| Definition | Treponema pallidum subsp. pallidum SS14, complete genome. |
|---|---|
| Accession | NC_010741 |
| Length | 1,139,457 |
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The map label for this gene is pbp2 [H]
Identifier: 189025930
GI number: 189025930
Start: 772281
End: 774935
Strand: Reverse
Name: pbp2 [H]
Synonym: TPASS_0705
Alternate gene names: 189025930
Gene position: 774935-772281 (Counterclockwise)
Preceding gene: 189025931
Following gene: 189025929
Centisome position: 68.01
GC content: 55.56
Gene sequence:
>2655_bases ATGCGTCGCGTTTGTTACCTGTATCTGGTGTTGCTGTGCGGTCTGTTGGTGGGGGGAGCTGCGCTCTTTGGGTTCTTGCT TGCCTCCATTGAAAACATTAAGCAGAGCGAACGGTTCACCCGCTTTAATCCGGCGCTTCCCACCAGAATCCTGGACATTC GGGGTGATTTGATCACTGAGTTTTCCTCAGACGAAAAGCGCGAAATCGTTTCCTTTGCTGACTTGTCTTCACACCTTGTG CACGCTCTACTCACCCGCGAAGACCGCTCCTTCTATACCCACCACGGCTACAGCATCAAGGCTATTTTCCGTGCCCTTGT CGGCACCCTCACCGGTCGCGCCTTAGGGGGCGGGAGTACGCTGACCCAGCAGATAGCAGGTCTTCTCTATTCAGACCGCA GCGACCGCAGTCTCAGGCGTAAGATCAAAGAGTTGTGGTGGGCACTCCATATGGAGCGGCGTTATTCCAAGAACGAAATT ATGGAGTTGTATTTGAACCGCGTCTACTTCGGTGGCGGCACCTACGGCGTAGGAGCGGCTGCCCGCTTCTACTTTGGCCA TTCGGTACGTCAGATGAGCGCAGCAGAGGCGGCGCTCTTGGTTATTTTGCTTTCTAACCCGGCACACTACAATCCCTTTG AATATCCTAACCGCGCTCAAGACCGTCAGCGTTACGTACTCCATGAAATGACGCGCCTTGGCTATCTCAGTGAACAAGAA CGGGATGAGTCCTACGAGCACTACTGGGCGCATTTCGATTACACTCGCACCACAAGTTCTGCGTTCTATGCCCGTGCGGA TAAGGCGCGTTGGTTTTCCGAGTATGTGCGGAGGCAGCTGGACCGCATGATGTACGGCACGATGAATTTGTACCAGGACG GGTATACCGTGCATACCACGTGCGATTTGCGTCATCAGTTGGTTGCAGAGCAGCAAGTTGAGCAAACGCTGGAGCAGGCC AATGCACACGTGCAAAAATCTTCTCTCACACACGTTGCGCGCAGAGAACTGTACAGCAATATCAGCGAGCTATTGGGGTT GGTGTTCAACGTTCCGCAGTTGCACGTCGGTGACCGGCGCATGAAGGCAAAAAGCGGCGCGTATTACCGCAGTACGCTCA GTCCCCTGGTGAATGTTATGGCGCTGATGTTCGGCCTCGACAATCTTAAAACGTTGTCTGACAAAGGCGCCTCTCTGGTG CGCGACGAAATTGCACGTAAGCGGGTGGAAGGTGCGCTCATCGCGCTTGAGAACGATACCGGATACATTACAGCTCTCGT AGGGGGCAGCAGATTCGGTGCTTCTAACCAAGTGATTCGTGCAACGCAAGGATTGTTGCAGCCAGGCAGTGTATTTAAGC CTCTGGTGTATTCTGCGGCGTTGGATAGCAAAAAGCTCACGATGGCAACGCAGTTGCACGATGCACCGCAGGTGTTCAGC CGCAATGGTGTTTCGTATATTCCCAACAACTATGGGGGAAAATGGCAGGGGGTAGTGCTTGCATGGAAGGCGCTTGCGCA GTCGCTCAATATTCCTGCTATTCGTGTACTGGATATGGTCGGTTTCGACGCGGTAATCCAGCGTGCGGCGACGCTCCTGC ATATAACCGATCGGCAGGAGATTGAGCGCACCTTCCCACGCGTCTATCCGCTTGCGTTGGGCGTAGTTGCCCTCCGGCCG ATTCAGCTTGCGCGTGCATTTGCAGCGTTTGGAAATGGGGGCAAAGCGGTAGAACCGATTGCAGTGCGTTCAGTGGAGGA TCGTTTAGGGCGGGTGATTTTGGATCCAGAACGGGAAGTGCGGGCCCGCCTGCGCGCGCAGGGTGCGGCAACGCAACTGA TCTCTGCGGAGAACGCGGCGCTCATGACGAATATGCTAGAGAAAACGGTAACGATGGGGACGTTGGCGGTGGCCTCTGAG CGGGGGCGCGCATTTACATACCAAGACCCTGCAACGGGGCGATCGTTTGTTATGCCGGTTGCGGGGAAGACGGGGACTAC GCAAAACTGGTCTGATGCGTGGGCGGTTGGATACTCTCCTTATTACACTGCAGTGTTGTGGTTTGGCTTTGACAAAGGAG ACCGATCGCTCGGATTGCATAGCACGGGCGCGACGCTTGCAGGTCCTCCGTGGGCGCGTTTTATGCGGGCTATTCATCAG GATAAGCCGCACCGGGCATTTGTTCGTCCTGAAACAGGGTTGATGTACCAGGCGGTGTGTGCAAAATCAGGATTGCTGCC TACCCCGTACTGTGGGGATGAGCTTGTTTCTCTGTCATTTTTGCCTGGCACGGTGCCTGAGCGCTTTTGTTCGTACCATG AAAGTGGGAAGATGCTTGAGGAACTGGCTAAAGAACGGTTGAAGGAAAGTGGATACAGCACTGGGTTCTGGCCGGCAGTG AGCGAAGAAGGGCTGCATATAGACCCGCGCGTCTTTGAAGATCCGCCACTGGGTTCACCGGGCGTGCAGGGGGAGGTGCT TGTCCCGAGCAATCCTTTTGCGCCGGTGCATCCGCAGGAAGCGCCGCTTTTTGATGCGCCGCATGTGCCTGTGCCGTCTG CATCCGACCCGTCGCGTGACGCTCCAGAGGAGGAGTCAGAAGACGTGCAGGACGATCCTGCTCGTGGTGTGCAGAGTCTG GATACCGGTCCGTAA
Upstream 100 bases:
>100_bases TTTTGTGTGTCTGCCTGAGTGCATCGTGCGGTGTGCGCCGTTGACGGTCTTCTGCCTCTTGCCTTGAAGTTTTCGCCTTT TTGTGTTCCGCTCTTGGCCC
Downstream 100 bases:
>100_bases GAAAGATTGGGCAGTCTCTTTAGAGGAAGATGGCTTCGCCGACGGAAAGCGTCGCGGCACGCGGGGCGCGTGTGTGGTGC GTGTGGCCGTTCTGGCGGGT
Product: penicillin-binding protein
Products: NA
Alternate protein names: PBP-1a; PBP1a; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Penicillin-sensitive transpeptidase; DD-transpeptidase [H]
Number of amino acids: Translated: 884; Mature: 884
Protein sequence:
>884_residues MRRVCYLYLVLLCGLLVGGAALFGFLLASIENIKQSERFTRFNPALPTRILDIRGDLITEFSSDEKREIVSFADLSSHLV HALLTREDRSFYTHHGYSIKAIFRALVGTLTGRALGGGSTLTQQIAGLLYSDRSDRSLRRKIKELWWALHMERRYSKNEI MELYLNRVYFGGGTYGVGAAARFYFGHSVRQMSAAEAALLVILLSNPAHYNPFEYPNRAQDRQRYVLHEMTRLGYLSEQE RDESYEHYWAHFDYTRTTSSAFYARADKARWFSEYVRRQLDRMMYGTMNLYQDGYTVHTTCDLRHQLVAEQQVEQTLEQA NAHVQKSSLTHVARRELYSNISELLGLVFNVPQLHVGDRRMKAKSGAYYRSTLSPLVNVMALMFGLDNLKTLSDKGASLV RDEIARKRVEGALIALENDTGYITALVGGSRFGASNQVIRATQGLLQPGSVFKPLVYSAALDSKKLTMATQLHDAPQVFS RNGVSYIPNNYGGKWQGVVLAWKALAQSLNIPAIRVLDMVGFDAVIQRAATLLHITDRQEIERTFPRVYPLALGVVALRP IQLARAFAAFGNGGKAVEPIAVRSVEDRLGRVILDPEREVRARLRAQGAATQLISAENAALMTNMLEKTVTMGTLAVASE RGRAFTYQDPATGRSFVMPVAGKTGTTQNWSDAWAVGYSPYYTAVLWFGFDKGDRSLGLHSTGATLAGPPWARFMRAIHQ DKPHRAFVRPETGLMYQAVCAKSGLLPTPYCGDELVSLSFLPGTVPERFCSYHESGKMLEELAKERLKESGYSTGFWPAV SEEGLHIDPRVFEDPPLGSPGVQGEVLVPSNPFAPVHPQEAPLFDAPHVPVPSASDPSRDAPEEESEDVQDDPARGVQSL DTGP
Sequences:
>Translated_884_residues MRRVCYLYLVLLCGLLVGGAALFGFLLASIENIKQSERFTRFNPALPTRILDIRGDLITEFSSDEKREIVSFADLSSHLV HALLTREDRSFYTHHGYSIKAIFRALVGTLTGRALGGGSTLTQQIAGLLYSDRSDRSLRRKIKELWWALHMERRYSKNEI MELYLNRVYFGGGTYGVGAAARFYFGHSVRQMSAAEAALLVILLSNPAHYNPFEYPNRAQDRQRYVLHEMTRLGYLSEQE RDESYEHYWAHFDYTRTTSSAFYARADKARWFSEYVRRQLDRMMYGTMNLYQDGYTVHTTCDLRHQLVAEQQVEQTLEQA NAHVQKSSLTHVARRELYSNISELLGLVFNVPQLHVGDRRMKAKSGAYYRSTLSPLVNVMALMFGLDNLKTLSDKGASLV RDEIARKRVEGALIALENDTGYITALVGGSRFGASNQVIRATQGLLQPGSVFKPLVYSAALDSKKLTMATQLHDAPQVFS RNGVSYIPNNYGGKWQGVVLAWKALAQSLNIPAIRVLDMVGFDAVIQRAATLLHITDRQEIERTFPRVYPLALGVVALRP IQLARAFAAFGNGGKAVEPIAVRSVEDRLGRVILDPEREVRARLRAQGAATQLISAENAALMTNMLEKTVTMGTLAVASE RGRAFTYQDPATGRSFVMPVAGKTGTTQNWSDAWAVGYSPYYTAVLWFGFDKGDRSLGLHSTGATLAGPPWARFMRAIHQ DKPHRAFVRPETGLMYQAVCAKSGLLPTPYCGDELVSLSFLPGTVPERFCSYHESGKMLEELAKERLKESGYSTGFWPAV SEEGLHIDPRVFEDPPLGSPGVQGEVLVPSNPFAPVHPQEAPLFDAPHVPVPSASDPSRDAPEEESEDVQDDPARGVQSL DTGP >Mature_884_residues MRRVCYLYLVLLCGLLVGGAALFGFLLASIENIKQSERFTRFNPALPTRILDIRGDLITEFSSDEKREIVSFADLSSHLV HALLTREDRSFYTHHGYSIKAIFRALVGTLTGRALGGGSTLTQQIAGLLYSDRSDRSLRRKIKELWWALHMERRYSKNEI MELYLNRVYFGGGTYGVGAAARFYFGHSVRQMSAAEAALLVILLSNPAHYNPFEYPNRAQDRQRYVLHEMTRLGYLSEQE RDESYEHYWAHFDYTRTTSSAFYARADKARWFSEYVRRQLDRMMYGTMNLYQDGYTVHTTCDLRHQLVAEQQVEQTLEQA NAHVQKSSLTHVARRELYSNISELLGLVFNVPQLHVGDRRMKAKSGAYYRSTLSPLVNVMALMFGLDNLKTLSDKGASLV RDEIARKRVEGALIALENDTGYITALVGGSRFGASNQVIRATQGLLQPGSVFKPLVYSAALDSKKLTMATQLHDAPQVFS RNGVSYIPNNYGGKWQGVVLAWKALAQSLNIPAIRVLDMVGFDAVIQRAATLLHITDRQEIERTFPRVYPLALGVVALRP IQLARAFAAFGNGGKAVEPIAVRSVEDRLGRVILDPEREVRARLRAQGAATQLISAENAALMTNMLEKTVTMGTLAVASE RGRAFTYQDPATGRSFVMPVAGKTGTTQNWSDAWAVGYSPYYTAVLWFGFDKGDRSLGLHSTGATLAGPPWARFMRAIHQ DKPHRAFVRPETGLMYQAVCAKSGLLPTPYCGDELVSLSFLPGTVPERFCSYHESGKMLEELAKERLKESGYSTGFWPAV SEEGLHIDPRVFEDPPLGSPGVQGEVLVPSNPFAPVHPQEAPLFDAPHVPVPSASDPSRDAPEEESEDVQDDPARGVQSL DTGP
Specific function: Cell Wall Formation. Synthesis Of Cross-Linked Peptidoglycan From The Lipid Intermediates. The Enzyme Has A Penicillin-Insensitive Transglycosylase N-Terminal Domain (Formation Of Linear Glycan Strands) And A Penicillin-Sensitive Transpeptidase C-Terminal
COG id: COG5009
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI87082258, Length=323, Percent_Identity=34.0557275541796, Blast_Score=170, Evalue=5e-43, Organism=Escherichia coli, GI1788867, Length=182, Percent_Identity=40.6593406593407, Blast_Score=125, Evalue=1e-29, Organism=Escherichia coli, GI1786343, Length=204, Percent_Identity=40.1960784313725, Blast_Score=118, Evalue=2e-27, Organism=Escherichia coli, GI1789601, Length=246, Percent_Identity=28.8617886178862, Blast_Score=82, Evalue=1e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011816 - InterPro: IPR001460 [H]
Pfam domain/function: PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-; 3.4.-.-
Molecular weight: Translated: 98425; Mature: 98425
Theoretical pI: Translated: 8.46; Mature: 8.46
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.3 %Met (Translated Protein) 2.9 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.3 %Met (Mature Protein) 2.9 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MRRVCYLYLVLLCGLLVGGAALFGFLLASIENIKQSERFTRFNPALPTRILDIRGDLITE CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHH FSSDEKREIVSFADLSSHLVHALLTREDRSFYTHHGYSIKAIFRALVGTLTGRALGGGST CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCHH LTQQIAGLLYSDRSDRSLRRKIKELWWALHMERRYSKNEIMELYLNRVYFGGGTYGVGAA HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCHHHH ARFYFGHSVRQMSAAEAALLVILLSNPAHYNPFEYPNRAQDRQRYVLHEMTRLGYLSEQE HHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH RDESYEHYWAHFDYTRTTSSAFYARADKARWFSEYVRRQLDRMMYGTMNLYQDGYTVHTT HCCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE CDLRHQLVAEQQVEQTLEQANAHVQKSSLTHVARRELYSNISELLGLVFNVPQLHVGDRR HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH MKAKSGAYYRSTLSPLVNVMALMFGLDNLKTLSDKGASLVRDEIARKRVEGALIALENDT HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCEEEEEECCC GYITALVGGSRFGASNQVIRATQGLLQPGSVFKPLVYSAALDSKKLTMATQLHDAPQVFS CEEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHH RNGVSYIPNNYGGKWQGVVLAWKALAQSLNIPAIRVLDMVGFDAVIQRAATLLHITDRQE CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHH IERTFPRVYPLALGVVALRPIQLARAFAAFGNGGKAVEPIAVRSVEDRLGRVILDPEREV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCCHHH RARLRAQGAATQLISAENAALMTNMLEKTVTMGTLAVASERGRAFTYQDPATGRSFVMPV HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEE AGKTGTTQNWSDAWAVGYSPYYTAVLWFGFDKGDRSLGLHSTGATLAGPPWARFMRAIHQ CCCCCCCCCCCCCEEECCCHHEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHC DKPHRAFVRPETGLMYQAVCAKSGLLPTPYCGDELVSLSFLPGTVPERFCSYHESGKMLE CCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCHHEEEECCCCCHHHHHHHHHHCHHHHH ELAKERLKESGYSTGFWPAVSEEGLHIDPRVFEDPPLGSPGVQGEVLVPSNPFAPVHPQE HHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC APLFDAPHVPVPSASDPSRDAPEEESEDVQDDPARGVQSLDTGP CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC >Mature Secondary Structure MRRVCYLYLVLLCGLLVGGAALFGFLLASIENIKQSERFTRFNPALPTRILDIRGDLITE CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHCHHHHHH FSSDEKREIVSFADLSSHLVHALLTREDRSFYTHHGYSIKAIFRALVGTLTGRALGGGST CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHHHCCCCCCCHH LTQQIAGLLYSDRSDRSLRRKIKELWWALHMERRYSKNEIMELYLNRVYFGGGTYGVGAA HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHEECCCCCCHHHH ARFYFGHSVRQMSAAEAALLVILLSNPAHYNPFEYPNRAQDRQRYVLHEMTRLGYLSEQE HHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHH RDESYEHYWAHFDYTRTTSSAFYARADKARWFSEYVRRQLDRMMYGTMNLYQDGYTVHTT HCCCHHHHHHEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE CDLRHQLVAEQQVEQTLEQANAHVQKSSLTHVARRELYSNISELLGLVFNVPQLHVGDRR HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHH MKAKSGAYYRSTLSPLVNVMALMFGLDNLKTLSDKGASLVRDEIARKRVEGALIALENDT HHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHHHHHHHHHHCCEEEEEECCC GYITALVGGSRFGASNQVIRATQGLLQPGSVFKPLVYSAALDSKKLTMATQLHDAPQVFS CEEEEEECCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHH RNGVSYIPNNYGGKWQGVVLAWKALAQSLNIPAIRVLDMVGFDAVIQRAATLLHITDRQE CCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHEEECCHHH IERTFPRVYPLALGVVALRPIQLARAFAAFGNGGKAVEPIAVRSVEDRLGRVILDPEREV HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCEEECCCHHH RARLRAQGAATQLISAENAALMTNMLEKTVTMGTLAVASERGRAFTYQDPATGRSFVMPV HHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCEEEEEE AGKTGTTQNWSDAWAVGYSPYYTAVLWFGFDKGDRSLGLHSTGATLAGPPWARFMRAIHQ CCCCCCCCCCCCCEEECCCHHEEEEEEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHC DKPHRAFVRPETGLMYQAVCAKSGLLPTPYCGDELVSLSFLPGTVPERFCSYHESGKMLE CCCCCEEECCCCCHHHHHHHHCCCCCCCCCCCCHHEEEECCCCCHHHHHHHHHHCHHHHH ELAKERLKESGYSTGFWPAVSEEGLHIDPRVFEDPPLGSPGVQGEVLVPSNPFAPVHPQE HHHHHHHHHCCCCCCCCCCCCCCCCEECCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCC APLFDAPHVPVPSASDPSRDAPEEESEDVQDDPARGVQSLDTGP CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: Transferases; Acyltransferases; Aminoacyltransferases [C]
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 9537320 [H]