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The map label for this gene is phoP [H]

Identifier: 188585611

GI number: 188585611

Start: 1047557

End: 1048297

Strand: Direct

Name: phoP [H]

Synonym: Nther_0984

Alternate gene names: 188585611

Gene position: 1047557-1048297 (Clockwise)

Preceding gene: 188585610

Following gene: 188585612

Centisome position: 33.09

GC content: 32.79

Gene sequence:

>741_bases
ATGCATAGAATATTATTAGTCGAGGATGAACACCATATTGCTAAACTAGTTAATCACAACTTAATAAAAGAAGGGTATGA
AGTTGAACATGTAACCCATGGAGATGAAGCTTTTAACAAATATTTTGAAAATGACTATGATTTAATTATTTTAGATCTAA
TGCTTCCTGGTTTAGATGGGCTAGAAGTTTGTAGAAAAATACGTGGTAATTCCTCCCTGCATATTCCAGTTATTATGTTA
ACAGCAAAAAGTGATGAGATTGAAAAAATAGTAGGTTTAGAAATGGGTGCCGATGATTATGTAACTAAACCTTTTAGTCC
TAGAGAGCTGTTAGCTAGAGTAAAAGCTCAATTGCGTGGAAGAACTAAAGAGTTAACAGATGAAAAAAGCCAAGATAATT
CTAACAAGATTTTTGATCAAAGGGATAAAAGTGAAGATGTTAAAAAGAATGGTCCTTTATCAATTAAACCTGAAAAATAT
CGAGCATATATTGAAAATCAAGAATTACAGTTAACTCCAAAAGAATTTGAGCTTTTAAATATTATGGTTACAAACTCTGG
ACAAGTTTTGACGAGAGAAAAATTACTTGAAAAAATTTGGGGCTACGATTTTCTTGGAGATACCAGAACTGTAGATGTTC
ATATTAGACATCTACGCCAGAAAATTAGTGAAGCGGGTGGTCCTCCTGACTTAGTAGAGACAGTCAGGGGCATAGGATAT
CGTTTAAAAGAAATGGAGTAA

Upstream 100 bases:

>100_bases
GGGTGATTTTTATGGTGACTGGTGATAGAATAGATGTATAGAATTAAACTCAGACTATTTAATTCAAGATATTTTAAGGT
TTAAGGGAGGATCATCCAAG

Downstream 100 bases:

>100_bases
TTGTTATGAGAACAATTAAAAGTAAAATTAATACAGCTTTTTCCATATTAATTGCCCTTGCTTTCATAAGCATGGGATTA
TATTTATTTAATTATTTTTC

Product: two component transcriptional regulator, winged helix family

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MHRILLVEDEHHIAKLVNHNLIKEGYEVEHVTHGDEAFNKYFENDYDLIILDLMLPGLDGLEVCRKIRGNSSLHIPVIML
TAKSDEIEKIVGLEMGADDYVTKPFSPRELLARVKAQLRGRTKELTDEKSQDNSNKIFDQRDKSEDVKKNGPLSIKPEKY
RAYIENQELQLTPKEFELLNIMVTNSGQVLTREKLLEKIWGYDFLGDTRTVDVHIRHLRQKISEAGGPPDLVETVRGIGY
RLKEME

Sequences:

>Translated_246_residues
MHRILLVEDEHHIAKLVNHNLIKEGYEVEHVTHGDEAFNKYFENDYDLIILDLMLPGLDGLEVCRKIRGNSSLHIPVIML
TAKSDEIEKIVGLEMGADDYVTKPFSPRELLARVKAQLRGRTKELTDEKSQDNSNKIFDQRDKSEDVKKNGPLSIKPEKY
RAYIENQELQLTPKEFELLNIMVTNSGQVLTREKLLEKIWGYDFLGDTRTVDVHIRHLRQKISEAGGPPDLVETVRGIGY
RLKEME
>Mature_246_residues
MHRILLVEDEHHIAKLVNHNLIKEGYEVEHVTHGDEAFNKYFENDYDLIILDLMLPGLDGLEVCRKIRGNSSLHIPVIML
TAKSDEIEKIVGLEMGADDYVTKPFSPRELLARVKAQLRGRTKELTDEKSQDNSNKIFDQRDKSEDVKKNGPLSIKPEKY
RAYIENQELQLTPKEFELLNIMVTNSGQVLTREKLLEKIWGYDFLGDTRTVDVHIRHLRQKISEAGGPPDLVETVRGIGY
RLKEME

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788394, Length=240, Percent_Identity=40, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1786599, Length=242, Percent_Identity=40.495867768595, Blast_Score=165, Evalue=3e-42,
Organism=Escherichia coli, GI1789809, Length=239, Percent_Identity=35.5648535564854, Blast_Score=164, Evalue=7e-42,
Organism=Escherichia coli, GI87082012, Length=238, Percent_Identity=35.7142857142857, Blast_Score=151, Evalue=3e-38,
Organism=Escherichia coli, GI1789402, Length=242, Percent_Identity=35.9504132231405, Blast_Score=142, Evalue=2e-35,
Organism=Escherichia coli, GI1790860, Length=249, Percent_Identity=36.144578313253, Blast_Score=137, Evalue=4e-34,
Organism=Escherichia coli, GI1786784, Length=241, Percent_Identity=34.0248962655602, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI1790863, Length=247, Percent_Identity=35.6275303643725, Blast_Score=127, Evalue=8e-31,
Organism=Escherichia coli, GI1786911, Length=242, Percent_Identity=33.8842975206612, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI2367329, Length=240, Percent_Identity=34.5833333333333, Blast_Score=125, Evalue=3e-30,
Organism=Escherichia coli, GI1787229, Length=244, Percent_Identity=36.4754098360656, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790552, Length=240, Percent_Identity=34.5833333333333, Blast_Score=121, Evalue=5e-29,
Organism=Escherichia coli, GI145693140, Length=240, Percent_Identity=33.3333333333333, Blast_Score=120, Evalue=9e-29,
Organism=Escherichia coli, GI1787375, Length=240, Percent_Identity=30, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI1788550, Length=127, Percent_Identity=28.3464566929134, Blast_Score=68, Evalue=6e-13,
Organism=Escherichia coli, GI1788191, Length=109, Percent_Identity=34.8623853211009, Blast_Score=68, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 28376; Mature: 28376

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHRILLVEDEHHIAKLVNHNLIKEGYEVEHVTHGDEAFNKYFENDYDLIILDLMLPGLDG
CCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCEEEEEHHCCCCCH
LEVCRKIRGNSSLHIPVIMLTAKSDEIEKIVGLEMGADDYVTKPFSPRELLARVKAQLRG
HHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RTKELTDEKSQDNSNKIFDQRDKSEDVKKNGPLSIKPEKYRAYIENQELQLTPKEFELLN
CHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
IMVTNSGQVLTREKLLEKIWGYDFLGDTRTVDVHIRHLRQKISEAGGPPDLVETVRGIGY
EEEECCCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
RLKEME
HHHCCC
>Mature Secondary Structure
MHRILLVEDEHHIAKLVNHNLIKEGYEVEHVTHGDEAFNKYFENDYDLIILDLMLPGLDG
CCEEEEEECCHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHCCCCCEEEEEHHCCCCCH
LEVCRKIRGNSSLHIPVIMLTAKSDEIEKIVGLEMGADDYVTKPFSPRELLARVKAQLRG
HHHHHHHCCCCCEEEEEEEEEECCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCC
RTKELTDEKSQDNSNKIFDQRDKSEDVKKNGPLSIKPEKYRAYIENQELQLTPKEFELLN
CHHHHCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHCCCCCEEECCCCEEEEE
IMVTNSGQVLTREKLLEKIWGYDFLGDTRTVDVHIRHLRQKISEAGGPPDLVETVRGIGY
EEEECCCCCHHHHHHHHHHCCCCCCCCCEEEHHHHHHHHHHHHHCCCCHHHHHHHHHCCH
RLKEME
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]