| Definition | Orientia tsutsugamushi str. Ikeda, complete genome. |
|---|---|
| Accession | NC_010793 |
| Length | 2,008,987 |
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The map label for this gene is topA [H]
Identifier: 189184232
GI number: 189184232
Start: 1345500
End: 1347866
Strand: Reverse
Name: topA [H]
Synonym: OTT_1325
Alternate gene names: 189184232
Gene position: 1347866-1345500 (Counterclockwise)
Preceding gene: 189184233
Following gene: 189184231
Centisome position: 67.09
GC content: 30.8
Gene sequence:
>2367_bases ATGAAATTATTAATTGTAGAATCTCCAGCAAAGGCTAAAACCATAAATAAATATTTAGGTTCAGACTTTCAAGTAGTAGC ATCTTATGGGCACGTAAGAGATCTACTTGCAAAAGCAGGATCAGTACTGCCAGAGCAAGATTTTTTAATTAAATACGAAA TTAATCCAAAATCCACTCGACATATTAAAACCATTTGCGATCTTGCTAAAAAATCAGAATGTATTTATTTAGCAACTGAC CCTGATCGAGAAGGAGAATCAATTTCTTGGCATATTGTAGAAGTACTAAAAGAAAAAAAGATTTTTGCTAATTTTAAAAG AATAATATTTAATGAAATTACTAAAAAAGCTATAGGTGATGCACTACAACAGCCACGCGATATTAATTTAAACTTAGTAA ATGCTCAACAAGCTAGACGATCATTAGACTATCTAGTAGGATTTAGCCTTTCCCCTTTGCTATGGCGTAAATTACCAGGC TGTAAGTCAGCTGGACGAGTACAATCCGTAGGACTCAGGCTAATTTGTGAACGCGAAGAAGAAATATCAAAATTTATATC TCAAGAATATTGGAATATTCACATTGATATGATTAGCAACAAAGATGAAATAGTAACAGCGAAACTAATAGAATTTGATG GCAATAAATTAGAAAAGTTCTCCATCACTAATCAATCCCAAGCTCAAGATATCGTTAAGAATATTGAAAATCAACAATTC AAAGTTATTGACATTACCAGAAAACAAAGAAAAAAATCCCCTCCTCCACCATTTATTACTTCTTCTTTACAACAAGAAGC TGCTGGTAAATTAGGATTTACAGCCAAAAAAACTATGACTATTGCTCAAAAGCTTTATGAAGGAATTGATCTAAATAATG AATCTACTGCTCTAATTACCTATATGAGAACTGATAGTGTAATGCTGTCTAAAGATTTCATTGATGAAACTAGAAACTTT ATTAGTTCAAGCTTTGGTAGTAATTATTTACCTAAACAAATTAGAGCATTTAAATCAAAAGTTAAAAATGCACAAGAAGC TCATGAAGCTATTAGACCTATTAACATTAACTTAACACCAGAGTTGCTATTAAACAAAATTGAAAAAGATTATCTAAAAT TATATGAATTAATTTGGCAACGTACAGTAGCTTGCCAAATGGAAAATGTAATTCTAAACTTAGAATCAATTAATTTTGCT AGTTTTAATCAACTACATGTAGCTAAAGCTACTGGTTCAACCATAGCTTTTGATGGTTTCTATAAAGTTTACAAAGAAAT TAATGACGAAGAAGAAAATAAAAAACTACTACCTAATCTAAGCCAAAATGAAGTGATGCAAGTAAAAAATATTTTGCCAA AACAACATTTTACTGAACCTCCTCCTCGTTATTCTGAGGCTACACTAGTCAAAACCCTTGAAGATCTTGGAATTGGTAGA CCATCAACGTACGCCACAATTATATCTGTATTACAAGAAAGAGATTATGTTATTCTAGACCAAAAACGTTTCATACCACA AAATAAAGGAAGGTTAGTTACAGCATTCTTAACTGCATTTTTTAAAAAGTATGTTGAATATGACTTTACAGCTAAGCTTG AGGACCAACTTGATAGCATTGCTAAAGGAATGATTGAATGGCAAGAAATACTCAAAAACTTTTGGACTGGATTTAATAAT AACGTACAAGAAATAGAGCAATATAAAATTACAGATATAATACCTCAGATAGAAACATTATTATCTAACTTTCTATTTCC AGCACAAAATGATGAAACTGATCATAAATTGTGTACTCTCTGCAAAGTAGGTAAGTTATCGTTAAAACTAAGCAAATATG GAGCATTTTTAGCCTGTGATAATTATCCTAGCTGTAATTTTACTCGCAATATTGCAGCTGCTTTTGAAAATAATGATAAT CTACCTAAAGGTAAAAATAATAAAGCAATTGGTTACTCAGATGATATGCAAAAAACAATATACCTTAAAGAAGGACCTTT TGGTTGGTATATTCAAGCAGGAGAAGATAGTACTAATAAAAATGATAAGCCAAAAAGAGTGCCAATATCTGTAATTAGCA GTAGTCCACAGGATATAACATTAGAAACAGCAGTAAAATTGCTTGCATTACCTAAAGTAATTGGATTAAATCCCAATACT AACAAAGAAATCACTGTAGCTGTTGGCAGATATGGTCCATACTTGAAACACGATGGAAAGTTTATTTCAATACCCAAAAA TTATGATTATCTTAATTTATCAATTAATGACTGCATAAAAATAATTACAAGCTCTTCATCTCAATTACGCAAAGCCAAAA AAGATGCACCTACTAACTCTGATAAAGTTGCTAAATCAAAATCTTAA
Upstream 100 bases:
>100_bases AATTATAATCAATTGTGCTGTAGAAAAATTATTAAAATAAATATAACCTTTAAACACTTTTATACTTTAAAGTTAATAAA TACAAATCTTTGAATTAAAA
Downstream 100 bases:
>100_bases TGAGAATAAAATTAGTCAATAACTCAGCATATATAAAGCAATTAGGCATTGTCATTATCATAGCTAAAATCATATATTCT ACAATATTATTTTGTGTAGA
Product: DNA topoisomerase I
Products: NA
Alternate protein names: DNA topoisomerase I; Omega-protein; Relaxing enzyme; Swivelase; Untwisting enzyme [H]
Number of amino acids: Translated: 788; Mature: 788
Protein sequence:
>788_residues MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATD PDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPG CKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQF KVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNF ISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFA SFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGR PSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIEWQEILKNFWTGFNN NVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTLCKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDN LPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNT NKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNSDKVAKSKS
Sequences:
>Translated_788_residues MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATD PDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPG CKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQF KVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNF ISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFA SFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGR PSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIEWQEILKNFWTGFNN NVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTLCKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDN LPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNT NKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNSDKVAKSKS >Mature_788_residues MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTRHIKTICDLAKKSECIYLATD PDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGDALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPG CKSAGRVQSVGLRLICEREEEISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQF KVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALITYMRTDSVMLSKDFIDETRNF ISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTPELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFA SFNQLHVAKATGSTIAFDGFYKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGR PSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSIAKGMIEWQEILKNFWTGFNN NVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTLCKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDN LPKGKNNKAIGYSDDMQKTIYLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNT NKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNSDKVAKSKS
Specific function: The reaction catalyzed by topoisomerases leads to the conversion of one topological isomer of DNA to another [H]
COG id: COG0550
COG function: function code L; Topoisomerase IA
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 Toprim domain [H]
Homologues:
Organism=Homo sapiens, GI10835218, Length=594, Percent_Identity=24.4107744107744, Blast_Score=116, Evalue=1e-25, Organism=Homo sapiens, GI4507635, Length=579, Percent_Identity=21.9343696027634, Blast_Score=99, Evalue=2e-20, Organism=Escherichia coli, GI1787529, Length=649, Percent_Identity=38.9830508474576, Blast_Score=456, Evalue=1e-129, Organism=Escherichia coli, GI1788061, Length=651, Percent_Identity=23.963133640553, Blast_Score=114, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17555378, Length=536, Percent_Identity=25.3731343283582, Blast_Score=121, Evalue=2e-27, Organism=Caenorhabditis elegans, GI32563869, Length=561, Percent_Identity=22.9946524064171, Blast_Score=120, Evalue=4e-27, Organism=Saccharomyces cerevisiae, GI6323263, Length=477, Percent_Identity=24.3186582809224, Blast_Score=108, Evalue=2e-24, Organism=Drosophila melanogaster, GI24585251, Length=597, Percent_Identity=23.785594639866, Blast_Score=124, Evalue=3e-28,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR003601 - InterPro: IPR013497 - InterPro: IPR013824 - InterPro: IPR013825 - InterPro: IPR000380 - InterPro: IPR003602 - InterPro: IPR013498 - InterPro: IPR005733 - InterPro: IPR006171 [H]
Pfam domain/function: PF01131 Topoisom_bac; PF01751 Toprim; PF01396 zf-C4_Topoisom [H]
EC number: =5.99.1.2 [H]
Molecular weight: Translated: 89602; Mature: 89602
Theoretical pI: Translated: 9.31; Mature: 9.31
Prosite motif: PS00396 TOPOISOMERASE_I_PROK
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.3 %Cys (Translated Protein) 1.1 %Met (Translated Protein) 2.4 %Cys+Met (Translated Protein) 1.3 %Cys (Mature Protein) 1.1 %Met (Mature Protein) 2.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTR CEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHH HIKTICDLAKKSECIYLATDPDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGD HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPGCKSAGRVQSVGLRLICEREE HHCCCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHCCHHEEECCHH EISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQF HHHHHHHHCCCEEEEEEECCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCE KVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALIT EEEEEEHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE YMRTDSVMLSKDFIDETRNFISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTP EEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEECCCCH ELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGF HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCCCEEEEHHH YKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGR HHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCC PSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSI CHHHHHHHHHHHCCCEEEEECHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH AKGMIEWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTL HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH CKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTI HHHCCCEEEEECCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE YLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNT EEEECCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCC NKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNS CCEEEEEEECCCCCEECCCEEEECCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCC DKVAKSKS CCCCCCCC >Mature Secondary Structure MKLLIVESPAKAKTINKYLGSDFQVVASYGHVRDLLAKAGSVLPEQDFLIKYEINPKSTR CEEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCHH HIKTICDLAKKSECIYLATDPDREGESISWHIVEVLKEKKIFANFKRIIFNEITKKAIGD HHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ALQQPRDINLNLVNAQQARRSLDYLVGFSLSPLLWRKLPGCKSAGRVQSVGLRLICEREE HHCCCCCCCEEEECHHHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCHHHCCHHEEECCHH EISKFISQEYWNIHIDMISNKDEIVTAKLIEFDGNKLEKFSITNQSQAQDIVKNIENQQF HHHHHHHHCCCEEEEEEECCCCCEEEEEEEECCCCCEEEEECCCHHHHHHHHHHCCCCCE KVIDITRKQRKKSPPPPFITSSLQQEAAGKLGFTAKKTMTIAQKLYEGIDLNNESTALIT EEEEEEHHHHCCCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEE YMRTDSVMLSKDFIDETRNFISSSFGSNYLPKQIRAFKSKVKNAQEAHEAIRPININLTP EEECCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCHHHHHHHHCCEECCCCH ELLLNKIEKDYLKLYELIWQRTVACQMENVILNLESINFASFNQLHVAKATGSTIAFDGF HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCEEEEECCCCEEEEHHH YKVYKEINDEEENKKLLPNLSQNEVMQVKNILPKQHFTEPPPRYSEATLVKTLEDLGIGR HHHHHHHCCCCCCHHHCCCCCHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHHHHHHCCCC PSTYATIISVLQERDYVILDQKRFIPQNKGRLVTAFLTAFFKKYVEYDFTAKLEDQLDSI CHHHHHHHHHHHCCCEEEEECHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH AKGMIEWQEILKNFWTGFNNNVQEIEQYKITDIIPQIETLLSNFLFPAQNDETDHKLCTL HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH CKVGKLSLKLSKYGAFLACDNYPSCNFTRNIAAAFENNDNLPKGKNNKAIGYSDDMQKTI HHHCCCEEEEECCCCEEEECCCCCCCCHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEE YLKEGPFGWYIQAGEDSTNKNDKPKRVPISVISSSPQDITLETAVKLLALPKVIGLNPNT EEEECCCEEEEECCCCCCCCCCCCCCCEEEEECCCCCCEEHHHHHHHHHHHHHCCCCCCC NKEITVAVGRYGPYLKHDGKFISIPKNYDYLNLSINDCIKIITSSSSQLRKAKKDAPTNS CCEEEEEEECCCCCEECCCEEEECCCCCCEEEEEHHHHHHHHHCCHHHHHHHHHCCCCCC DKVAKSKS CCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA