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The map label for this gene is ndhS [H]

Identifier: 188586761

GI number: 188586761

Start: 2277499

End: 2277993

Strand: Reverse

Name: ndhS [H]

Synonym: Nther_2152

Alternate gene names: 188586761

Gene position: 2277993-2277499 (Counterclockwise)

Preceding gene: 188586762

Following gene: 188586760

Centisome position: 71.96

GC content: 41.01

Gene sequence:

>495_bases
ATGAATAAAACAGTGAAGATCTCCTTTGAATTAAATGGGAAACAGGTAGATGTAGAGACTAAACCCAATAAACGCTTATT
GGACCTGTTAAGAGACGACTTTAACTTGACAGGAGTAAAAGAAGGCTGTGGTGAAGGCGAGTGTGGTGTTTGCACCGTGA
TCATGGATGGCGAAATAGTGAACTCCTGTATGGTACTAGCACCTCAAGCCGAGGGTTCTAAAATAACAACAATAGAAGGG
GTATCAAATGGGGAGAATGAGTTGGATGTCATACAAGAAGCTTTTATTGAACAAGGGGCAGTACAGTGTGGCTTTTGTAT
CCCAGGCATGATTCTATCAACCAAGACTCTACTGGATAAGAATGATACTCCCTCAGAAGAGGAAATTAAGACGTCAATAT
CTGGTAATCTCTGTAGATGTACTGGATATACCAAAATAGTTGATGGAGTTAAGCAAGCGGCTAAGTATAGAAGGGAGGGC
AAAGGCAATGGATAA

Upstream 100 bases:

>100_bases
TCTTCAGCTCCTTTTAAACGAGAAAGTATCAAAGGAGTTGCTAAAAAAGCTTTAATTAAGGCCATGGATTCGGCAGACAA
AATTTAAGGAGGGGCAGAGA

Downstream 100 bases:

>100_bases
GATCAGACAAATTGGATCTGATGCCGTCAAACGAGATGCATTGGATAAAGTTACAGGACAAGCCCTTTTTGGTAATGATA
TCAAAATGGAAGGGATGCTT

Product: (2Fe-2S)-binding domain protein

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase small FeS subunit; NAH [H]

Number of amino acids: Translated: 164; Mature: 164

Protein sequence:

>164_residues
MNKTVKISFELNGKQVDVETKPNKRLLDLLRDDFNLTGVKEGCGEGECGVCTVIMDGEIVNSCMVLAPQAEGSKITTIEG
VSNGENELDVIQEAFIEQGAVQCGFCIPGMILSTKTLLDKNDTPSEEEIKTSISGNLCRCTGYTKIVDGVKQAAKYRREG
KGNG

Sequences:

>Translated_164_residues
MNKTVKISFELNGKQVDVETKPNKRLLDLLRDDFNLTGVKEGCGEGECGVCTVIMDGEIVNSCMVLAPQAEGSKITTIEG
VSNGENELDVIQEAFIEQGAVQCGFCIPGMILSTKTLLDKNDTPSEEEIKTSISGNLCRCTGYTKIVDGVKQAAKYRREG
KGNG
>Mature_164_residues
MNKTVKISFELNGKQVDVETKPNKRLLDLLRDDFNLTGVKEGCGEGECGVCTVIMDGEIVNSCMVLAPQAEGSKITTIEG
VSNGENELDVIQEAFIEQGAVQCGFCIPGMILSTKTLLDKNDTPSEEEIKTSISGNLCRCTGYTKIVDGVKQAAKYRREG
KGNG

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG2080

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=161, Percent_Identity=37.888198757764, Blast_Score=90, Evalue=9e-19,
Organism=Homo sapiens, GI71773480, Length=166, Percent_Identity=34.9397590361446, Blast_Score=84, Evalue=4e-17,
Organism=Escherichia coli, GI1789232, Length=154, Percent_Identity=44.1558441558442, Blast_Score=129, Evalue=9e-32,
Organism=Escherichia coli, GI1786480, Length=165, Percent_Identity=36.3636363636364, Blast_Score=117, Evalue=4e-28,
Organism=Escherichia coli, GI1789246, Length=142, Percent_Identity=32.3943661971831, Blast_Score=70, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17540638, Length=158, Percent_Identity=38.6075949367089, Blast_Score=112, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI17539860, Length=155, Percent_Identity=37.4193548387097, Blast_Score=103, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI32566215, Length=155, Percent_Identity=35.4838709677419, Blast_Score=100, Evalue=3e-22,
Organism=Drosophila melanogaster, GI17737937, Length=166, Percent_Identity=37.3493975903614, Blast_Score=117, Evalue=5e-27,
Organism=Drosophila melanogaster, GI24647197, Length=164, Percent_Identity=31.0975609756098, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24647195, Length=164, Percent_Identity=31.0975609756098, Blast_Score=91, Evalue=3e-19,
Organism=Drosophila melanogaster, GI24647199, Length=154, Percent_Identity=35.0649350649351, Blast_Score=91, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24647193, Length=161, Percent_Identity=33.5403726708075, Blast_Score=88, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24647201, Length=155, Percent_Identity=34.1935483870968, Blast_Score=87, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002888
- InterPro:   IPR006058
- InterPro:   IPR012675
- InterPro:   IPR001041 [H]

Pfam domain/function: PF00111 Fer2; PF01799 Fer2_2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 17683; Mature: 17683

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS00197 2FE2S_FER_1 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
7.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKTVKISFELNGKQVDVETKPNKRLLDLLRDDFNLTGVKEGCGEGECGVCTVIMDGEIV
CCCEEEEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHH
NSCMVLAPQAEGSKITTIEGVSNGENELDVIQEAFIEQGAVQCGFCIPGMILSTKTLLDK
CCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCC
NDTPSEEEIKTSISGNLCRCTGYTKIVDGVKQAAKYRREGKGNG
CCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNKTVKISFELNGKQVDVETKPNKRLLDLLRDDFNLTGVKEGCGEGECGVCTVIMDGEIV
CCCEEEEEEEECCEEEEEECCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCHHH
NSCMVLAPQAEGSKITTIEGVSNGENELDVIQEAFIEQGAVQCGFCIPGMILSTKTLLDK
CCEEEEEECCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCC
NDTPSEEEIKTSISGNLCRCTGYTKIVDGVKQAAKYRREGKGNG
CCCCCHHHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA