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The map label for this gene is manB [H]

Identifier: 189025867

GI number: 189025867

Start: 704496

End: 706256

Strand: Direct

Name: manB [H]

Synonym: TPASS_0642

Alternate gene names: 189025867

Gene position: 704496-706256 (Clockwise)

Preceding gene: 189025865

Following gene: 189025868

Centisome position: 61.83

GC content: 49.69

Gene sequence:

>1761_bases
ATGCACTCCAGTCAATTGTTCGAACGTGCTCGTCTTTATCTTGAAGAAGAAACAGATCCTTTCTTTGCACAGCAGGTACG
GGATCTTGTTGCACAGAATAATATAGCAGAGCTCGAAGAGCGCTTTTTGCAAACTCTTTCGTTTGGCACCGCCGGGCTGC
GGGGTGTTGTCGGCGGAGGAACAAACAGAATGAACCCCTTCATGATCAAAAAGATCACGCACGCGATTGCGCTCTATTTA
CTAAAAACTTTTCCTGAAAAGGCAGCGCGCGGCGCGCTCCGTGCCGTTATAGCCTACGACTCGCGTGTACATTCTCGTCT
GTTCGCACACACTGCTGCGCACGTGTTTCTTGCACATGACATTACCGCCTACCTCTTTTCGGATCCACGCCCGACTCCAG
AACTTTCCTACGCAGTACAGTATCTTACCTGTGACGTGGGCATCGTGGTCACCGCATCGCACAACCCACCGCAGTATAAC
GGATACAAAGTGTACTGGAACGACGGGGCACAGATAGCGCATCCTCACGAAAAAAATATCACCGAAGAAATGAACGCTAT
CACGAGTGTCGTGAACCTTGAGGAAAAGGTACCTGTCAAACGCAGTGCACCCACGATCATTGATGCAGAAATTGATGAAC
CGTACTGCACCTCTATAAAGGAAAAGCTTTTTCGCCCCGGTCTTACGAAAGAGACCGTCCAGTCGATGCGTATTGCATAC
ACCCCATTACACGGAACGGGTGCACTCCACGTCGAGCGCATACTGGGGGATATGGGGTTCTCCATTATGACCGTGCCTGA
GCAACGGTTGCCAGATGGGAACTTCCCTACGGTGTCGTCTCCTAATCCAGAAGATCCGGCCGCGTTGGTGCATGCGTGTG
CATATGCTGATCGCGTACATGCTGAGGTTCTTATGGCGACTGATCCTGACGCAGACCGCTTTGCATGTGCAGTAAGAAAC
ACCCGCGGTGTGTTGCAGTTGCTCACGGGCAATCAAATGGGAGCGCTCTTCACTGACTACATTCTGCTAACCCTGCAGGA
ACAAAACAATATGCCCGCGCGTCCTGCAATTGTACGCTCCGTTGTTACGTCCCCACTTAGCGACCGTATAGCACGCACAT
ATGGCGCAACGTGTGTAGAGTGCCTTACCGGATTCAAATGGATATGTGGTACTGCAGAAAAGATTTCACAGTCAGGAGCG
TACTCCTACGTATATGGATTTGAAGAAAGTTACGGACACAATTTTGGTATTCAGGTGAGAGACAAAGACGGTATCAACGC
CGCAGCGCTCTGTGCAGAAATGGGTGTGTACTGGAAGTTGCGCGGAATGAGCCTGATCGATCGCCTTCACCAGTTATTCA
GGACGCATGGCCTGTTTTGTGAAAAGACGCTGAACAAAACCTATGCGGGCGTCGCGGGTGTAAGCACCATGAATGCAATA
ATGAATACGCTCAGGAGACAGCCGCTAACCCAAATTGCGCGCAAGCGGGTAATGAAGGTGAGGGATATATATCTTGGTGT
TGAGTTTAGTCCAGAAAATCCTGCGCAGACATCTGCCCTTTCTTTTCCTCAGAGTAACGTGCTGCAGTATTTTGTACAGG
ATGGCAGTATTGTAAGTATACGACCGAGTGGAACAGAACAAAAAATAAAGTGTTATATCATCCACCCTCTGACCGTCAGT
ACCTCGATAGAAGAAGCAGAACAGGCGGGCAACATGTTTATCACCGCAGTTGAACAAGAGATGGGTACATATCTGCAATG
A

Upstream 100 bases:

>100_bases
TTTTGTGAGCATTGCACAGAGCAGCACCTTCCCATTACAATGCCCCTCTATCCTGTGGTGCCGTAAATAGTCCAGTACTT
TTAAAGGTGAGGAAGCGCTC

Downstream 100 bases:

>100_bases
TATATGATTGGGTTTTTGCGGTGCATGAACACGTTGCATTCACCGCCTTCGACACCGAAACAACTGGTTTAAAAGCAGAA
GAAGATCGCATTATAGAAAT

Product: phosphomannomutase

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 586; Mature: 586

Protein sequence:

>586_residues
MHSSQLFERARLYLEEETDPFFAQQVRDLVAQNNIAELEERFLQTLSFGTAGLRGVVGGGTNRMNPFMIKKITHAIALYL
LKTFPEKAARGALRAVIAYDSRVHSRLFAHTAAHVFLAHDITAYLFSDPRPTPELSYAVQYLTCDVGIVVTASHNPPQYN
GYKVYWNDGAQIAHPHEKNITEEMNAITSVVNLEEKVPVKRSAPTIIDAEIDEPYCTSIKEKLFRPGLTKETVQSMRIAY
TPLHGTGALHVERILGDMGFSIMTVPEQRLPDGNFPTVSSPNPEDPAALVHACAYADRVHAEVLMATDPDADRFACAVRN
TRGVLQLLTGNQMGALFTDYILLTLQEQNNMPARPAIVRSVVTSPLSDRIARTYGATCVECLTGFKWICGTAEKISQSGA
YSYVYGFEESYGHNFGIQVRDKDGINAAALCAEMGVYWKLRGMSLIDRLHQLFRTHGLFCEKTLNKTYAGVAGVSTMNAI
MNTLRRQPLTQIARKRVMKVRDIYLGVEFSPENPAQTSALSFPQSNVLQYFVQDGSIVSIRPSGTEQKIKCYIIHPLTVS
TSIEEAEQAGNMFITAVEQEMGTYLQ

Sequences:

>Translated_586_residues
MHSSQLFERARLYLEEETDPFFAQQVRDLVAQNNIAELEERFLQTLSFGTAGLRGVVGGGTNRMNPFMIKKITHAIALYL
LKTFPEKAARGALRAVIAYDSRVHSRLFAHTAAHVFLAHDITAYLFSDPRPTPELSYAVQYLTCDVGIVVTASHNPPQYN
GYKVYWNDGAQIAHPHEKNITEEMNAITSVVNLEEKVPVKRSAPTIIDAEIDEPYCTSIKEKLFRPGLTKETVQSMRIAY
TPLHGTGALHVERILGDMGFSIMTVPEQRLPDGNFPTVSSPNPEDPAALVHACAYADRVHAEVLMATDPDADRFACAVRN
TRGVLQLLTGNQMGALFTDYILLTLQEQNNMPARPAIVRSVVTSPLSDRIARTYGATCVECLTGFKWICGTAEKISQSGA
YSYVYGFEESYGHNFGIQVRDKDGINAAALCAEMGVYWKLRGMSLIDRLHQLFRTHGLFCEKTLNKTYAGVAGVSTMNAI
MNTLRRQPLTQIARKRVMKVRDIYLGVEFSPENPAQTSALSFPQSNVLQYFVQDGSIVSIRPSGTEQKIKCYIIHPLTVS
TSIEEAEQAGNMFITAVEQEMGTYLQ
>Mature_586_residues
MHSSQLFERARLYLEEETDPFFAQQVRDLVAQNNIAELEERFLQTLSFGTAGLRGVVGGGTNRMNPFMIKKITHAIALYL
LKTFPEKAARGALRAVIAYDSRVHSRLFAHTAAHVFLAHDITAYLFSDPRPTPELSYAVQYLTCDVGIVVTASHNPPQYN
GYKVYWNDGAQIAHPHEKNITEEMNAITSVVNLEEKVPVKRSAPTIIDAEIDEPYCTSIKEKLFRPGLTKETVQSMRIAY
TPLHGTGALHVERILGDMGFSIMTVPEQRLPDGNFPTVSSPNPEDPAALVHACAYADRVHAEVLMATDPDADRFACAVRN
TRGVLQLLTGNQMGALFTDYILLTLQEQNNMPARPAIVRSVVTSPLSDRIARTYGATCVECLTGFKWICGTAEKISQSGA
YSYVYGFEESYGHNFGIQVRDKDGINAAALCAEMGVYWKLRGMSLIDRLHQLFRTHGLFCEKTLNKTYAGVAGVSTMNAI
MNTLRRQPLTQIARKRVMKVRDIYLGVEFSPENPAQTSALSFPQSNVLQYFVQDGSIVSIRPSGTEQKIKCYIIHPLTVS
TSIEEAEQAGNMFITAVEQEMGTYLQ

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI63055049, Length=607, Percent_Identity=31.6309719934102, Blast_Score=277, Evalue=2e-74,
Organism=Homo sapiens, GI31377548, Length=568, Percent_Identity=32.5704225352113, Blast_Score=258, Evalue=1e-68,
Organism=Escherichia coli, GI1789566, Length=162, Percent_Identity=31.4814814814815, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71993870, Length=550, Percent_Identity=35.2727272727273, Blast_Score=279, Evalue=2e-75,
Organism=Caenorhabditis elegans, GI71993878, Length=303, Percent_Identity=36.3036303630363, Blast_Score=182, Evalue=5e-46,
Organism=Saccharomyces cerevisiae, GI6323934, Length=585, Percent_Identity=30.5982905982906, Blast_Score=233, Evalue=4e-62,
Organism=Drosophila melanogaster, GI20129809, Length=551, Percent_Identity=30.6715063520871, Blast_Score=248, Evalue=7e-66,
Organism=Drosophila melanogaster, GI24653722, Length=578, Percent_Identity=29.757785467128, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI24651977, Length=448, Percent_Identity=32.3660714285714, Blast_Score=234, Evalue=9e-62,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 65138; Mature: 65138

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHSSQLFERARLYLEEETDPFFAQQVRDLVAQNNIAELEERFLQTLSFGTAGLRGVVGGG
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCC
TNRMNPFMIKKITHAIALYLLKTFPEKAARGALRAVIAYDSRVHSRLFAHTAAHVFLAHD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITAYLFSDPRPTPELSYAVQYLTCDVGIVVTASHNPPQYNGYKVYWNDGAQIAHPHEKNI
HHHEEECCCCCCCCHHHHHHEEEECCEEEEEECCCCCCCCCEEEEECCCCEECCCCCCCH
TEEMNAITSVVNLEEKVPVKRSAPTIIDAEIDEPYCTSIKEKLFRPGLTKETVQSMRIAY
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHEEE
TPLHGTGALHVERILGDMGFSIMTVPEQRLPDGNFPTVSSPNPEDPAALVHACAYADRVH
ECCCCCCHHHHHHHHHHCCCEEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
AEVLMATDPDADRFACAVRNTRGVLQLLTGNQMGALFTDYILLTLQEQNNMPARPAIVRS
EEEEEECCCCHHHHHHHHHCCCCHHEECCCCCCHHHHHHEEEEEEECCCCCCCCHHHHHH
VVTSPLSDRIARTYGATCVECLTGFKWICGTAEKISQSGAYSYVYGFEESYGHNFGIQVR
HHHCCHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHCCCCEEEEECCHHHCCCCCCEEEE
DKDGINAAALCAEMGVYWKLRGMSLIDRLHQLFRTHGLFCEKTLNKTYAGVAGVSTMNAI
CCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MNTLRRQPLTQIARKRVMKVRDIYLGVEFSPENPAQTSALSFPQSNVLQYFVQDGSIVSI
HHHHHCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHCCCCHHHHHHHHHCCCCEEEE
RPSGTEQKIKCYIIHPLTVSTSIEEAEQAGNMFITAVEQEMGTYLQ
CCCCCCCEEEEEEEECEEECCCHHHHHHCCCEEEEEEHHHHCCCCC
>Mature Secondary Structure
MHSSQLFERARLYLEEETDPFFAQQVRDLVAQNNIAELEERFLQTLSFGTAGLRGVVGGG
CCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEECCC
TNRMNPFMIKKITHAIALYLLKTFPEKAARGALRAVIAYDSRVHSRLFAHTAAHVFLAHD
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ITAYLFSDPRPTPELSYAVQYLTCDVGIVVTASHNPPQYNGYKVYWNDGAQIAHPHEKNI
HHHEEECCCCCCCCHHHHHHEEEECCEEEEEECCCCCCCCCEEEEECCCCEECCCCCCCH
TEEMNAITSVVNLEEKVPVKRSAPTIIDAEIDEPYCTSIKEKLFRPGLTKETVQSMRIAY
HHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCHHHHHHHHEEE
TPLHGTGALHVERILGDMGFSIMTVPEQRLPDGNFPTVSSPNPEDPAALVHACAYADRVH
ECCCCCCHHHHHHHHHHCCCEEEECCHHHCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHC
AEVLMATDPDADRFACAVRNTRGVLQLLTGNQMGALFTDYILLTLQEQNNMPARPAIVRS
EEEEEECCCCHHHHHHHHHCCCCHHEECCCCCCHHHHHHEEEEEEECCCCCCCCHHHHHH
VVTSPLSDRIARTYGATCVECLTGFKWICGTAEKISQSGAYSYVYGFEESYGHNFGIQVR
HHHCCHHHHHHHHHHHHHHHHHHCCHHHCCCHHHHHCCCCEEEEECCHHHCCCCCCEEEE
DKDGINAAALCAEMGVYWKLRGMSLIDRLHQLFRTHGLFCEKTLNKTYAGVAGVSTMNAI
CCCCCCHHHHHHHHCCEEEECCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
MNTLRRQPLTQIARKRVMKVRDIYLGVEFSPENPAQTSALSFPQSNVLQYFVQDGSIVSI
HHHHHCCHHHHHHHHHHHHHHHEEEEEEECCCCCCCHHHCCCCHHHHHHHHHCCCCEEEE
RPSGTEQKIKCYIIHPLTVSTSIEEAEQAGNMFITAVEQEMGTYLQ
CCCCCCCEEEEEEEECEEECCCHHHHHHCCCEEEEEEHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]