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The map label for this gene is hdrA2 [H]

Identifier: 188587260

GI number: 188587260

Start: 2866384

End: 2868360

Strand: Reverse

Name: hdrA2 [H]

Synonym: Nther_2662

Alternate gene names: 188587260

Gene position: 2868360-2866384 (Counterclockwise)

Preceding gene: 188587261

Following gene: 188587259

Centisome position: 90.61

GC content: 43.45

Gene sequence:

>1977_bases
ATGAGAATAGGAGTATTCATCTGCTGGTGTGGCAGTAATATTAAAAATATGGTGGATGTTGAACGTGTAGCTCAAGAAGC
TAAAAGAATGCCTAGGGTTGTTTATTCCCAGGATGTGCAGTATCTTTGCTCTGAAGTAGGACAGGCCGATATTAGAGACG
CAATTGCCGAGCATAACTTGGACCGAGTAGTTATTGGTGCCTGTTCCCCACGTATGCACGAACCGACATTCCAGAAGCTT
TTAGAAGAACAGGGTTTAAATCCTTTTTATGTTGAGATAGCAAATATTAGAGAACAGTGTTCATGGGTACATTCTGATAA
AGACAAGGCTACGGAAAAAGCTACCGAGCTAGTACAAAAAGCTGTTGCCAAGTCTTATCATTCAATACCTTTAACATCTG
ATCTCTTAGATGTTAATAAACGAGCCTTAGTAGTCGGTGGTGGTATAGCAGGTATTCAAGCTGCTTTAGATATAGCGGAA
GCGGGGTATCCAGTCGATCTGGTTGAAAAAGAACCATCAATTGGCGGTAGAATGGCCCAATTCGATAAAACCTTTCCAAC
ATTGGATTGCTCGGCTTGTATATTGACACCGAAAATGGTTGAAGCAGCTTCCCACGAGAATATCAATCTCTATACCTATT
CTGAGATAGAAGATTTATCTGGATATGTTGGAAACTTTAAAGTTCGTATTAAGCAAAAGGCTAAAAGCGTCAAACCCGAT
AAATGTAACGGATGCGGTGACTGTATGGCAAAATGTCCTAAAAAGGTTGACAATGAATTCGATGAAGGAAACAGCAAGCG
TAAAGCAATCTATACTTTATTCCCCCAGGCCGTGCCTAACAAACCTGTTCTGGATAGAGAAAACTGTATTTATTTCCAAA
CAGGTAAATGCGGTGTCTGCCAGAAGATTTGTCCTACCGGGGCTATCGACTATGAAGAACAGGATGAAATTATCGAAAAT
GAATATGGAGCTATAGTTGCCGCTACAGGATTTGACTTGAAAAAGCCAGTGGAGCTTGGAGAGTACTGCTACGGTGATCA
TTCCGATGTGATTACCAGCCTGGAATTAGAAAGAATGTTAAATGCCTCAGGGCCAACGGGTGGAAAGGTAGTTAGACCGT
CAAACGGTGAAACACCCAAGAGGATAGCCTTTATCCAGTGTGTAGGCTCCCGGGATAGAAATGAAGGTAACCCTTACTGT
TCTAAGGTTTGTTGCCTGTACACAGCCAAGCATACACTGCTCATGAGTGAAAAGTTCCCAGAAACTGAAAATTTCGTGTT
CAATATAGATGTTAGAACTGCTGGTAAGGATTACGAAGAGTTTTACGAAAGAGCTAGACAGCAAGGTGCTAATTATCTAA
GAGGACAAGTTTCTAAAGTTGAACCTTTAGAAGATGATAACAATCGATTACTAGTCCGTGGTTATGACAGTTCCCTGGGA
GAACAGGTAGAGATTGAAGCCGATTTAGTGGTCTTGGCTTCTAGCATAGAACCAAAACCTGATTCTCAAGATGTGGCTAC
AGTACTGGGGATATCCGTAGACCAAAATGGTTTCTTTTCAGAAGCCCATCCCAAATTGCGGCCCGTCGAGACTCAAGCCC
AGGGGGTATACCTGGCCGGCGTGTGTCAGGGACCAAAGGATATTCCAGAAACAGTCGCTCAGGCCAGTGGAGCCTCTGCC
AAAGTCATCACTCTCTTTAATAAAGGCCAGGTCAAGAGTGTACCGACCACTGCCATAGTTAATACAGATATTTGCAGCGG
CTGTATGCAATGTAAAACAGTTTGTCCTTATGAAGCTATCAGCCAAGATCATGTGGAAGAAAAAGTGGCTGGAGAAGTTA
GACAGCGACCCGTCGCTTCCGTAAACAGAGCCCTTTGTCAAGGATGCGGTGCTTGTGCCGGGCTTTGCAGAAGTGGAGCT
ATGGATCTAGGTGGATTTACCAGCAAACAACTTATGGCGGAGGTGGATACCCTGTGA

Upstream 100 bases:

>100_bases
GACACTAAAGGAGTTCCAAGACAAGCTTTAATTGCTTCCATGAGGAAATTTAGACGATAAAGACAAGCTGCTATCAAGCT
GCGAGTAGAGGAGGGAAACA

Downstream 100 bases:

>100_bases
CACAGCAAAATTTCGAGCCAAAAATTGTAGCTTTTTGTTGTAACTGGTGTAGTTATGCCGGAGCTGACCTGGCGGGTACA
GGAAGGCTCAAATATCCTGA

Product: CoB--CoM heterodisulfide reductase subunit A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 658; Mature: 658

Protein sequence:

>658_residues
MRIGVFICWCGSNIKNMVDVERVAQEAKRMPRVVYSQDVQYLCSEVGQADIRDAIAEHNLDRVVIGACSPRMHEPTFQKL
LEEQGLNPFYVEIANIREQCSWVHSDKDKATEKATELVQKAVAKSYHSIPLTSDLLDVNKRALVVGGGIAGIQAALDIAE
AGYPVDLVEKEPSIGGRMAQFDKTFPTLDCSACILTPKMVEAASHENINLYTYSEIEDLSGYVGNFKVRIKQKAKSVKPD
KCNGCGDCMAKCPKKVDNEFDEGNSKRKAIYTLFPQAVPNKPVLDRENCIYFQTGKCGVCQKICPTGAIDYEEQDEIIEN
EYGAIVAATGFDLKKPVELGEYCYGDHSDVITSLELERMLNASGPTGGKVVRPSNGETPKRIAFIQCVGSRDRNEGNPYC
SKVCCLYTAKHTLLMSEKFPETENFVFNIDVRTAGKDYEEFYERARQQGANYLRGQVSKVEPLEDDNNRLLVRGYDSSLG
EQVEIEADLVVLASSIEPKPDSQDVATVLGISVDQNGFFSEAHPKLRPVETQAQGVYLAGVCQGPKDIPETVAQASGASA
KVITLFNKGQVKSVPTTAIVNTDICSGCMQCKTVCPYEAISQDHVEEKVAGEVRQRPVASVNRALCQGCGACAGLCRSGA
MDLGGFTSKQLMAEVDTL

Sequences:

>Translated_658_residues
MRIGVFICWCGSNIKNMVDVERVAQEAKRMPRVVYSQDVQYLCSEVGQADIRDAIAEHNLDRVVIGACSPRMHEPTFQKL
LEEQGLNPFYVEIANIREQCSWVHSDKDKATEKATELVQKAVAKSYHSIPLTSDLLDVNKRALVVGGGIAGIQAALDIAE
AGYPVDLVEKEPSIGGRMAQFDKTFPTLDCSACILTPKMVEAASHENINLYTYSEIEDLSGYVGNFKVRIKQKAKSVKPD
KCNGCGDCMAKCPKKVDNEFDEGNSKRKAIYTLFPQAVPNKPVLDRENCIYFQTGKCGVCQKICPTGAIDYEEQDEIIEN
EYGAIVAATGFDLKKPVELGEYCYGDHSDVITSLELERMLNASGPTGGKVVRPSNGETPKRIAFIQCVGSRDRNEGNPYC
SKVCCLYTAKHTLLMSEKFPETENFVFNIDVRTAGKDYEEFYERARQQGANYLRGQVSKVEPLEDDNNRLLVRGYDSSLG
EQVEIEADLVVLASSIEPKPDSQDVATVLGISVDQNGFFSEAHPKLRPVETQAQGVYLAGVCQGPKDIPETVAQASGASA
KVITLFNKGQVKSVPTTAIVNTDICSGCMQCKTVCPYEAISQDHVEEKVAGEVRQRPVASVNRALCQGCGACAGLCRSGA
MDLGGFTSKQLMAEVDTL
>Mature_658_residues
MRIGVFICWCGSNIKNMVDVERVAQEAKRMPRVVYSQDVQYLCSEVGQADIRDAIAEHNLDRVVIGACSPRMHEPTFQKL
LEEQGLNPFYVEIANIREQCSWVHSDKDKATEKATELVQKAVAKSYHSIPLTSDLLDVNKRALVVGGGIAGIQAALDIAE
AGYPVDLVEKEPSIGGRMAQFDKTFPTLDCSACILTPKMVEAASHENINLYTYSEIEDLSGYVGNFKVRIKQKAKSVKPD
KCNGCGDCMAKCPKKVDNEFDEGNSKRKAIYTLFPQAVPNKPVLDRENCIYFQTGKCGVCQKICPTGAIDYEEQDEIIEN
EYGAIVAATGFDLKKPVELGEYCYGDHSDVITSLELERMLNASGPTGGKVVRPSNGETPKRIAFIQCVGSRDRNEGNPYC
SKVCCLYTAKHTLLMSEKFPETENFVFNIDVRTAGKDYEEFYERARQQGANYLRGQVSKVEPLEDDNNRLLVRGYDSSLG
EQVEIEADLVVLASSIEPKPDSQDVATVLGISVDQNGFFSEAHPKLRPVETQAQGVYLAGVCQGPKDIPETVAQASGASA
KVITLFNKGQVKSVPTTAIVNTDICSGCMQCKTVCPYEAISQDHVEEKVAGEVRQRPVASVNRALCQGCGACAGLCRSGA
MDLGGFTSKQLMAEVDTL

Specific function: Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). May act as the catalytic subunit [H]

COG id: COG1148

COG function: function code C; Heterodisulfide reductase, subunit A and related polyferredoxins

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 4Fe-4S ferredoxin-type domains [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001450
- InterPro:   IPR017896
- InterPro:   IPR017900
- InterPro:   IPR003953
- InterPro:   IPR012285 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF00037 Fer4 [H]

EC number: =1.8.98.1 [H]

Molecular weight: Translated: 72047; Mature: 72047

Theoretical pI: Translated: 4.97; Mature: 4.97

Prosite motif: PS00198 4FE4S_FERREDOXIN ; PS00261 GLYCO_HORMONE_BETA_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.4 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
4.4 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGVFICWCGSNIKNMVDVERVAQEAKRMPRVVYSQDVQYLCSEVGQADIRDAIAEHNL
CEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
DRVVIGACSPRMHEPTFQKLLEEQGLNPFYVEIANIREQCSWVHSDKDKATEKATELVQK
CEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AVAKSYHSIPLTSDLLDVNKRALVVGGGIAGIQAALDIAEAGYPVDLVEKEPSIGGRMAQ
HHHHHHCCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
FDKTFPTLDCSACILTPKMVEAASHENINLYTYSEIEDLSGYVGNFKVRIKQKAKSVKPD
HHCCCCCCCCCCEECCHHHHHHCCCCCEEEEECCCHHHHCCCCCCEEEEEEHHHCCCCCC
KCNGCGDCMAKCPKKVDNEFDEGNSKRKAIYTLFPQAVPNKPVLDRENCIYFQTGKCGVC
CCCCHHHHHHHCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHH
QKICPTGAIDYEEQDEIIENEYGAIVAATGFDLKKPVELGEYCYGDHSDVITSLELERML
HHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
NASGPTGGKVVRPSNGETPKRIAFIQCVGSRDRNEGNPYCSKVCCLYTAKHTLLMSEKFP
CCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
ETENFVFNIDVRTAGKDYEEFYERARQQGANYLRGQVSKVEPLEDDNNRLLVRGYDSSLG
CCCCEEEEEEEECCCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCC
EQVEIEADLVVLASSIEPKPDSQDVATVLGISVDQNGFFSEAHPKLRPVETQAQGVYLAG
CEEEEEEEEEEEEECCCCCCCCCHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCEEEEE
VCQGPKDIPETVAQASGASAKVITLFNKGQVKSVPTTAIVNTDICSGCMQCKTVCPYEAI
ECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHCCCCCHHHH
SQDHVEEKVAGEVRQRPVASVNRALCQGCGACAGLCRSGAMDLGGFTSKQLMAEVDTL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure
MRIGVFICWCGSNIKNMVDVERVAQEAKRMPRVVYSQDVQYLCSEVGQADIRDAIAEHNL
CEEEEEEEECCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHCCC
DRVVIGACSPRMHEPTFQKLLEEQGLNPFYVEIANIREQCSWVHSDKDKATEKATELVQK
CEEEEECCCCCCCCHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHH
AVAKSYHSIPLTSDLLDVNKRALVVGGGIAGIQAALDIAEAGYPVDLVEKEPSIGGRMAQ
HHHHHHCCCCCCHHHHHCCCCEEEEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCHHH
FDKTFPTLDCSACILTPKMVEAASHENINLYTYSEIEDLSGYVGNFKVRIKQKAKSVKPD
HHCCCCCCCCCCEECCHHHHHHCCCCCEEEEECCCHHHHCCCCCCEEEEEEHHHCCCCCC
KCNGCGDCMAKCPKKVDNEFDEGNSKRKAIYTLFPQAVPNKPVLDRENCIYFQTGKCGVC
CCCCHHHHHHHCHHHHCCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCEEEEECCCCCHH
QKICPTGAIDYEEQDEIIENEYGAIVAATGFDLKKPVELGEYCYGDHSDVITSLELERML
HHHCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHH
NASGPTGGKVVRPSNGETPKRIAFIQCVGSRDRNEGNPYCSKVCCLYTAKHTLLMSEKFP
CCCCCCCCEEECCCCCCCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHEEECCCCC
ETENFVFNIDVRTAGKDYEEFYERARQQGANYLRGQVSKVEPLEDDNNRLLVRGYDSSLG
CCCCEEEEEEEECCCCCHHHHHHHHHHHCCHHHHCCCCCCCCCCCCCCEEEEEECCCCCC
EQVEIEADLVVLASSIEPKPDSQDVATVLGISVDQNGFFSEAHPKLRPVETQAQGVYLAG
CEEEEEEEEEEEEECCCCCCCCCHHHHHHEEEECCCCCCCCCCCCCCCCCCCCCCEEEEE
VCQGPKDIPETVAQASGASAKVITLFNKGQVKSVPTTAIVNTDICSGCMQCKTVCPYEAI
ECCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCEEEECCHHHHHHHHHCCCCCHHHH
SQDHVEEKVAGEVRQRPVASVNRALCQGCGACAGLCRSGAMDLGGFTSKQLMAEVDTL
HHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9063468; 11930014 [H]