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The map label for this gene is gcp

Identifier: 189025905

GI number: 189025905

Start: 745357

End: 746415

Strand: Reverse

Name: gcp

Synonym: TPASS_0680

Alternate gene names: 189025905

Gene position: 746415-745357 (Counterclockwise)

Preceding gene: 189025906

Following gene: 189025902

Centisome position: 65.51

GC content: 52.88

Gene sequence:

>1059_bases
GTGAATGTCCTCGGAATTGAGACCTCTTGTGATGAGACTGCAGTTGCAATTGTAAAAGATGGCACGCACGTGTGCAGCAA
TGTTGTGGCTACGCAAATTCCTTTTCATGCGCCGTATCGTGGCATTGTCCCAGAACTTGCAAGTCGCAAGCACATTGAGT
GGATTTTGCCAACGGTGAAAGAGGCGCTTGCACGCGCTCAGCTGACGCTTGCTGATATCGATGGCATCGCCGTAACACAT
GCACCTGGGCTGACCGGATCTCTCCTGGTAGGCCTGACGTTTGCGAAAACACTCGCATGGTCAATGCACCTTCCTTTCAT
TGCGGTTAATCACCTTCATGCACACTTTTGTGCCGCGCACGTGGAGCACGATCTGGCATATCCCTACGTGGGCTTGCTGG
CGTCTGGAGGACATGCGCTCGTATGTGTTGTGCACGATTTTGATCAGGTAGAAGCGCTTGGCGCAACGATCGACGACGCT
CCCGGGGAAGCCTTTGATAAGGTTGCAGCCTTTTATGGCTTTGGATATCCGGGAGGCAAGGTAATTGAAACGTTAGCAGA
ACAGGGTGACGCGCGTGCCGCGCGTTTTCCGCTTCCTCATTTTCACGGAAAAGGGCATCGGTATGATGTATCATATTCAG
GATTGAAGACAGCAGTTATTCATCAGCTCGATCACTTTTGGAACAAGGAATACGAGCGCACTGCGCAGAACATTGCTGCG
GCGTTTCAAGCGTGTGCAATCAACATCTTGCTCCGTCCGCTTGCGCGCGCATTACAGGATACAGGGCTGCCAACGGCAGT
AGTGTGCGGAGGTGTTGCAGCAAACAGTTTGCTCAGAAAATCTGTAGCGGACTGGAAGCATGCGCGGTGTGTGTTCCCTT
CGCGTGAGTACTGTACAGACAACGCGGTGATGGTTGCTGCGCTCGGGTACCGCTATTTGATCCGTGGTGATAGGAGTTTC
TATGGGGTAACAGAGCGTTCGCGCATTGCGCACTTCAGTAAGCGCGGGGGAGATCGTCTCGCTGCACAGAGAAGCGCTGC
TTCTCAGCCTCTTTTTTGA

Upstream 100 bases:

>100_bases
AGCTTTTGTGCGCGATTGGTAAGCGTGTCGAACGGGTGTACATCCGGTGAATATGTTTTTGCAACGTTTATAAAAAGAGA
CAAAGGGAGGAAGGCGCGCA

Downstream 100 bases:

>100_bases
GCATGTGCGGCTCAGTCCTTGCTAGGCAGTGTCCCGTTACCTAGATGCTGTGCCGTTTGATGGTAAAAATGAGCGACGCG
ATGAAGCACGCCAATGGCAG

Product: DNA-binding/iron metalloprotein/AP endonuclease

Products: NA

Alternate protein names: Glycoprotease

Number of amino acids: Translated: 352; Mature: 352

Protein sequence:

>352_residues
MNVLGIETSCDETAVAIVKDGTHVCSNVVATQIPFHAPYRGIVPELASRKHIEWILPTVKEALARAQLTLADIDGIAVTH
APGLTGSLLVGLTFAKTLAWSMHLPFIAVNHLHAHFCAAHVEHDLAYPYVGLLASGGHALVCVVHDFDQVEALGATIDDA
PGEAFDKVAAFYGFGYPGGKVIETLAEQGDARAARFPLPHFHGKGHRYDVSYSGLKTAVIHQLDHFWNKEYERTAQNIAA
AFQACAINILLRPLARALQDTGLPTAVVCGGVAANSLLRKSVADWKHARCVFPSREYCTDNAVMVAALGYRYLIRGDRSF
YGVTERSRIAHFSKRGGDRLAAQRSAASQPLF

Sequences:

>Translated_352_residues
MNVLGIETSCDETAVAIVKDGTHVCSNVVATQIPFHAPYRGIVPELASRKHIEWILPTVKEALARAQLTLADIDGIAVTH
APGLTGSLLVGLTFAKTLAWSMHLPFIAVNHLHAHFCAAHVEHDLAYPYVGLLASGGHALVCVVHDFDQVEALGATIDDA
PGEAFDKVAAFYGFGYPGGKVIETLAEQGDARAARFPLPHFHGKGHRYDVSYSGLKTAVIHQLDHFWNKEYERTAQNIAA
AFQACAINILLRPLARALQDTGLPTAVVCGGVAANSLLRKSVADWKHARCVFPSREYCTDNAVMVAALGYRYLIRGDRSF
YGVTERSRIAHFSKRGGDRLAAQRSAASQPLF
>Mature_352_residues
MNVLGIETSCDETAVAIVKDGTHVCSNVVATQIPFHAPYRGIVPELASRKHIEWILPTVKEALARAQLTLADIDGIAVTH
APGLTGSLLVGLTFAKTLAWSMHLPFIAVNHLHAHFCAAHVEHDLAYPYVGLLASGGHALVCVVHDFDQVEALGATIDDA
PGEAFDKVAAFYGFGYPGGKVIETLAEQGDARAARFPLPHFHGKGHRYDVSYSGLKTAVIHQLDHFWNKEYERTAQNIAA
AFQACAINILLRPLARALQDTGLPTAVVCGGVAANSLLRKSVADWKHARCVFPSREYCTDNAVMVAALGYRYLIRGDRSF
YGVTERSRIAHFSKRGGDRLAAQRSAASQPLF

Specific function: Could Be A Metalloprotease. [C]

COG id: COG0533

COG function: function code O; Metal-dependent proteases with possible chaperone activity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M22 family

Homologues:

Organism=Homo sapiens, GI116812636, Length=342, Percent_Identity=33.6257309941521, Blast_Score=152, Evalue=6e-37,
Organism=Homo sapiens, GI8923380, Length=334, Percent_Identity=30.2395209580838, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1789445, Length=332, Percent_Identity=41.8674698795181, Blast_Score=239, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI17557464, Length=341, Percent_Identity=29.0322580645161, Blast_Score=129, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71995670, Length=324, Percent_Identity=31.4814814814815, Blast_Score=100, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6320099, Length=340, Percent_Identity=28.8235294117647, Blast_Score=105, Evalue=1e-23,
Organism=Saccharomyces cerevisiae, GI6322891, Length=346, Percent_Identity=26.878612716763, Blast_Score=81, Evalue=3e-16,
Organism=Drosophila melanogaster, GI20129063, Length=344, Percent_Identity=35.1744186046512, Blast_Score=166, Evalue=2e-41,
Organism=Drosophila melanogaster, GI21357207, Length=344, Percent_Identity=28.4883720930233, Blast_Score=109, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GCP_TREPA (O83686)

Other databases:

- EMBL:   AE000520
- PIR:   H71294
- RefSeq:   NP_219117.1
- ProteinModelPortal:   O83686
- SMR:   O83686
- MEROPS:   M22.001
- GeneID:   2611265
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0680
- NMPDR:   fig|243276.1.peg.676
- TIGR:   TP_0680
- HOGENOM:   HBG304663
- OMA:   PAVGVHH
- ProtClustDB:   PRK09604
- BioCyc:   TPAL243276:TP_0680-MONOMER
- BRENDA:   3.4.24.57
- GO:   GO:0006508
- HAMAP:   MF_01445
- InterPro:   IPR022450
- InterPro:   IPR000905
- InterPro:   IPR017860
- InterPro:   IPR017861
- PANTHER:   PTHR11735
- PRINTS:   PR00789
- TIGRFAMs:   TIGR03723
- TIGRFAMs:   TIGR00329

Pfam domain/function: PF00814 Peptidase_M22

EC number: =3.4.24.57

Molecular weight: Translated: 38132; Mature: 38132

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS01016 GLYCOPROTEASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVLGIETSCDETAVAIVKDGTHVCSNVVATQIPFHAPYRGIVPELASRKHIEWILPTVK
CCEECCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
EALARAQLTLADIDGIAVTHAPGLTGSLLVGLTFAKTLAWSMHLPFIAVNHLHAHFCAAH
HHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VEHDLAYPYVGLLASGGHALVCVVHDFDQVEALGATIDDAPGEAFDKVAAFYGFGYPGGK
HHHHHCCHHHHHHCCCCCEEEEEEECCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHH
VIETLAEQGDARAARFPLPHFHGKGHRYDVSYSGLKTAVIHQLDHFWNKEYERTAQNIAA
HHHHHHHCCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHH
AFQACAINILLRPLARALQDTGLPTAVVCGGVAANSLLRKSVADWKHARCVFPSREYCTD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHCEEECCCHHHCCC
NAVMVAALGYRYLIRGDRSFYGVTERSRIAHFSKRGGDRLAAQRSAASQPLF
CCEEEHHHCEEEEEECCCCEECCCHHHHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure
MNVLGIETSCDETAVAIVKDGTHVCSNVVATQIPFHAPYRGIVPELASRKHIEWILPTVK
CCEECCCCCCCCCEEEEEECCHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCHHHHHHHHH
EALARAQLTLADIDGIAVTHAPGLTGSLLVGLTFAKTLAWSMHLPFIAVNHLHAHFCAAH
HHHHHHHHEEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
VEHDLAYPYVGLLASGGHALVCVVHDFDQVEALGATIDDAPGEAFDKVAAFYGFGYPGGK
HHHHHCCHHHHHHCCCCCEEEEEEECCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCHH
VIETLAEQGDARAARFPLPHFHGKGHRYDVSYSGLKTAVIHQLDHFWNKEYERTAQNIAA
HHHHHHHCCCCCEECCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHCHHHHHHHHHHHH
AFQACAINILLRPLARALQDTGLPTAVVCGGVAANSLLRKSVADWKHARCVFPSREYCTD
HHHHHHHHHHHHHHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHHHHCEEECCCHHHCCC
NAVMVAALGYRYLIRGDRSFYGVTERSRIAHFSKRGGDRLAAQRSAASQPLF
CCEEEHHHCEEEEEECCCCEECCCHHHHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9665876