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The map label for this gene is ndhL [H]

Identifier: 188586760

GI number: 188586760

Start: 2276232

End: 2277506

Strand: Reverse

Name: ndhL [H]

Synonym: Nther_2151

Alternate gene names: 188586760

Gene position: 2277506-2276232 (Counterclockwise)

Preceding gene: 188586761

Following gene: 188586759

Centisome position: 71.95

GC content: 40.55

Gene sequence:

>1275_bases
ATGGATAAGATCAGACAAATTGGATCTGATGCCGTCAAACGAGATGCATTGGATAAAGTTACAGGACAAGCCCTTTTTGG
TAATGATATCAAAATGGAAGGGATGCTTTACGGTAAAGTACTCCGAAGTCATGTCCCTCATGCCAATGTAAAAAGTATTA
ATACTCAAAAAGCCAGGGAAATGCCAGGGGTAAAAGCGATTCTTACTCATGAAGATATTCCCGGAGAAAATGGTGTAGGT
ATTATATTTAAAGATGAACCCGTCCTAGTAGAAGATAAAATTCGAAGAAATCAAGACGCTCTTTGTTTGATAGCAGCTGA
AAGCCCTGAAATAGCAGAAGCTGCTGCCCGTAATGTAGAGGTAGAGCTTGAAGAAATTACACCGGTATCAGATGTTAAAG
ATGCTATGGATGAAAAGGCACCGAAAGTCCATGGTGATTCAAATGTGGCTATAACGAAAAACCTAATTAAAAACGATGTG
GACAAGGCCTTTGAAGAATGTGATGTAATTGTAGAAAATAACTACACTACTCAACAAGTAGCTCACGCCTTTATCGAACC
TCAAGTAACTGTAGCTCATTATAATGAAGGAATTATGAAATTTTGGGCTGCTTCACAAAATATTCACTTTGATAGAGGTG
AGGTCAGCCGAGTATTAGGCTTACCTCAAAACAAAGTTAGGGGAATTCAGGCCGTAACTGGTGCAGGTTTTGGTGGAAAA
TTGGACATTGCAGGTCAGTGTCATGCTTCTCTTCTCAGTTACTATACCGGAAGGCCTGTTAAAATAGTGCACACTTTTGA
AGAGACGATGCATACTTCTTCCAAGCGTCATCCCTATCTTATGAAATATAAAACTGGTGCAACCAAAGATGGCAAGATCG
TAGCTTTAGATGCCGAAATCCTCTTGGATACTGGTGCTTATGCATCCTACGGACCGGGTGTTCTTACAAGAGGGATAGTA
CACGCTACTGGTCCTTATGAAGTCCCCAATGTTCGTATAAAAGGGCATCTAGTCTATACCAACAATCCTATGGCAGGAGC
TATGCGTGGATTTGGAGTTCCGCAAGTTGCAGTAGCCCATGAAAGTCAAATGGATATACTGGCAGAAAAACTTAATATGA
ACCCCTTCGATATCAGATTGAAGAATGCTCTTAGAAAAGGTTCCAAAACTGCTACGAATCAGGTATTAGAACACAGTGTG
GGAATTGCAGAAACGATAGAGCAAGCACGAGATAAAGCCGAAGAAATTTTTGGAGATGAAGGGAGGAACAATTAA

Upstream 100 bases:

>100_bases
AAGACGTCAATATCTGGTAATCTCTGTAGATGTACTGGATATACCAAAATAGTTGATGGAGTTAAGCAAGCGGCTAAGTA
TAGAAGGGAGGGCAAAGGCA

Downstream 100 bases:

>100_bases
TGAAACAAAAAGGTATAGGTATTGGTTGCATGTGGTATGGAATAGGTAATACCGGTCTTCCCAATCCAGCTTCAGCCTTT
GTAGAAGTGCATTCCGATTG

Product: aldehyde oxidase and xanthine dehydrogenase a/b hammerhead

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase large molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 424; Mature: 424

Protein sequence:

>424_residues
MDKIRQIGSDAVKRDALDKVTGQALFGNDIKMEGMLYGKVLRSHVPHANVKSINTQKAREMPGVKAILTHEDIPGENGVG
IIFKDEPVLVEDKIRRNQDALCLIAAESPEIAEAAARNVEVELEEITPVSDVKDAMDEKAPKVHGDSNVAITKNLIKNDV
DKAFEECDVIVENNYTTQQVAHAFIEPQVTVAHYNEGIMKFWAASQNIHFDRGEVSRVLGLPQNKVRGIQAVTGAGFGGK
LDIAGQCHASLLSYYTGRPVKIVHTFEETMHTSSKRHPYLMKYKTGATKDGKIVALDAEILLDTGAYASYGPGVLTRGIV
HATGPYEVPNVRIKGHLVYTNNPMAGAMRGFGVPQVAVAHESQMDILAEKLNMNPFDIRLKNALRKGSKTATNQVLEHSV
GIAETIEQARDKAEEIFGDEGRNN

Sequences:

>Translated_424_residues
MDKIRQIGSDAVKRDALDKVTGQALFGNDIKMEGMLYGKVLRSHVPHANVKSINTQKAREMPGVKAILTHEDIPGENGVG
IIFKDEPVLVEDKIRRNQDALCLIAAESPEIAEAAARNVEVELEEITPVSDVKDAMDEKAPKVHGDSNVAITKNLIKNDV
DKAFEECDVIVENNYTTQQVAHAFIEPQVTVAHYNEGIMKFWAASQNIHFDRGEVSRVLGLPQNKVRGIQAVTGAGFGGK
LDIAGQCHASLLSYYTGRPVKIVHTFEETMHTSSKRHPYLMKYKTGATKDGKIVALDAEILLDTGAYASYGPGVLTRGIV
HATGPYEVPNVRIKGHLVYTNNPMAGAMRGFGVPQVAVAHESQMDILAEKLNMNPFDIRLKNALRKGSKTATNQVLEHSV
GIAETIEQARDKAEEIFGDEGRNN
>Mature_424_residues
MDKIRQIGSDAVKRDALDKVTGQALFGNDIKMEGMLYGKVLRSHVPHANVKSINTQKAREMPGVKAILTHEDIPGENGVG
IIFKDEPVLVEDKIRRNQDALCLIAAESPEIAEAAARNVEVELEEITPVSDVKDAMDEKAPKVHGDSNVAITKNLIKNDV
DKAFEECDVIVENNYTTQQVAHAFIEPQVTVAHYNEGIMKFWAASQNIHFDRGEVSRVLGLPQNKVRGIQAVTGAGFGGK
LDIAGQCHASLLSYYTGRPVKIVHTFEETMHTSSKRHPYLMKYKTGATKDGKIVALDAEILLDTGAYASYGPGVLTRGIV
HATGPYEVPNVRIKGHLVYTNNPMAGAMRGFGVPQVAVAHESQMDILAEKLNMNPFDIRLKNALRKGSKTATNQVLEHSV
GIAETIEQARDKAEEIFGDEGRNN

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=384, Percent_Identity=30.46875, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI71773480, Length=393, Percent_Identity=28.7531806615776, Blast_Score=150, Evalue=2e-36,
Organism=Escherichia coli, GI1789230, Length=423, Percent_Identity=31.2056737588652, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1789246, Length=464, Percent_Identity=26.5086206896552, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1786478, Length=393, Percent_Identity=26.2086513994911, Blast_Score=91, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17540638, Length=402, Percent_Identity=27.363184079602, Blast_Score=133, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI17539860, Length=382, Percent_Identity=24.3455497382199, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI32566215, Length=404, Percent_Identity=23.2673267326733, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI17737937, Length=429, Percent_Identity=30.3030303030303, Blast_Score=166, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24647193, Length=392, Percent_Identity=27.0408163265306, Blast_Score=114, Evalue=9e-26,
Organism=Drosophila melanogaster, GI24647199, Length=416, Percent_Identity=24.7596153846154, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24647201, Length=394, Percent_Identity=23.6040609137056, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24647195, Length=385, Percent_Identity=22.8571428571429, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647197, Length=381, Percent_Identity=22.8346456692913, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000674
- InterPro:   IPR008274 [H]

Pfam domain/function: PF01315 Ald_Xan_dh_C; PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 46410; Mature: 46410

Theoretical pI: Translated: 6.57; Mature: 6.57

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDKIRQIGSDAVKRDALDKVTGQALFGNDIKMEGMLYGKVLRSHVPHANVKSINTQKARE
CCHHHHHHHHHHHHHHHHHHCCCEEECCCEEECHHHHHHHHHHHCCCCCCCCCCHHHHHH
MPGVKAILTHEDIPGENGVGIIFKDEPVLVEDKIRRNQDALCLIAAESPEIAEAAARNVE
CCCCEEEEEECCCCCCCCCEEEECCCCEEEHHHHCCCCCCEEEEECCCCHHHHHHHCCCE
VELEEITPVSDVKDAMDEKAPKVHGDSNVAITKNLIKNDVDKAFEECDVIVENNYTTQQV
EEHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCEEEECCCCHHHH
AHAFIEPQVTVAHYNEGIMKFWAASQNIHFDRGEVSRVLGLPQNKVRGIQAVTGAGFGGK
HHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHCCCHHHHCCEEEEECCCCCCE
LDIAGQCHASLLSYYTGRPVKIVHTFEETMHTSSKRHPYLMKYKTGATKDGKIVALDAEI
EEECCHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEHEE
LLDTGAYASYGPGVLTRGIVHATGPYEVPNVRIKGHLVYTNNPMAGAMRGFGVPQVAVAH
EEECCCCCCCCCCHHHCCEEECCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCCEEEECC
ESQMDILAEKLNMNPFDIRLKNALRKGSKTATNQVLEHSVGIAETIEQARDKAEEIFGDE
CHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
GRNN
CCCC
>Mature Secondary Structure
MDKIRQIGSDAVKRDALDKVTGQALFGNDIKMEGMLYGKVLRSHVPHANVKSINTQKARE
CCHHHHHHHHHHHHHHHHHHCCCEEECCCEEECHHHHHHHHHHHCCCCCCCCCCHHHHHH
MPGVKAILTHEDIPGENGVGIIFKDEPVLVEDKIRRNQDALCLIAAESPEIAEAAARNVE
CCCCEEEEEECCCCCCCCCEEEECCCCEEEHHHHCCCCCCEEEEECCCCHHHHHHHCCCE
VELEEITPVSDVKDAMDEKAPKVHGDSNVAITKNLIKNDVDKAFEECDVIVENNYTTQQV
EEHHHCCCHHHHHHHHHHCCCCCCCCCCEEEEHHHHHHHHHHHHHHCCEEEECCCCHHHH
AHAFIEPQVTVAHYNEGIMKFWAASQNIHFDRGEVSRVLGLPQNKVRGIQAVTGAGFGGK
HHHHHCCCEEEEECCCCHHHHHHCCCCCCCCHHHHHHHHCCCHHHHCCEEEEECCCCCCE
LDIAGQCHASLLSYYTGRPVKIVHTFEETMHTSSKRHPYLMKYKTGATKDGKIVALDAEI
EEECCHHHHHHHHHHCCCCEEEEEEHHHHHHCCCCCCCEEEEEECCCCCCCEEEEEEHEE
LLDTGAYASYGPGVLTRGIVHATGPYEVPNVRIKGHLVYTNNPMAGAMRGFGVPQVAVAH
EEECCCCCCCCCCHHHCCEEECCCCCCCCCEEEEEEEEEECCCCHHHHHCCCCCEEEECC
ESQMDILAEKLNMNPFDIRLKNALRKGSKTATNQVLEHSVGIAETIEQARDKAEEIFGDE
CHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCC
GRNN
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA