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The map label for this gene is hutH

Identifier: 188587411

GI number: 188587411

Start: 3050122

End: 3051645

Strand: Reverse

Name: hutH

Synonym: Nther_2820

Alternate gene names: 188587411

Gene position: 3051645-3050122 (Counterclockwise)

Preceding gene: 188587413

Following gene: 188587410

Centisome position: 96.4

GC content: 41.4

Gene sequence:

>1524_bases
TTGATACACCTGACTGGTGAAAATCTAAAATTTAAAGAGATTGAAAAAGTTATCAATCACGGAGAACAAGTAGAACTGTC
CACGCAAGCTAAGGAAAACATAATTGCCAGCAGGCGACTCATTGATGATTTAACTGAAAAAGAATCAATAGTATATGGAG
TTACAACAGGTTTTGGTAAATTTAGTGACACTTTCATCTCTAGTGAAAATTTACAACAGCTTCAGGAAAACTTGATTTTA
AGTCATTCAGCTGGAGTTGGTGAACCTTTTTCCGAGCAAGTGGTACGGGGAATGATGCTTTTTAGAGCTAATAGCCTGGC
CAAGGGTCATTCTGGAATACGTTTAGAGACGGTGCAATTATTGATAGATATGTTAAATAAAGGAGTACACCCTATTATCC
CTTCTAAAGGGTCTTTGGGAGCTAGTGGTGATCTAGCGCCTTTAGCTCACATGGTTTTAGTGATGATTGGAAAGGGAGAA
GCATATTATCATGGCGATAGAATGGCAGGTGACAAAGCATTATCGGAGGCTGGTTTATCTCCCGTCAAACTAGGAGCAAA
AGAGGGCTTGGCCTTAATAAATGGCACCCAGGCCATCGTTTCAGTGGGCACTTTAACATGGTTAAGAATGAAAAACCTTT
TAAAGACTGCCGATATATGTGCAGCTATGACCATTGATTCTTTGGAAGGAATCTTGGATGCATTTCAAGACAAGATTTTT
CGTCTGCGACCTCATCCGGGGCATGGCAAAACAGCTGAAAATATCCGCCGACTGCTACAGGACAGTGAAATCATAGAAAA
TAGGGAACACAAGCGAGTACAGGATGCTTATACACTGCGATGTATTCCTCAAATCCATGGTGCTTCTAAGGATGCCCATG
AGCATATAGGGGGAATTCTTAATAGGGAAATTAATTCAACTACCGACAACCCATTGATTTTCCCTCAAGAAAATGAGGTC
ATATCCGGCGGAAACTTTCACGGGCAACCTTTAGCTCTACCTATGGATTATATGAGTATGGCTATAGCCGAGTTGGCCAA
TGTCGCCGAACGGAGGATAGAAAGACTGGTAAATCCTAATTTAAATTTTGGATTGCCTCCTTTTTTAATTAAAGATGGTG
GTGTCAGTTCTGGATTTATGATTGCCCAGTACACTGCTGCATCTTTGGTAAGTGAGAATAAAAGTCTAGCTCATCCAGCT
AGTGTAGACTCAATACCGAGTTCGGCTAATCAAGAAGACCATGTTAGCATGGGTACAATTGGAGCCCGAAAAGCATTATC
CATACTGGAGAACACTGAAAAAGTATTGGCTATTGAGCTGTTGTGTGCCTCTCAAGCATTGGATTATAGGCAGCCACGTC
AAAGTGGAAGTGGTACAAGAAAGGCTTATGAACTGGTAAGAGAACAAGTCCCCCACTTAGCCGAGGATAGAGAATTAGCT
TCGGATATAGAAACTGTTGAACAGCTGATTGTTGAAGGTCGCCTAGTTTCGGAACTAGAGAAAACCATAGGAGAACTGAA
GTAG

Upstream 100 bases:

>100_bases
CGAAATTCACAATACCCTAAAAAAAGGGTGAACAAATTATAGGAAACTAACTGCAAGTTTATAGATAAGTTACGATAATT
AATAAAAGGGAGGGTACTTT

Downstream 100 bases:

>100_bases
CAATCATACTGATAGATTAGAAAGTTTTATCACCATGTTAATAAAAATTCGGCCTTATGTTACAAAGAGATGTTTTACTA
TTGTAAAGGCCGAATTTACT

Product: histidine ammonia-lyase

Products: NA

Alternate protein names: Histidase

Number of amino acids: Translated: 507; Mature: 507

Protein sequence:

>507_residues
MIHLTGENLKFKEIEKVINHGEQVELSTQAKENIIASRRLIDDLTEKESIVYGVTTGFGKFSDTFISSENLQQLQENLIL
SHSAGVGEPFSEQVVRGMMLFRANSLAKGHSGIRLETVQLLIDMLNKGVHPIIPSKGSLGASGDLAPLAHMVLVMIGKGE
AYYHGDRMAGDKALSEAGLSPVKLGAKEGLALINGTQAIVSVGTLTWLRMKNLLKTADICAAMTIDSLEGILDAFQDKIF
RLRPHPGHGKTAENIRRLLQDSEIIENREHKRVQDAYTLRCIPQIHGASKDAHEHIGGILNREINSTTDNPLIFPQENEV
ISGGNFHGQPLALPMDYMSMAIAELANVAERRIERLVNPNLNFGLPPFLIKDGGVSSGFMIAQYTAASLVSENKSLAHPA
SVDSIPSSANQEDHVSMGTIGARKALSILENTEKVLAIELLCASQALDYRQPRQSGSGTRKAYELVREQVPHLAEDRELA
SDIETVEQLIVEGRLVSELEKTIGELK

Sequences:

>Translated_507_residues
MIHLTGENLKFKEIEKVINHGEQVELSTQAKENIIASRRLIDDLTEKESIVYGVTTGFGKFSDTFISSENLQQLQENLIL
SHSAGVGEPFSEQVVRGMMLFRANSLAKGHSGIRLETVQLLIDMLNKGVHPIIPSKGSLGASGDLAPLAHMVLVMIGKGE
AYYHGDRMAGDKALSEAGLSPVKLGAKEGLALINGTQAIVSVGTLTWLRMKNLLKTADICAAMTIDSLEGILDAFQDKIF
RLRPHPGHGKTAENIRRLLQDSEIIENREHKRVQDAYTLRCIPQIHGASKDAHEHIGGILNREINSTTDNPLIFPQENEV
ISGGNFHGQPLALPMDYMSMAIAELANVAERRIERLVNPNLNFGLPPFLIKDGGVSSGFMIAQYTAASLVSENKSLAHPA
SVDSIPSSANQEDHVSMGTIGARKALSILENTEKVLAIELLCASQALDYRQPRQSGSGTRKAYELVREQVPHLAEDRELA
SDIETVEQLIVEGRLVSELEKTIGELK
>Mature_507_residues
MIHLTGENLKFKEIEKVINHGEQVELSTQAKENIIASRRLIDDLTEKESIVYGVTTGFGKFSDTFISSENLQQLQENLIL
SHSAGVGEPFSEQVVRGMMLFRANSLAKGHSGIRLETVQLLIDMLNKGVHPIIPSKGSLGASGDLAPLAHMVLVMIGKGE
AYYHGDRMAGDKALSEAGLSPVKLGAKEGLALINGTQAIVSVGTLTWLRMKNLLKTADICAAMTIDSLEGILDAFQDKIF
RLRPHPGHGKTAENIRRLLQDSEIIENREHKRVQDAYTLRCIPQIHGASKDAHEHIGGILNREINSTTDNPLIFPQENEV
ISGGNFHGQPLALPMDYMSMAIAELANVAERRIERLVNPNLNFGLPPFLIKDGGVSSGFMIAQYTAASLVSENKSLAHPA
SVDSIPSSANQEDHVSMGTIGARKALSILENTEKVLAIELLCASQALDYRQPRQSGSGTRKAYELVREQVPHLAEDRELA
SDIETVEQLIVEGRLVSELEKTIGELK

Specific function: Unknown

COG id: COG2986

COG function: function code E; Histidine ammonia-lyase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PAL/histidase family

