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The map label for this gene is bcr2 [H]

Identifier: 189183544

GI number: 189183544

Start: 667002

End: 668207

Strand: Reverse

Name: bcr2 [H]

Synonym: OTT_0637

Alternate gene names: 189183544

Gene position: 668207-667002 (Counterclockwise)

Preceding gene: 189183545

Following gene: 189183543

Centisome position: 33.26

GC content: 30.93

Gene sequence:

>1206_bases
ATGCAGAATGATATAATGAAATATAATTTAACAATAGTCACTGTATTAATATTCATTACACAGTTAGCAGTTGATATTTA
TATACCTGGATTACCTAGAATAGCAAACGCATTTAACGTTCCAGAACATAAAGTAATGTGGACTGTAAGCTTAAATTTAA
TAGGATTATCACTATCAGGATTAGTATATGGCCCATTATCTGATGCAATAGGTCGTAAGAAAGCTTTATTACTAGGAACA
ACTATTTTTTGTTTTTCTAGTTTCTTTTGCATATACTCTAGGTCTATTGAATTGGTTGCATTTTGGATACTTTTACAAGG
CATTGGAGCAGGAGCAGCTATACCAGTAAGTTTCGCATCCATAAGCGACATATACAAAGGCAATGAACAAGCAAAAATAA
TGTCACGTCTACATATGATAATGGCCTTTTCGCCGGTACTTGGCCCAGTAATTGGCAATAGAATATCTTCATATGATGAT
AGGTGGTATTTGCCAATAGCAGTTGTTCCTATGATTGCTTTTCCGGCTTTATTGTTATTGATAACTATATTTAAAGAAAC
TTTAACCGTAATAACCAAAAAATTTGATTTTAATAATCTTAAAGTCGGCTTTAAGAATGCGCTTGTTAATAAAAATTTTG
TATGCTATTCACTCATTCAATCTTTAACATTTTTGTGGTTATGGGCAGATTCAGTAATTTTACCTTTCATTTTTAAAGAC
ATGAATATTCCAAGTAGATATTACGAGTACTATATTATAGCATGTATTGGGACTTTTATGATAGCTTCTATAATTAATCA
AAAGTTAGTGATATTACATGGAGCAGAAAAAATGTTATTTTATGGAGTTATATTTGTATTATTTGGCGGCATATTATCAA
CCTTTAGCTTTACATACTTTGCTGCAAAGTTGCATATAGTTTTATTACTCAAACTAATAGCATCGTTTGGAATTGGATTT
ATTTTAGGTAATGCAGCAGCACTATCTGTAGCAACAATTACCAATTACGGAGCTGCAGTTGCACTACTAAGTTCAGCAGA
AATGCTTTTTGGTTCATTAGGAGTAGAAATGGCAGGCTATTTTTACAATGGAACAATATTACCAGTTCTATTATTCATAA
TAGCAACTTCATTAACTTCTTTATTGATTCTTAAGTGTTATAGCATAATACGCAAAAGTAGTAGTTACACATTTTGTAAA
ATGTAA

Upstream 100 bases:

>100_bases
ATAAAAAATAGTATAACTAATCTATTAATACTTAAGTGTACTGCATATTGTTTAAAGTTTATAAAATACTGTTAGTTAAT
TAAGTTTTATAGGAAATAAT

Downstream 100 bases:

>100_bases
ACAACAACATTAAAAAAAGTCCTTAAATATCCAGGTTCTATATTAAGAAAGTCAACATAGATAATATAAATAAAAATCTT
TAAATATATGAATGACTTAA

Product: drug resistance transporter, Bcr/CflA family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 401; Mature: 401

Protein sequence:

>401_residues
MQNDIMKYNLTIVTVLIFITQLAVDIYIPGLPRIANAFNVPEHKVMWTVSLNLIGLSLSGLVYGPLSDAIGRKKALLLGT
TIFCFSSFFCIYSRSIELVAFWILLQGIGAGAAIPVSFASISDIYKGNEQAKIMSRLHMIMAFSPVLGPVIGNRISSYDD
RWYLPIAVVPMIAFPALLLLITIFKETLTVITKKFDFNNLKVGFKNALVNKNFVCYSLIQSLTFLWLWADSVILPFIFKD
MNIPSRYYEYYIIACIGTFMIASIINQKLVILHGAEKMLFYGVIFVLFGGILSTFSFTYFAAKLHIVLLLKLIASFGIGF
ILGNAAALSVATITNYGAAVALLSSAEMLFGSLGVEMAGYFYNGTILPVLLFIIATSLTSLLILKCYSIIRKSSSYTFCK
M

Sequences:

>Translated_401_residues
MQNDIMKYNLTIVTVLIFITQLAVDIYIPGLPRIANAFNVPEHKVMWTVSLNLIGLSLSGLVYGPLSDAIGRKKALLLGT
TIFCFSSFFCIYSRSIELVAFWILLQGIGAGAAIPVSFASISDIYKGNEQAKIMSRLHMIMAFSPVLGPVIGNRISSYDD
RWYLPIAVVPMIAFPALLLLITIFKETLTVITKKFDFNNLKVGFKNALVNKNFVCYSLIQSLTFLWLWADSVILPFIFKD
MNIPSRYYEYYIIACIGTFMIASIINQKLVILHGAEKMLFYGVIFVLFGGILSTFSFTYFAAKLHIVLLLKLIASFGIGF
ILGNAAALSVATITNYGAAVALLSSAEMLFGSLGVEMAGYFYNGTILPVLLFIIATSLTSLLILKCYSIIRKSSSYTFCK
M
>Mature_401_residues
MQNDIMKYNLTIVTVLIFITQLAVDIYIPGLPRIANAFNVPEHKVMWTVSLNLIGLSLSGLVYGPLSDAIGRKKALLLGT
TIFCFSSFFCIYSRSIELVAFWILLQGIGAGAAIPVSFASISDIYKGNEQAKIMSRLHMIMAFSPVLGPVIGNRISSYDD
RWYLPIAVVPMIAFPALLLLITIFKETLTVITKKFDFNNLKVGFKNALVNKNFVCYSLIQSLTFLWLWADSVILPFIFKD
MNIPSRYYEYYIIACIGTFMIASIINQKLVILHGAEKMLFYGVIFVLFGGILSTFSFTYFAAKLHIVLLLKLIASFGIGF
ILGNAAALSVATITNYGAAVALLSSAEMLFGSLGVEMAGYFYNGTILPVLLFIIATSLTSLLILKCYSIIRKSSSYTFCK
M

Specific function: Involved In Sulfonamide (Sulfathiazole) And Bicyclomycin Resistance. Probable Membrane Translocase. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. Bcr/CmlA family [H]

Homologues:

Organism=Escherichia coli, GI1788509, Length=274, Percent_Identity=25.9124087591241, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790146, Length=376, Percent_Identity=26.063829787234, Blast_Score=88, Evalue=8e-19,
Organism=Escherichia coli, GI48994889, Length=225, Percent_Identity=27.5555555555556, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790794, Length=254, Percent_Identity=21.6535433070866, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004812
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 44409; Mature: 44409

Theoretical pI: Translated: 9.49; Mature: 9.49

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNDIMKYNLTIVTVLIFITQLAVDIYIPGLPRIANAFNVPEHKVMWTVSLNLIGLSLSG
CCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEEEEEEEEEECC
LVYGPLSDAIGRKKALLLGTTIFCFSSFFCIYSRSIELVAFWILLQGIGAGAAIPVSFAS
EEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHH
ISDIYKGNEQAKIMSRLHMIMAFSPVLGPVIGNRISSYDDRWYLPIAVVPMIAFPALLLL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHH
ITIFKETLTVITKKFDFNNLKVGFKNALVNKNFVCYSLIQSLTFLWLWADSVILPFIFKD
HHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MNIPSRYYEYYIIACIGTFMIASIINQKLVILHGAEKMLFYGVIFVLFGGILSTFSFTYF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
AAKLHIVLLLKLIASFGIGFILGNAAALSVATITNYGAAVALLSSAEMLFGSLGVEMAGY
HHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHH
FYNGTILPVLLFIIATSLTSLLILKCYSIIRKSSSYTFCKM
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure
MQNDIMKYNLTIVTVLIFITQLAVDIYIPGLPRIANAFNVPEHKVMWTVSLNLIGLSLSG
CCCCCEEHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHCCCCCCEEEEEEEEEEEEEEECC
LVYGPLSDAIGRKKALLLGTTIFCFSSFFCIYSRSIELVAFWILLQGIGAGAAIPVSFAS
EEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCHHHH
ISDIYKGNEQAKIMSRLHMIMAFSPVLGPVIGNRISSYDDRWYLPIAVVPMIAFPALLLL
HHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHHHHHHHH
ITIFKETLTVITKKFDFNNLKVGFKNALVNKNFVCYSLIQSLTFLWLWADSVILPFIFKD
HHHHHHHHHHHHHHCCCCCCEEEHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
MNIPSRYYEYYIIACIGTFMIASIINQKLVILHGAEKMLFYGVIFVLFGGILSTFSFTYF
CCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHH
AAKLHIVLLLKLIASFGIGFILGNAAALSVATITNYGAAVALLSSAEMLFGSLGVEMAGY
HHHHHHHHHHHHHHHCCHHHHHCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHCHHHHHH
FYNGTILPVLLFIIATSLTSLLILKCYSIIRKSSSYTFCKM
EECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 9202461 [H]