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The map label for this gene is atpB [H]

Identifier: 188527325

GI number: 188527325

Start: 516470

End: 517150

Strand: Direct

Name: atpB [H]

Synonym: HPSH_02660

Alternate gene names: 188527325

Gene position: 516470-517150 (Clockwise)

Preceding gene: 188527324

Following gene: 188527327

Centisome position: 32.11

GC content: 40.97

Gene sequence:

>681_bases
ATGGAACACAGAGTATTTACTATTGCTAATTTTTTTAGCTCCAATCATGATTTTATCACCGGGTTTTTTGTTGTTTTGAC
GGCGGTTTTGATGTTTTTAATCTCGCTTGGCGCGTCGCGCAAAATGCAGATGGTGCCTATGGGTTTGCAGAATGTGTATG
AGAGCATCATTAGCGCGATTTTGAGCGTGGCTAAGGATATTATAGGCGAAGAATTAGCCCGCAAATACTTCCCACTAGCA
GGCACGATCGCTTTGTATGTCTTTTTTTCTAACATGATAGGCATCATTCCTGGTTTTGAATCCCCTACGGCCAGTTGGAG
CTTTACGCTGGTTTTAGCGCTGATTGTGTTTTTTTATTACCATTTTGAAGGCATTAGAGTGCAGGGCTTTTTTAAGTATT
TCGCTCATTTTGCAGGCCCTGTGAAATGGCTCGCCCCTTTCATGTTCCCTATTGAGATTATCTCGCATTTTTCTAGGATT
GTGTCTTTATCGTTTCGTTTGTTTGGGAATATCAAGGGCGATGACATGTTCTTGCTTATCATGCTTTTATTAGTGCCTTG
GGCTGTTCCTGTAGCGCCCTTTATGGTCTTGTTTTTTATGGGGATTTTACAAGCTTTTGTTTTTATGATTCTCACTTATG
TGTATTTGGCAGGGGCTGTTTTAACCGATGAAGGGCATTAA

Upstream 100 bases:

>100_bases
AATCGTTAAAAAACTCGTTAAAAAGCTTGGTTTAATGAGTTTTTAAAACTTAATTGCTACAATTAAGGAAATTTTCAATA
AGGCTTAGAGAAACTTTTTC

Downstream 100 bases:

>100_bases
GCAAAACATTCTTGTTTGGCTTTAATATTGTTTTTTAAAACTTTTTTTATGGTAAAGCTTTTCAAAGGATAGGGGGGCGA
TTTTGAAACCATGCTCTCTC

Product: F0F1 ATP synthase subunit A

Products: ADP; phosphate; H+

Alternate protein names: ATP synthase F0 sector subunit a; F-ATPase subunit 6 [H]

Number of amino acids: Translated: 226; Mature: 226

Protein sequence:

>226_residues
MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLA
GTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRI
VSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH

Sequences:

>Translated_226_residues
MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLA
GTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRI
VSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
>Mature_226_residues
MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAILSVAKDIIGEELARKYFPLA
GTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYYHFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRI
VSLSFRLFGNIKGDDMFLLIMLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH

Specific function: Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane [H]

COG id: COG0356

COG function: function code C; F0F1-type ATP synthase, subunit a

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase A chain family [H]

Homologues:

Organism=Escherichia coli, GI1790176, Length=212, Percent_Identity=30.188679245283, Blast_Score=66, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6226527, Length=185, Percent_Identity=30.2702702702703, Blast_Score=69, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000568
- InterPro:   IPR023011 [H]

Pfam domain/function: PF00119 ATP-synt_A [H]

EC number: 3.6.3.14

Molecular weight: Translated: 25615; Mature: 25615

Theoretical pI: Translated: 7.18; Mature: 7.18

Prosite motif: PS00449 ATPASE_A

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAI
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHH
LSVAKDIIGEELARKYFPLAGTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
HFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRIVSLSFRLFGNIKGDDMFLLI
HHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MEHRVFTIANFFSSNHDFITGFFVVLTAVLMFLISLGASRKMQMVPMGLQNVYESIISAI
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHH
LSVAKDIIGEELARKYFPLAGTIALYVFFSNMIGIIPGFESPTASWSFTLVLALIVFFYY
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
HFEGIRVQGFFKYFAHFAGPVKWLAPFMFPIEIISHFSRIVSLSFRLFGNIKGDDMFLLI
HHCCHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH
MLLLVPWAVPVAPFMVLFFMGILQAFVFMILTYVYLAGAVLTDEGH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: Borate; diphosphate; HCO3- [C]

Metal ions: Co2+; Fe2+; Mn2+; Zn2+ [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O; H+

Specific reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: Ca2+; CN-; Efrapeptin; Ethidiumbromide; Guanidines analogs; Oligomycin; Quercetin; Trialkyl tin derivatives; Venturicidin [C]

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA