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The map label for this gene is cobQ [H]

Identifier: 188585572

GI number: 188585572

Start: 1000805

End: 1002487

Strand: Direct

Name: cobQ [H]

Synonym: Nther_0944

Alternate gene names: 188585572

Gene position: 1000805-1002487 (Clockwise)

Preceding gene: 188585571

Following gene: 188585573

Centisome position: 31.62

GC content: 38.62

Gene sequence:

>1683_bases
TTGACTAAAAATTTTATAGATAATAACTCGGCAGCAAGAAATCTGAGAGACAGAAACGTGACAGATAGAAACGTGGACGC
GGCAGATAGTGACCTGGCACCATGTTTAATGCTTCAGGGGACCTCATCCCATGTAGGTAAAAGTGTCTTGGTTACTGCTT
TTTGCAGAATTTTTTCTCGCCTAGGATATCGGATTGCACCATTTAAGGCTCAAAATATGGCAAATAATTCTTACGTAACC
CCACAGGGTTATGAAATAGGTCGGGCTCAAGGTATACAAGCGGAAGCTGCTCAGAGACAAGCAAATACCAATATGAACCC
GGTATTGTTGAAGCCATCTAGTGATGGAACCTCTCAAGTTGTATTGCACGGAAAACCCCGGGGTGAAGTAAAGGCCAGGG
AATATAGAGAGGATTGGATAGCTTTTTTGTGGCCCCAAATCAAAACAGCCTTGTATGAACTGAGACGGGATTCGGATATG
GTAATAATTGAAGGTGCTGGTAGCCCCAGTGAAATTAACTTGAGAGATGGAGATATGGCTAATATGAGTGTAGCCAAGGA
AGCCTCAGCCAGGGTTCTTCTAGTAAGTGATATTGAACGAGGAGGAATGCTGGCGTCAGTTGTTGGCACCTTAGAGCTTT
TACCAGAAGATGAAAGAGATTTAGTAAAAGGGATACTGGTTAATAAATTTCGTGGAGATCTATCTCTACTGCAACCCGGG
TTAAAATTTTTGGAAGAAAAGACAAATAAACCTGTACTAGGAACTTTGCCATATATTAAGGAAAAATTAGTCGATGAAGA
AGATTCTGTAGCACTGGAAGAAAATAAAAATACTCAGACTAACAGGACTCAAGGAAAAAACAGCCGCCCCCTTATAAAAA
TTGGCGTAGTAAAACTGCCACGGATTTCTAATTTTACTGATTTTGAACCATTAAAAGAACATCCTGCAGTAGAATTGCGA
TACCTTCCATTAGAATCGAAAGCACCTAAACTAGATTGCTTGATCATTCCAGGTACTAAAGCTACATTGGCGGATTTACA
GGAATTTGTGAATTCCACCTTATATGTTTCCTTATCAGAACAAAAACAACTAGAAAATCTCCCTATTTTTGGAATTTGTG
GTGGTTATCAAATGTTAGGATTGTCACTAAATGATGAACAAGGTATAGAAGGAAAGGCTGGAGAACTTTTAGGATTAGGG
CTGTTACCTGTGGTGACTAATTTTTCCCCGGGAAAGCACACTTATAGAACAGCTCTTACGGTGAATCAAAGTGAATCTTC
TAGTTCTAAAAACAGCTATACATTTGATCGTTTATTCAGTGATTTAAAGGGAACTCGACTAATAGGATACGAAATCCACA
TGGGGGAAACTGAACCGGTTGAACCCGGATATAGCTGGCTTATCGACGAGAATAATCAACCGAAAGGCACATTTTCTCAA
AACGGGCGTGTAATGGGAACTTTTTTACATGGTATTTTTAATAATAATTCATTCACTAATTGGTTTCTTTCCTGGGTTGT
TTTATGGAATGAATGTGGATCTTCCCAGGATTTTTTGCAGAAAAATGAAGGGTATTTGAGTGATATGGAGAAATTTAATA
TATTGGCAGACCATGTAGAATCTGCTCTGGATATGGGATATATATCTAAAATGTTAAATTGCAATTTGCAATGTAAAAAT
TAA

Upstream 100 bases:

>100_bases
CGAAACATTGGATGTGAAATTGAAGAGTTCAACTATCAACATTCAACTTTAACATAGCCTAGTTTAAAGTAAATTTCTAC
GAGAGAAGGAGTGAGCTATT

Downstream 100 bases:

>100_bases
CTACAAATTGATGAAAAGGTGACTTTAAATGGGTATTATCTGGGATTTGGATGGTACTTTATACAATTTCTACTTACCGG
CCAAAATATCTTTACATGTA

Product: cobyric acid synthase CobQ

Products: ADP; phosphate; adenosylcobyric acid; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 560; Mature: 559

Protein sequence:

>560_residues
MTKNFIDNNSAARNLRDRNVTDRNVDAADSDLAPCLMLQGTSSHVGKSVLVTAFCRIFSRLGYRIAPFKAQNMANNSYVT
PQGYEIGRAQGIQAEAAQRQANTNMNPVLLKPSSDGTSQVVLHGKPRGEVKAREYREDWIAFLWPQIKTALYELRRDSDM
VIIEGAGSPSEINLRDGDMANMSVAKEASARVLLVSDIERGGMLASVVGTLELLPEDERDLVKGILVNKFRGDLSLLQPG
LKFLEEKTNKPVLGTLPYIKEKLVDEEDSVALEENKNTQTNRTQGKNSRPLIKIGVVKLPRISNFTDFEPLKEHPAVELR
YLPLESKAPKLDCLIIPGTKATLADLQEFVNSTLYVSLSEQKQLENLPIFGICGGYQMLGLSLNDEQGIEGKAGELLGLG
LLPVVTNFSPGKHTYRTALTVNQSESSSSKNSYTFDRLFSDLKGTRLIGYEIHMGETEPVEPGYSWLIDENNQPKGTFSQ
NGRVMGTFLHGIFNNNSFTNWFLSWVVLWNECGSSQDFLQKNEGYLSDMEKFNILADHVESALDMGYISKMLNCNLQCKN

Sequences:

>Translated_560_residues
MTKNFIDNNSAARNLRDRNVTDRNVDAADSDLAPCLMLQGTSSHVGKSVLVTAFCRIFSRLGYRIAPFKAQNMANNSYVT
PQGYEIGRAQGIQAEAAQRQANTNMNPVLLKPSSDGTSQVVLHGKPRGEVKAREYREDWIAFLWPQIKTALYELRRDSDM
VIIEGAGSPSEINLRDGDMANMSVAKEASARVLLVSDIERGGMLASVVGTLELLPEDERDLVKGILVNKFRGDLSLLQPG
LKFLEEKTNKPVLGTLPYIKEKLVDEEDSVALEENKNTQTNRTQGKNSRPLIKIGVVKLPRISNFTDFEPLKEHPAVELR
YLPLESKAPKLDCLIIPGTKATLADLQEFVNSTLYVSLSEQKQLENLPIFGICGGYQMLGLSLNDEQGIEGKAGELLGLG
LLPVVTNFSPGKHTYRTALTVNQSESSSSKNSYTFDRLFSDLKGTRLIGYEIHMGETEPVEPGYSWLIDENNQPKGTFSQ
NGRVMGTFLHGIFNNNSFTNWFLSWVVLWNECGSSQDFLQKNEGYLSDMEKFNILADHVESALDMGYISKMLNCNLQCKN
>Mature_559_residues
TKNFIDNNSAARNLRDRNVTDRNVDAADSDLAPCLMLQGTSSHVGKSVLVTAFCRIFSRLGYRIAPFKAQNMANNSYVTP
QGYEIGRAQGIQAEAAQRQANTNMNPVLLKPSSDGTSQVVLHGKPRGEVKAREYREDWIAFLWPQIKTALYELRRDSDMV
IIEGAGSPSEINLRDGDMANMSVAKEASARVLLVSDIERGGMLASVVGTLELLPEDERDLVKGILVNKFRGDLSLLQPGL
KFLEEKTNKPVLGTLPYIKEKLVDEEDSVALEENKNTQTNRTQGKNSRPLIKIGVVKLPRISNFTDFEPLKEHPAVELRY
LPLESKAPKLDCLIIPGTKATLADLQEFVNSTLYVSLSEQKQLENLPIFGICGGYQMLGLSLNDEQGIEGKAGELLGLGL
LPVVTNFSPGKHTYRTALTVNQSESSSSKNSYTFDRLFSDLKGTRLIGYEIHMGETEPVEPGYSWLIDENNQPKGTFSQN
GRVMGTFLHGIFNNNSFTNWFLSWVVLWNECGSSQDFLQKNEGYLSDMEKFNILADHVESALDMGYISKMLNCNLQCKN

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.5.10

Molecular weight: Translated: 62279; Mature: 62147

Theoretical pI: Translated: 5.44; Mature: 5.44

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKNFIDNNSAARNLRDRNVTDRNVDAADSDLAPCLMLQGTSSHVGKSVLVTAFCRIFSR
CCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
LGYRIAPFKAQNMANNSYVTPQGYEIGRAQGIQAEAAQRQANTNMNPVLLKPSSDGTSQV
CCCEECCCCHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEE
VLHGKPRGEVKAREYREDWIAFLWPQIKTALYELRRDSDMVIIEGAGSPSEINLRDGDMA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCC
NMSVAKEASARVLLVSDIERGGMLASVVGTLELLPEDERDLVKGILVNKFRGDLSLLQPG
CHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHH
LKFLEEKTNKPVLGTLPYIKEKLVDEEDSVALEENKNTQTNRTQGKNSRPLIKIGVVKLP
HHHHHHHCCCCEEECCHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
RISNFTDFEPLKEHPAVELRYLPLESKAPKLDCLIIPGTKATLADLQEFVNSTLYVSLSE
CCCCCCCCCHHHCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEECC
QKQLENLPIFGICGGYQMLGLSLNDEQGIEGKAGELLGLGLLPVVTNFSPGKHTYRTALT
HHHHHCCCEEEEECCEEEEEEEECCCCCCCCCCCCEECCCHHHHHCCCCCCCCEEEEEEE
VNQSESSSSKNSYTFDRLFSDLKGTRLIGYEIHMGETEPVEPGYSWLIDENNQPKGTFSQ
EECCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCC
NGRVMGTFLHGIFNNNSFTNWFLSWVVLWNECGSSQDFLQKNEGYLSDMEKFNILADHVE
CCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
SALDMGYISKMLNCNLQCKN
HHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure 
TKNFIDNNSAARNLRDRNVTDRNVDAADSDLAPCLMLQGTSSHVGKSVLVTAFCRIFSR
CCCCCCCCHHHHHHCCCCCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHH
LGYRIAPFKAQNMANNSYVTPQGYEIGRAQGIQAEAAQRQANTNMNPVLLKPSSDGTSQV
CCCEECCCCHHCCCCCCEECCCCCCCCCCCCCHHHHHHHHHCCCCCEEEEECCCCCCCEE
VLHGKPRGEVKAREYREDWIAFLWPQIKTALYELRRDSDMVIIEGAGSPSEINLRDGDMA
EEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCC
NMSVAKEASARVLLVSDIERGGMLASVVGTLELLPEDERDLVKGILVNKFRGDLSLLQPG
CHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCHHHHHHH
LKFLEEKTNKPVLGTLPYIKEKLVDEEDSVALEENKNTQTNRTQGKNSRPLIKIGVVKLP
HHHHHHHCCCCEEECCHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCEEEEEEEECC
RISNFTDFEPLKEHPAVELRYLPLESKAPKLDCLIIPGTKATLADLQEFVNSTLYVSLSE
CCCCCCCCCHHHCCCCEEEEEEECCCCCCCEEEEEECCCCHHHHHHHHHHCCEEEEEECC
QKQLENLPIFGICGGYQMLGLSLNDEQGIEGKAGELLGLGLLPVVTNFSPGKHTYRTALT
HHHHHCCCEEEEECCEEEEEEEECCCCCCCCCCCCEECCCHHHHHCCCCCCCCEEEEEEE
VNQSESSSSKNSYTFDRLFSDLKGTRLIGYEIHMGETEPVEPGYSWLIDENNQPKGTFSQ
EECCCCCCCCCCCCHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEECCCCCCCCCCCC
NGRVMGTFLHGIFNNNSFTNWFLSWVVLWNECGSSQDFLQKNEGYLSDMEKFNILADHVE
CCEEEEEEHHHHHCCCCHHHHHHHHHHHHHHCCCCHHHHHHCCCHHHHHHHHHHHHHHHH
SALDMGYISKMLNCNLQCKN
HHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; adenosylcobyrinic acid a,c-diamide; L-glutamine; H2O

Specific reaction: 4 ATP + adenosylcobyrinic acid a,c-diamide + 4 L-glutamine + 4 H2O = 4 ADP + 4 phosphate + adenosylcobyric acid + 4 L-glutamate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA