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The map label for this gene is pyrD [H]

Identifier: 188527244

GI number: 188527244

Start: 428819

End: 429874

Strand: Reverse

Name: pyrD [H]

Synonym: HPSH_02255

Alternate gene names: 188527244

Gene position: 429874-428819 (Counterclockwise)

Preceding gene: 188527245

Following gene: 188527243

Centisome position: 26.72

GC content: 38.64

Gene sequence:

>1056_bases
ATGCTTTATTCGTTATTAAAAAAATATCTTTTTAGCCTAGACGCTGAAGACGCGCATGAAAAAGTGTGTAAAATTTTAAG
AATGCTTTCTTCATCGCCCTTTTTGTGTGGTTTGATTGATTCTCAATGGGGTTATAAAAACCCAAAGCTTGAAAATGAAA
TTTTAGGCTTGCATTTCCCTAACCCTTTAGGCTTAGCCGCTGGTTTTGATAAAAATATCTCCATGCTCAGAGCCTTAATC
GCTTTTGGGTTTGGCTATTTAGAAGCAGGCACTCTCACCAATGAAGCGCAAGTGGGGAATGAAAGACCAAGGCTTTTTAG
GCACATTGAAGAAGAGTCCTTGCAAAATGCGATGGGGTTTAATAATCATGGGGCAATTTTAGCAGCGAGATCGTTCAATC
GCTTCGCCCCTTATAAAACCCCTATTGGCATCAATTTAGGCAAAAACAAACGCATAGAGCAAGTACATGCCCTAGAAGAT
TACAAGGCGGTTTTAAATAAATGTTTAAACATTGGCGATTATTACACTTTCAACCTTTCTTCGCCCAACACCCCTAATTT
AAGGGATTTACAAAACAAAGCGTTTGTGAATGAGCTTTTTTGCATGGCGAAAGAAATGACCCATAAGCCTTTATTTTTAA
AAATCGCCCCGGATTTAGAAATAGATGACATGCTAGAGGTGGTCAATAGCGCTATTGAAGCAGGAGCGCATGGGATCATT
GCGACTAACACCACGATTGATAAAAGCCTGGTGTTCGCACCTAAAGAAATGGGGGGCTTGAGCGGGAAATGTTTGACTAA
AAAAAGCCGTGAAATCTTTAAAGAATTGGCTAAAGCTTTTTTTAATAAAAGCGTTCTTGTTTCTGTGGGGGGGATTAGCG
ATGCTAAAGAAGCTTATGAAAGGATTAAAATGGGAGCGAGTCTGTTACAAATTTATAGCGCTTTTATTTACAACGGGCCA
AATTTATGCCAAAATATTCTTAAAGATTTGGTAAAATTACTCCAAAAAGATGGATTTTTGAGCGTCAAAGAGGCTATAGG
AGCGGATTTAAGATGA

Upstream 100 bases:

>100_bases
AAACCCTAACGATCCTTTAAATTCACAAGATTACTTTGAAAAGCAAGCCCTTAAAACCTTTTAAGGGTTATCGTTCAAAT
CATAAAAGATAAGGATTTAA

Downstream 100 bases:

>100_bases
GATATTTTTCTGTTAAAAGACTTTTGAGGCTTAGTTCTGTCTTGCTAGTCACTTTAGGAGCGAGCATGCACGCACAATCT
TACTTACCCAAACATGAGAG

Product: dihydroorotate dehydrogenase 2

Products: NA

Alternate protein names: DHOdehase; DHOD; DHODase; Dihydroorotate oxidase [H]

Number of amino acids: Translated: 351; Mature: 351

Protein sequence:

>351_residues
MLYSLLKKYLFSLDAEDAHEKVCKILRMLSSSPFLCGLIDSQWGYKNPKLENEILGLHFPNPLGLAAGFDKNISMLRALI
AFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGFNNHGAILAARSFNRFAPYKTPIGINLGKNKRIEQVHALED
YKAVLNKCLNIGDYYTFNLSSPNTPNLRDLQNKAFVNELFCMAKEMTHKPLFLKIAPDLEIDDMLEVVNSAIEAGAHGII
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYNGP
NLCQNILKDLVKLLQKDGFLSVKEAIGADLR

Sequences:

>Translated_351_residues
MLYSLLKKYLFSLDAEDAHEKVCKILRMLSSSPFLCGLIDSQWGYKNPKLENEILGLHFPNPLGLAAGFDKNISMLRALI
AFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGFNNHGAILAARSFNRFAPYKTPIGINLGKNKRIEQVHALED
YKAVLNKCLNIGDYYTFNLSSPNTPNLRDLQNKAFVNELFCMAKEMTHKPLFLKIAPDLEIDDMLEVVNSAIEAGAHGII
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYNGP
NLCQNILKDLVKLLQKDGFLSVKEAIGADLR
>Mature_351_residues
MLYSLLKKYLFSLDAEDAHEKVCKILRMLSSSPFLCGLIDSQWGYKNPKLENEILGLHFPNPLGLAAGFDKNISMLRALI
AFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGFNNHGAILAARSFNRFAPYKTPIGINLGKNKRIEQVHALED
YKAVLNKCLNIGDYYTFNLSSPNTPNLRDLQNKAFVNELFCMAKEMTHKPLFLKIAPDLEIDDMLEVVNSAIEAGAHGII
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYERIKMGASLLQIYSAFIYNGP
NLCQNILKDLVKLLQKDGFLSVKEAIGADLR

Specific function: Pyrimidine biosynthesis; fourth step. [C]

COG id: COG0167

COG function: function code F; Dihydroorotate dehydrogenase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily [H]

Homologues:

Organism=Homo sapiens, GI45006951, Length=356, Percent_Identity=35.3932584269663, Blast_Score=208, Evalue=5e-54,
Organism=Escherichia coli, GI1787177, Length=339, Percent_Identity=41.0029498525074, Blast_Score=232, Evalue=2e-62,
Organism=Caenorhabditis elegans, GI17509475, Length=362, Percent_Identity=38.3977900552486, Blast_Score=202, Evalue=2e-52,
Organism=Drosophila melanogaster, GI281361352, Length=352, Percent_Identity=34.0909090909091, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI17137316, Length=352, Percent_Identity=34.0909090909091, Blast_Score=196, Evalue=3e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR012135
- InterPro:   IPR005719
- InterPro:   IPR001295 [H]

Pfam domain/function: PF01180 DHO_dh [H]

EC number: =1.3.5.2 [H]

Molecular weight: Translated: 39051; Mature: 39051

Theoretical pI: Translated: 8.54; Mature: 8.54

Prosite motif: PS00911 DHODEHASE_1 ; PS00912 DHODEHASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLYSLLKKYLFSLDAEDAHEKVCKILRMLSSSPFLCGLIDSQWGYKNPKLENEILGLHFP
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEECC
NPLGLAAGFDKNISMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGF
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCC
NNHGAILAARSFNRFAPYKTPIGINLGKNKRIEQVHALEDYKAVLNKCLNIGDYYTFNLS
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SPNTPNLRDLQNKAFVNELFCMAKEMTHKPLFLKIAPDLEIDDMLEVVNSAIEAGAHGII
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYE
EECCCCCCHHEECCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
RIKMGASLLQIYSAFIYNGPNLCQNILKDLVKLLQKDGFLSVKEAIGADLR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCC
>Mature Secondary Structure
MLYSLLKKYLFSLDAEDAHEKVCKILRMLSSSPFLCGLIDSQWGYKNPKLENEILGLHFP
CHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCCCCCEEEEECC
NPLGLAAGFDKNISMLRALIAFGFGYLEAGTLTNEAQVGNERPRLFRHIEEESLQNAMGF
CCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHCCCCCHHHHHHHHHHHHHHHCCC
NNHGAILAARSFNRFAPYKTPIGINLGKNKRIEQVHALEDYKAVLNKCLNIGDYYTFNLS
CCCCCEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECC
SPNTPNLRDLQNKAFVNELFCMAKEMTHKPLFLKIAPDLEIDDMLEVVNSAIEAGAHGII
CCCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEE
ATNTTIDKSLVFAPKEMGGLSGKCLTKKSREIFKELAKAFFNKSVLVSVGGISDAKEAYE
EECCCCCCHHEECCHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHH
RIKMGASLLQIYSAFIYNGPNLCQNILKDLVKLLQKDGFLSVKEAIGADLR
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCEEHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA