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The map label for this gene is pgi

Identifier: 189025706

GI number: 189025706

Start: 504846

End: 506453

Strand: Reverse

Name: pgi

Synonym: TPASS_0475

Alternate gene names: 189025706

Gene position: 506453-504846 (Counterclockwise)

Preceding gene: 189025707

Following gene: 189025705

Centisome position: 44.45

GC content: 53.73

Gene sequence:

>1608_bases
GTGAATTGGAGAAATCTTGACGAGTGTGCCGCATACGCCCGCCTGCAGGCGATTCGTGCGCCGTCGCTGAAGACAGTACT
CTGTGGACCAGAGGGGATAGAACGTGTGCGGCGCTATTGTACCGACGCGGGGGCTGGGCTGCGCTATCACTACGCAGCGA
AAACAGTGAATGAAGAAATTCTCACGGCGCTTGCTGCTCTTGCAGACGAGCAGGAATTAGTCGCAAAGTACGACGCCCTG
CGCGCAGGAGCACAGATAAACACGGGGGAAAAACGTAAGGTGCTGCATCACCTAACGCGCCTCGGCGTGCAGGGGTCATC
GCTTGCCTCGTTGCCGTGCGAAGTGCGCGATATGCACGCCTTTTATACAAAAGAATACGAAAGAGTATGTGCGTTCGCAC
GGCAAGTACACGAAGGGGGGCTGCGCACGTCTCGCGGCGCACCGTTTACCGACGTTGTACAAATTGGAATTGGTGGATCA
GATCTCGGTCCACGGGCGTTGTATCTCGCGCTGGAAGGTTGGGCACAGAGGCACCAGGCGGTTAAGATGCGCACACATTT
TATCTCCAACGTGGACCCAGACGACGCAGCGCTTGTACTCTCAAAACTACCGCTTGAGACCACGCTTTTTATTTTGGTAT
CAAAGAGTGGTACGACGCTTGAAACACTCAGTAATGAGCTTTTCGTCGCACACGTCCTTCGTCAAGCAGGTCTAGAACCG
CACACACAGTTCGTGGCAGTTACCAGCGAGACCAGTCCACTTGCAAATAATCCCCAGTACCTTGCTTCCTTCTACATGGA
TGATTTTATCGGTGGACGCTACTCTAGTTCCTCTGTCTGTGGCGCTGTGGTACTCACGCTTGCGTTTGGACCGCAGGTGT
TTGGGCACTTCCTCTCCGGTGCGGCAGAGGCGGACCGAGCAGCACAGGAACAAGACATACGGCGTAATGCAGCACTTCTT
GACGCGCTCATCGGTGTGTACGAGCGCACTATTCTGGGATACGAGCACACCGCGGTGTTGCCCTATAGCCAGGCGTTGGC
TCGCTTTCCTGCACATTTGCAACAACTAGATATGGAATCTAACGGCAAGAGTGTTAACCGCTTCGGCATTCCGATAACGT
ATAAGACCGGCCCGGTGATCTTTGGAGAGCCTGGGACAAACGGTCAGCACTCGTTCTACCAACATTTGCATCAAGGAACA
TCGGTGGTGCCGCTTCAGTTCATTGCCTTTCAACATAGTCAGCTCGGGCAGGATCCGATAATCCGTGGATCTACCGGTCA
GCAGAAGCTCCTTGCAAATGTCGTCGCACAAATTGTCGCGTTCGCCAGGGGAAAAGAGCACGCGGATGCAAATAAAACGT
TTTCCGGGGAGCGTCCATCCAGTCTGCTATACGCTAAAGCGCTTACCCCACAAACGCTCGGCGCACTTCTTGCACACTTT
GAAAACAAGATTATGTTCCAAGGATTTGCGTGGAACTTGAACAGCTTTGATCAAGAAGGAGTGCAGCTGGGCAAGACGCT
TGCACAACACATATTAGCAGGAGAGGTGGAAGGCGTGTTGCGCGCCTACGCAGATCTGTTTGATTTAGCACACGCGCCGA
CGTGCTAG

Upstream 100 bases:

>100_bases
ACTCGCGACGATTGTCGTGCCGCGTCTTGATACATAGAACAGCCGGCGATATGTCTGTAGGTAAACCCTACGGGGTAGAA
CGATAAAAGGAGAACGCGCA

Downstream 100 bases:

>100_bases
GTCTGTGCTTCTTAAGCCCGCGGTAATTACGCGGGCCGTGCAATATGCGCCAGCGGGACTTGGAGAAAAGCGCACACCGT
GCTAGCATCAGGCGCCCGCG

Product: glucose-6-phosphate isomerase

Products: NA

Alternate protein names: GPI; Phosphoglucose isomerase; PGI; Phosphohexose isomerase; PHI

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MNWRNLDECAAYARLQAIRAPSLKTVLCGPEGIERVRRYCTDAGAGLRYHYAAKTVNEEILTALAALADEQELVAKYDAL
RAGAQINTGEKRKVLHHLTRLGVQGSSLASLPCEVRDMHAFYTKEYERVCAFARQVHEGGLRTSRGAPFTDVVQIGIGGS
DLGPRALYLALEGWAQRHQAVKMRTHFISNVDPDDAALVLSKLPLETTLFILVSKSGTTLETLSNELFVAHVLRQAGLEP
HTQFVAVTSETSPLANNPQYLASFYMDDFIGGRYSSSSVCGAVVLTLAFGPQVFGHFLSGAAEADRAAQEQDIRRNAALL
DALIGVYERTILGYEHTAVLPYSQALARFPAHLQQLDMESNGKSVNRFGIPITYKTGPVIFGEPGTNGQHSFYQHLHQGT
SVVPLQFIAFQHSQLGQDPIIRGSTGQQKLLANVVAQIVAFARGKEHADANKTFSGERPSSLLYAKALTPQTLGALLAHF
ENKIMFQGFAWNLNSFDQEGVQLGKTLAQHILAGEVEGVLRAYADLFDLAHAPTC

Sequences:

>Translated_535_residues
MNWRNLDECAAYARLQAIRAPSLKTVLCGPEGIERVRRYCTDAGAGLRYHYAAKTVNEEILTALAALADEQELVAKYDAL
RAGAQINTGEKRKVLHHLTRLGVQGSSLASLPCEVRDMHAFYTKEYERVCAFARQVHEGGLRTSRGAPFTDVVQIGIGGS
DLGPRALYLALEGWAQRHQAVKMRTHFISNVDPDDAALVLSKLPLETTLFILVSKSGTTLETLSNELFVAHVLRQAGLEP
HTQFVAVTSETSPLANNPQYLASFYMDDFIGGRYSSSSVCGAVVLTLAFGPQVFGHFLSGAAEADRAAQEQDIRRNAALL
DALIGVYERTILGYEHTAVLPYSQALARFPAHLQQLDMESNGKSVNRFGIPITYKTGPVIFGEPGTNGQHSFYQHLHQGT
SVVPLQFIAFQHSQLGQDPIIRGSTGQQKLLANVVAQIVAFARGKEHADANKTFSGERPSSLLYAKALTPQTLGALLAHF
ENKIMFQGFAWNLNSFDQEGVQLGKTLAQHILAGEVEGVLRAYADLFDLAHAPTC
>Mature_535_residues
MNWRNLDECAAYARLQAIRAPSLKTVLCGPEGIERVRRYCTDAGAGLRYHYAAKTVNEEILTALAALADEQELVAKYDAL
RAGAQINTGEKRKVLHHLTRLGVQGSSLASLPCEVRDMHAFYTKEYERVCAFARQVHEGGLRTSRGAPFTDVVQIGIGGS
DLGPRALYLALEGWAQRHQAVKMRTHFISNVDPDDAALVLSKLPLETTLFILVSKSGTTLETLSNELFVAHVLRQAGLEP
HTQFVAVTSETSPLANNPQYLASFYMDDFIGGRYSSSSVCGAVVLTLAFGPQVFGHFLSGAAEADRAAQEQDIRRNAALL
DALIGVYERTILGYEHTAVLPYSQALARFPAHLQQLDMESNGKSVNRFGIPITYKTGPVIFGEPGTNGQHSFYQHLHQGT
SVVPLQFIAFQHSQLGQDPIIRGSTGQQKLLANVVAQIVAFARGKEHADANKTFSGERPSSLLYAKALTPQTLGALLAHF
ENKIMFQGFAWNLNSFDQEGVQLGKTLAQHILAGEVEGVLRAYADLFDLAHAPTC

Specific function: Involved in glycolysis and in gluconeogenesis. [C]

COG id: COG0166

COG function: function code G; Glucose-6-phosphate isomerase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GPI family

Homologues:

Organism=Homo sapiens, GI18201905, Length=486, Percent_Identity=36.2139917695473, Blast_Score=285, Evalue=7e-77,
Organism=Homo sapiens, GI296080693, Length=487, Percent_Identity=33.8809034907598, Blast_Score=244, Evalue=1e-64,
Organism=Escherichia coli, GI1790457, Length=512, Percent_Identity=37.3046875, Blast_Score=287, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI71996708, Length=511, Percent_Identity=35.0293542074364, Blast_Score=267, Evalue=1e-71,
Organism=Caenorhabditis elegans, GI71996703, Length=511, Percent_Identity=35.0293542074364, Blast_Score=267, Evalue=1e-71,
Organism=Saccharomyces cerevisiae, GI6319673, Length=541, Percent_Identity=35.6746765249538, Blast_Score=283, Evalue=4e-77,
Organism=Drosophila melanogaster, GI24651916, Length=546, Percent_Identity=35.8974358974359, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24651914, Length=546, Percent_Identity=35.8974358974359, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI17737445, Length=546, Percent_Identity=35.8974358974359, Blast_Score=290, Evalue=2e-78,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G6PI_TREPA (O83488)

Other databases:

- EMBL:   AE000520
- PIR:   A71319
- RefSeq:   NP_218916.1
- ProteinModelPortal:   O83488
- SMR:   O83488
- GeneID:   2611115
- GenomeReviews:   AE000520_GR
- KEGG:   tpa:TP0475
- NMPDR:   fig|243276.1.peg.475
- TIGR:   TP_0475
- HOGENOM:   HBG352954
- OMA:   GPKIVSQ
- ProtClustDB:   PRK14095
- BioCyc:   TPAL243276:TP_0475-MONOMER
- BRENDA:   5.3.1.9
- GO:   GO:0005737
- GO:   GO:0006094
- GO:   GO:0006096
- HAMAP:   MF_00473
- InterPro:   IPR001672
- InterPro:   IPR023096
- InterPro:   IPR018189
- Gene3D:   G3DSA:1.10.1390.10
- PANTHER:   PTHR11469
- PRINTS:   PR00662

Pfam domain/function: PF00342 PGI

EC number: =5.3.1.9

Molecular weight: Translated: 58419; Mature: 58419

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: PS00765 P_GLUCOSE_ISOMERASE_1; PS00174 P_GLUCOSE_ISOMERASE_2; PS51463 P_GLUCOSE_ISOMERASE_3

Important sites: ACT_SITE 359-359 ACT_SITE 390-390 ACT_SITE 505-505

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNWRNLDECAAYARLQAIRAPSLKTVLCGPEGIERVRRYCTDAGAGLRYHYAAKTVNEEI
CCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
LTALAALADEQELVAKYDALRAGAQINTGEKRKVLHHLTRLGVQGSSLASLPCEVRDMHA
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
FYTKEYERVCAFARQVHEGGLRTSRGAPFTDVVQIGIGGSDLGPRALYLALEGWAQRHQA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCCCHHEEEHHHHHHHHHHH
VKMRTHFISNVDPDDAALVLSKLPLETTLFILVSKSGTTLETLSNELFVAHVLRQAGLEP
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
HTQFVAVTSETSPLANNPQYLASFYMDDFIGGRYSSSSVCGAVVLTLAFGPQVFGHFLSG
CCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
AAEADRAAQEQDIRRNAALLDALIGVYERTILGYEHTAVLPYSQALARFPAHLQQLDMES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCC
NGKSVNRFGIPITYKTGPVIFGEPGTNGQHSFYQHLHQGTSVVPLQFIAFQHSQLGQDPI
CCCCCEEECCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
IRGSTGQQKLLANVVAQIVAFARGKEHADANKTFSGERPSSLLYAKALTPQTLGALLAHF
EECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHCCHHHHHHHHHHH
ENKIMFQGFAWNLNSFDQEGVQLGKTLAQHILAGEVEGVLRAYADLFDLAHAPTC
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MNWRNLDECAAYARLQAIRAPSLKTVLCGPEGIERVRRYCTDAGAGLRYHYAAKTVNEEI
CCCCCHHHHHHHHHHHHHCCCCCEEEEECHHHHHHHHHHHHCCCCCCEEEHHHHHHHHHH
LTALAALADEQELVAKYDALRAGAQINTGEKRKVLHHLTRLGVQGSSLASLPCEVRDMHA
HHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHH
FYTKEYERVCAFARQVHEGGLRTSRGAPFTDVVQIGIGGSDLGPRALYLALEGWAQRHQA
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHEEECCCCCCCCCHHEEEHHHHHHHHHHH
VKMRTHFISNVDPDDAALVLSKLPLETTLFILVSKSGTTLETLSNELFVAHVLRQAGLEP
HHHHHHHHCCCCCCHHHHHHHHCCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCC
HTQFVAVTSETSPLANNPQYLASFYMDDFIGGRYSSSSVCGAVVLTLAFGPQVFGHFLSG
CCEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
AAEADRAAQEQDIRRNAALLDALIGVYERTILGYEHTAVLPYSQALARFPAHLQQLDMES
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCHHHHHHHHHHHHHHHCCCC
NGKSVNRFGIPITYKTGPVIFGEPGTNGQHSFYQHLHQGTSVVPLQFIAFQHSQLGQDPI
CCCCCEEECCEEEECCCCEEECCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCC
IRGSTGQQKLLANVVAQIVAFARGKEHADANKTFSGERPSSLLYAKALTPQTLGALLAHF
EECCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEEHHCCHHHHHHHHHHH
ENKIMFQGFAWNLNSFDQEGVQLGKTLAQHILAGEVEGVLRAYADLFDLAHAPTC
CCCEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9665876