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The map label for this gene is nuoN [H]

Identifier: 188585147

GI number: 188585147

Start: 530763

End: 532262

Strand: Direct

Name: nuoN [H]

Synonym: Nther_0508

Alternate gene names: 188585147

Gene position: 530763-532262 (Clockwise)

Preceding gene: 188585146

Following gene: 188585148

Centisome position: 16.77

GC content: 35.2

Gene sequence:

>1500_bases
TTGGAAGGCCATTTTCACCTGCCAATCATTATAGTTTTAATCGGTATTTTCGTATCATTTATATTACCGGGATTACATTT
TATCAAAAAAAATCTAAATGAATATGTTTCACTCTCTGCCATGATTTTGATGCTGGTAATAGCTATTTATCTTGTAATAG
AAGTTTCCAGTAATGGACCCTTTACCTACGTTGTAGGTGAATGGGCCCCGCCCTGGGGGATTGAGTTTAATGTAGATTAT
CTAGGTGTATATATGACACTTATTATAACAGGGATAGGTTTTCTCGCTTTATTGTATGCTTCTCGTGATTTACATCATGA
ATTGCAGGAAAATGCTTTATCATTATATTATCCTTTATACATGTTATTAATGGCTTCTATGATAGGAATGGTTCTAACCA
ATGATATTTTCAACTTATTCGTATTATTAGAAATAACTTTATTGACTTCGGTTGCCATAATATGCGTTAAAGAAAATAAA
GATACCATTGAAGCAAGCTTAAAGTATCTAATGTTAAATGCCTTGGGTTCTGCAACGGTTTTGATGGGGATTGCATTGCT
ATATATCATTACTGGTCATTTAAATATGACATATATTGCTCAAGAATTGGCGGTTAATTTTGAGCAATATCCGACTGTAA
TTATGGCCATTGTGGCGCTGTTCTTTGTGGGATTTGGAGTCAAAAGTGCATTGTTTCCTATGCATGTATGGTTGCCGGAT
GCTCACGGTTCTGCTCCATCCCCTTCTAGTGCAGTATTGAGTGGATTAGTTATTAAAGTTTATGTAGTATCTTTAATAAG
ATTCTATTTTATTGTTCTTCCTGAAGAAATTTTGGAGTTAATGCCAGTTGGAGAAATTCTTCTTTGGTTTGCTGCTGCTG
GTATGATTCTGGGCTCCATGTTTGCTATTGCTCAGGAAGATATTAAAAAAATGTTGGCATACTCTTCTGTTGCTCAGATA
AGTTATGTTTTTTTAGGAATAGGATTATTGAGTCTTACTAGTTTTCAAGGTGGATTGCTTCACATTTTAAATCACGCTAT
AATTAAATCTATGCTATTTTTAATTGCAGGGGCTATCATATATACTTCGGGTATCCGCAAGATATCTCATATGCATGGTG
TGGGCTTGCGTTATCCCTTAATCATGATATGTTTCACTTTAGGAGCCTTTGCTATGATTGGGATTCCGGGAACTAATGGC
TTTATAAGTAAATGGTACTTGGCCTTAGGAGCCTTAGATGCGGGGAGGCCTTTTTTTGTACTAGTTATTCTAGTGAGTAG
TTTGTTAAATGGTGTCTATTATTTGCCGATAGTTGTCAACAGTTTTTTTGGAGATATGCAGGATGCAGACATTAATTTTA
TAAAATGTAACAAGCTACCCTGGCAAATGTTTTTTCCCATCGTTTTATGTGGTTTTTTGATTATTTTTATCGGATTATAT
CCGGCACTTCCCTTGAGCTTGGTAGAACCTGCTGTAGAATTTTTAATGCCGGAATTGTAA

Upstream 100 bases:

>100_bases
TAGTATTACTTCATTGTTACTTAGCTTAATTGTGAAAATATACAAATATTATGGCACTTTGAATGCGGACAAAATTTCCA
AAATGAGGGGTTGATTTTAA

Downstream 100 bases:

>100_bases
TTTAAAGGGGGCGTTGTCCATGACGGATCTGGTAACAGAACAAGCAGAATTTACGTCAATATTGCCTATATTAATTATAT
TTGTCCCCTTATTGGGATCT

Product: proton-translocating NADH-quinone oxidoreductase, chain M

Products: NA

Alternate protein names: NADH dehydrogenase I subunit N; NDH-1 subunit N [H]

Number of amino acids: Translated: 499; Mature: 499

Protein sequence:

>499_residues
MEGHFHLPIIIVLIGIFVSFILPGLHFIKKNLNEYVSLSAMILMLVIAIYLVIEVSSNGPFTYVVGEWAPPWGIEFNVDY
LGVYMTLIITGIGFLALLYASRDLHHELQENALSLYYPLYMLLMASMIGMVLTNDIFNLFVLLEITLLTSVAIICVKENK
DTIEASLKYLMLNALGSATVLMGIALLYIITGHLNMTYIAQELAVNFEQYPTVIMAIVALFFVGFGVKSALFPMHVWLPD
AHGSAPSPSSAVLSGLVIKVYVVSLIRFYFIVLPEEILELMPVGEILLWFAAAGMILGSMFAIAQEDIKKMLAYSSVAQI
SYVFLGIGLLSLTSFQGGLLHILNHAIIKSMLFLIAGAIIYTSGIRKISHMHGVGLRYPLIMICFTLGAFAMIGIPGTNG
FISKWYLALGALDAGRPFFVLVILVSSLLNGVYYLPIVVNSFFGDMQDADINFIKCNKLPWQMFFPIVLCGFLIIFIGLY
PALPLSLVEPAVEFLMPEL

Sequences:

>Translated_499_residues
MEGHFHLPIIIVLIGIFVSFILPGLHFIKKNLNEYVSLSAMILMLVIAIYLVIEVSSNGPFTYVVGEWAPPWGIEFNVDY
LGVYMTLIITGIGFLALLYASRDLHHELQENALSLYYPLYMLLMASMIGMVLTNDIFNLFVLLEITLLTSVAIICVKENK
DTIEASLKYLMLNALGSATVLMGIALLYIITGHLNMTYIAQELAVNFEQYPTVIMAIVALFFVGFGVKSALFPMHVWLPD
AHGSAPSPSSAVLSGLVIKVYVVSLIRFYFIVLPEEILELMPVGEILLWFAAAGMILGSMFAIAQEDIKKMLAYSSVAQI
SYVFLGIGLLSLTSFQGGLLHILNHAIIKSMLFLIAGAIIYTSGIRKISHMHGVGLRYPLIMICFTLGAFAMIGIPGTNG
FISKWYLALGALDAGRPFFVLVILVSSLLNGVYYLPIVVNSFFGDMQDADINFIKCNKLPWQMFFPIVLCGFLIIFIGLY
PALPLSLVEPAVEFLMPEL
>Mature_499_residues
MEGHFHLPIIIVLIGIFVSFILPGLHFIKKNLNEYVSLSAMILMLVIAIYLVIEVSSNGPFTYVVGEWAPPWGIEFNVDY
LGVYMTLIITGIGFLALLYASRDLHHELQENALSLYYPLYMLLMASMIGMVLTNDIFNLFVLLEITLLTSVAIICVKENK
DTIEASLKYLMLNALGSATVLMGIALLYIITGHLNMTYIAQELAVNFEQYPTVIMAIVALFFVGFGVKSALFPMHVWLPD
AHGSAPSPSSAVLSGLVIKVYVVSLIRFYFIVLPEEILELMPVGEILLWFAAAGMILGSMFAIAQEDIKKMLAYSSVAQI
SYVFLGIGLLSLTSFQGGLLHILNHAIIKSMLFLIAGAIIYTSGIRKISHMHGVGLRYPLIMICFTLGAFAMIGIPGTNG
FISKWYLALGALDAGRPFFVLVILVSSLLNGVYYLPIVVNSFFGDMQDADINFIKCNKLPWQMFFPIVLCGFLIIFIGLY
PALPLSLVEPAVEFLMPEL

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translo

COG id: COG0651

COG function: function code CP; Formate hydrogenlyase subunit 3/Multisubunit Na+/H+ antiporter, MnhD subunit

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I subunit 2 family [H]

Homologues:

Organism=Homo sapiens, GI251831117, Length=340, Percent_Identity=25.5882352941176, Blast_Score=86, Evalue=7e-17,
Organism=Homo sapiens, GI251831116, Length=263, Percent_Identity=27.3764258555133, Blast_Score=86, Evalue=7e-17,
Organism=Escherichia coli, GI1788831, Length=394, Percent_Identity=29.1878172588832, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1788827, Length=357, Percent_Identity=29.1316526610644, Blast_Score=152, Evalue=5e-38,
Organism=Escherichia coli, GI1788613, Length=406, Percent_Identity=25.3694581280788, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1788829, Length=337, Percent_Identity=28.1899109792285, Blast_Score=133, Evalue=2e-32,
Organism=Escherichia coli, GI1788614, Length=431, Percent_Identity=26.4501160092807, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI145693160, Length=397, Percent_Identity=26.1964735516373, Blast_Score=102, Evalue=4e-23,
Organism=Escherichia coli, GI2367154, Length=340, Percent_Identity=27.6470588235294, Blast_Score=97, Evalue=3e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010096
- InterPro:   IPR001750
- InterPro:   IPR003918 [H]

Pfam domain/function: PF00361 Oxidored_q1 [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 55134; Mature: 55134

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEGHFHLPIIIVLIGIFVSFILPGLHFIKKNLNEYVSLSAMILMLVIAIYLVIEVSSNGP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
FTYVVGEWAPPWGIEFNVDYLGVYMTLIITGIGFLALLYASRDLHHELQENALSLYYPLY
EEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLMASMIGMVLTNDIFNLFVLLEITLLTSVAIICVKENKDTIEASLKYLMLNALGSATV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHH
LMGIALLYIITGHLNMTYIAQELAVNFEQYPTVIMAIVALFFVGFGVKSALFPMHVWLPD
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEECC
AHGSAPSPSSAVLSGLVIKVYVVSLIRFYFIVLPEEILELMPVGEILLWFAAAGMILGSM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FAIAQEDIKKMLAYSSVAQISYVFLGIGLLSLTSFQGGLLHILNHAIIKSMLFLIAGAII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YTSGIRKISHMHGVGLRYPLIMICFTLGAFAMIGIPGTNGFISKWYLALGALDAGRPFFV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHH
LVILVSSLLNGVYYLPIVVNSFFGDMQDADINFIKCNKLPWQMFFPIVLCGFLIIFIGLY
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
PALPLSLVEPAVEFLMPEL
HCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEGHFHLPIIIVLIGIFVSFILPGLHFIKKNLNEYVSLSAMILMLVIAIYLVIEVSSNGP
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCC
FTYVVGEWAPPWGIEFNVDYLGVYMTLIITGIGFLALLYASRDLHHELQENALSLYYPLY
EEEEEECCCCCCCCEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
MLLMASMIGMVLTNDIFNLFVLLEITLLTSVAIICVKENKDTIEASLKYLMLNALGSATV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHHHHHHHH
LMGIALLYIITGHLNMTYIAQELAVNFEQYPTVIMAIVALFFVGFGVKSALFPMHVWLPD
HHHHHHHHHHHCCCHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCHHHHHHHHEEEECC
AHGSAPSPSSAVLSGLVIKVYVVSLIRFYFIVLPEEILELMPVGEILLWFAAAGMILGSM
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
FAIAQEDIKKMLAYSSVAQISYVFLGIGLLSLTSFQGGLLHILNHAIIKSMLFLIAGAII
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHH
YTSGIRKISHMHGVGLRYPLIMICFTLGAFAMIGIPGTNGFISKWYLALGALDAGRPFFV
HHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHH
LVILVSSLLNGVYYLPIVVNSFFGDMQDADINFIKCNKLPWQMFFPIVLCGFLIIFIGLY
HHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHH
PALPLSLVEPAVEFLMPEL
HCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA