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The map label for this gene is oadA [H]

Identifier: 189025290

GI number: 189025290

Start: 64360

End: 66141

Strand: Direct

Name: oadA [H]

Synonym: TPASS_0056

Alternate gene names: 189025290

Gene position: 64360-66141 (Clockwise)

Preceding gene: 189025289

Following gene: 189025291

Centisome position: 5.65

GC content: 54.04

Gene sequence:

>1782_bases
ATGAGTACCCCGGTTCGCATTAGCGAAATGGTCCTACGTGATGCGCATCAGTCTTTGCACGCTACGCGCATGACTACCGA
AGACATGCTCCCTATTTGTGACAAGCTAGATCGCGTTGGGTATTGGAGTTTGGAGGCGTGGGGAGGCGCCACGTACGACG
CCTGCATTCGCTTTCTAAATGAGGATCCCTGGGAGCGTTTGCGTGCTCTCAAATCTCGGTTACCTAAGACCCCTATTATG
ATGCTTTTGCGTGGGCAAAACTTGCTAGGCTACCGGCATTACGCGGATGACGTTGTAGATGCGTTCGTAGAGGCCGCTGC
ACGCAACGGCGTTGATGTGTTCCGCATCTTCGATGCACTTAATGACCCACGTAACCTCAGTCAGGCTGCGCGTGCTGCAA
AGAAAACAGGCAAGCATGTGCAGATGGCTATCTCTTACGCTACCACACCCTATCATACCGCAGAGAAGTACGTAGAGTTA
GCAAAGGAGTATGCGCGCTTCGGTGCGGATTCTATTTGCATTAAGGATATGTCGGGGTTGCTGACCCCGTACGGGGCGTA
CGATCTGGTTTCTGCCATTAAAAAGAGTGTCGATTTGCCCGTTGAGTTGCACACCCACGCCACTACTGGTATGTCTGTTG
CAACCCTGGTGAAGGCGGCAGAAGCAGGTGTTGATGTAATTGACACTGCCATTGCTTCTATGTCCATGGGTACTTCCCAC
AGCCCTACAGAGACTTTAGTGGAAATCCTACGGCACACGGGCCGTGACTCAGGGCTCGACATAAATCTCCTGCTAGAAAT
AGCAGCCTACTTCCGTCAGGTACGGAAGTGCTATGCCCAGTTTGAGTCTAGTTTTCTGGGTGCAGACACGCGTATCCTCG
TGTCCCAGGTGCCTGGGGGTATGCTTTCCAATTTAGAAAACCAGTTGCGTGAGCAGGGAGCCCTGGATAAGATGGACCAG
GTTCTTAAGGAAATTCCCCTGGTACAGAAGGACTGCGGTTATATCCCGCTTGTGACTCCTACGAGTCAGATTGTAGGTAC
GCAGTCAGTATTGAACGTGCTGTTTGGCCGGTACCACCGGCTTACTGCTGAGACAAGGCGTCTGCTCACGGGTCAGTATG
GCCGGACTCCCGCCTCCTGTGATGCAGGTTTGGTGGAGCGGGCCTTGAAGGAAGAAAAGTTATCGCAGTCGCTTGTCTGC
CGCCCAGCGGATGCCTTGCCTCATGAGCTTGATCGCATGAGGTCTGAGGCGCGCGCCGCAGGCGCACAGGATACCATTGA
GGATGTGCTCACGTATGCTATGTTTCCCAAGATCGCTCCCACATTCTTTGCTTCCCGTGCGCAAGGGCCTATTTCGTTCA
GAGGAAAGGGGCAGGGGCAAAAACAGAAGGGTGAGAGTGCAGGGTCGGTAGCTTCTTATGTGGCTACCGTAAATGGTACT
GCGTACACAGTTGTGCAGGAAGGCGCTGTTCTCCGGGTAAATGGTACTCCCTACACCGTTAGGGTTGAGGCAGGCCCGTC
CGTTGCTTCGGGTACGTCGCAGGGTACCGTGACTACGGCAAAGGTTGGGGCGTGTACTACGCTACCCGCGCCGGTCGCAG
GTAGCGTAGTTAAACACACCGTGCAAGATGGAGCTACGGTAAATTCGGGGGAGACGGTGCTCATGGTGGAGTCCATGAAG
ATGGAACTTGAAGTGAAGGCCACCGCTGCTGGTACTATCCATTTCCTAATAGCGCCTGGCGCGCATGTCAGTGCGGGGCA
AGTCTTAGCAGAGATTCGCTAG

Upstream 100 bases:

>100_bases
ATCGCGGTCCTGACGAAGGTGTCGGCGCTGCAGTCCCTGCAGGAGGAGCACTCGCCGCGGCTATCGCAGTCGCCGTTCAT
GAGAAGGCAAGGAGTACTTC

Downstream 100 bases:

>100_bases
AGGATGTGACCATGAATACGCGTTTACCCCTTCGAGTACTCCAGTGCGTGTTGGTGGGATTGCTTGTGTGCGGGCCCCTG
TGTGCAGCTACGCGCCGCCC

Product: pyruvate carboxylase subunit B

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 593; Mature: 592

Protein sequence:

>593_residues
MSTPVRISEMVLRDAHQSLHATRMTTEDMLPICDKLDRVGYWSLEAWGGATYDACIRFLNEDPWERLRALKSRLPKTPIM
MLLRGQNLLGYRHYADDVVDAFVEAAARNGVDVFRIFDALNDPRNLSQAARAAKKTGKHVQMAISYATTPYHTAEKYVEL
AKEYARFGADSICIKDMSGLLTPYGAYDLVSAIKKSVDLPVELHTHATTGMSVATLVKAAEAGVDVIDTAIASMSMGTSH
SPTETLVEILRHTGRDSGLDINLLLEIAAYFRQVRKCYAQFESSFLGADTRILVSQVPGGMLSNLENQLREQGALDKMDQ
VLKEIPLVQKDCGYIPLVTPTSQIVGTQSVLNVLFGRYHRLTAETRRLLTGQYGRTPASCDAGLVERALKEEKLSQSLVC
RPADALPHELDRMRSEARAAGAQDTIEDVLTYAMFPKIAPTFFASRAQGPISFRGKGQGQKQKGESAGSVASYVATVNGT
AYTVVQEGAVLRVNGTPYTVRVEAGPSVASGTSQGTVTTAKVGACTTLPAPVAGSVVKHTVQDGATVNSGETVLMVESMK
MELEVKATAAGTIHFLIAPGAHVSAGQVLAEIR

Sequences:

>Translated_593_residues
MSTPVRISEMVLRDAHQSLHATRMTTEDMLPICDKLDRVGYWSLEAWGGATYDACIRFLNEDPWERLRALKSRLPKTPIM
MLLRGQNLLGYRHYADDVVDAFVEAAARNGVDVFRIFDALNDPRNLSQAARAAKKTGKHVQMAISYATTPYHTAEKYVEL
AKEYARFGADSICIKDMSGLLTPYGAYDLVSAIKKSVDLPVELHTHATTGMSVATLVKAAEAGVDVIDTAIASMSMGTSH
SPTETLVEILRHTGRDSGLDINLLLEIAAYFRQVRKCYAQFESSFLGADTRILVSQVPGGMLSNLENQLREQGALDKMDQ
VLKEIPLVQKDCGYIPLVTPTSQIVGTQSVLNVLFGRYHRLTAETRRLLTGQYGRTPASCDAGLVERALKEEKLSQSLVC
RPADALPHELDRMRSEARAAGAQDTIEDVLTYAMFPKIAPTFFASRAQGPISFRGKGQGQKQKGESAGSVASYVATVNGT
AYTVVQEGAVLRVNGTPYTVRVEAGPSVASGTSQGTVTTAKVGACTTLPAPVAGSVVKHTVQDGATVNSGETVLMVESMK
MELEVKATAAGTIHFLIAPGAHVSAGQVLAEIR
>Mature_592_residues
STPVRISEMVLRDAHQSLHATRMTTEDMLPICDKLDRVGYWSLEAWGGATYDACIRFLNEDPWERLRALKSRLPKTPIMM
LLRGQNLLGYRHYADDVVDAFVEAAARNGVDVFRIFDALNDPRNLSQAARAAKKTGKHVQMAISYATTPYHTAEKYVELA
KEYARFGADSICIKDMSGLLTPYGAYDLVSAIKKSVDLPVELHTHATTGMSVATLVKAAEAGVDVIDTAIASMSMGTSHS
PTETLVEILRHTGRDSGLDINLLLEIAAYFRQVRKCYAQFESSFLGADTRILVSQVPGGMLSNLENQLREQGALDKMDQV
LKEIPLVQKDCGYIPLVTPTSQIVGTQSVLNVLFGRYHRLTAETRRLLTGQYGRTPASCDAGLVERALKEEKLSQSLVCR
PADALPHELDRMRSEARAAGAQDTIEDVLTYAMFPKIAPTFFASRAQGPISFRGKGQGQKQKGESAGSVASYVATVNGTA
YTVVQEGAVLRVNGTPYTVRVEAGPSVASGTSQGTVTTAKVGACTTLPAPVAGSVVKHTVQDGATVNSGETVLMVESMKM
ELEVKATAAGTIHFLIAPGAHVSAGQVLAEIR

Specific function: Lyase and sodium transporter [H]

COG id: COG5016

COG function: function code C; Pyruvate/oxaloacetate carboxyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotinyl-binding domain [H]

Homologues:

Organism=Homo sapiens, GI106049528, Length=606, Percent_Identity=31.5181518151815, Blast_Score=246, Evalue=6e-65,
Organism=Homo sapiens, GI106049295, Length=606, Percent_Identity=31.5181518151815, Blast_Score=246, Evalue=6e-65,
Organism=Homo sapiens, GI106049292, Length=606, Percent_Identity=31.5181518151815, Blast_Score=246, Evalue=6e-65,
Organism=Caenorhabditis elegans, GI17562816, Length=629, Percent_Identity=32.1144674085851, Blast_Score=272, Evalue=3e-73,
Organism=Saccharomyces cerevisiae, GI6319695, Length=619, Percent_Identity=31.3408723747981, Blast_Score=270, Evalue=7e-73,
Organism=Saccharomyces cerevisiae, GI6321376, Length=619, Percent_Identity=31.0177705977383, Blast_Score=265, Evalue=2e-71,
Organism=Drosophila melanogaster, GI24652212, Length=619, Percent_Identity=32.4717285945073, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24652210, Length=619, Percent_Identity=32.4717285945073, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24652214, Length=619, Percent_Identity=32.4717285945073, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI19921944, Length=619, Percent_Identity=32.4717285945073, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI24652216, Length=619, Percent_Identity=32.4717285945073, Blast_Score=273, Evalue=3e-73,
Organism=Drosophila melanogaster, GI281363050, Length=619, Percent_Identity=32.4717285945073, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24652224, Length=619, Percent_Identity=32.4717285945073, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24652222, Length=619, Percent_Identity=32.4717285945073, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24652220, Length=619, Percent_Identity=32.4717285945073, Blast_Score=272, Evalue=4e-73,
Organism=Drosophila melanogaster, GI24652218, Length=619, Percent_Identity=32.4717285945073, Blast_Score=272, Evalue=4e-73,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR001882
- InterPro:   IPR000089
- InterPro:   IPR003379
- InterPro:   IPR005776
- InterPro:   IPR000891
- InterPro:   IPR011053 [H]

Pfam domain/function: PF00364 Biotin_lipoyl; PF00682 HMGL-like; PF02436 PYC_OADA [H]

EC number: =4.1.1.3 [H]

Molecular weight: Translated: 64100; Mature: 63969

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50991 PYR_CT ; PS50968 BIOTINYL_LIPOYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTPVRISEMVLRDAHQSLHATRMTTEDMLPICDKLDRVGYWSLEAWGGATYDACIRFLN
CCCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHC
EDPWERLRALKSRLPKTPIMMLLRGQNLLGYRHYADDVVDAFVEAAARNGVDVFRIFDAL
CCHHHHHHHHHHHCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NDPRNLSQAARAAKKTGKHVQMAISYATTPYHTAEKYVELAKEYARFGADSICIKDMSGL
CCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTPYGAYDLVSAIKKSVDLPVELHTHATTGMSVATLVKAAEAGVDVIDTAIASMSMGTSH
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
SPTETLVEILRHTGRDSGLDINLLLEIAAYFRQVRKCYAQFESSFLGADTRILVSQVPGG
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCH
MLSNLENQLREQGALDKMDQVLKEIPLVQKDCGYIPLVTPTSQIVGTQSVLNVLFGRYHR
HHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
LTAETRRLLTGQYGRTPASCDAGLVERALKEEKLSQSLVCRPADALPHELDRMRSEARAA
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
GAQDTIEDVLTYAMFPKIAPTFFASRAQGPISFRGKGQGQKQKGESAGSVASYVATVNGT
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHCCCCHHHHHHHHEECCCC
AYTVVQEGAVLRVNGTPYTVRVEAGPSVASGTSQGTVTTAKVGACTTLPAPVAGSVVKHT
EEEEEECCEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
VQDGATVNSGETVLMVESMKMELEVKATAAGTIHFLIAPGAHVSAGQVLAEIR
HHCCCEECCCCEEEEEECCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHCC
>Mature Secondary Structure 
STPVRISEMVLRDAHQSLHATRMTTEDMLPICDKLDRVGYWSLEAWGGATYDACIRFLN
CCCHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCEEEEECCCCCCHHHHHHHHC
EDPWERLRALKSRLPKTPIMMLLRGQNLLGYRHYADDVVDAFVEAAARNGVDVFRIFDAL
CCHHHHHHHHHHHCCCCCHHHHEECCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
NDPRNLSQAARAAKKTGKHVQMAISYATTPYHTAEKYVELAKEYARFGADSICIKDMSGL
CCCHHHHHHHHHHHHCCCEEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
LTPYGAYDLVSAIKKSVDLPVELHTHATTGMSVATLVKAAEAGVDVIDTAIASMSMGTSH
CCCCCHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCC
SPTETLVEILRHTGRDSGLDINLLLEIAAYFRQVRKCYAQFESSFLGADTRILVSQVPGG
CCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCH
MLSNLENQLREQGALDKMDQVLKEIPLVQKDCGYIPLVTPTSQIVGTQSVLNVLFGRYHR
HHHHHHHHHHHCCCHHHHHHHHHHCCCCHHCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
LTAETRRLLTGQYGRTPASCDAGLVERALKEEKLSQSLVCRPADALPHELDRMRSEARAA
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHC
GAQDTIEDVLTYAMFPKIAPTFFASRAQGPISFRGKGQGQKQKGESAGSVASYVATVNGT
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCHHCCCCHHHHHHHHEECCCC
AYTVVQEGAVLRVNGTPYTVRVEAGPSVASGTSQGTVTTAKVGACTTLPAPVAGSVVKHT
EEEEEECCEEEEECCCCEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
VQDGATVNSGETVLMVESMKMELEVKATAAGTIHFLIAPGAHVSAGQVLAEIR
HHCCCEECCCCEEEEEECCCEEEEEEEECCCEEEEEECCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2454915 [H]