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The map label for this gene is tmk

Identifier: 188528244

GI number: 188528244

Start: 1466820

End: 1467395

Strand: Reverse

Name: tmk

Synonym: HPSH_07550

Alternate gene names: 188528244

Gene position: 1467395-1466820 (Counterclockwise)

Preceding gene: 188528245

Following gene: 188528243

Centisome position: 91.22

GC content: 40.8

Gene sequence:

>576_bases
ATGTATGTGGTGTTAGAAGGCGTTGATGGCGCGGGCAAAAGCACTCAAGTAGGATTATTAAAAGACAGGTTTAAAAACGC
CCTTGTTACCAAAGAGCCAGGGGGGACGAGAATGGGCGAACATTTAAGGCATATCGCTTTAAATGAAAACATCAGCGAAT
TGGCTAGAGCGTTTTTATTCTTAAGCGATAGGGCTGAGCATATAGAAAGCGTGATAAAACCGGCATTGAAAGAAAAAAAG
CTCATCATTAGCGACAGGAGTTTGATTTCTGGCATGGCTTATAGCCAATTTTCAAGCTTAGAATTAAACCTGCTTGCCAC
TCAAAGCGTCTTGCCTGACAAAATCATTCTGTTACTCATAGACAAAGAGGGTTTAAAACAGCGCTTAAGCCATAAAAGTT
TAGACAAAATAGAAAACCAAGGCACAGAAAAATTACTCACAATCCAGCAAAAGCTCAAAACTCACGCTCATGCGTTAAAA
GAACAATTCGGGTGCGAAGTTTTGGAATTAGACGCTCAAAAAAGCGTTTGGGATCTGCACCGCCAGATCGTAGCCTTTAT
TGAATGCGTTGTTTAA

Upstream 100 bases:

>100_bases
TTCATAAGCTCTTCTATCGTGCGATCCATTATCGCGCATAAGGGCGATGCGAGTCATTTAGTGCCTAAAGAAATTCACCC
TTTTATTTCAAAGGTTTAAA

Downstream 100 bases:

>100_bases
CTTGTTTGAAGCTTTCTTTTAAGCCCCTTTGCCCAAATTGCTTGAACGATTTGCCCTTAAGCTTAAAAGTAAGGGTTTTA
GAGGGCGTGAGCGTGTATAG

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MYVVLEGVDGAGKSTQVGLLKDRFKNALVTKEPGGTRMGEHLRHIALNENISELARAFLFLSDRAEHIESVIKPALKEKK
LIISDRSLISGMAYSQFSSLELNLLATQSVLPDKIILLLIDKEGLKQRLSHKSLDKIENQGTEKLLTIQQKLKTHAHALK
EQFGCEVLELDAQKSVWDLHRQIVAFIECVV

Sequences:

>Translated_191_residues
MYVVLEGVDGAGKSTQVGLLKDRFKNALVTKEPGGTRMGEHLRHIALNENISELARAFLFLSDRAEHIESVIKPALKEKK
LIISDRSLISGMAYSQFSSLELNLLATQSVLPDKIILLLIDKEGLKQRLSHKSLDKIENQGTEKLLTIQQKLKTHAHALK
EQFGCEVLELDAQKSVWDLHRQIVAFIECVV
>Mature_191_residues
MYVVLEGVDGAGKSTQVGLLKDRFKNALVTKEPGGTRMGEHLRHIALNENISELARAFLFLSDRAEHIESVIKPALKEKK
LIISDRSLISGMAYSQFSSLELNLLATQSVLPDKIILLLIDKEGLKQRLSHKSLDKIENQGTEKLLTIQQKLKTHAHALK
EQFGCEVLELDAQKSVWDLHRQIVAFIECVV

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=158, Percent_Identity=33.5443037974684, Blast_Score=79, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 21422; Mature: 21422

Theoretical pI: Translated: 8.26; Mature: 8.26

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYVVLEGVDGAGKSTQVGLLKDRFKNALVTKEPGGTRMGEHLRHIALNENISELARAFLF
CEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPDKIILLLI
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCEEEEEEE
DKEGLKQRLSHKSLDKIENQGTEKLLTIQQKLKTHAHALKEQFGCEVLELDAQKSVWDLH
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHH
RQIVAFIECVV
HHHHHHHHHCC
>Mature Secondary Structure
MYVVLEGVDGAGKSTQVGLLKDRFKNALVTKEPGGTRMGEHLRHIALNENISELARAFLF
CEEEEECCCCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCHHHHHHHHHH
LSDRAEHIESVIKPALKEKKLIISDRSLISGMAYSQFSSLELNLLATQSVLPDKIILLLI
HHHHHHHHHHHHHHHHHHCHHHCCHHHHHHHHHHHHHCCCEEEEEHHHHCCCCEEEEEEE
DKEGLKQRLSHKSLDKIENQGTEKLLTIQQKLKTHAHALKEQFGCEVLELDAQKSVWDLH
CCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHHHHHHH
RQIVAFIECVV
HHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA