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The map label for this gene is phoP [H]

Identifier: 188584894

GI number: 188584894

Start: 266841

End: 267560

Strand: Direct

Name: phoP [H]

Synonym: Nther_0252

Alternate gene names: 188584894

Gene position: 266841-267560 (Clockwise)

Preceding gene: 188584893

Following gene: 188584895

Centisome position: 8.43

GC content: 33.61

Gene sequence:

>720_bases
ATGAATAAAAAGCTATTAATTGTTGATGATGAAAAGAATATTAGAATGACTCTGAAAAACTGTTTATCTTATGAGGGCTA
TGAATTAGAGATTGCATTGAATGGTGAAGAGGCTTTGGAAAAATTAAGAACTCAAGATTATGATTTAGTTTTACTCGACT
TGAAATTACCAGGTTTAAATGGGTTACAAGTATTAGAAAAAGTTCGGGACGAAGGAAGGGATGTCAAAGTCATAATGATG
ACGGCTTATGGAACTGTAGAAAGAGCCGTCAATGCTATGAAGCTTGGAGCAATTGACTTTATTAATAAGCCTTTTTCACC
AAATCAAATACGTGCTTTAGTTAATGATGTTCTCTCAAGGCCAAATTTAAGTGAAGAAAACTTGCAAACTTATAAAGATC
ATGTCGAGTTTGCAAAAAAATGTATTATTGAAAGTAATTATACAGAAGCAGAGAAACATCTAACGAAAGCTTTAGAAAAA
GATTACGATAAACCAGAGCCTAATAATTTATTAGGTGTCCTCGCTGAATACAATGGTGAGCTTGGCAAAGCAAGAAAACA
TTATCGTGCGGCTTTAGCTTTAGACCCTTCTTATAAACCAGCAAATACTAATCTCGAACGTGTAACAAGGTTTAAATACA
CTAAAGACGGTATAACATTTGGGAATGAGGAAGAAAAAGGAGAGGAAGAACAAGGAGAGGATAAAAATGAAGAACAGTAA

Upstream 100 bases:

>100_bases
AAAGCGTTAGCGATGGGTGGGGATGATTACCTTATTAAGCCTTTTACCCATACGAAGTTATATGAAGTTATCAAGAAATA
TTTAAAGGAGGAGAATAGCC

Downstream 100 bases:

>100_bases
TGACTACATCATTATAGTTGGTTGTGGTCGTTTAGGATCATCTTTGGCCAATAACCTTTCTATATCAAATAAAAGCGTTG
TTGTAATTGATTGGAAAGAA

Product: response regulator receiver protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 239

Protein sequence:

>239_residues
MNKKLLIVDDEKNIRMTLKNCLSYEGYELEIALNGEEALEKLRTQDYDLVLLDLKLPGLNGLQVLEKVRDEGRDVKVIMM
TAYGTVERAVNAMKLGAIDFINKPFSPNQIRALVNDVLSRPNLSEENLQTYKDHVEFAKKCIIESNYTEAEKHLTKALEK
DYDKPEPNNLLGVLAEYNGELGKARKHYRAALALDPSYKPANTNLERVTRFKYTKDGITFGNEEEKGEEEQGEDKNEEQ

Sequences:

>Translated_239_residues
MNKKLLIVDDEKNIRMTLKNCLSYEGYELEIALNGEEALEKLRTQDYDLVLLDLKLPGLNGLQVLEKVRDEGRDVKVIMM
TAYGTVERAVNAMKLGAIDFINKPFSPNQIRALVNDVLSRPNLSEENLQTYKDHVEFAKKCIIESNYTEAEKHLTKALEK
DYDKPEPNNLLGVLAEYNGELGKARKHYRAALALDPSYKPANTNLERVTRFKYTKDGITFGNEEEKGEEEQGEDKNEEQ
>Mature_239_residues
MNKKLLIVDDEKNIRMTLKNCLSYEGYELEIALNGEEALEKLRTQDYDLVLLDLKLPGLNGLQVLEKVRDEGRDVKVIMM
TAYGTVERAVNAMKLGAIDFINKPFSPNQIRALVNDVLSRPNLSEENLQTYKDHVEFAKKCIIESNYTEAEKHLTKALEK
DYDKPEPNNLLGVLAEYNGELGKARKHYRAALALDPSYKPANTNLERVTRFKYTKDGITFGNEEEKGEEEQGEDKNEEQ

Specific function: Member of the two-component regulatory system phoP/phoR involved in the regulation of alkaline phosphatase genes phoA and phoB and of phosphodiesterase [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=123, Percent_Identity=35.7723577235772, Blast_Score=92, Evalue=4e-20,
Organism=Escherichia coli, GI1786784, Length=145, Percent_Identity=32.4137931034483, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=118, Percent_Identity=34.7457627118644, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1790299, Length=115, Percent_Identity=34.7826086956522, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1789809, Length=120, Percent_Identity=35.8333333333333, Blast_Score=82, Evalue=5e-17,
Organism=Escherichia coli, GI1786599, Length=122, Percent_Identity=36.0655737704918, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1789402, Length=124, Percent_Identity=30.6451612903226, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI1790863, Length=134, Percent_Identity=33.5820895522388, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788394, Length=120, Percent_Identity=33.3333333333333, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI87082012, Length=111, Percent_Identity=32.4324324324324, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787229, Length=149, Percent_Identity=28.1879194630872, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788905, Length=114, Percent_Identity=31.5789473684211, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787487, Length=115, Percent_Identity=33.0434782608696, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1790860, Length=116, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1790552, Length=119, Percent_Identity=31.0924369747899, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788222, Length=117, Percent_Identity=29.9145299145299, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=30.8333333333333, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI2367329, Length=123, Percent_Identity=34.9593495934959, Blast_Score=61, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27316; Mature: 27316

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50005 TPR ; PS50293 TPR_REGION

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKKLLIVDDEKNIRMTLKNCLSYEGYELEIALNGEEALEKLRTQDYDLVLLDLKLPGLN
CCCCEEEEECCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCC
GLQVLEKVRDEGRDVKVIMMTAYGTVERAVNAMKLGAIDFINKPFSPNQIRALVNDVLSR
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCC
PNLSEENLQTYKDHVEFAKKCIIESNYTEAEKHLTKALEKDYDKPEPNNLLGVLAEYNGE
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
LGKARKHYRAALALDPSYKPANTNLERVTRFKYTKDGITFGNEEEKGEEEQGEDKNEEQ
HHHHHHHHHHHEEECCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCHHCCCCCCCCC
>Mature Secondary Structure
MNKKLLIVDDEKNIRMTLKNCLSYEGYELEIALNGEEALEKLRTQDYDLVLLDLKLPGLN
CCCCEEEEECCCCHHHHHHHHHCCCCEEEEEEECCHHHHHHHHCCCCCEEEEEEECCCCC
GLQVLEKVRDEGRDVKVIMMTAYGTVERAVNAMKLGAIDFINKPFSPNQIRALVNDVLSR
HHHHHHHHHHCCCCEEEEEEECCHHHHHHHHHHHHCHHHHHCCCCCHHHHHHHHHHHHCC
PNLSEENLQTYKDHVEFAKKCIIESNYTEAEKHLTKALEKDYDKPEPNNLLGVLAEYNGE
CCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
LGKARKHYRAALALDPSYKPANTNLERVTRFKYTKDGITFGNEEEKGEEEQGEDKNEEQ
HHHHHHHHHHHEEECCCCCCCCCCHHHHHHHEECCCCCCCCCCCCCCCHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1454550; 3036763; 9387221; 9384377; 8045898; 3142862 [H]