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The map label for this gene is ndhM [H]

Identifier: 188586759

GI number: 188586759

Start: 2275246

End: 2276232

Strand: Reverse

Name: ndhM [H]

Synonym: Nther_2150

Alternate gene names: 188586759

Gene position: 2276232-2275246 (Counterclockwise)

Preceding gene: 188586760

Following gene: 188586758

Centisome position: 71.91

GC content: 40.73

Gene sequence:

>987_bases
ATGAAACAAAAAGGTATAGGTATTGGTTGCATGTGGTATGGAATAGGTAATACCGGTCTTCCCAATCCAGCTTCAGCCTT
TGTAGAAGTGCATTCCGATTGTTCAGCAACCGTGCTTACTGGTTGTGCCGATATTGGACAAGGTTCTGATACTACCATGG
CTCAGATAGTAGCTGAAACTTTAGGTTTAAATTTTGAAAACATTTTTGTAACTTCAGCAGACACAGGAGTGACACCAGAG
AGTGGAGCAACATCAGCCAGTAGGCAGACATATATTTCTGGAAATGCTTGCAAAAAGGCTGCTGAAATGGCTCGTGATAC
TTTATTAGAAGTCGCCTCTCAGTTGCTAAATACAGAAAAAGATAAAATTAATTTGGAATCAGGGCAGGCCATTGATACTT
CTACTAAGAATAGTGTTAAAATAACTGAAATCATGGCCGAGTGTAAAAAACAAGGAATTTTGGTCATTGGAAGTGGTTCC
TTCAACCCAGAGACAGTACCTTTGGATCCTGAAACAATGGAAGGTAGTCCTTATGCGACTTATGCTTTTGCTACTCATGT
GGCAGAAGTAGAAGTTAATACAGAAACAGGTGAATTAGAGATCAACAGGGTTATTGCTGCCCACGATGTTGGTAAGGCAG
TCAATCCCAAGCAGGTGGAAAGTCAAATTGAAGGGGGGTGCGTAATGGGGGCGAGTTTTGCCGCCCTTGAAGAACTAAAG
GTAAAGGATTGTAAGATTCAAAACCCAAATTATTCGGACTATTTAATTTCAACTACTAAGGATGTACCTGAAATTTATCC
CTTGATCGTAGAGGATCCAGAACCAACTGGGCCCTATGGGGCGAAGGGAGTCGGTGAACCAGCCTTGATACCCACAGCAC
CGGCCGTATTAAATGGAATTTATAATGCAACAGGTTTAAGGCTTAAAGAATTACCGATAACTCAAGAAAAAATTATTGAG
AAAAAAATTGAAGAGGGAGGTAATTAA

Upstream 100 bases:

>100_bases
CGAATCAGGTATTAGAACACAGTGTGGGAATTGCAGAAACGATAGAGCAAGCACGAGATAAAGCCGAAGAAATTTTTGGA
GATGAAGGGAGGAACAATTA

Downstream 100 bases:

>100_bases
TTTGACTGAAGAAACTCAACAACAAAGTTTTTTACAGCGGAAAAATATTGAGATTTCGCTTAGACGTTACGGAATTGAAG
TTTTAGGTTTCATGGCACAA

Product: aldehyde oxidase and xanthine dehydrogenase molybdopterin binding

Products: NA

Alternate protein names: NDH; Nicotinic acid hydroxylase medium molybdopterin subunit; NAH [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKQKGIGIGCMWYGIGNTGLPNPASAFVEVHSDCSATVLTGCADIGQGSDTTMAQIVAETLGLNFENIFVTSADTGVTPE
SGATSASRQTYISGNACKKAAEMARDTLLEVASQLLNTEKDKINLESGQAIDTSTKNSVKITEIMAECKKQGILVIGSGS
FNPETVPLDPETMEGSPYATYAFATHVAEVEVNTETGELEINRVIAAHDVGKAVNPKQVESQIEGGCVMGASFAALEELK
VKDCKIQNPNYSDYLISTTKDVPEIYPLIVEDPEPTGPYGAKGVGEPALIPTAPAVLNGIYNATGLRLKELPITQEKIIE
KKIEEGGN

Sequences:

>Translated_328_residues
MKQKGIGIGCMWYGIGNTGLPNPASAFVEVHSDCSATVLTGCADIGQGSDTTMAQIVAETLGLNFENIFVTSADTGVTPE
SGATSASRQTYISGNACKKAAEMARDTLLEVASQLLNTEKDKINLESGQAIDTSTKNSVKITEIMAECKKQGILVIGSGS
FNPETVPLDPETMEGSPYATYAFATHVAEVEVNTETGELEINRVIAAHDVGKAVNPKQVESQIEGGCVMGASFAALEELK
VKDCKIQNPNYSDYLISTTKDVPEIYPLIVEDPEPTGPYGAKGVGEPALIPTAPAVLNGIYNATGLRLKELPITQEKIIE
KKIEEGGN
>Mature_328_residues
MKQKGIGIGCMWYGIGNTGLPNPASAFVEVHSDCSATVLTGCADIGQGSDTTMAQIVAETLGLNFENIFVTSADTGVTPE
SGATSASRQTYISGNACKKAAEMARDTLLEVASQLLNTEKDKINLESGQAIDTSTKNSVKITEIMAECKKQGILVIGSGS
FNPETVPLDPETMEGSPYATYAFATHVAEVEVNTETGELEINRVIAAHDVGKAVNPKQVESQIEGGCVMGASFAALEELK
VKDCKIQNPNYSDYLISTTKDVPEIYPLIVEDPEPTGPYGAKGVGEPALIPTAPAVLNGIYNATGLRLKELPITQEKIIE
KKIEEGGN

Specific function: Catalyzes the hydroxylation of nicotinate to 6- hydroxynicotinate. Also active against 2-pyrazinecarboxylic acid, but inactive against other nicotinate analogs [H]

COG id: COG1529

COG function: function code C; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the xanthine dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI91823271, Length=335, Percent_Identity=26.5671641791045, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI71773480, Length=331, Percent_Identity=23.8670694864048, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1789230, Length=326, Percent_Identity=30.6748466257669, Blast_Score=148, Evalue=6e-37,
Organism=Escherichia coli, GI1786478, Length=309, Percent_Identity=30.7443365695793, Blast_Score=121, Evalue=7e-29,
Organism=Escherichia coli, GI1789246, Length=309, Percent_Identity=27.831715210356, Blast_Score=107, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17540638, Length=296, Percent_Identity=27.3648648648649, Blast_Score=81, Evalue=6e-16,
Organism=Drosophila melanogaster, GI17737937, Length=297, Percent_Identity=26.2626262626263, Blast_Score=77, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24647193, Length=295, Percent_Identity=26.7796610169492, Blast_Score=74, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24647197, Length=292, Percent_Identity=23.6301369863014, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24647195, Length=292, Percent_Identity=23.6301369863014, Blast_Score=73, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008274 [H]

Pfam domain/function: PF02738 Ald_Xan_dh_C2 [H]

EC number: =1.17.1.5 [H]

Molecular weight: Translated: 34663; Mature: 34663

Theoretical pI: Translated: 4.29; Mature: 4.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQKGIGIGCMWYGIGNTGLPNPASAFVEVHSDCSATVLTGCADIGQGSDTTMAQIVAET
CCCCCCEEEEEEEECCCCCCCCHHHHHHEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
LGLNFENIFVTSADTGVTPESGATSASRQTYISGNACKKAAEMARDTLLEVASQLLNTEK
HCCCCHHEEEECCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
DKINLESGQAIDTSTKNSVKITEIMAECKKQGILVIGSGSFNPETVPLDPETMEGSPYAT
CEEECCCCCEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCEE
YAFATHVAEVEVNTETGELEINRVIAAHDVGKAVNPKQVESQIEGGCVMGASFAALEELK
EEEEEEEEEEEEECCCCCEEEEEEEEEHHCCCCCCHHHHHHHHCCCEEECCHHHHHHHHH
VKDCKIQNPNYSDYLISTTKDVPEIYPLIVEDPEPTGPYGAKGVGEPALIPTAPAVLNGI
HCCCEECCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHH
YNATGLRLKELPITQEKIIEKKIEEGGN
HCCCCCEEECCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MKQKGIGIGCMWYGIGNTGLPNPASAFVEVHSDCSATVLTGCADIGQGSDTTMAQIVAET
CCCCCCEEEEEEEECCCCCCCCHHHHHHEECCCCCHHHHHHHHHCCCCCCHHHHHHHHHH
LGLNFENIFVTSADTGVTPESGATSASRQTYISGNACKKAAEMARDTLLEVASQLLNTEK
HCCCCHHEEEECCCCCCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHCCCC
DKINLESGQAIDTSTKNSVKITEIMAECKKQGILVIGSGSFNPETVPLDPETMEGSPYAT
CEEECCCCCEECCCCCCCCHHHHHHHHHHHCCEEEEECCCCCCCCCCCCCCCCCCCCCEE
YAFATHVAEVEVNTETGELEINRVIAAHDVGKAVNPKQVESQIEGGCVMGASFAALEELK
EEEEEEEEEEEEECCCCCEEEEEEEEEHHCCCCCCHHHHHHHHCCCEEECCHHHHHHHHH
VKDCKIQNPNYSDYLISTTKDVPEIYPLIVEDPEPTGPYGAKGVGEPALIPTAPAVLNGI
HCCCEECCCCCCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHH
YNATGLRLKELPITQEKIIEKKIEEGGN
HCCCCCEEECCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA