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The map label for this gene is cobDQ [H]

Identifier: 188585571

GI number: 188585571

Start: 999532

End: 1000623

Strand: Direct

Name: cobDQ [H]

Synonym: Nther_0943

Alternate gene names: 188585571

Gene position: 999532-1000623 (Clockwise)

Preceding gene: 188585570

Following gene: 188585572

Centisome position: 31.58

GC content: 36.26

Gene sequence:

>1092_bases
ATTAACTCTCATGGTGGACAAGTATGGCGTTGGCAACGAGAATTTAATTTAAATCCCAAAGAGATTATTGACTTTAGTGC
TAATATTAACCCACTGGGGCCCCCTAAGGAAATTATTAATCAGCTAAGTTCACAGTTGGATGCATTGCAGCATTATCCAG
AGCCTTATGGAATCAGTCTTAAACAAATTATAGCTGAACATCACGGAGTTTTGCCTGAACAGGTGATTGTAGGAAATGGA
GCCAGTGAATTGATTGACTTAATTATCCTTCATAGGCTAGTGAAAAGTGATAATATTAATGAACATTTAACTGCTTTAAT
TCCCGAGCCTAATTTTAGTGAGTACAAGCGGGGAGTCCAGGCTTTGAGAGGGAAAGTTAATAGCTTTACTACTTTGTCAT
TAAATAATGATTTAAGCTATATGAAAACAAAAATGATGGAGATGCGACCACAGCTGCTATTTTTGTCGTCTCCCAACAAT
CCTACCGGTGAACTTATCAATAATTATACTTTGAAAAATATTGTCCAATCCATGGAGCAATGGGATGGAGAGCTTATTTT
AGATTATTCTTTTCTTCCCTTTGTCAAGTCTTCTTGGCCAAAAGCCAGTTTAGAGGAGATAAACTTTGATCAAACATTTT
TATTATTTTCTCTAACTAAGATGTTTGCCCTTCCGGGACTTAGATTAGGTTATGGAATTACGAGTCAAGAGAAGATATGG
CAATTGGAAAAGTTAAGAAATCAATGGGCGGTTAATTCACTGGCACAGACAGCCTTTAAAGAGTGCTTTAGTTTACAAAA
CTATGAAAACAAAACTAGAAAGTTAATTCATAGCGAACGGGAAAGATTACGAGCAGAGCTGGAGTTTCTAGGATTTAGCA
CCTTTAAGTCTTCAGCTAATTTTTTACTAATTAAAAACAATAATTTTCCAGGTACTGTCAAGAACCTCTGGCATCATCTT
GCCTGTAAGGGAATATTCATTCGGCTTTGTGAGAATTTCCAAGGACTTGATGAATCATATTTTAGGATAGCCATTAGATT
ACCTGAAGAAAATGACCGCTTTCTTGAGGAACTTAGCAGTTTTACACCTTAG

Upstream 100 bases:

>100_bases
TCGAGAATGGTATCTCAAATATCAAATTGAGGATACGGCCGAATTTTTAGGGTTTTATAATTTGGTTAATGGCGGGATAG
ATTAATGGAGGTGATTAATC

Downstream 100 bases:

>100_bases
TTTTAGGCTCTTTTATACTCCGTTGTTGATAGATTAACTCTTCGATTGAACGAATTTTGTGTAGAGTTAGTTGTAACAAC
CCGAAACATTGGATGTGAAA

Product: aminotransferase class I and II

Products: NA

Alternate protein names: Putative threonine-phosphate decarboxylase; L-threonine-O-3-phosphate decarboxylase; Cobyric acid synthase [H]

Number of amino acids: Translated: 363; Mature: 363

Protein sequence:

>363_residues
MNSHGGQVWRWQREFNLNPKEIIDFSANINPLGPPKEIINQLSSQLDALQHYPEPYGISLKQIIAEHHGVLPEQVIVGNG
ASELIDLIILHRLVKSDNINEHLTALIPEPNFSEYKRGVQALRGKVNSFTTLSLNNDLSYMKTKMMEMRPQLLFLSSPNN
PTGELINNYTLKNIVQSMEQWDGELILDYSFLPFVKSSWPKASLEEINFDQTFLLFSLTKMFALPGLRLGYGITSQEKIW
QLEKLRNQWAVNSLAQTAFKECFSLQNYENKTRKLIHSERERLRAELEFLGFSTFKSSANFLLIKNNNFPGTVKNLWHHL
ACKGIFIRLCENFQGLDESYFRIAIRLPEENDRFLEELSSFTP

Sequences:

>Translated_363_residues
MNSHGGQVWRWQREFNLNPKEIIDFSANINPLGPPKEIINQLSSQLDALQHYPEPYGISLKQIIAEHHGVLPEQVIVGNG
ASELIDLIILHRLVKSDNINEHLTALIPEPNFSEYKRGVQALRGKVNSFTTLSLNNDLSYMKTKMMEMRPQLLFLSSPNN
PTGELINNYTLKNIVQSMEQWDGELILDYSFLPFVKSSWPKASLEEINFDQTFLLFSLTKMFALPGLRLGYGITSQEKIW
QLEKLRNQWAVNSLAQTAFKECFSLQNYENKTRKLIHSERERLRAELEFLGFSTFKSSANFLLIKNNNFPGTVKNLWHHL
ACKGIFIRLCENFQGLDESYFRIAIRLPEENDRFLEELSSFTP
>Mature_363_residues
MNSHGGQVWRWQREFNLNPKEIIDFSANINPLGPPKEIINQLSSQLDALQHYPEPYGISLKQIIAEHHGVLPEQVIVGNG
ASELIDLIILHRLVKSDNINEHLTALIPEPNFSEYKRGVQALRGKVNSFTTLSLNNDLSYMKTKMMEMRPQLLFLSSPNN
PTGELINNYTLKNIVQSMEQWDGELILDYSFLPFVKSSWPKASLEEINFDQTFLLFSLTKMFALPGLRLGYGITSQEKIW
QLEKLRNQWAVNSLAQTAFKECFSLQNYENKTRKLIHSERERLRAELEFLGFSTFKSSANFLLIKNNNFPGTVKNLWHHL
ACKGIFIRLCENFQGLDESYFRIAIRLPEENDRFLEELSSFTP

Specific function: Catalyzes two activities which are involved in the adenosylcobalamin biosynthesis:decarboxylates L-threonine-O-3- phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cob

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=335, Percent_Identity=26.5671641791045, Blast_Score=93, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6322075, Length=380, Percent_Identity=23.9473684210526, Blast_Score=75, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2; PF01656 CbiA; PF07685 GATase_3 [H]

EC number: =4.1.1.81 [H]

Molecular weight: Translated: 41942; Mature: 41942

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSHGGQVWRWQREFNLNPKEIIDFSANINPLGPPKEIINQLSSQLDALQHYPEPYGISL
CCCCCCCEEEEEHHCCCCHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
KQIIAEHHGVLPEQVIVGNGASELIDLIILHRLVKSDNINEHLTALIPEPNFSEYKRGVQ
HHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHH
ALRGKVNSFTTLSLNNDLSYMKTKMMEMRPQLLFLSSPNNPTGELINNYTLKNIVQSMEQ
HHHCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
WDGELILDYSFLPFVKSSWPKASLEEINFDQTFLLFSLTKMFALPGLRLGYGITSQEKIW
CCCCEEEEECHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
QLEKLRNQWAVNSLAQTAFKECFSLQNYENKTRKLIHSERERLRAELEFLGFSTFKSSAN
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FLLIKNNNFPGTVKNLWHHLACKGIFIRLCENFQGLDESYFRIAIRLPEENDRFLEELSS
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHC
FTP
CCC
>Mature Secondary Structure
MNSHGGQVWRWQREFNLNPKEIIDFSANINPLGPPKEIINQLSSQLDALQHYPEPYGISL
CCCCCCCEEEEEHHCCCCHHHHEECCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCH
KQIIAEHHGVLPEQVIVGNGASELIDLIILHRLVKSDNINEHLTALIPEPNFSEYKRGVQ
HHHHHHHCCCCCCCEEECCCHHHHHHHHHHHHHHHCCCCCCHHEEECCCCCHHHHHHHHH
ALRGKVNSFTTLSLNNDLSYMKTKMMEMRPQLLFLSSPNNPTGELINNYTLKNIVQSMEQ
HHHCCCCCEEEEEECCCHHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHH
WDGELILDYSFLPFVKSSWPKASLEEINFDQTFLLFSLTKMFALPGLRLGYGITSQEKIW
CCCCEEEEECHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHH
QLEKLRNQWAVNSLAQTAFKECFSLQNYENKTRKLIHSERERLRAELEFLGFSTFKSSAN
HHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
FLLIKNNNFPGTVKNLWHHLACKGIFIRLCENFQGLDESYFRIAIRLPEENDRFLEELSS
EEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCHHHHHHHHC
FTP
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12712204 [H]