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The map label for this gene is alr

Identifier: 189025906

GI number: 189025906

Start: 746466

End: 747599

Strand: Reverse

Name: alr

Synonym: TPASS_0681

Alternate gene names: 189025906

Gene position: 747599-746466 (Counterclockwise)

Preceding gene: 189025907

Following gene: 189025905

Centisome position: 65.61

GC content: 55.82

Gene sequence:

>1134_bases
GTGGCATGCAATCAGGCATTGATCCATTTAGCAAACTTGCGTCATAACCTCGGTGAAATTATGAGCCGTACACGCGCGCG
TGTGTGTCTACCTGTTAAGGCGGACGCGTATGGACACGGTGCGTGTGACGTCGCACAGGCGGCGCTTTCGTGCGGGGTGC
ACTCGTTCGCCGTTGCATGTGTGCAAGAAGCGTCGCAACTGCGTGCGGCAGGTGTTCGCGCGCCGATTTTGTGTTTAAGT
ACTCCAACTGCTGAAGAGATTTCTAGTCTTATTGAGCATCGTGTGCACACCGTGATTTCTGAGCGCGCGCATATTGCCCT
TATCGCACGCGCGCTCCGTCAGTCTGCTGATACGGGTGCCACGTGTGGGGTACACGTAAAGATTGATACCGGAATGGGGA
GAATCGGCTGTGCGCCGGATGAGGCCTGTGCGCTCGTGCAGATGGTGTGCGCAACACCGGGTCTCCATCTTGAGGGGGTA
TGTACGCATTTTTCTGTCGCGGATTCTGTGCGTGCTGAGGACCTGCAGTACACTGAGATGCAACGTGCACATTTTATGCA
TTGCGTACAGTACATACGGAAAAGTGGCATATCGATTCCATTGGTGCATGCGGCAAACTCTGCAGCGCTGTTGTGCCATC
CGCGGGCACACTTCGACATGGTGCGTCCGGGATTGTTGGCATACGGCTATGCCCCTGAGTCTGTGCATCCTGCTGTGCGC
AGTGTGTTCCTTCCCGTCATGGAGCTTGTTACCCAAGTCCGTGCAATCAAAAAAATACCTGCAGGCGCGTACGTTTCTTA
CCAGCGCTTGTGGCGTGCGCATACAGAAACACATGTAGGTATTCTGCCTATCGGATATGCAGACGGAGTTATGCGCGCGC
TGTCGCCGGGTTTGCAGGTGTGCATTGGGGGGAAGTGGTATCCGGTGGTGGGGGCAATTTGCATGGACCAGTGTGTAGTG
GACCTAGGTACCCCGCTGCGTGTGACAGTTGGAGATAGGGTGACACTTTTCGGTCCTCAGGACGCAGGTGGCCCAGGACA
GGGGGCAGATGTGCTCGCCTCGCATGCAGGCACCATTCCCTATGAGCTTTTGTGCGCGATTGGTAAGCGTGTCGAACGGG
TGTACATCCGGTGA

Upstream 100 bases:

>100_bases
CCTGCTTCTCGTCCCCGTAGTTGTGAGTTATATGTGGTGGCGCGTTTCTTTCGCGGTACGTGCGGCAAGTAATGGGTAAG
AATAGGGAGCGTAGGCGCCT

Downstream 100 bases:

>100_bases
ATATGTTTTTGCAACGTTTATAAAAAGAGACAAAGGGAGGAAGGCGCGCAGTGAATGTCCTCGGAATTGAGACCTCTTGT
GATGAGACTGCAGTTGCAAT

Product: alanine racemase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 377; Mature: 376

Protein sequence:

>377_residues
MACNQALIHLANLRHNLGEIMSRTRARVCLPVKADAYGHGACDVAQAALSCGVHSFAVACVQEASQLRAAGVRAPILCLS
TPTAEEISSLIEHRVHTVISERAHIALIARALRQSADTGATCGVHVKIDTGMGRIGCAPDEACALVQMVCATPGLHLEGV
CTHFSVADSVRAEDLQYTEMQRAHFMHCVQYIRKSGISIPLVHAANSAALLCHPRAHFDMVRPGLLAYGYAPESVHPAVR
SVFLPVMELVTQVRAIKKIPAGAYVSYQRLWRAHTETHVGILPIGYADGVMRALSPGLQVCIGGKWYPVVGAICMDQCVV
DLGTPLRVTVGDRVTLFGPQDAGGPGQGADVLASHAGTIPYELLCAIGKRVERVYIR

Sequences:

>Translated_377_residues
MACNQALIHLANLRHNLGEIMSRTRARVCLPVKADAYGHGACDVAQAALSCGVHSFAVACVQEASQLRAAGVRAPILCLS
TPTAEEISSLIEHRVHTVISERAHIALIARALRQSADTGATCGVHVKIDTGMGRIGCAPDEACALVQMVCATPGLHLEGV
CTHFSVADSVRAEDLQYTEMQRAHFMHCVQYIRKSGISIPLVHAANSAALLCHPRAHFDMVRPGLLAYGYAPESVHPAVR
SVFLPVMELVTQVRAIKKIPAGAYVSYQRLWRAHTETHVGILPIGYADGVMRALSPGLQVCIGGKWYPVVGAICMDQCVV
DLGTPLRVTVGDRVTLFGPQDAGGPGQGADVLASHAGTIPYELLCAIGKRVERVYIR
>Mature_376_residues
ACNQALIHLANLRHNLGEIMSRTRARVCLPVKADAYGHGACDVAQAALSCGVHSFAVACVQEASQLRAAGVRAPILCLST
PTAEEISSLIEHRVHTVISERAHIALIARALRQSADTGATCGVHVKIDTGMGRIGCAPDEACALVQMVCATPGLHLEGVC
THFSVADSVRAEDLQYTEMQRAHFMHCVQYIRKSGISIPLVHAANSAALLCHPRAHFDMVRPGLLAYGYAPESVHPAVRS
VFLPVMELVTQVRAIKKIPAGAYVSYQRLWRAHTETHVGILPIGYADGVMRALSPGLQVCIGGKWYPVVGAICMDQCVVD
LGTPLRVTVGDRVTLFGPQDAGGPGQGADVLASHAGTIPYELLCAIGKRVERVYIR

Specific function: Provides the D-alanine required for cell wall biosynthesis

COG id: COG0787

COG function: function code M; Alanine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alanine racemase family

Homologues:

Organism=Escherichia coli, GI1787439, Length=376, Percent_Identity=32.1808510638298, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790487, Length=381, Percent_Identity=30.7086614173228, Blast_Score=148, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ALR_TREPA (Q56346)

Other databases:

- EMBL:   AE000520
- EMBL:   U57756
- PIR:   A71295
- RefSeq:   NP_219118.1
- ProteinModelPortal:   Q56346
- SMR:   Q56346
- IntAct:   Q56346
- GeneID:   2611266
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0681
- NMPDR:   fig|243276.1.peg.677
- TIGR:   TP_0681
- HOGENOM:   HBG712172
- OMA:   TRKEDAN
- ProtClustDB:   CLSK218816
- BioCyc:   TPAL243276:TP_0681-MONOMER
- BRENDA:   5.1.1.1
- HAMAP:   MF_01201
- InterPro:   IPR000821
- InterPro:   IPR009006
- InterPro:   IPR011079
- InterPro:   IPR001608
- InterPro:   IPR020622
- Gene3D:   G3DSA:2.40.37.10
- PRINTS:   PR00992
- TIGRFAMs:   TIGR00492

Pfam domain/function: PF00842 Ala_racemase_C; PF01168 Ala_racemase_N; SSF50621 Racem_decarbox_C

EC number: =5.1.1.1

Molecular weight: Translated: 40312; Mature: 40181

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: PS00395 ALANINE_RACEMASE

Important sites: ACT_SITE 33-33 ACT_SITE 267-267

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.5 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
7.2 %Cys+Met (Translated Protein)
4.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MACNQALIHLANLRHNLGEIMSRTRARVCLPVKADAYGHGACDVAQAALSCGVHSFAVAC
CCCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHH
VQEASQLRAAGVRAPILCLSTPTAEEISSLIEHRVHTVISERAHIALIARALRQSADTGA
HHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
TCGVHVKIDTGMGRIGCAPDEACALVQMVCATPGLHLEGVCTHFSVADSVRAEDLQYTEM
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
QRAHFMHCVQYIRKSGISIPLVHAANSAALLCHPRAHFDMVRPGLLAYGYAPESVHPAVR
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCHHHHHHCCCCEEECCCCHHHHHHHH
SVFLPVMELVTQVRAIKKIPAGAYVSYQRLWRAHTETHVGILPIGYADGVMRALSPGLQV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEE
CIGGKWYPVVGAICMDQCVVDLGTPLRVTVGDRVTLFGPQDAGGPGQGADVLASHAGTIP
EECCCHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCCCCHHHHHHCCCCCH
YELLCAIGKRVERVYIR
HHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ACNQALIHLANLRHNLGEIMSRTRARVCLPVKADAYGHGACDVAQAALSCGVHSFAVAC
CCHHHHHHHHHHHHHHHHHHHHHHCEEEEEEECCCCCCCHHHHHHHHHHHCHHHHHHHH
VQEASQLRAAGVRAPILCLSTPTAEEISSLIEHRVHTVISERAHIALIARALRQSADTGA
HHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCC
TCGVHVKIDTGMGRIGCAPDEACALVQMVCATPGLHLEGVCTHFSVADSVRAEDLQYTEM
EEEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCHHHHH
QRAHFMHCVQYIRKSGISIPLVHAANSAALLCHPRAHFDMVRPGLLAYGYAPESVHPAVR
HHHHHHHHHHHHHHCCCCEEEEECCCCCEEEECCCHHHHHHCCCCEEECCCCHHHHHHHH
SVFLPVMELVTQVRAIKKIPAGAYVSYQRLWRAHTETHVGILPIGYADGVMRALSPGLQV
HHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCCEE
CIGGKWYPVVGAICMDQCVVDLGTPLRVTVGDRVTLFGPQDAGGPGQGADVLASHAGTIP
EECCCHHHHHHHHHHHHHHHHCCCCEEEEECCEEEEECCCCCCCCCCCHHHHHHCCCCCH
YELLCAIGKRVERVYIR
HHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876