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The map label for this gene is fadH [C]

Identifier: 188586464

GI number: 188586464

Start: 1927978

End: 1929981

Strand: Direct

Name: fadH [C]

Synonym: Nther_1849

Alternate gene names: 188586464

Gene position: 1927978-1929981 (Clockwise)

Preceding gene: 188586463

Following gene: 188586465

Centisome position: 60.9

GC content: 40.17

Gene sequence:

>2004_bases
ATGAACAACAAGTACGCTAGTCTTTTCGAACCAATGAAAATTGGAAAAACCAAAATCAAAAACCGAATTGGGATGTCTCC
TATGGCTGCCTCGGGAATGATAACCCCTCACAACTGTTTTGATAAAAGAGCTGCAGAGTACTATGTGGAAAGAGCTCGAG
GTGGAGCCGGACTAATCATAACTGGTGGAGTAGAAGTAGAAAATGAAATAGAACAAACCAAACTGGGAATTTTCCAAAAC
ATCTCCACAAATCCCGTGGCCTTTGCTCTCAATTCCAGTGAAATGATAGAAAGAGTCCATGCCCACGGCTCCAAAATCTT
CTTACAGCTGACAATGGGATTTGGAAGATCTTTGTTTCTAGATTTTGTCGATAGTCATCCTGTAGCGCCTTCGGCCATCC
CACATTTTTGGGAGCCAGATGTCACTTGTCGTGAATTAACAACCAACGAAGTAGAATATATGGTAGAAAAAATGGCAGAA
GCGGCTAAAGTTGCAGCTTCTGCAGGTTATGACGGTGTAGAAGTTCACGCTATGCACGAAGGATATTTACTCGATCAATT
TACTTTAAAGGCTTTCAACAAAAGAACTGATAAATACGGCGGCGATTTACGGGGACGCTTGCAGCTACCCATCGAAATCT
TACAAGCTATTAAATCAGAAGTAGGCCAGGATTTTCCTGTCATTTTAAGATATGGTGTTAAAAGCTGCATTAAAGCACCA
CATCAAGGTGGTTTGCCGGGAGAAGATTATCAAGAACACGGAAGAGATTTGGAAGAAGGTCTAGAAGCTGCCAAAATTCT
AGAAGAAGCGGGTTATGACGGATTTAATGCGGATTTAGGTTCTTATGAAGCTCTGTATTGGGCCCATCCCCCTACCTATA
TTGAACACGGTTGTTATCTACCTTATACAAAACAGCTCAAAGAAGTAATAGATGTTCCTGTTTTAACAGCAGGTAGAATG
GACAATCCCGAAGTAGCTGCCGAAGCTGTCACTAGCGAAAAAACCGATATGGCTTTACTCGGTCGAGGTCTCTTGGCTGA
TCCGGATTGGCCCAATAAAGTTAAATCAGGTGAAACCGATAAAATCAGACCCTGCCTCGGTTGCCATGACGGATGTATGG
GAAGATTGGAAAGCGGTAAAGTGATCTCATGTGCTGTCAACCCTGCTTGTGGAAGAGAAGAAGAATACAAACTTCATCCG
CCATTGAAACAAAAAGATGTCATGGTTGTTGGCGGTGGAATAGCAGGAATGGAAGCTGCTAGAGTTGCTGCAATACGCGG
ACATAAAGTTTCTCTTTACGAGAAGAATAACTCTCTAGGTGGACATGTGGTTGAAGCCTCTGTCCCAGAGTTTAAAAAAG
ATGAACGAGAGCTATTGAGATGGTACGGACAAGAACTAAAAGAGAATGATGTAGAACTAAATTTAGGAACTGAAGTAGAC
AGCCAACTTGTAAAAGAAATTAATCCTGATGAAATAATATTAGCTACTGGTGCAAAGGAAAAAATTCCACCAATTCAAGG
TATCGATCAAGACCATGTCCTCACAGCCTGTGATGCTTTAATGAATCCAGATAAAGTTGGCAAAAACGTAGCCATTATTG
GTGGAGGGCTTGTAGGTTGCGAAATCGCTATATGGTTGGCTCAACAAAATAAACAAATTACCATCGTAGAAATGATAGAG
GAATTAATGGGAGCTGTATTCGTCTCTCATGCTAATGAAATGATGCTAAAAGATATGATAAAACATGAAGGTATTGAAGT
TAAAACTGACACTAGCCTATTAGAAGTACAAGAGAATGAAATTGTGACAATTAATAAAGAATTTAAAAAGCAAAATTTAA
ATGCAGATACAGTCCTACTGGCAATCGGTTACGAGTCTGATACAAAACTTTATGAAGAACTTAAAGATATTCACCCTAAA
ACACACTTAATTGGAGATGCAAGAACTGTCCAAAACATCATGTATGGAATTTGGGAAGGGTATGAAGTGGCTAGAACTTT
ATAA

Upstream 100 bases:

>100_bases
AAATTAAAAAGCTAAATTTTGATTTCCACTCAGCATTCCAATTTTACAAATTTATAAAACTAATTCTAATTTATCCAAAA
TGCGAAAGGAGGAGTCAAGT

Downstream 100 bases:

>100_bases
ACCAAAACTCTATTACAATTAATAAAAATCTAAGATGGGAGGTAGTAATATGAACGAAAAGTTTGTCGGTACTGATGCGA
TTATGAGACGAGCTATGCTC

Product: NADH:flavin oxidoreductase/NADH oxidase

Products: trans-transtetradehydroacyl-CoA; NADPH [C]

Alternate protein names: NA

Number of amino acids: Translated: 667; Mature: 667

Protein sequence:

>667_residues
MNNKYASLFEPMKIGKTKIKNRIGMSPMAASGMITPHNCFDKRAAEYYVERARGGAGLIITGGVEVENEIEQTKLGIFQN
ISTNPVAFALNSSEMIERVHAHGSKIFLQLTMGFGRSLFLDFVDSHPVAPSAIPHFWEPDVTCRELTTNEVEYMVEKMAE
AAKVAASAGYDGVEVHAMHEGYLLDQFTLKAFNKRTDKYGGDLRGRLQLPIEILQAIKSEVGQDFPVILRYGVKSCIKAP
HQGGLPGEDYQEHGRDLEEGLEAAKILEEAGYDGFNADLGSYEALYWAHPPTYIEHGCYLPYTKQLKEVIDVPVLTAGRM
DNPEVAAEAVTSEKTDMALLGRGLLADPDWPNKVKSGETDKIRPCLGCHDGCMGRLESGKVISCAVNPACGREEEYKLHP
PLKQKDVMVVGGGIAGMEAARVAAIRGHKVSLYEKNNSLGGHVVEASVPEFKKDERELLRWYGQELKENDVELNLGTEVD
SQLVKEINPDEIILATGAKEKIPPIQGIDQDHVLTACDALMNPDKVGKNVAIIGGGLVGCEIAIWLAQQNKQITIVEMIE
ELMGAVFVSHANEMMLKDMIKHEGIEVKTDTSLLEVQENEIVTINKEFKKQNLNADTVLLAIGYESDTKLYEELKDIHPK
THLIGDARTVQNIMYGIWEGYEVARTL

Sequences:

>Translated_667_residues
MNNKYASLFEPMKIGKTKIKNRIGMSPMAASGMITPHNCFDKRAAEYYVERARGGAGLIITGGVEVENEIEQTKLGIFQN
ISTNPVAFALNSSEMIERVHAHGSKIFLQLTMGFGRSLFLDFVDSHPVAPSAIPHFWEPDVTCRELTTNEVEYMVEKMAE
AAKVAASAGYDGVEVHAMHEGYLLDQFTLKAFNKRTDKYGGDLRGRLQLPIEILQAIKSEVGQDFPVILRYGVKSCIKAP
HQGGLPGEDYQEHGRDLEEGLEAAKILEEAGYDGFNADLGSYEALYWAHPPTYIEHGCYLPYTKQLKEVIDVPVLTAGRM
DNPEVAAEAVTSEKTDMALLGRGLLADPDWPNKVKSGETDKIRPCLGCHDGCMGRLESGKVISCAVNPACGREEEYKLHP
PLKQKDVMVVGGGIAGMEAARVAAIRGHKVSLYEKNNSLGGHVVEASVPEFKKDERELLRWYGQELKENDVELNLGTEVD
SQLVKEINPDEIILATGAKEKIPPIQGIDQDHVLTACDALMNPDKVGKNVAIIGGGLVGCEIAIWLAQQNKQITIVEMIE
ELMGAVFVSHANEMMLKDMIKHEGIEVKTDTSLLEVQENEIVTINKEFKKQNLNADTVLLAIGYESDTKLYEELKDIHPK
THLIGDARTVQNIMYGIWEGYEVARTL
>Mature_667_residues
MNNKYASLFEPMKIGKTKIKNRIGMSPMAASGMITPHNCFDKRAAEYYVERARGGAGLIITGGVEVENEIEQTKLGIFQN
ISTNPVAFALNSSEMIERVHAHGSKIFLQLTMGFGRSLFLDFVDSHPVAPSAIPHFWEPDVTCRELTTNEVEYMVEKMAE
AAKVAASAGYDGVEVHAMHEGYLLDQFTLKAFNKRTDKYGGDLRGRLQLPIEILQAIKSEVGQDFPVILRYGVKSCIKAP
HQGGLPGEDYQEHGRDLEEGLEAAKILEEAGYDGFNADLGSYEALYWAHPPTYIEHGCYLPYTKQLKEVIDVPVLTAGRM
DNPEVAAEAVTSEKTDMALLGRGLLADPDWPNKVKSGETDKIRPCLGCHDGCMGRLESGKVISCAVNPACGREEEYKLHP
PLKQKDVMVVGGGIAGMEAARVAAIRGHKVSLYEKNNSLGGHVVEASVPEFKKDERELLRWYGQELKENDVELNLGTEVD
SQLVKEINPDEIILATGAKEKIPPIQGIDQDHVLTACDALMNPDKVGKNVAIIGGGLVGCEIAIWLAQQNKQITIVEMIE
ELMGAVFVSHANEMMLKDMIKHEGIEVKTDTSLLEVQENEIVTINKEFKKQNLNADTVLLAIGYESDTKLYEELKDIHPK
THLIGDARTVQNIMYGIWEGYEVARTL

Specific function: Reduces a range of alternative electron acceptors [H]

COG id: COG1902

COG function: function code C; NADH:flavin oxidoreductases, Old Yellow Enzyme family

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the N-terminal section; belongs to the NADH:flavin oxidoreductase/NADH oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1789463, Length=553, Percent_Identity=33.4538878842676, Blast_Score=286, Evalue=3e-78,
Organism=Escherichia coli, GI1787939, Length=359, Percent_Identity=27.5766016713092, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17564188, Length=241, Percent_Identity=29.4605809128631, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI72001454, Length=218, Percent_Identity=32.1100917431193, Blast_Score=100, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17559802, Length=216, Percent_Identity=29.6296296296296, Blast_Score=98, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17565138, Length=204, Percent_Identity=29.9019607843137, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI17540738, Length=274, Percent_Identity=28.1021897810219, Blast_Score=97, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI17559804, Length=208, Percent_Identity=29.8076923076923, Blast_Score=95, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI17566914, Length=328, Percent_Identity=25, Blast_Score=81, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6325086, Length=374, Percent_Identity=27.0053475935829, Blast_Score=81, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6321973, Length=261, Percent_Identity=27.9693486590038, Blast_Score=78, Evalue=6e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR013027
- InterPro:   IPR016040
- InterPro:   IPR001155
- InterPro:   IPR001327
- InterPro:   IPR000103 [H]

Pfam domain/function: PF00724 Oxidored_FMN; PF00070 Pyr_redox; PF07992 Pyr_redox_2 [H]

EC number: 1.3.1.34 [C]

Molecular weight: Translated: 73681; Mature: 73681

Theoretical pI: Translated: 4.93; Mature: 4.93

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKYASLFEPMKIGKTKIKNRIGMSPMAASGMITPHNCFDKRAAEYYVERARGGAGLII
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
TGGVEVENEIEQTKLGIFQNISTNPVAFALNSSEMIERVHAHGSKIFLQLTMGFGRSLFL
ECCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHCCCEEEEEEECCCCHHHHH
DFVDSHPVAPSAIPHFWEPDVTCRELTTNEVEYMVEKMAEAAKVAASAGYDGVEVHAMHE
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GYLLDQFTLKAFNKRTDKYGGDLRGRLQLPIEILQAIKSEVGQDFPVILRYGVKSCIKAP
CEEHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
HQGGLPGEDYQEHGRDLEEGLEAAKILEEAGYDGFNADLGSYEALYWAHPPTYIEHGCYL
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHCCCCC
PYTKQLKEVIDVPVLTAGRMDNPEVAAEAVTSEKTDMALLGRGLLADPDWPNKVKSGETD
CHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
KIRPCLGCHDGCMGRLESGKVISCAVNPACGREEEYKLHPPLKQKDVMVVGGGIAGMEAA
CCCCHHCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHH
RVAAIRGHKVSLYEKNNSLGGHVVEASVPEFKKDERELLRWYGQELKENDVELNLGTEVD
HHHHHCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHH
SQLVKEINPDEIILATGAKEKIPPIQGIDQDHVLTACDALMNPDKVGKNVAIIGGGLVGC
HHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEEEECCEEEE
EIAIWLAQQNKQITIVEMIEELMGAVFVSHANEMMLKDMIKHEGIEVKTDTSLLEVQENE
EEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCC
IVTINKEFKKQNLNADTVLLAIGYESDTKLYEELKDIHPKTHLIGDARTVQNIMYGIWEG
EEEEEHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHCC
YEVARTL
HHHHHCC
>Mature Secondary Structure
MNNKYASLFEPMKIGKTKIKNRIGMSPMAASGMITPHNCFDKRAAEYYVERARGGAGLII
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCEEE
TGGVEVENEIEQTKLGIFQNISTNPVAFALNSSEMIERVHAHGSKIFLQLTMGFGRSLFL
ECCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHHCCCEEEEEEECCCCHHHHH
DFVDSHPVAPSAIPHFWEPDVTCRELTTNEVEYMVEKMAEAAKVAASAGYDGVEVHAMHE
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECC
GYLLDQFTLKAFNKRTDKYGGDLRGRLQLPIEILQAIKSEVGQDFPVILRYGVKSCIKAP
CEEHHHHHHHHHHHHHHHCCCCCCCEEECCHHHHHHHHHHHCCCCHHHHHHHHHHHHCCC
HQGGLPGEDYQEHGRDLEEGLEAAKILEEAGYDGFNADLGSYEALYWAHPPTYIEHGCYL
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEECCCCHHHHCCCCC
PYTKQLKEVIDVPVLTAGRMDNPEVAAEAVTSEKTDMALLGRGLLADPDWPNKVKSGETD
CHHHHHHHHHCCCCEECCCCCCHHHHHHHHHCCCCCHHHHCCCCCCCCCCCCCCCCCCCC
KIRPCLGCHDGCMGRLESGKVISCAVNPACGREEEYKLHPPLKQKDVMVVGGGIAGMEAA
CCCCHHCCCCHHHCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHH
RVAAIRGHKVSLYEKNNSLGGHVVEASVPEFKKDERELLRWYGQELKENDVELNLGTEVD
HHHHHCCCEEEEEECCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHCCCCEEEEECCHHH
SQLVKEINPDEIILATGAKEKIPPIQGIDQDHVLTACDALMNPDKVGKNVAIIGGGLVGC
HHHHHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCHHHHCCEEEEEECCEEEE
EIAIWLAQQNKQITIVEMIEELMGAVFVSHANEMMLKDMIKHEGIEVKTDTSLLEVQENE
EEEEEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCCEEEECCCC
IVTINKEFKKQNLNADTVLLAIGYESDTKLYEELKDIHPKTHLIGDARTVQNIMYGIWEG
EEEEEHHHHHCCCCCCEEEEEEECCCHHHHHHHHHHCCCCHHCCCCHHHHHHHHHHHHCC
YEVARTL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: FAD. [C]

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: transDidehydroacyl-CoA; NADP+ [C]

Specific reaction: transDidehydroacyl-CoA + NADP+ =trans-transtetradehydroacyl-CoA + NADPH [C]

General reaction: Redox reaction [C]

Inhibitor: Iodoacetic acid; N-Ethyl maleimide [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8357835 [H]