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The map label for this gene is degS [H]

Identifier: 189353017

GI number: 189353017

Start: 1181146

End: 1183257

Strand: Reverse

Name: degS [H]

Synonym: BMULJ_04251

Alternate gene names: 189353017

Gene position: 1183257-1181146 (Counterclockwise)

Preceding gene: 189353026

Following gene: 189353016

Centisome position: 47.84

GC content: 71.02

Gene sequence:

>2112_bases
ATGACCGCCAGAGGAACCCCAACCCGTGGCGCCCGAGAGCCCGCGCGCCTCCGGACCATGTTACGCCAGCCGCTTGCGGC
CGGCACCGCGGCGCTCCTGATGGGCGCAGCACTGTCGCTCGGCGTCGCGCTGCTGGTGCGCGACGAGTGGCAGGACGCCG
TCCATGCGCGCTTCGAGCGCCGTACCGCGCGCGTCACCGCGATGCTGCGCCACGAACTGCTGGCCGGCGTCGGGATACTC
GACAGCGCGCGCGGCGCGCTCGCGCTCGTCCCGCAGATGACGCCCGAACAGTGGACGCGCTACGCCGAATCGCTCGATCT
CGACGCCAGGCACTCGCCCGTTCGGCAGCTCGGCTACGCGCCGCTGTCGGACGCGACGCGCGCCGCACTCGCCGGCCACG
CGCCGATGCCGGCCGGCCCGCTCGCGACCGCAACGCTGAGCGCACCGCCGTCCGTCGCACCGGTCGTGCGCTTCGGCGCA
CCGGACGCGCAGCCGCTCGCGCGCACGCTGCGTACCGGCGAAGTTGCGCTCGGCGTGCATCCGGCCGACGACGATCTGTC
CTACGACGCGCGCACGCTGACGCTGTTCGTGCCGGTCGCCGCTGCGCGGCGCGCTGCCGGTGCACCGCCCGGCGCGAGCG
ACCTCGAACCCGACGGCATCCTGTTCGCCGCGTTGAGCCCGCAGCGGCTGATCGACCGCGCGCTCGACGCCGAACGCGGA
ATCGATCTGAAGATCGGCGCGGGCAGCGATCCGCGCCCGGTCGTCAGCGCCGAGACGACGACCGACGAGGCCGCGACGTC
GCCGTCCCTGCTGCGGCGCACCGAGATCCTTAATTTCGGCGGCACTGCGCTCACGCTCGCGTATTCGGCCGACGGGCGGC
CGAGCGCAACGGGCGCGCAGCGCGCGGCCGCCACCGTGCTCGCGGCCGGGCTGCTCGCGTCGATCGCGTTCGCGGTGCTC
GTCCACGCGCTCATGCGTAGCCGCGCGGCCGCCGCGGGCGACGCGGGCGCCGGCAGCCGTCATCTGAACGAAGCGCGCAT
GATGGGCATCATCCGCTCGTCGATGGAGGCGATCATCACGATCGACGAGAAGCAGACGGTCGTGATCTTCAATCCGATGG
CCGAGCAGGTGTTCGGCGTATCGGCGATGGAAGCGATCGGCGCGCCGCTGTCGCGCTTCATCCCCGAACGGTTTCGCGCC
GCGCATGCGAAGCACGTCGACCAGTTCGGCGTGACGGGCGTATCGGAGCGGCAAATGGGACGCCAGCGCGTGCTGTTCGG
GCTGCGCGCGAACGGCGAGGAGTTTCCGATCGAGGCATCGATCTCGCAGATCCGCGACGGCTCCGGCAAGCTGTACACGG
TAATGCTGCGCGACATCACCGAGCGGCTGCGCGCCGAGAACGCGGTCAGGCAGTCGCGCGAGGAACTGCGCGAGCTGTCG
GCGAACCTGCAGAACGTGCGCGAAGAGGAAAAGACGCGCATCGCGCGCGAACTGCACGACGATCTCGGCCAGCAGCTCAC
CGCGCTGAAGATGGATCTGTCGGTCGTCGAGCAGCGGCTGCGCGCGCCGGCCCACGCGGCGCCCGACGCCAGCGTGCTCG
CGCATCTGCAGGGCATGCGCAAGCTGATCGACGCGACGGTCGCGTCGGTGCGGCGCATCGCGGCCGATCTGCGTCCGGTG
ATGCTCGACGATCTCGGCCTCGTGCCGGCGATCGAATGGCTCGCCAACGATTTCACGAACCGCTACGGCATCGACGTCGA
ACGCCATGTCGAAACGGGCGGCATCGCCTTCACGAGCGCGGGCGCGACCACGCTGTTCCGCATCGTCCAGGAAGCGCTGA
CGAACGTCGCGCGCCATGCGGATGCGACGCGCGTCGCGCTGCGGCTCGACGTCGAAGACGGCTTCTGCGTGCTGCGTGTC
GCCGACAACGGCCACGGCGCACCGCCCGGCGGCCCCGCGCACGAGGACAAATCGTTCGGGCTGATCGGCATTCGCGAGCG
CGCCCACATGCTCGGTGGCACCGTGACGATCGATACCGCGCCGGCGCGCGGCTTTTCGATCACCGTCGCCCTGCCGCTCG
GCAACGTTGAACAGGACAACCCCATCTCATGA

Upstream 100 bases:

>100_bases
TTCGCGTTGAAAACACAATCGACTGTGCCGGGCGCGGCTCTCGCCCGGGCAGCGCGCGTCGCCCGAGTGCCCGGGCGGCG
GACAACAGAATGGCCAGCCA

Downstream 100 bases:

>100_bases
TCAAGGTGCTCATCGCCGACGACCATACGCTCGTGCGCGACGGTCTGCGGCACATCCTTCAGAACGCGACCGGTTTCGAA
GTGGCCGGCGAAGCGTGCGA

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 703; Mature: 702

Protein sequence:

>703_residues
MTARGTPTRGAREPARLRTMLRQPLAAGTAALLMGAALSLGVALLVRDEWQDAVHARFERRTARVTAMLRHELLAGVGIL
DSARGALALVPQMTPEQWTRYAESLDLDARHSPVRQLGYAPLSDATRAALAGHAPMPAGPLATATLSAPPSVAPVVRFGA
PDAQPLARTLRTGEVALGVHPADDDLSYDARTLTLFVPVAAARRAAGAPPGASDLEPDGILFAALSPQRLIDRALDAERG
IDLKIGAGSDPRPVVSAETTTDEAATSPSLLRRTEILNFGGTALTLAYSADGRPSATGAQRAAATVLAAGLLASIAFAVL
VHALMRSRAAAAGDAGAGSRHLNEARMMGIIRSSMEAIITIDEKQTVVIFNPMAEQVFGVSAMEAIGAPLSRFIPERFRA
AHAKHVDQFGVTGVSERQMGRQRVLFGLRANGEEFPIEASISQIRDGSGKLYTVMLRDITERLRAENAVRQSREELRELS
ANLQNVREEEKTRIARELHDDLGQQLTALKMDLSVVEQRLRAPAHAAPDASVLAHLQGMRKLIDATVASVRRIAADLRPV
MLDDLGLVPAIEWLANDFTNRYGIDVERHVETGGIAFTSAGATTLFRIVQEALTNVARHADATRVALRLDVEDGFCVLRV
ADNGHGAPPGGPAHEDKSFGLIGIRERAHMLGGTVTIDTAPARGFSITVALPLGNVEQDNPIS

Sequences:

>Translated_703_residues
MTARGTPTRGAREPARLRTMLRQPLAAGTAALLMGAALSLGVALLVRDEWQDAVHARFERRTARVTAMLRHELLAGVGIL
DSARGALALVPQMTPEQWTRYAESLDLDARHSPVRQLGYAPLSDATRAALAGHAPMPAGPLATATLSAPPSVAPVVRFGA
PDAQPLARTLRTGEVALGVHPADDDLSYDARTLTLFVPVAAARRAAGAPPGASDLEPDGILFAALSPQRLIDRALDAERG
IDLKIGAGSDPRPVVSAETTTDEAATSPSLLRRTEILNFGGTALTLAYSADGRPSATGAQRAAATVLAAGLLASIAFAVL
VHALMRSRAAAAGDAGAGSRHLNEARMMGIIRSSMEAIITIDEKQTVVIFNPMAEQVFGVSAMEAIGAPLSRFIPERFRA
AHAKHVDQFGVTGVSERQMGRQRVLFGLRANGEEFPIEASISQIRDGSGKLYTVMLRDITERLRAENAVRQSREELRELS
ANLQNVREEEKTRIARELHDDLGQQLTALKMDLSVVEQRLRAPAHAAPDASVLAHLQGMRKLIDATVASVRRIAADLRPV
MLDDLGLVPAIEWLANDFTNRYGIDVERHVETGGIAFTSAGATTLFRIVQEALTNVARHADATRVALRLDVEDGFCVLRV
ADNGHGAPPGGPAHEDKSFGLIGIRERAHMLGGTVTIDTAPARGFSITVALPLGNVEQDNPIS
>Mature_702_residues
TARGTPTRGAREPARLRTMLRQPLAAGTAALLMGAALSLGVALLVRDEWQDAVHARFERRTARVTAMLRHELLAGVGILD
SARGALALVPQMTPEQWTRYAESLDLDARHSPVRQLGYAPLSDATRAALAGHAPMPAGPLATATLSAPPSVAPVVRFGAP
DAQPLARTLRTGEVALGVHPADDDLSYDARTLTLFVPVAAARRAAGAPPGASDLEPDGILFAALSPQRLIDRALDAERGI
DLKIGAGSDPRPVVSAETTTDEAATSPSLLRRTEILNFGGTALTLAYSADGRPSATGAQRAAATVLAAGLLASIAFAVLV
HALMRSRAAAAGDAGAGSRHLNEARMMGIIRSSMEAIITIDEKQTVVIFNPMAEQVFGVSAMEAIGAPLSRFIPERFRAA
HAKHVDQFGVTGVSERQMGRQRVLFGLRANGEEFPIEASISQIRDGSGKLYTVMLRDITERLRAENAVRQSREELRELSA
NLQNVREEEKTRIARELHDDLGQQLTALKMDLSVVEQRLRAPAHAAPDASVLAHLQGMRKLIDATVASVRRIAADLRPVM
LDDLGLVPAIEWLANDFTNRYGIDVERHVETGGIAFTSAGATTLFRIVQEALTNVARHADATRVALRLDVEDGFCVLRVA
DNGHGAPPGGPAHEDKSFGLIGIRERAHMLGGTVTIDTAPARGFSITVALPLGNVEQDNPIS

Specific function: Member of the two-component regulatory system degS/degU. Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=239, Percent_Identity=36.4016736401674, Blast_Score=96, Evalue=8e-21,
Organism=Escherichia coli, GI1787474, Length=203, Percent_Identity=30.0492610837438, Blast_Score=86, Evalue=1e-17,
Organism=Escherichia coli, GI1788812, Length=204, Percent_Identity=26.4705882352941, Blast_Score=70, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 74856; Mature: 74725

Theoretical pI: Translated: 7.01; Mature: 7.01

Prosite motif: PS50112 PAS ; PS50113 PAC ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTARGTPTRGAREPARLRTMLRQPLAAGTAALLMGAALSLGVALLVRDEWQDAVHARFER
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHH
RTARVTAMLRHELLAGVGILDSARGALALVPQMTPEQWTRYAESLDLDARHSPVRQLGYA
HHHHHHHHHHHHHHHCCCHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHCCC
PLSDATRAALAGHAPMPAGPLATATLSAPPSVAPVVRFGAPDAQPLARTLRTGEVALGVH
CCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEEEECCCCHHHHHHHHHCCCEEEEEC
PADDDLSYDARTLTLFVPVAAARRAAGAPPGASDLEPDGILFAALSPQRLIDRALDAERG
CCCCCCCCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCC
IDLKIGAGSDPRPVVSAETTTDEAATSPSLLRRTEILNFGGTALTLAYSADGRPSATGAQ
CEEEECCCCCCCCEEECCCCCCHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHH
RAAATVLAAGLLASIAFAVLVHALMRSRAAAAGDAGAGSRHLNEARMMGIIRSSMEAIIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
IDEKQTVVIFNPMAEQVFGVSAMEAIGAPLSRFIPERFRAAHAKHVDQFGVTGVSERQMG
ECCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
RQRVLFGLRANGEEFPIEASISQIRDGSGKLYTVMLRDITERLRAENAVRQSREELRELS
HHHEEEEEECCCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLQNVREEEKTRIARELHDDLGQQLTALKMDLSVVEQRLRAPAHAAPDASVLAHLQGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
KLIDATVASVRRIAADLRPVMLDDLGLVPAIEWLANDFTNRYGIDVERHVETGGIAFTSA
HHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHEECCCCEEEECC
GATTLFRIVQEALTNVARHADATRVALRLDVEDGFCVLRVADNGHGAPPGGPAHEDKSFG
CHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCC
LIGIRERAHMLGGTVTIDTAPARGFSITVALPLGNVEQDNPIS
EEEEHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
TARGTPTRGAREPARLRTMLRQPLAAGTAALLMGAALSLGVALLVRDEWQDAVHARFER
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHHHHHHHHHHHH
RTARVTAMLRHELLAGVGILDSARGALALVPQMTPEQWTRYAESLDLDARHSPVRQLGYA
HHHHHHHHHHHHHHHCCCHHHCCCCCEEECCCCCHHHHHHHHHHCCCCCCCCHHHHHCCC
PLSDATRAALAGHAPMPAGPLATATLSAPPSVAPVVRFGAPDAQPLARTLRTGEVALGVH
CCCHHHHHHHCCCCCCCCCCCCEEECCCCCCCCCEEEECCCCHHHHHHHHHCCCEEEEEC
PADDDLSYDARTLTLFVPVAAARRAAGAPPGASDLEPDGILFAALSPQRLIDRALDAERG
CCCCCCCCCCEEEEEEEEHHHHHHHCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHCC
IDLKIGAGSDPRPVVSAETTTDEAATSPSLLRRTEILNFGGTALTLAYSADGRPSATGAQ
CEEEECCCCCCCCEEECCCCCCHHCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCCCHHH
RAAATVLAAGLLASIAFAVLVHALMRSRAAAAGDAGAGSRHLNEARMMGIIRSSMEAIIT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHCCCEEEE
IDEKQTVVIFNPMAEQVFGVSAMEAIGAPLSRFIPERFRAAHAKHVDQFGVTGVSERQMG
ECCCCEEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
RQRVLFGLRANGEEFPIEASISQIRDGSGKLYTVMLRDITERLRAENAVRQSREELRELS
HHHEEEEEECCCCCCCCHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANLQNVREEEKTRIARELHDDLGQQLTALKMDLSVVEQRLRAPAHAAPDASVLAHLQGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHH
KLIDATVASVRRIAADLRPVMLDDLGLVPAIEWLANDFTNRYGIDVERHVETGGIAFTSA
HHHHHHHHHHHHHHHHHCHHHHHHCCHHHHHHHHHHHHCCCCCCCHHHEECCCCEEEECC
GATTLFRIVQEALTNVARHADATRVALRLDVEDGFCVLRVADNGHGAPPGGPAHEDKSFG
CHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCCEEEEEEECCCCCCCCCCCCCCCCCCC
LIGIRERAHMLGGTVTIDTAPARGFSITVALPLGNVEQDNPIS
EEEEHHHHHHCCCEEEEECCCCCCEEEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 3141378; 3141377; 9384377; 3136143 [H]