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The map label for this gene is uvrY [H]

Identifier: 189353016

GI number: 189353016

Start: 1180502

End: 1181149

Strand: Reverse

Name: uvrY [H]

Synonym: BMULJ_04250

Alternate gene names: 189353016

Gene position: 1181149-1180502 (Counterclockwise)

Preceding gene: 189353017

Following gene: 189353009

Centisome position: 47.76

GC content: 66.82

Gene sequence:

>648_bases
ATGATCAAGGTGCTCATCGCCGACGACCATACGCTCGTGCGCGACGGTCTGCGGCACATCCTTCAGAACGCGACCGGTTT
CGAAGTGGCCGGCGAAGCGTGCGACGGCCCGTCGACGATCGCGCTCGTCCGCGCGACGCCCGCGCAGGTGCTCGTGCTCG
ACCTGTCGATGCCGGGCCGCAACGGCGTCGAGCTGATCAAGCAGATCAAGGACGAGAAACCCGCGCTGCGCGTGCTCGTG
CTGACGATGCACGCCGAACAGCAGTACGCGGTGCGCGCGTTCCGCGCGGGCGCGTCCGGCTATCTGACGAAGGAAAGTGC
GAGTGCGGAGCTCGTCGGCGCGGTCACGAAGGTCGCGTCCGGCGGCGTGTACGTCAGTCTCGCGATGGCCGAGCAGTTCG
CGCAAAGCCTCAACGAGCCGGCCGACACGCTGCCGCATCAGCGGCTGTCCGACCGCGAGTTCGACGTGTTCCGGCGCATC
GCGGCCGGCCAGACGCTGACCGAAATCGCGCAGGCGCTATGCGTGAGCGCGAAGACGGTCAGCACCTACAAGACGCGGAT
TCTGGAAAAGATGCAGATGCCGCACGAAGCGGCACTCGTGCGCTACGCGCTGCGGCACAAGCTCGTCGACGAGGCCGACG
ACATATGA

Upstream 100 bases:

>100_bases
TGCTCGGTGGCACCGTGACGATCGATACCGCGCCGGCGCGCGGCTTTTCGATCACCGTCGCCCTGCCGCTCGGCAACGTT
GAACAGGACAACCCCATCTC

Downstream 100 bases:

>100_bases
CGCGTGACGCGCGGGCGCGCGACCGCGCGTGTCGCTACTTCGCGGGCACCGGGCACGCGAGATCGCCCTCCTCGCACGAC
AGATACGCCTTCAGCGTTTC

Product: two-component system invasion response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 215; Mature: 215

Protein sequence:

>215_residues
MIKVLIADDHTLVRDGLRHILQNATGFEVAGEACDGPSTIALVRATPAQVLVLDLSMPGRNGVELIKQIKDEKPALRVLV
LTMHAEQQYAVRAFRAGASGYLTKESASAELVGAVTKVASGGVYVSLAMAEQFAQSLNEPADTLPHQRLSDREFDVFRRI
AAGQTLTEIAQALCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHKLVDEADDI

Sequences:

>Translated_215_residues
MIKVLIADDHTLVRDGLRHILQNATGFEVAGEACDGPSTIALVRATPAQVLVLDLSMPGRNGVELIKQIKDEKPALRVLV
LTMHAEQQYAVRAFRAGASGYLTKESASAELVGAVTKVASGGVYVSLAMAEQFAQSLNEPADTLPHQRLSDREFDVFRRI
AAGQTLTEIAQALCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHKLVDEADDI
>Mature_215_residues
MIKVLIADDHTLVRDGLRHILQNATGFEVAGEACDGPSTIALVRATPAQVLVLDLSMPGRNGVELIKQIKDEKPALRVLV
LTMHAEQQYAVRAFRAGASGYLTKESASAELVGAVTKVASGGVYVSLAMAEQFAQSLNEPADTLPHQRLSDREFDVFRRI
AAGQTLTEIAQALCVSAKTVSTYKTRILEKMQMPHEAALVRYALRHKLVDEADDI

Specific function: Member of the two-component regulatory system UvrY/BarA involved in the regulation of carbon metabolism via the CsrA/CsrB regulatory system. UvrY activates the transcription of the untranslated csrB RNA and of barA, in an autoregulatory loop. Mediates the

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788222, Length=211, Percent_Identity=37.4407582938389, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786747, Length=209, Percent_Identity=29.6650717703349, Blast_Score=102, Evalue=1e-23,
Organism=Escherichia coli, GI1790102, Length=201, Percent_Identity=31.3432835820896, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI1788712, Length=204, Percent_Identity=26.4705882352941, Blast_Score=98, Evalue=5e-22,
Organism=Escherichia coli, GI1788521, Length=201, Percent_Identity=31.8407960199005, Blast_Score=96, Evalue=2e-21,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=31.8627450980392, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1787473, Length=182, Percent_Identity=30.2197802197802, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI87082052, Length=111, Percent_Identity=36.036036036036, Blast_Score=67, Evalue=7e-13,
Organism=Escherichia coli, GI1788191, Length=119, Percent_Identity=32.7731092436975, Blast_Score=62, Evalue=3e-11,
Organism=Escherichia coli, GI1790299, Length=121, Percent_Identity=36.3636363636364, Blast_Score=61, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 23394; Mature: 23394

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKVLIADDHTLVRDGLRHILQNATGFEVAGEACDGPSTIALVRATPAQVLVLDLSMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEEECCCEEEEEEECCCCC
NGVELIKQIKDEKPALRVLVLTMHAEQQYAVRAFRAGASGYLTKESASAELVGAVTKVAS
CHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHC
GGVYVSLAMAEQFAQSLNEPADTLPHQRLSDREFDVFRRIAAGQTLTEIAQALCVSAKTV
CCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STYKTRILEKMQMPHEAALVRYALRHKLVDEADDI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIKVLIADDHTLVRDGLRHILQNATGFEVAGEACDGPSTIALVRATPAQVLVLDLSMPGR
CEEEEEECCHHHHHHHHHHHHCCCCCCEECCCCCCCCCEEEEEEECCCEEEEEEECCCCC
NGVELIKQIKDEKPALRVLVLTMHAEQQYAVRAFRAGASGYLTKESASAELVGAVTKVAS
CHHHHHHHHHCCCCHHEEEEEECCCCHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHC
GGVYVSLAMAEQFAQSLNEPADTLPHQRLSDREFDVFRRIAAGQTLTEIAQALCVSAKTV
CCEEEEHHHHHHHHHHHCCHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHH
STYKTRILEKMQMPHEAALVRYALRHKLVDEADDI
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]