Homologues:

Organism=Homo sapiens, GI4504333, Length=503, Percent_Identity=47.3161033797217, Blast_Score=447, Evalue=1e-125,
Organism=Caenorhabditis elegans, GI17567831, Length=478, Percent_Identity=46.652719665272, Blast_Score=413, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HUTH_NATTJ (B2A3D9)

Other databases:

- EMBL:   CP001034
- RefSeq:   YP_001918956.1
- ProteinModelPortal:   B2A3D9
- SMR:   B2A3D9
- GeneID:   6316814
- GenomeReviews:   CP001034_GR
- KEGG:   nth:Nther_2820
- HOGENOM:   HBG510887
- OMA:   QKGQIDS
- GO:   GO:0005737
- HAMAP:   MF_00229
- InterPro:   IPR005921
- InterPro:   IPR008948
- InterPro:   IPR001106
- InterPro:   IPR022313
- TIGRFAMs:   TIGR01225

Pfam domain/function: PF00221 PAL; SSF48557 L-Aspartase-like

EC number: =4.3.1.3

Molecular weight: Translated: 55363; Mature: 55363

Theoretical pI: Translated: 5.96; Mature: 5.96

Prosite motif: PS00488 PAL_HISTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIHLTGENLKFKEIEKVINHGEQVELSTQAKENIIASRRLIDDLTEKESIVYGVTTGFGK
CEEECCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
FSDTFISSENLQQLQENLILSHSAGVGEPFSEQVVRGMMLFRANSLAKGHSGIRLETVQL
HHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LIDMLNKGVHPIIPSKGSLGASGDLAPLAHMVLVMIGKGEAYYHGDRMAGDKALSEAGLS
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCC
PVKLGAKEGLALINGTQAIVSVGTLTWLRMKNLLKTADICAAMTIDSLEGILDAFQDKIF
CCCCCHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
RLRPHPGHGKTAENIRRLLQDSEIIENREHKRVQDAYTLRCIPQIHGASKDAHEHIGGIL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCHHHHHHHHHH
NREINSTTDNPLIFPQENEVISGGNFHGQPLALPMDYMSMAIAELANVAERRIERLVNPN
HCCCCCCCCCCEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LNFGLPPFLIKDGGVSSGFMIAQYTAASLVSENKSLAHPASVDSIPSSANQEDHVSMGTI
CCCCCCCEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
GARKALSILENTEKVLAIELLCASQALDYRQPRQSGSGTRKAYELVREQVPHLAEDRELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SDIETVEQLIVEGRLVSELEKTIGELK
HHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIHLTGENLKFKEIEKVINHGEQVELSTQAKENIIASRRLIDDLTEKESIVYGVTTGFGK
CEEECCCCCCHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCEEEEEECCCCC
FSDTFISSENLQQLQENLILSHSAGVGEPFSEQVVRGMMLFRANSLAKGHSGIRLETVQL
HHHHHCCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHH
LIDMLNKGVHPIIPSKGSLGASGDLAPLAHMVLVMIGKGEAYYHGDRMAGDKALSEAGLS
HHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEECCCHHHHHHHHHHCCCC
PVKLGAKEGLALINGTQAIVSVGTLTWLRMKNLLKTADICAAMTIDSLEGILDAFQDKIF
CCCCCHHCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHE
RLRPHPGHGKTAENIRRLLQDSEIIENREHKRVQDAYTLRCIPQIHGASKDAHEHIGGIL
EECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCHHHHHHHHHH
NREINSTTDNPLIFPQENEVISGGNFHGQPLALPMDYMSMAIAELANVAERRIERLVNPN
HCCCCCCCCCCEEECCCCCEECCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
LNFGLPPFLIKDGGVSSGFMIAQYTAASLVSENKSLAHPASVDSIPSSANQEDHVSMGTI
CCCCCCCEEEECCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCH
GARKALSILENTEKVLAIELLCASQALDYRQPRQSGSGTRKAYELVREQVPHLAEDRELA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHH
SDIETVEQLIVEGRLVSELEKTIGELK
HHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA