Click here to switch to the map view.

The map label for this gene is ctaB [H]

Identifier: 189184102

GI number: 189184102

Start: 1223524

End: 1224462

Strand: Reverse

Name: ctaB [H]

Synonym: OTT_1195

Alternate gene names: 189184102

Gene position: 1224462-1223524 (Counterclockwise)

Preceding gene: 189184103

Following gene: 189184097

Centisome position: 60.95

GC content: 30.56

Gene sequence:

>939_bases
ATGCCAAACTCACATAGTACACAAAGTACTCCTGTTAAAAATTTTCAAAATAAGTTTCTAGTATTAACTTCTACTCCAAA
AGATTTTTTACTGTTAATGAAACCTAGTGTAATGCTTTTGGCTGTTTTCACTGCAATCACTGGCTTATTTATTGCACCTA
ATAAAATTCATCCTTTATTATCATCAATTGCAATTTTGTGCATTAGCACAGGAGCAGGAGCAGCAGGTGCTATCAACATG
TGGTATGATGCTGATATCGATAGTATCATGAAACGAACACGTAACCGCCCTACTGTTACAGGTAAAATTCCCCCCAGTAC
CGCCCTTACATTTGGTATCATTTTAGCATTTTTTTCTGTATTAGTAATGGCCATATGCGTAAATTACATATCTAGCATTT
TATTATTAATTTCTATTAGCTTTTACATTATAGTGTATACTATGTGGTTAAAAAGAAGGACTGCCCAAAACATTGTTATT
GGTGGAGCTGCAGGGGCATTACCTCCAGTAATAGGTTATAGCGCTGTTACTAATAGTATAGATACTACATGTTTAATGCT
ATTTTTAATAATATTTTTGTGGACACCGGCACATTTCTGGACATTATCATTATATTATACCAATGATTATAAACTAGCTA
ATGTACCAATCTTACCATTAGTTAAAGGCATTAATTATACCAAATACAGTATATTAGCGTATACATTTTTAACTGTTATT
TCTGCTTCCCTACCCTATTTTACTGATATAGCAGGCTTGCTATATTTAATATGCTCTACTATCTCTGGGATTATATTTTT
ATGTTATGCTAGTATGTTATTTAATGATAGAAACAACATACTAGCTCGAAAAATGTTTAAATATTCAATAATTTACTTAT
TTAATATCTTTCTATATCTAATTATAGAACATTGTATAAAGCATTTTAATATTTCTTAA

Upstream 100 bases:

>100_bases
GGAGCTACAACTCTAGAATGGAGCTTAGAATCCCCTCCACCTTATCATTGCTTTCAAGACCCACCAAAAATTGAGAATGT
AGATCACTAAGAAGAGTAAT

Downstream 100 bases:

>100_bases
CTAATCACTGAGCCTGGCATCATATATTAGCCAAGATTCGATCTATAACATTCATGTATTTTGAAGTATAAATCTCTTAT
AGTTGTTTTGCTACGACTTT

Product: protoheme IX farnesyltransferase

Products: NA

Alternate protein names: Heme B farnesyltransferase; Heme O synthase [H]

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MPNSHSTQSTPVKNFQNKFLVLTSTPKDFLLLMKPSVMLLAVFTAITGLFIAPNKIHPLLSSIAILCISTGAGAAGAINM
WYDADIDSIMKRTRNRPTVTGKIPPSTALTFGIILAFFSVLVMAICVNYISSILLLISISFYIIVYTMWLKRRTAQNIVI
GGAAGALPPVIGYSAVTNSIDTTCLMLFLIIFLWTPAHFWTLSLYYTNDYKLANVPILPLVKGINYTKYSILAYTFLTVI
SASLPYFTDIAGLLYLICSTISGIIFLCYASMLFNDRNNILARKMFKYSIIYLFNIFLYLIIEHCIKHFNIS

Sequences:

>Translated_312_residues
MPNSHSTQSTPVKNFQNKFLVLTSTPKDFLLLMKPSVMLLAVFTAITGLFIAPNKIHPLLSSIAILCISTGAGAAGAINM
WYDADIDSIMKRTRNRPTVTGKIPPSTALTFGIILAFFSVLVMAICVNYISSILLLISISFYIIVYTMWLKRRTAQNIVI
GGAAGALPPVIGYSAVTNSIDTTCLMLFLIIFLWTPAHFWTLSLYYTNDYKLANVPILPLVKGINYTKYSILAYTFLTVI
SASLPYFTDIAGLLYLICSTISGIIFLCYASMLFNDRNNILARKMFKYSIIYLFNIFLYLIIEHCIKHFNIS
>Mature_311_residues
PNSHSTQSTPVKNFQNKFLVLTSTPKDFLLLMKPSVMLLAVFTAITGLFIAPNKIHPLLSSIAILCISTGAGAAGAINMW
YDADIDSIMKRTRNRPTVTGKIPPSTALTFGIILAFFSVLVMAICVNYISSILLLISISFYIIVYTMWLKRRTAQNIVIG
GAAGALPPVIGYSAVTNSIDTTCLMLFLIIFLWTPAHFWTLSLYYTNDYKLANVPILPLVKGINYTKYSILAYTFLTVIS
ASLPYFTDIAGLLYLICSTISGIIFLCYASMLFNDRNNILARKMFKYSIIYLFNIFLYLIIEHCIKHFNIS

Specific function: Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group [H]

COG id: COG0109

COG function: function code O; Polyprenyltransferase (cytochrome oxidase assembly factor)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ubiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily [H]

Homologues:

Organism=Homo sapiens, GI17921982, Length=209, Percent_Identity=32.0574162679426, Blast_Score=96, Evalue=3e-20,
Organism=Escherichia coli, GI1786631, Length=267, Percent_Identity=29.9625468164794, Blast_Score=127, Evalue=8e-31,
Organism=Caenorhabditis elegans, GI71998235, Length=270, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6325085, Length=304, Percent_Identity=28.6184210526316, Blast_Score=90, Evalue=4e-19,
Organism=Drosophila melanogaster, GI19921064, Length=274, Percent_Identity=25.9124087591241, Blast_Score=94, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006369
- InterPro:   IPR000537 [H]

Pfam domain/function: PF01040 UbiA [H]

EC number: 2.5.1.-

Molecular weight: Translated: 34821; Mature: 34690

Theoretical pI: Translated: 9.66; Mature: 9.66

Prosite motif: PS00943 UBIA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNSHSTQSTPVKNFQNKFLVLTSTPKDFLLLMKPSVMLLAVFTAITGLFIAPNKIHPLL
CCCCCCCCCCCHHHHCCCEEEEECCCHHHEEHHCHHHHHHHHHHHHHHHHCCCCHHHHHH
SSIAILCISTGAGAAGAINMWYDADIDSIMKRTRNRPTVTGKIPPSTALTFGIILAFFSV
HHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
LVMAICVNYISSILLLISISFYIIVYTMWLKRRTAQNIVIGGAAGALPPVIGYSAVTNSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCH
DTTCLMLFLIIFLWTPAHFWTLSLYYTNDYKLANVPILPLVKGINYTKYSILAYTFLTVI
HHHHHHHHHHHHHHCCCHHEEEEEEEECCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHH
SASLPYFTDIAGLLYLICSTISGIIFLCYASMLFNDRNNILARKMFKYSIIYLFNIFLYL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IIEHCIKHFNIS
HHHHHHHHCCCC
>Mature Secondary Structure 
PNSHSTQSTPVKNFQNKFLVLTSTPKDFLLLMKPSVMLLAVFTAITGLFIAPNKIHPLL
CCCCCCCCCCHHHHCCCEEEEECCCHHHEEHHCHHHHHHHHHHHHHHHHCCCCHHHHHH
SSIAILCISTGAGAAGAINMWYDADIDSIMKRTRNRPTVTGKIPPSTALTFGIILAFFSV
HHHHHHHHCCCCCCCCEEEEEECCCHHHHHHHHCCCCEEECCCCCHHHHHHHHHHHHHHH
LVMAICVNYISSILLLISISFYIIVYTMWLKRRTAQNIVIGGAAGALPPVIGYSAVTNSI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCHHHHHHHHHCCH
DTTCLMLFLIIFLWTPAHFWTLSLYYTNDYKLANVPILPLVKGINYTKYSILAYTFLTVI
HHHHHHHHHHHHHHCCCHHEEEEEEEECCEEEECCCHHHHHHCCCCHHHHHHHHHHHHHH
SASLPYFTDIAGLLYLICSTISGIIFLCYASMLFNDRNNILARKMFKYSIIYLFNIFLYL
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHH
IIEHCIKHFNIS
HHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA