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The map label for this gene is degU [H]

Identifier: 188586933

GI number: 188586933

Start: 2470498

End: 2471184

Strand: Reverse

Name: degU [H]

Synonym: Nther_2325

Alternate gene names: 188586933

Gene position: 2471184-2470498 (Counterclockwise)

Preceding gene: 188586934

Following gene: 188586932

Centisome position: 78.06

GC content: 35.81

Gene sequence:

>687_bases
ATGAAAACCATGGATGAAAATAAAACAATCCGCATTCTTTTAGCTGATGACCATGCACTGTTTAGGCAAGGACTTAAAAA
AATACTCGACATGGAAGAAGATTTGGCAGTATGTGGTGAAGCACAAAATGGAGAAGAAGTGGTAGATAAAGTTAAACTAC
TAAAACCTAATATAATTTTAATGGATATTAATATGCCTTTATTAAATGGAGTGGAAGCTACTAAATACGTAAAAGAAGTT
TCTCCTGAAACTAAAGTGATTGCACTGACCATTCACGAAGATGAAGAATATCTCTTCGAAATAGTCAAAGAGGGAGCTGC
AGGGTTCTTGTTAAAAGATGTGGAAACACCTACCCTTGTACAAGCCATTCAGGAAGTTAATAAAGGTAATTCTTTTATCC
ATCCTACTATTACCCACAAGCTCCTTGGCGAATTTAATCGCCTGGCACAGAATTCTCCCAGAAATATTAAATCCGATGAA
GCAGTGCAATCAGAATTAACTGGTAGGGAGAAAGAGATTTTAGAGTTAATGGCCCAGGGATACACCAATAAAGAAATATC
CAAAGAACTATACATATCAGAGAAGACAGTCAAGAACCATGTATCAAATATTTTACGGAAAATGGATGTAACAGATCGAA
CACAAGCAGTTATAACTGCTCTAAAATGTGGTGTAGTGCAAATTTAG

Upstream 100 bases:

>100_bases
TGAGATTAATTTTAGTTCCAAACCAAAGCAAGGAACTAAAATTTCTATTAAAGTACCAGTCTTTGTTAACTAATTATCTA
AAGGAAAGGGGGGGGGGAAT

Downstream 100 bases:

>100_bases
TAAGCTTAATCAAAATGATTTATCACCCCGGCGATATTAGAAACATATAATGAACTATCAAAGAAGAGGAGAAAACGCTG
GGGGTGAAAGATTGGAATTT

Product: two component transcriptional regulator, LuxR family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKTMDENKTIRILLADDHALFRQGLKKILDMEEDLAVCGEAQNGEEVVDKVKLLKPNIILMDINMPLLNGVEATKYVKEV
SPETKVIALTIHEDEEYLFEIVKEGAAGFLLKDVETPTLVQAIQEVNKGNSFIHPTITHKLLGEFNRLAQNSPRNIKSDE
AVQSELTGREKEILELMAQGYTNKEISKELYISEKTVKNHVSNILRKMDVTDRTQAVITALKCGVVQI

Sequences:

>Translated_228_residues
MKTMDENKTIRILLADDHALFRQGLKKILDMEEDLAVCGEAQNGEEVVDKVKLLKPNIILMDINMPLLNGVEATKYVKEV
SPETKVIALTIHEDEEYLFEIVKEGAAGFLLKDVETPTLVQAIQEVNKGNSFIHPTITHKLLGEFNRLAQNSPRNIKSDE
AVQSELTGREKEILELMAQGYTNKEISKELYISEKTVKNHVSNILRKMDVTDRTQAVITALKCGVVQI
>Mature_228_residues
MKTMDENKTIRILLADDHALFRQGLKKILDMEEDLAVCGEAQNGEEVVDKVKLLKPNIILMDINMPLLNGVEATKYVKEV
SPETKVIALTIHEDEEYLFEIVKEGAAGFLLKDVETPTLVQAIQEVNKGNSFIHPTITHKLLGEFNRLAQNSPRNIKSDE
AVQSELTGREKEILELMAQGYTNKEISKELYISEKTVKNHVSNILRKMDVTDRTQAVITALKCGVVQI

Specific function: Regulating factor for the production of extracellular proteases. The N-terminal region acts as an inhibitor, whereas the C-terminal region carries enhancing activity [H]

COG id: COG2197

COG function: function code TK; Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788521, Length=219, Percent_Identity=31.0502283105023, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787473, Length=215, Percent_Identity=34.8837209302326, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1788222, Length=216, Percent_Identity=31.0185185185185, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1790102, Length=203, Percent_Identity=29.5566502463054, Blast_Score=98, Evalue=4e-22,
Organism=Escherichia coli, GI1786747, Length=201, Percent_Identity=26.3681592039801, Blast_Score=79, Evalue=2e-16,
Organism=Escherichia coli, GI1788712, Length=198, Percent_Identity=22.7272727272727, Blast_Score=75, Evalue=5e-15,
Organism=Escherichia coli, GI1788546, Length=204, Percent_Identity=25.4901960784314, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1789937, Length=214, Percent_Identity=24.2990654205607, Blast_Score=65, Evalue=6e-12,
Organism=Escherichia coli, GI1787277, Length=198, Percent_Identity=27.2727272727273, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI87082052, Length=130, Percent_Identity=29.2307692307692, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR000792
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00196 GerE; PF00072 Response_reg [H]

EC number: NA

Molecular weight: Translated: 25657; Mature: 25657

Theoretical pI: Translated: 5.07; Mature: 5.07

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00622 HTH_LUXR_1 ; PS50043 HTH_LUXR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTMDENKTIRILLADDHALFRQGLKKILDMEEDLAVCGEAQNGEEVVDKVKLLKPNIIL
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCEEE
MDINMPLLNGVEATKYVKEVSPETKVIALTIHEDEEYLFEIVKEGAAGFLLKDVETPTLV
EECCCHHHCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCEEECCCCCHHHH
QAIQEVNKGNSFIHPTITHKLLGEFNRLAQNSPRNIKSDEAVQSELTGREKEILELMAQG
HHHHHHHCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCC
YTNKEISKELYISEKTVKNHVSNILRKMDVTDRTQAVITALKCGVVQI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MKTMDENKTIRILLADDHALFRQGLKKILDMEEDLAVCGEAQNGEEVVDKVKLLKPNIIL
CCCCCCCCEEEEEEECCHHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHCCCEEE
MDINMPLLNGVEATKYVKEVSPETKVIALTIHEDEEYLFEIVKEGAAGFLLKDVETPTLV
EECCCHHHCCHHHHHHHHHCCCCCEEEEEEEECCHHHHHHHHHCCCCCEEECCCCCHHHH
QAIQEVNKGNSFIHPTITHKLLGEFNRLAQNSPRNIKSDEAVQSELTGREKEILELMAQG
HHHHHHHCCCCEECHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCCHHHHHHHHHCC
YTNKEISKELYISEKTVKNHVSNILRKMDVTDRTQAVITALKCGVVQI
CCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7765823 [H]