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The map label for this gene is hisG2 [H]

Identifier: 188586611

GI number: 188586611

Start: 2108880

End: 2109515

Strand: Reverse

Name: hisG2 [H]

Synonym: Nther_2001

Alternate gene names: 188586611

Gene position: 2109515-2108880 (Counterclockwise)

Preceding gene: 188586612

Following gene: 188586610

Centisome position: 66.64

GC content: 35.69

Gene sequence:

>636_bases
ATGAGAACGGGAGAACAACTGACAATTGCTTTACCAAAGGGTAGGATTCTTGATGAAAGTGTTAAACTACTGGAACAAGC
AGGTATAGCCTGTGATCAGGTTAATGAAAATGGTAGAAAGTTAATTTTTACCGATCAAGAGCAGTCTTTGTCTTTTATAT
TAGGAAAACCTATGGATGTACCAACTTATGTTGAACACGGTGCAGCTGATATAGGAATTGTTGGCAAAGATGTGATTGAA
GAGGTTAAAGGTGAATATTACGAGTTACTTGATATGAAGATGGGTTACTGTAAAATGGTACTAGCTCGAGAAAAATCTAA
TGAAACATTTGATATAAACTCTGTAAATGCTGTAGCTACTAAATATCCTCAAATAACCCAAGAATACTTCCAGGAGTTTG
GCCGACAGGTAAAAATAATTAAATTAAATGGGTCAGTGGAACTAGCCCCCCTTATCGGCTTGTCTGATACTATAGCAGAC
TTGGTTTCAACAGGCAAAACCTTAAAGGAAAATAATTTAGAAGAAGTATCTTCGATTATGGATATTACAACCCGCTTGAT
TGCCAATAAAGGGAGCTATCAATTGAAACAGAATCGCATTGGCCAACTAGTGGAAAATTTAAAAGATTTAGTTTAA

Upstream 100 bases:

>100_bases
AAAGCGAAAGAACAGGGAGCTGACCAATTTTATTATATAGGTAATCATGGAATGGTTAAGGAAAATATCAGCACTAATTC
GGAAAGAAAGGATGTCTAGG

Downstream 100 bases:

>100_bases
TTAGGATAATTAAATAGTATAAGAGAGGTGTTATCAATGGAAAGAAGGGTTGCCACAGTAGAAAGAAAAACTTCAGAAAC
GGAAATTCAACTTTCCGTCA

Product: ATP phosphoribosyltransferase catalytic subunit

Products: NA

Alternate protein names: ATP-PRT 2; ATP-PRTase 2 [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MRTGEQLTIALPKGRILDESVKLLEQAGIACDQVNENGRKLIFTDQEQSLSFILGKPMDVPTYVEHGAADIGIVGKDVIE
EVKGEYYELLDMKMGYCKMVLAREKSNETFDINSVNAVATKYPQITQEYFQEFGRQVKIIKLNGSVELAPLIGLSDTIAD
LVSTGKTLKENNLEEVSSIMDITTRLIANKGSYQLKQNRIGQLVENLKDLV

Sequences:

>Translated_211_residues
MRTGEQLTIALPKGRILDESVKLLEQAGIACDQVNENGRKLIFTDQEQSLSFILGKPMDVPTYVEHGAADIGIVGKDVIE
EVKGEYYELLDMKMGYCKMVLAREKSNETFDINSVNAVATKYPQITQEYFQEFGRQVKIIKLNGSVELAPLIGLSDTIAD
LVSTGKTLKENNLEEVSSIMDITTRLIANKGSYQLKQNRIGQLVENLKDLV
>Mature_211_residues
MRTGEQLTIALPKGRILDESVKLLEQAGIACDQVNENGRKLIFTDQEQSLSFILGKPMDVPTYVEHGAADIGIVGKDVIE
EVKGEYYELLDMKMGYCKMVLAREKSNETFDINSVNAVATKYPQITQEYFQEFGRQVKIIKLNGSVELAPLIGLSDTIAD
LVSTGKTLKENNLEEVSSIMDITTRLIANKGSYQLKQNRIGQLVENLKDLV

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Short subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788330, Length=225, Percent_Identity=34.6666666666667, Blast_Score=106, Evalue=1e-24,
Organism=Saccharomyces cerevisiae, GI6320896, Length=195, Percent_Identity=26.1538461538462, Blast_Score=72, Evalue=6e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198 [H]

Pfam domain/function: PF01634 HisG [H]

EC number: =2.4.2.17 [H]

Molecular weight: Translated: 23503; Mature: 23503

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRTGEQLTIALPKGRILDESVKLLEQAGIACDQVNENGRKLIFTDQEQSLSFILGKPMDV
CCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCC
PTYVEHGAADIGIVGKDVIEEVKGEYYELLDMKMGYCKMVLAREKSNETFDINSVNAVAT
CHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHH
KYPQITQEYFQEFGRQVKIIKLNGSVELAPLIGLSDTIADLVSTGKTLKENNLEEVSSIM
CCHHHHHHHHHHHCCEEEEEEECCCEEEEEECCCHHHHHHHHHCCCHHHCCCHHHHHHHH
DITTRLIANKGSYQLKQNRIGQLVENLKDLV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRTGEQLTIALPKGRILDESVKLLEQAGIACDQVNENGRKLIFTDQEQSLSFILGKPMDV
CCCCCEEEEECCCCCHHHHHHHHHHHHCCCCCCCCCCCCEEEEECCCCCHHHHHCCCCCC
PTYVEHGAADIGIVGKDVIEEVKGEYYELLDMKMGYCKMVLAREKSNETFDINSVNAVAT
CHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCHHHHH
KYPQITQEYFQEFGRQVKIIKLNGSVELAPLIGLSDTIADLVSTGKTLKENNLEEVSSIM
CCHHHHHHHHHHHCCEEEEEEECCCEEEEEECCCHHHHHHHHHCCCHHHCCCHHHHHHHH
DITTRLIANKGSYQLKQNRIGQLVENLKDLV
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA