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The map label for this gene is coxA [H]

Identifier: 189184103

GI number: 189184103

Start: 1224473

End: 1226059

Strand: Reverse

Name: coxA [H]

Synonym: OTT_1196

Alternate gene names: 189184103

Gene position: 1226059-1224473 (Counterclockwise)

Preceding gene: 189184104

Following gene: 189184102

Centisome position: 61.03

GC content: 35.66

Gene sequence:

>1587_bases
ATGAGCAGCAAACATAGTGATACTCCTCGTGGATGGCGCAGATGGTTATTATCAACTAACCATAAAGATATAGGCAGTAT
GTATTTAATATTTGCAATTTTAGCAGGACTAATTGGAGGATTGTTCTCATTTATTTTTAGATTGCAATTAGCAGTACCTG
GAAGCAATTTTTTAGGGGGCAATTTTCAACTTTTTAATGTATTAATTACAGCTCATGCTATAATAATGGTATTCTTTATG
ATTATGCCAGCTCTATTTGGCGGCTTTGGAAATTGGTTCGTACCATTAATGATTGGAGCTCCAGATGTTGCTTTTCCAAG
ATTAAATAATATTAGCTTTTGGCTATTAGTACCAGCTTTTATTTTGCTTATTGCATCAGTTTTTGTTGACGAGGGAGCTG
GTACTGGCTGGACTCTATATCCTCCTTTAAGTAGTAGTTTAAGCCATCCAGGAGCTGCTGTTGACATGGTAATTTTTAGC
TTACATTTAGTTGGACTATCTTCTATCCTTGGATCAATGAACCTTATAGTAACAATTTTTAATATGAGAGCCCCAGGCAT
GGGATTATTACAAATTCCATTGTTTGTATGGTCAATACTAATTACTGCATTTCTATTAATTATAGTAATTCCAGTTCTAG
GAGGAGCTATTACAATGCTATTAATGGATCGTAACTTCAATACCTCATTTTTTGTTCCATCAGGTGGTGGAGATCCAGTA
TTATTTCAGCACTTATTTTGGTTTTTTGGTCACCCTGAAGTATATATAGTTATTTTACCAGGGTTTGGAGTTATTAGCCA
CGTTATATCAACTTTTTCTAAAAAGCCAATATTTGGCTATTTAGGTATGGTAGGGGCAATGATTGCCATTGGAGTAATCG
GCACATTAGTATGGGCTCACCACATGTTTACGGTTGGATTATCGCCGCAAGCCTTAATATTTTTTACTGCAGGGTCAATG
ATTATAGCTTTGCCAACTGGAATCAAAATCTTCAGCTGGCTAGCAACTATGTGGGGAGGATCAATTGAATTTAAGACTCC
AATGCTATTTAGTATAGGATTTATTATATTATTTACTATTGGAGGAGTAACTGGAGTAGTATTAGCTAACTCATCAATTG
ACAGAGTATTACACGATACATATTATGTAGTAGCTCACTTTCATTACACAATGTCCTTGGGAGCATTGTTTTCGGCATTC
GCTGGATTTTATTACTGGATCGGAAAAATATCAGGTCGACAATATCCAGAAATACTTGGAAAAATTCACTTTTGGATAAC
TTTTATCGGAGTTAATCTTACTTTTTTTCCTCAACATTTTTTAGGACTTGCTGGTATGCCAAGAAGAATTCCAGATTATC
CTGATGCTTTTGCTGGCTGGAATATGGTATCATCCATAGGTTCTACAATTTCAATAATCGCTGCATTCTTTTTTATCTAC
ATAGCAATCTACACAATATTCTATGGTAAAAAATGCCCAGCTAATCCATGGGGACAAGGAGCTACAACTCTAGAATGGAG
CTTAGAATCCCCTCCACCTTATCATTGCTTTCAAGACCCACCAAAAATTGAGAATGTAGATCACTAA

Upstream 100 bases:

>100_bases
TACATTAAATATTTTTTTGATATAGTTATCCTATAACATTTTAGATAATATGCTTATTATTAACTTAAGTAACTAATTTA
AAATAATTAAATCAAATACT

Downstream 100 bases:

>100_bases
GAAGAGTAATATGCCAAACTCACATAGTACACAAAGTACTCCTGTTAAAAATTTTCAAAATAAGTTTCTAGTATTAACTT
CTACTCCAAAAGATTTTTTA

Product: cytochrome c oxidase polypeptide I

Products: NA

Alternate protein names: Cytochrome aa3 subunit 1; Cytochrome c oxidase polypeptide I [H]

Number of amino acids: Translated: 528; Mature: 527

Protein sequence:

>528_residues
MSSKHSDTPRGWRRWLLSTNHKDIGSMYLIFAILAGLIGGLFSFIFRLQLAVPGSNFLGGNFQLFNVLITAHAIIMVFFM
IMPALFGGFGNWFVPLMIGAPDVAFPRLNNISFWLLVPAFILLIASVFVDEGAGTGWTLYPPLSSSLSHPGAAVDMVIFS
LHLVGLSSILGSMNLIVTIFNMRAPGMGLLQIPLFVWSILITAFLLIIVIPVLGGAITMLLMDRNFNTSFFVPSGGGDPV
LFQHLFWFFGHPEVYIVILPGFGVISHVISTFSKKPIFGYLGMVGAMIAIGVIGTLVWAHHMFTVGLSPQALIFFTAGSM
IIALPTGIKIFSWLATMWGGSIEFKTPMLFSIGFIILFTIGGVTGVVLANSSIDRVLHDTYYVVAHFHYTMSLGALFSAF
AGFYYWIGKISGRQYPEILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNMVSSIGSTISIIAAFFFIY
IAIYTIFYGKKCPANPWGQGATTLEWSLESPPPYHCFQDPPKIENVDH

Sequences:

>Translated_528_residues
MSSKHSDTPRGWRRWLLSTNHKDIGSMYLIFAILAGLIGGLFSFIFRLQLAVPGSNFLGGNFQLFNVLITAHAIIMVFFM
IMPALFGGFGNWFVPLMIGAPDVAFPRLNNISFWLLVPAFILLIASVFVDEGAGTGWTLYPPLSSSLSHPGAAVDMVIFS
LHLVGLSSILGSMNLIVTIFNMRAPGMGLLQIPLFVWSILITAFLLIIVIPVLGGAITMLLMDRNFNTSFFVPSGGGDPV
LFQHLFWFFGHPEVYIVILPGFGVISHVISTFSKKPIFGYLGMVGAMIAIGVIGTLVWAHHMFTVGLSPQALIFFTAGSM
IIALPTGIKIFSWLATMWGGSIEFKTPMLFSIGFIILFTIGGVTGVVLANSSIDRVLHDTYYVVAHFHYTMSLGALFSAF
AGFYYWIGKISGRQYPEILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNMVSSIGSTISIIAAFFFIY
IAIYTIFYGKKCPANPWGQGATTLEWSLESPPPYHCFQDPPKIENVDH
>Mature_527_residues
SSKHSDTPRGWRRWLLSTNHKDIGSMYLIFAILAGLIGGLFSFIFRLQLAVPGSNFLGGNFQLFNVLITAHAIIMVFFMI
MPALFGGFGNWFVPLMIGAPDVAFPRLNNISFWLLVPAFILLIASVFVDEGAGTGWTLYPPLSSSLSHPGAAVDMVIFSL
HLVGLSSILGSMNLIVTIFNMRAPGMGLLQIPLFVWSILITAFLLIIVIPVLGGAITMLLMDRNFNTSFFVPSGGGDPVL
FQHLFWFFGHPEVYIVILPGFGVISHVISTFSKKPIFGYLGMVGAMIAIGVIGTLVWAHHMFTVGLSPQALIFFTAGSMI
IALPTGIKIFSWLATMWGGSIEFKTPMLFSIGFIILFTIGGVTGVVLANSSIDRVLHDTYYVVAHFHYTMSLGALFSAFA
GFYYWIGKISGRQYPEILGKIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNMVSSIGSTISIIAAFFFIYI
AIYTIFYGKKCPANPWGQGATTLEWSLESPPPYHCFQDPPKIENVDH

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=514, Percent_Identity=58.5603112840467, Blast_Score=583, Evalue=1e-166,
Organism=Escherichia coli, GI1786634, Length=523, Percent_Identity=41.6826003824092, Blast_Score=376, Evalue=1e-105,
Organism=Saccharomyces cerevisiae, GI6226519, Length=528, Percent_Identity=57.9545454545455, Blast_Score=613, Evalue=1e-176,
Organism=Saccharomyces cerevisiae, GI6226524, Length=322, Percent_Identity=62.111801242236, Blast_Score=417, Evalue=1e-117,
Organism=Saccharomyces cerevisiae, GI6226523, Length=247, Percent_Identity=57.4898785425101, Blast_Score=280, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6226521, Length=66, Percent_Identity=54.5454545454545, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6226522, Length=79, Percent_Identity=51.8987341772152, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6226520, Length=54, Percent_Identity=55.5555555555556, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 58170; Mature: 58038

Theoretical pI: Translated: 8.60; Mature: 8.60

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKHSDTPRGWRRWLLSTNHKDIGSMYLIFAILAGLIGGLFSFIFRLQLAVPGSNFLGG
CCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NFQLFNVLITAHAIIMVFFMIMPALFGGFGNWFVPLMIGAPDVAFPRLNNISFWLLVPAF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHEECCCCCCCCCCCCCHHHHHHHHH
ILLIASVFVDEGAGTGWTLYPPLSSSLSHPGAAVDMVIFSLHLVGLSSILGSMNLIVTIF
HHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEE
NMRAPGMGLLQIPLFVWSILITAFLLIIVIPVLGGAITMLLMDRNFNTSFFVPSGGGDPV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHH
LFQHLFWFFGHPEVYIVILPGFGVISHVISTFSKKPIFGYLGMVGAMIAIGVIGTLVWAH
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HMFTVGLSPQALIFFTAGSMIIALPTGIKIFSWLATMWGGSIEFKTPMLFSIGFIILFTI
HHHEECCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
GGVTGVVLANSSIDRVLHDTYYVVAHFHYTMSLGALFSAFAGFYYWIGKISGRQYPEILG
HCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNMVSSIGSTISIIAAFFFIY
HHHHHHHHHHCCCEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAIYTIFYGKKCPANPWGQGATTLEWSLESPPPYHCFQDPPKIENVDH
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SSKHSDTPRGWRRWLLSTNHKDIGSMYLIFAILAGLIGGLFSFIFRLQLAVPGSNFLGG
CCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
NFQLFNVLITAHAIIMVFFMIMPALFGGFGNWFVPLMIGAPDVAFPRLNNISFWLLVPAF
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHEECCCCCCCCCCCCCHHHHHHHHH
ILLIASVFVDEGAGTGWTLYPPLSSSLSHPGAAVDMVIFSLHLVGLSSILGSMNLIVTIF
HHHHHHHHHHCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCHHHEEEEE
NMRAPGMGLLQIPLFVWSILITAFLLIIVIPVLGGAITMLLMDRNFNTSFFVPSGGGDPV
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEEEECCCCCHH
LFQHLFWFFGHPEVYIVILPGFGVISHVISTFSKKPIFGYLGMVGAMIAIGVIGTLVWAH
HHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
HMFTVGLSPQALIFFTAGSMIIALPTGIKIFSWLATMWGGSIEFKTPMLFSIGFIILFTI
HHHEECCCCCEEEEEECCCEEEEECCHHHHHHHHHHHHCCCEEECCCHHHHHHHHHHHHH
GGVTGVVLANSSIDRVLHDTYYVVAHFHYTMSLGALFSAFAGFYYWIGKISGRQYPEILG
HCHHEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHH
KIHFWITFIGVNLTFFPQHFLGLAGMPRRIPDYPDAFAGWNMVSSIGSTISIIAAFFFIY
HHHHHHHHHHCCCEEHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
IAIYTIFYGKKCPANPWGQGATTLEWSLESPPPYHCFQDPPKIENVDH
HHHHHHHCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]