTGTGGTT
CGTCGCCGCGCACGGGCTGATCGGCATCGCCGCGTATGCGTGGCTCGCGGGCCGCTTCGAGCGCATTCGCGTCGCAGCGG
ACCGGTGA

Upstream 100 bases:

>100_bases
CAGCGTCACGACCTGAACGGGTCGCGCCGCGCAATCGGCGCGCGCCCCTCGCCACGACACACACAACATGCCTCCGCACG
ACGGAGGCCAGGAGACACGC

Downstream 100 bases:

>100_bases
TCGCCGCGGTGCAGGATCGCGCGTTCGGGCGATACTCCCGCGCGCCGCATCACGCGCGCTTCAGACCGCCGCTTTGCGCC
TGCTCGATCGTGAGCCGGTC

Product: sodium-dependent inorganic phosphate cotransporter

Products: NA

Alternate protein names: D-glucarate permease [H]

Number of amino acids: Translated: 455; Mature: 454

Protein sequence:

>455_residues
MPDRSSGAAVAAPAAAASRTIGRVRYAVLALIFAVTVVNYADRATMSIAGTGVARDLGLTPVQLGIVFSAFAWAYAIGQI
PGGWLLDRYGARRVYGLSLLLWSVFTMLQGTVGWLGVQAGAATLALFAMRFMLGLVESPAFPANSRIVACWFPTAERGTA
SALFNSAQYMAVVLFTPAMAWLTHALGWTHVFLWMGMLGIALAALWFAWYREPHSHPRVSDAERDYLRAHGALVDLEANR
VRHRARVSWRAASQLFRHRNLWAIYIGQYCITALTYFFITWFPIYLIKGRGMTIMEAGWVAALPAICGFTGGVLGGVLSD
WLIRRGVHPSRARKTPFVAGMAMATLLVLANGASSNTVVIALMTIAFFGKGLAAVGWAVLADTAPAGMVGLSGGVFNGLG
NIAGIVTPLVIGYFVAHTGSFAGALWFVAAHGLIGIAAYAWLAGRFERIRVAADR

Sequences:

>Translated_455_residues
MPDRSSGAAVAAPAAAASRTIGRVRYAVLALIFAVTVVNYADRATMSIAGTGVARDLGLTPVQLGIVFSAFAWAYAIGQI
PGGWLLDRYGARRVYGLSLLLWSVFTMLQGTVGWLGVQAGAATLALFAMRFMLGLVESPAFPANSRIVACWFPTAERGTA
SALFNSAQYMAVVLFTPAMAWLTHALGWTHVFLWMGMLGIALAALWFAWYREPHSHPRVSDAERDYLRAHGALVDLEANR
VRHRARVSWRAASQLFRHRNLWAIYIGQYCITALTYFFITWFPIYLIKGRGMTIMEAGWVAALPAICGFTGGVLGGVLSD
WLIRRGVHPSRARKTPFVAGMAMATLLVLANGASSNTVVIALMTIAFFGKGLAAVGWAVLADTAPAGMVGLSGGVFNGLG
NIAGIVTPLVIGYFVAHTGSFAGALWFVAAHGLIGIAAYAWLAGRFERIRVAADR
>Mature_454_residues
PDRSSGAAVAAPAAAASRTIGRVRYAVLALIFAVTVVNYADRATMSIAGTGVARDLGLTPVQLGIVFSAFAWAYAIGQIP
GGWLLDRYGARRVYGLSLLLWSVFTMLQGTVGWLGVQAGAATLALFAMRFMLGLVESPAFPANSRIVACWFPTAERGTAS
ALFNSAQYMAVVLFTPAMAWLTHALGWTHVFLWMGMLGIALAALWFAWYREPHSHPRVSDAERDYLRAHGALVDLEANRV
RHRARVSWRAASQLFRHRNLWAIYIGQYCITALTYFFITWFPIYLIKGRGMTIMEAGWVAALPAICGFTGGVLGGVLSDW
LIRRGVHPSRARKTPFVAGMAMATLLVLANGASSNTVVIALMTIAFFGKGLAAVGWAVLADTAPAGMVGLSGGVFNGLGN
IAGIVTPLVIGYFVAHTGSFAGALWFVAAHGLIGIAAYAWLAGRFERIRVAADR

Specific function: Uptake of D-glucarate [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Phthalate permease family [H]

Homologues:

Organism=Homo sapiens, GI9966811, Length=386, Percent_Identity=26.9430051813472, Blast_Score=129, Evalue=8e-30,
Organism=Homo sapiens, GI9945322, Length=391, Percent_Identity=27.8772378516624, Blast_Score=128, Evalue=1e-29,
Organism=Homo sapiens, GI21322234, Length=390, Percent_Identity=26.6666666666667, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI154350196, Length=423, Percent_Identity=26.0047281323877, Blast_Score=113, Evalue=4e-25,
Organism=Homo sapiens, GI4885441, Length=371, Percent_Identity=24.2587601078167, Blast_Score=102, Evalue=7e-22,
Organism=Homo sapiens, GI6912666, Length=351, Percent_Identity=24.7863247863248, Blast_Score=99, Evalue=6e-21,
Organism=Homo sapiens, GI148743791, Length=386, Percent_Identity=24.3523316062176, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI5031955, Length=270, Percent_Identity=25.5555555555556, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI223718438, Length=197, Percent_Identity=26.9035532994924, Blast_Score=86, Evalue=8e-17,
Organism=Homo sapiens, GI148728191, Length=320, Percent_Identity=24.0625, Blast_Score=76, Evalue=5e-14,
Organism=Homo sapiens, GI154800443, Length=281, Percent_Identity=22.4199288256228, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI1789152, Length=442, Percent_Identity=52.4886877828054, Blast_Score=486, Evalue=1e-138,
Organism=Escherichia coli, GI1789515, Length=431, Percent_Identity=51.0440835266821, Blast_Score=454, Evalue=1e-129,
Organism=Escherichia coli, GI87082320, Length=429, Percent_Identity=38.6946386946387, Blast_Score=322, Evalue=2e-89,
Organism=Escherichia coli, GI2367379, Length=448, Percent_Identity=29.9107142857143, Blast_Score=191, Evalue=6e-50,
Organism=Escherichia coli, GI2367193, Length=321, Percent_Identity=25.8566978193146, Blast_Score=111, Evalue=1e-25,
Organism=Escherichia coli, GI1788573, Length=425, Percent_Identity=25.1764705882353, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI87082071, Length=399, Percent_Identity=21.8045112781955, Blast_Score=62, Evalue=1e-10,
Organism=Caenorhabditis elegans, GI115533554, Length=440, Percent_Identity=27.2727272727273, Blast_Score=112, Evalue=5e-25,
Organism=Caenorhabditis elegans, GI115533556, Length=442, Percent_Identity=27.1493212669683, Blast_Score=111, Evalue=8e-25,
Organism=Caenorhabditis elegans, GI17552542, Length=444, Percent_Identity=24.5495495495495, Blast_Score=105, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI71997452, Length=373, Percent_Identity=25.7372654155496, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17535049, Length=426, Percent_Identity=23.943661971831, Blast_Score=89, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17560030, Length=352, Percent_Identity=23.0113636363636, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI32565916, Length=280, Percent_Identity=23.2142857142857, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI32565914, Length=280, Percent_Identity=23.2142857142857, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17554148, Length=350, Percent_Identity=24, Blast_Score=74, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI193205400, Length=274, Percent_Identity=24.0875912408759, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17532009, Length=411, Percent_Identity=24.5742092457421, Blast_Score=67, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17569727, Length=284, Percent_Identity=20.4225352112676, Blast_Score=65, Evalue=5e-11,
Organism=Caenorhabditis elegans, GI71989129, Length=259, Percent_Identity=25.8687258687259, Blast_Score=65, Evalue=6e-11,
Organism=Caenorhabditis elegans, GI17536545, Length=299, Percent_Identity=24.4147157190635, Blast_Score=65, Evalue=7e-11,
Organism=Drosophila melanogaster, GI24583789, Length=396, Percent_Identity=27.5252525252525, Blast_Score=124, Evalue=2e-28,
Organism=Drosophila melanogaster, GI62484226, Length=396, Percent_Identity=27.2727272727273, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI20130167, Length=386, Percent_Identity=26.1658031088083, Blast_Score=106, Evalue=4e-23,
Organism=Drosophila melanogaster, GI28573299, Length=422, Percent_Identity=25.3554502369668, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI24641682, Length=430, Percent_Identity=25.3488372093023, Blast_Score=102, Evalue=5e-22,
Organism=Drosophila melanogaster, GI24584153, Length=394, Percent_Identity=23.3502538071066, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24648416, Length=442, Percent_Identity=24.4343891402715, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI21356189, Length=442, Percent_Identity=24.4343891402715, Blast_Score=93, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19922400, Length=396, Percent_Identity=22.979797979798, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24654215, Length=396, Percent_Identity=22.979797979798, Blast_Score=87, Evalue=3e-17,
Organism=Drosophila melanogaster, GI19920686, Length=390, Percent_Identity=24.6153846153846, Blast_Score=86, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28573708, Length=432, Percent_Identity=23.6111111111111, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI28573707, Length=432, Percent_Identity=23.6111111111111, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20130135, Length=413, Percent_Identity=21.0653753026634, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24655271, Length=413, Percent_Identity=21.0653753026634, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24639764, Length=424, Percent_Identity=21.6981132075472, Blast_Score=83, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129235, Length=454, Percent_Identity=24.4493392070485, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45550460, Length=414, Percent_Identity=23.6714975845411, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24653727, Length=368, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24655255, Length=360, Percent_Identity=24.4444444444444, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24658658, Length=419, Percent_Identity=22.9116945107399, Blast_Score=76, Evalue=4e-14,
Organism=Drosophila melanogaster, GI281361682, Length=360, Percent_Identity=23.0555555555556, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221474708, Length=298, Percent_Identity=25.503355704698, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24580790, Length=358, Percent_Identity=24.3016759776536, Blast_Score=71, Evalue=1e-12,
Organism=Drosophila melanogaster, GI45550364, Length=418, Percent_Identity=24.1626794258373, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004744
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 48792; Mature: 48661

Theoretical pI: Translated: 10.83; Mature: 10.83

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDRSSGAAVAAPAAAASRTIGRVRYAVLALIFAVTVVNYADRATMSIAGTGVARDLGLT
CCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCC
PVQLGIVFSAFAWAYAIGQIPGGWLLDRYGARRVYGLSLLLWSVFTMLQGTVGWLGVQAG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AATLALFAMRFMLGLVESPAFPANSRIVACWFPTAERGTASALFNSAQYMAVVLFTPAMA
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHH
WLTHALGWTHVFLWMGMLGIALAALWFAWYREPHSHPRVSDAERDYLRAHGALVDLEANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEHHHH
VRHRARVSWRAASQLFRHRNLWAIYIGQYCITALTYFFITWFPIYLIKGRGMTIMEAGWV
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHH
AALPAICGFTGGVLGGVLSDWLIRRGVHPSRARKTPFVAGMAMATLLVLANGASSNTVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCCHHHH
ALMTIAFFGKGLAAVGWAVLADTAPAGMVGLSGGVFNGLGNIAGIVTPLVIGYFVAHTGS
HHHHHHHHHCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FAGALWFVAAHGLIGIAAYAWLAGRFERIRVAADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC
>Mature Secondary Structure 
PDRSSGAAVAAPAAAASRTIGRVRYAVLALIFAVTVVNYADRATMSIAGTGVARDLGLT
CCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHCCCC
PVQLGIVFSAFAWAYAIGQIPGGWLLDRYGARRVYGLSLLLWSVFTMLQGTVGWLGVQAG
HHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHH
AATLALFAMRFMLGLVESPAFPANSRIVACWFPTAERGTASALFNSAQYMAVVLFTPAMA
HHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCHHHHHHCCHHHHHHHHHHHHHH
WLTHALGWTHVFLWMGMLGIALAALWFAWYREPHSHPRVSDAERDYLRAHGALVDLEANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCCEEEEHHHH
VRHRARVSWRAASQLFRHRNLWAIYIGQYCITALTYFFITWFPIYLIKGRGMTIMEAGWV
HHHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCHH
AALPAICGFTGGVLGGVLSDWLIRRGVHPSRARKTPFVAGMAMATLLVLANGASSNTVVI
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCCHHHH
ALMTIAFFGKGLAAVGWAVLADTAPAGMVGLSGGVFNGLGNIAGIVTPLVIGYFVAHTGS
HHHHHHHHHCCHHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
FAGALWFVAAHGLIGIAAYAWLAGRFERIRVAADR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9278503; 9772162; 10762278 [H]