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The map label for this gene is degS [H]

Identifier: 188586934

GI number: 188586934

Start: 2471212

End: 2472402

Strand: Reverse

Name: degS [H]

Synonym: Nther_2326

Alternate gene names: 188586934

Gene position: 2472402-2471212 (Counterclockwise)

Preceding gene: 188586936

Following gene: 188586933

Centisome position: 78.1

GC content: 37.95

Gene sequence:

>1191_bases
ATGGCTGATGACAACCATTTCGCTCCGAGCGAAAAAGTGGATGTAAAAGTTGTAGATGACATCCTAGAAAAGACTATCGA
CAATATTCAAAACGGTAAAGTACAAATCTTTGAAATTGCCGAATCGGCTCGAACTGAATATGATCAGATGCAACAAGAAC
TAAAAGAGATAAAAAACAAGGTCAGAGAAGTGATTCAAGAAGTGGACAACCTGGAAAAAAAGTGCCATCAGGCCAAAGTC
CACTTGGCAGATGTCAGTAAGCACTTCGATACTTATTCTGAAGAAGATATTAAAGAAGCCTACGAACAAGCCAGTGATTT
GCGTGCACGTTTGACAATAATGAAGGAACGGGAACAGCAGCTTAGAAACCATAGGGACAGTACTGAACGTAGACTTAAGA
ACCTGAAAAAAACCATAGAGAAAGCCGAGAACATCGTTAATCAAATGGGAGTAATAGAAAATTACTTATCTCAGGGGCTG
GGCGGATTACAAGAAACCTTGGAAGACCTGGAAAAGAGAAAAGCTATTGGCCTGAAAATTATCAGAGCTCAAGAGGAAGA
ACGTAGGAGAGTTGCTCGGGAAATACACGATGGCCCTGCTCAGAACTTAGCTAATATGGTGCTCAGAACAGAATATTGTG
AAAAACTGATTGATGCTAACTCTGGAACTGATGAAATCAAAGAAGAATTAGGAGAACTCAAACAGCAGGTACGAACTAAC
TTAAAGGATGTCAGAAAAATTATTTTTGATCTTAGGCCTATGACATTGGATGATTTAGGACTAGTACCTGCCATACGCAA
GTTGATTCAAGGAGTGGAAGAGGAAAGCAATATTGAGGGTGAATTAAAAACTTTTGGAGAAGAAAAACGCCTGAACCGGT
ATATTGAAATTGCCTTGTTTAGGACTGTACAGGAAGCTCTGAATAATATCAAAAAGCATTCAGGGGCTAAGCGTTTTTGG
GTTAAAACAGATTTTAGCAATGATACTATTCATATTATTATTCGCGATGATGGTAAAGGTTTTAATCCTGAAGACAAGTT
GCAAGATAGTGAGGATGATAGTGATAGTGAACATTTTGGTATATCAAATATGAAAGAAAGAGTAGAAAGCCTCGGTGGTG
AGATTAATTTTAGTTCCAAACCAAAGCAAGGAACTAAAATTTCTATTAAAGTACCAGTCTTTGTTAACTAA

Upstream 100 bases:

>100_bases
GGTAATTAGCACTAGAGTAGACATAATTAAACAAATTGTTGCATGAGTATAGTTTTTAGTTAAAATTGTGACAGAACTAA
TCACACTGGGGGATTTAGAT

Downstream 100 bases:

>100_bases
TTATCTAAAGGAAAGGGGGGGGGGAATATGAAAACCATGGATGAAAATAAAACAATCCGCATTCTTTTAGCTGATGACCA
TGCACTGTTTAGGCAAGGAC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 396; Mature: 395

Protein sequence:

>396_residues
MADDNHFAPSEKVDVKVVDDILEKTIDNIQNGKVQIFEIAESARTEYDQMQQELKEIKNKVREVIQEVDNLEKKCHQAKV
HLADVSKHFDTYSEEDIKEAYEQASDLRARLTIMKEREQQLRNHRDSTERRLKNLKKTIEKAENIVNQMGVIENYLSQGL
GGLQETLEDLEKRKAIGLKIIRAQEEERRRVAREIHDGPAQNLANMVLRTEYCEKLIDANSGTDEIKEELGELKQQVRTN
LKDVRKIIFDLRPMTLDDLGLVPAIRKLIQGVEEESNIEGELKTFGEEKRLNRYIEIALFRTVQEALNNIKKHSGAKRFW
VKTDFSNDTIHIIIRDDGKGFNPEDKLQDSEDDSDSEHFGISNMKERVESLGGEINFSSKPKQGTKISIKVPVFVN

Sequences:

>Translated_396_residues
MADDNHFAPSEKVDVKVVDDILEKTIDNIQNGKVQIFEIAESARTEYDQMQQELKEIKNKVREVIQEVDNLEKKCHQAKV
HLADVSKHFDTYSEEDIKEAYEQASDLRARLTIMKEREQQLRNHRDSTERRLKNLKKTIEKAENIVNQMGVIENYLSQGL
GGLQETLEDLEKRKAIGLKIIRAQEEERRRVAREIHDGPAQNLANMVLRTEYCEKLIDANSGTDEIKEELGELKQQVRTN
LKDVRKIIFDLRPMTLDDLGLVPAIRKLIQGVEEESNIEGELKTFGEEKRLNRYIEIALFRTVQEALNNIKKHSGAKRFW
VKTDFSNDTIHIIIRDDGKGFNPEDKLQDSEDDSDSEHFGISNMKERVESLGGEINFSSKPKQGTKISIKVPVFVN
>Mature_395_residues
ADDNHFAPSEKVDVKVVDDILEKTIDNIQNGKVQIFEIAESARTEYDQMQQELKEIKNKVREVIQEVDNLEKKCHQAKVH
LADVSKHFDTYSEEDIKEAYEQASDLRARLTIMKEREQQLRNHRDSTERRLKNLKKTIEKAENIVNQMGVIENYLSQGLG
GLQETLEDLEKRKAIGLKIIRAQEEERRRVAREIHDGPAQNLANMVLRTEYCEKLIDANSGTDEIKEELGELKQQVRTNL
KDVRKIIFDLRPMTLDDLGLVPAIRKLIQGVEEESNIEGELKTFGEEKRLNRYIEIALFRTVQEALNNIKKHSGAKRFWV
KTDFSNDTIHIIIRDDGKGFNPEDKLQDSEDDSDSEHFGISNMKERVESLGGEINFSSKPKQGTKISIKVPVFVN

Specific function: Involved in a sensory transduction pathway that affect the production of enzymes that degrade polymeric carbon and nitrogen sources. DegS probably acts as a kinase that phosphorylates degU [H]

COG id: COG4585

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI87082311, Length=227, Percent_Identity=31.2775330396476, Blast_Score=85, Evalue=8e-18,
Organism=Escherichia coli, GI1788812, Length=206, Percent_Identity=26.2135922330097, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787474, Length=263, Percent_Identity=25.0950570342205, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR008595
- InterPro:   IPR011712
- InterPro:   IPR005467
- InterPro:   IPR016381 [H]

Pfam domain/function: PF05384 DegS; PF02518 HATPase_c; PF07730 HisKA_3 [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 45696; Mature: 45565

Theoretical pI: Translated: 5.25; Mature: 5.25

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADDNHFAPSEKVDVKVVDDILEKTIDNIQNGKVQIFEIAESARTEYDQMQQELKEIKNK
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
VREVIQEVDNLEKKCHQAKVHLADVSKHFDTYSEEDIKEAYEQASDLRARLTIMKEREQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRNHRDSTERRLKNLKKTIEKAENIVNQMGVIENYLSQGLGGLQETLEDLEKRKAIGLKI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IRAQEEERRRVAREIHDGPAQNLANMVLRTEYCEKLIDANSGTDEIKEELGELKQQVRTN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LKDVRKIIFDLRPMTLDDLGLVPAIRKLIQGVEEESNIEGELKTFGEEKRLNRYIEIALF
HHHHHHHHHHCCCCCHHHCCHHHHHHHHHHCCCHHCCCCHHHHHCCHHHHHHHHHHHHHH
RTVQEALNNIKKHSGAKRFWVKTDFSNDTIHIIIRDDGKGFNPEDKLQDSEDDSDSEHFG
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCC
ISNMKERVESLGGEINFSSKPKQGTKISIKVPVFVN
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECEEEC
>Mature Secondary Structure 
ADDNHFAPSEKVDVKVVDDILEKTIDNIQNGKVQIFEIAESARTEYDQMQQELKEIKNK
CCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHH
VREVIQEVDNLEKKCHQAKVHLADVSKHFDTYSEEDIKEAYEQASDLRARLTIMKEREQQ
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LRNHRDSTERRLKNLKKTIEKAENIVNQMGVIENYLSQGLGGLQETLEDLEKRKAIGLKI
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
IRAQEEERRRVAREIHDGPAQNLANMVLRTEYCEKLIDANSGTDEIKEELGELKQQVRTN
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LKDVRKIIFDLRPMTLDDLGLVPAIRKLIQGVEEESNIEGELKTFGEEKRLNRYIEIALF
HHHHHHHHHHCCCCCHHHCCHHHHHHHHHHCCCHHCCCCHHHHHCCHHHHHHHHHHHHHH
RTVQEALNNIKKHSGAKRFWVKTDFSNDTIHIIIRDDGKGFNPEDKLQDSEDDSDSEHFG
HHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCCCCC
ISNMKERVESLGGEINFSSKPKQGTKISIKVPVFVN
HHHHHHHHHHCCCCCCCCCCCCCCCEEEEEECEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]