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The map label for this gene is guaB [H]

Identifier: 188527324

GI number: 188527324

Start: 514903

End: 516348

Strand: Direct

Name: guaB [H]

Synonym: HPSH_02655

Alternate gene names: 188527324

Gene position: 514903-516348 (Clockwise)

Preceding gene: 188527323

Following gene: 188527325

Centisome position: 32.01

GC content: 43.78

Gene sequence:

>1446_bases
ATGAGAATTTTACAAAGGGCTTTGACTTTTGAAGATGTGTTGATGGTGCCTAGAAAATCCAGCGTTTTACCTAAAGATGT
GAGCTTAAAGTCTCGCCTGACCAAAAACATTAGTTTGAATATCCCCTTTATCAGTGCGGCTATGGATACGGTTACAGAGC
ATAAAACCGCTATCGCTATGGCGCGCCTTGGGGGTATTGGCATCGTGCATAAAAACATGGATATTCAAACGCAAGTCAAA
GAAATCACTAAGGTTAAAAAAAGTGAGAGCGGGGTGATTAATGATCCTATTTTTATCCATGCACACAGGACGCTAGCGGA
TGCTAAAGTCATAACGGATAATTACAAGATTTCAGGCGTGCCTGTGGTAGATGATAAGGGGTTGTTGATTGGGATTTTAA
CCAACAGAGATGTGCGCTTTGAAACCGATTTGAGTAAAAAAGTGGGCGATGTGATGACTAAAATGCCTTTAGTTACCGCT
CATGTGGGCATTAGTTTGGAAGAAGCTAGGGACTTGATGCACAAGCATAAGATTGAAAAATTGCCCATTGTGGATAAAGA
TAATGTTTTAAAAGGCTTGATCACGATTAAGGACATTCAAAAACGCATTGAATACCCTGAGGCTAATAAAGATGATTTTG
GGAGGTTGAGAGTGGGGGCGGCTATTGGAGTGGGGCAGTTGGATAGGGCTGAAATGTTAGTTAAAGCTGGGGTAGATGCG
TTAGTGTTAGACAGCGCGCATGGGCATTCAGCTAATATCTTACACACTTTAGAAGAGATTAAAAAAAGCTTGGTAGTGGA
TGTGATTGTGGGGAATGTGGTTACTAAAGAAGCCACAAGCGATTTGATTAGTGCGGGAGCGGACGCTGTTAAAGTGGGTA
TTGGGCCAGGAAGCATTTGCACCACTAGGATTGTGGCTGGGGTGGGAATGCCTCAAGTGAGCGCGATTGATAATTGCGTA
GAAGTGGCGTCTAAATTTGATATTCCTGTGATTGCAGATGGAGGGATCCGCTATTCAGGCGATGTGGCTAAGGCTTTGGC
TTTAGGGGCATCAAGCGTGATGATAGGCTCTTTACTCGCTGGCACAGAAGAATCGCCGGGGGATTTTATGATCTATCAAG
GGAGGCAATATAAAAGCTATAGGGGAATGGGTAGCATTGGGTCCATGACAAAAGGGAGTTCTGATCGGTATTTTCAAGAG
GGCGTGGCGAGTGAAAAATTAGTCCCAGAAGGCATTGAAGGGCGTGTGCCTTATCGTGGTAAGGTTTCGGATATGATTTT
CCAATTAGTAGGGGGCGTGCGCTCTTCTATGGGGTATCAGGGGGCGAAAAATATTTTGGAATTGTATCAAAACGCTGAAT
TTGTAGAAATCACTAGCGCGGGGTTAAAAGAAAGCCATGTGCATGGCGTGGATATTACTAAAGAAGCCCCTAATTATTAT
GGGTGA

Upstream 100 bases:

>100_bases
GATGCAATTTATTGCTAAGGCTTTTGATGAGCAAAGCCTTTTAGATGTTTCTTACGCTTTAGAGCAAGAATTAGATTTAA
AATTAGATTAAGGATAGAAA

Downstream 100 bases:

>100_bases
ATTTTAAAAGAAAATAAGACAAATCGTTAAAAAACTCGTTAAAAAGCTTGGTTTAATGAGTTTTTAAAACTTAATTGCTA
CAATTAAGGAAATTTTCAAT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 481; Mature: 481

Protein sequence:

>481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGSMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Sequences:

>Translated_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGSMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G
>Mature_481_residues
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAMARLGGIGIVHKNMDIQTQVK
EITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGVPVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTA
HVGISLEEARDLMHKHKIEKLPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSICTTRIVAGVGMPQVSAIDNCV
EVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLAGTEESPGDFMIYQGRQYKSYRGMGSIGSMTKGSSDRYFQE
GVASEKLVPEGIEGRVPYRGKVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
G

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI66933016, Length=479, Percent_Identity=40.7098121085595, Blast_Score=315, Evalue=6e-86,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=39.4572025052192, Blast_Score=315, Evalue=9e-86,
Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=39.4572025052192, Blast_Score=314, Evalue=9e-86,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=39.4572025052192, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=39.4572025052192, Blast_Score=314, Evalue=1e-85,
Organism=Homo sapiens, GI217035152, Length=486, Percent_Identity=39.3004115226337, Blast_Score=310, Evalue=2e-84,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=38.8308977035491, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=36.9519832985386, Blast_Score=278, Evalue=7e-75,
Organism=Homo sapiens, GI50541954, Length=258, Percent_Identity=37.984496124031, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541952, Length=258, Percent_Identity=37.984496124031, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541948, Length=258, Percent_Identity=37.984496124031, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI50541956, Length=258, Percent_Identity=37.984496124031, Blast_Score=163, Evalue=3e-40,
Organism=Homo sapiens, GI156104880, Length=246, Percent_Identity=37.8048780487805, Blast_Score=154, Evalue=3e-37,
Organism=Escherichia coli, GI1788855, Length=483, Percent_Identity=55.2795031055901, Blast_Score=478, Evalue=1e-136,
Organism=Escherichia coli, GI1786293, Length=221, Percent_Identity=37.10407239819, Blast_Score=144, Evalue=9e-36,
Organism=Caenorhabditis elegans, GI71994385, Length=476, Percent_Identity=35.7142857142857, Blast_Score=246, Evalue=2e-65,
Organism=Caenorhabditis elegans, GI71994389, Length=420, Percent_Identity=37.8571428571429, Blast_Score=239, Evalue=3e-63,
Organism=Caenorhabditis elegans, GI17560440, Length=254, Percent_Identity=37.7952755905512, Blast_Score=169, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322012, Length=481, Percent_Identity=40.7484407484407, Blast_Score=336, Evalue=4e-93,
Organism=Saccharomyces cerevisiae, GI6323585, Length=481, Percent_Identity=40.1247401247401, Blast_Score=332, Evalue=1e-91,
Organism=Saccharomyces cerevisiae, GI6323464, Length=481, Percent_Identity=41.5800415800416, Blast_Score=328, Evalue=8e-91,
Organism=Saccharomyces cerevisiae, GI6319352, Length=337, Percent_Identity=40.9495548961424, Blast_Score=249, Evalue=7e-67,
Organism=Saccharomyces cerevisiae, GI6319353, Length=118, Percent_Identity=41.5254237288136, Blast_Score=83, Evalue=9e-17,
Organism=Drosophila melanogaster, GI24641071, Length=480, Percent_Identity=39.1666666666667, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI24641073, Length=480, Percent_Identity=39.1666666666667, Blast_Score=299, Evalue=3e-81,
Organism=Drosophila melanogaster, GI28571163, Length=440, Percent_Identity=39.5454545454545, Blast_Score=271, Evalue=7e-73,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 51819; Mature: 51819

Theoretical pI: Translated: 8.21; Mature: 8.21

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCEEEECCEEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLEEARDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCCEEHCCCCCHHHHHHHHHHHHHCC
LPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFMIYQGRQYKSYRGMGSIGSMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C
>Mature Secondary Structure
MRILQRALTFEDVLMVPRKSSVLPKDVSLKSRLTKNISLNIPFISAAMDTVTEHKTAIAM
CCHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHH
ARLGGIGIVHKNMDIQTQVKEITKVKKSESGVINDPIFIHAHRTLADAKVITDNYKISGV
HHHCCEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCEEEEECCHHCCCEEEECCEEECCE
PVVDDKGLLIGILTNRDVRFETDLSKKVGDVMTKMPLVTAHVGISLEEARDLMHKHKIEK
EEECCCCEEEEEEECCCEEEECHHHHHHHHHHHHCCCEEHCCCCCHHHHHHHHHHHHHCC
LPIVDKDNVLKGLITIKDIQKRIEYPEANKDDFGRLRVGAAIGVGQLDRAEMLVKAGVDA
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECCCCCHHHHHHHHCCCCE
LVLDSAHGHSANILHTLEEIKKSLVVDVIVGNVVTKEATSDLISAGADAVKVGIGPGSIC
EEEECCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCEEEEECCCCHHH
TTRIVAGVGMPQVSAIDNCVEVASKFDIPVIADGGIRYSGDVAKALALGASSVMIGSLLA
HHHHHHCCCCCCHHHHHHHHHHHHHCCCCEEECCCEEECCHHHHHHHHCHHHHHHHHHHC
GTEESPGDFMIYQGRQYKSYRGMGSIGSMTKGSSDRYFQEGVASEKLVPEGIEGRVPYRG
CCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCC
KVSDMIFQLVGGVRSSMGYQGAKNILELYQNAEFVEITSAGLKESHVHGVDITKEAPNYY
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCCCCC
G
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]