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The map label for this gene is pqqL [C]

Identifier: 188527243

GI number: 188527243

Start: 427488

End: 428822

Strand: Reverse

Name: pqqL [C]

Synonym: HPSH_02250

Alternate gene names: 188527243

Gene position: 428822-427488 (Counterclockwise)

Preceding gene: 188527244

Following gene: 188527242

Centisome position: 26.66

GC content: 40.6

Gene sequence:

>1335_bases
ATGAGATATTTTTCTGTTAAAAGACTTTTGAGGCTTAGTTCTGTCTTGCTAGTCACTTTAGGAGCGAGCATGCACGCACA
ATCTTACTTACCCAAACATGAGAGTGTTACCTTAAAGAATGGGTTGCAAGTCGTAAGCGTCCCCCTAGAAAATAAAACCG
GGGTTATAGAAGTGGATGTGCTTTATAAAGTCGGCTCTAGAAACGAAGTCATGGGCAAGAGCGGGATCGCTCACATGTTA
GAGCATTTGAATTTTAAAAGCACCAAAAACCTTAAAGCTGGCGAATTTGACAAGATCGTTAAGCGTTTTGGGGGCGTGAG
TAACGCTTCTACGAGCTTTGATATTACACGCTACTTCATTAAAACCAGTCAGGCTAACTTGGATAAATCTTTAGAATTGT
TCGCTGAAACCATGGGTTCTTTGAATTTAAAAGAAGATGAGTTTTTGCCTGAGCGTCAAGTGGTCGCTGAAGAAAGGCGA
TGGCGCACTGATAATTCCCCTATCGGCATGCTTTATTTCCGCTTTTTTAACACCGCTTATGTCTATCACCCCTACCATTG
GACGCCCATTGGTTTTATGGACGATATTCAAAACTGGACTTTAAAAGACATTAAAAAATTCCATTCGCTCTACTATCAGC
CTAAAAACGCTATTATTTTAGTGGTAGGCGATGTCAATTCTCAAAAGGTTTTTGAATTGAGTAAAAAGCATTTTGAATCT
TTAAAAAACCTTGATGGAAAAGCTATCCCCACCCCCTACATGAAAGAGCCTAAGCAAGATGGAGCCAGAACGGCAGTCGT
GCATAAAGATGGAGTCCATTTAGAATGGGTAGCCCTTGGGTATAAAGTGCCTGCTTTCAAGCATAAAGATCAAGTCGCCC
TAGACGCGCTAAGCAAGCTTTTAGGCGAAGGTAAAAGCTCGTGGTTGCAAAGCGAATTGGTGGATAAAAAACGCCTGGCT
TCTCAAGCTTTCTCGCACAACATGCAATTACAAGATGAAAGCGTGTTTTTATTCATTGCGGGGGGTAACCCTAATGTCAA
AGCCGAAGCCTTACAAAAAGAAATCGTAGCGCTTTTAGAAAAGCTTAAAAAAGGCGAAATCACTCAAGCTGAGTTAGACA
AGCTCAAAATCAATCAAAAAGCCGACTTTATTTCTAATTTAGAAAGTTCTAGCGATGTTGCGGGGCTTTTTGCGGACTAT
TTAGTGCAAAATGATATTCAAGGCTTGACGGATTATCAGCAACAATTTTTGGATTTAAAAGTGAGCGATTTGGTGCGTGT
GGCCAATGAATATTTTAAAGACACCCAATCAACCACCGTGTTTTTGAAACCTTAA

Upstream 100 bases:

>100_bases
ACGGGCCAAATTTATGCCAAAATATTCTTAAAGATTTGGTAAAATTACTCCAAAAAGATGGATTTTTGAGCGTCAAAGAG
GCTATAGGAGCGGATTTAAG

Downstream 100 bases:

>100_bases
AAGAGCCTTATAACATGCAATTCCATTCATCTAGCGCGTTAATTACGCCTTTTAAAAAAGATTTGAGCGTTGATGAGGCC
GCTTATGAAGTCTTGATCAA

Product: putative zinc protease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 444; Mature: 444

Protein sequence:

>444_residues
MRYFSVKRLLRLSSVLLVTLGASMHAQSYLPKHESVTLKNGLQVVSVPLENKTGVIEVDVLYKVGSRNEVMGKSGIAHML
EHLNFKSTKNLKAGEFDKIVKRFGGVSNASTSFDITRYFIKTSQANLDKSLELFAETMGSLNLKEDEFLPERQVVAEERR
WRTDNSPIGMLYFRFFNTAYVYHPYHWTPIGFMDDIQNWTLKDIKKFHSLYYQPKNAIILVVGDVNSQKVFELSKKHFES
LKNLDGKAIPTPYMKEPKQDGARTAVVHKDGVHLEWVALGYKVPAFKHKDQVALDALSKLLGEGKSSWLQSELVDKKRLA
SQAFSHNMQLQDESVFLFIAGGNPNVKAEALQKEIVALLEKLKKGEITQAELDKLKINQKADFISNLESSSDVAGLFADY
LVQNDIQGLTDYQQQFLDLKVSDLVRVANEYFKDTQSTTVFLKP

Sequences:

>Translated_444_residues
MRYFSVKRLLRLSSVLLVTLGASMHAQSYLPKHESVTLKNGLQVVSVPLENKTGVIEVDVLYKVGSRNEVMGKSGIAHML
EHLNFKSTKNLKAGEFDKIVKRFGGVSNASTSFDITRYFIKTSQANLDKSLELFAETMGSLNLKEDEFLPERQVVAEERR
WRTDNSPIGMLYFRFFNTAYVYHPYHWTPIGFMDDIQNWTLKDIKKFHSLYYQPKNAIILVVGDVNSQKVFELSKKHFES
LKNLDGKAIPTPYMKEPKQDGARTAVVHKDGVHLEWVALGYKVPAFKHKDQVALDALSKLLGEGKSSWLQSELVDKKRLA
SQAFSHNMQLQDESVFLFIAGGNPNVKAEALQKEIVALLEKLKKGEITQAELDKLKINQKADFISNLESSSDVAGLFADY
LVQNDIQGLTDYQQQFLDLKVSDLVRVANEYFKDTQSTTVFLKP
>Mature_444_residues
MRYFSVKRLLRLSSVLLVTLGASMHAQSYLPKHESVTLKNGLQVVSVPLENKTGVIEVDVLYKVGSRNEVMGKSGIAHML
EHLNFKSTKNLKAGEFDKIVKRFGGVSNASTSFDITRYFIKTSQANLDKSLELFAETMGSLNLKEDEFLPERQVVAEERR
WRTDNSPIGMLYFRFFNTAYVYHPYHWTPIGFMDDIQNWTLKDIKKFHSLYYQPKNAIILVVGDVNSQKVFELSKKHFES
LKNLDGKAIPTPYMKEPKQDGARTAVVHKDGVHLEWVALGYKVPAFKHKDQVALDALSKLLGEGKSSWLQSELVDKKRLA
SQAFSHNMQLQDESVFLFIAGGNPNVKAEALQKEIVALLEKLKKGEITQAELDKLKINQKADFISNLESSSDVAGLFADY
LVQNDIQGLTDYQQQFLDLKVSDLVRVANEYFKDTQSTTVFLKP

Specific function: Unknown

COG id: COG0612

COG function: function code R; Predicted Zn-dependent peptidases

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M16 family [H]

Homologues:

Organism=Homo sapiens, GI46593007, Length=280, Percent_Identity=26.0714285714286, Blast_Score=97, Evalue=4e-20,
Organism=Homo sapiens, GI94538354, Length=302, Percent_Identity=25.4966887417219, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI24308013, Length=379, Percent_Identity=23.2189973614776, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1787770, Length=281, Percent_Identity=27.0462633451957, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI71999683, Length=279, Percent_Identity=24.7311827956989, Blast_Score=82, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI17553678, Length=403, Percent_Identity=23.8213399503722, Blast_Score=80, Evalue=3e-15,
Organism=Saccharomyces cerevisiae, GI6323192, Length=382, Percent_Identity=23.5602094240838, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI21357875, Length=283, Percent_Identity=24.0282685512367, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24646943, Length=283, Percent_Identity=24.0282685512367, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011249
- InterPro:   IPR011237
- InterPro:   IPR011765
- InterPro:   IPR001431
- InterPro:   IPR007863 [H]

Pfam domain/function: PF00675 Peptidase_M16; PF05193 Peptidase_M16_C [H]

EC number: 3.4.99.- [C]

Molecular weight: Translated: 50368; Mature: 50368

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00143 INSULINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRYFSVKRLLRLSSVLLVTLGASMHAQSYLPKHESVTLKNGLQVVSVPLENKTGVIEVDV
CCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCEEEEEE
LYKVGSRNEVMGKSGIAHMLEHLNFKSTKNLKAGEFDKIVKRFGGVSNASTSFDITRYFI
EEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHH
KTSQANLDKSLELFAETMGSLNLKEDEFLPERQVVAEERRWRTDNSPIGMLYFRFFNTAY
HHCCCCHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCEEE
VYHPYHWTPIGFMDDIQNWTLKDIKKFHSLYYQPKNAIILVVGDVNSQKVFELSKKHFES
EECCEECCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHH
LKNLDGKAIPTPYMKEPKQDGARTAVVHKDGVHLEWVALGYKVPAFKHKDQVALDALSKL
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECEECCCCCCCHHHHHHHHHHH
LGEGKSSWLQSELVDKKRLASQAFSHNMQLQDESVFLFIAGGNPNVKAEALQKEIVALLE
HCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEEECCCCCCHHHHHHHHHHHHHH
KLKKGEITQAELDKLKINQKADFISNLESSSDVAGLFADYLVQNDIQGLTDYQQQFLDLK
HHHCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VSDLVRVANEYFKDTQSTTVFLKP
HHHHHHHHHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MRYFSVKRLLRLSSVLLVTLGASMHAQSYLPKHESVTLKNGLQVVSVPLENKTGVIEVDV
CCHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCEECCCCCEEEEEECCCCCCEEEEEE
LYKVGSRNEVMGKSGIAHMLEHLNFKSTKNLKAGEFDKIVKRFGGVSNASTSFDITRYFI
EEEECCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHH
KTSQANLDKSLELFAETMGSLNLKEDEFLPERQVVAEERRWRTDNSPIGMLYFRFFNTAY
HHCCCCHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHCEEE
VYHPYHWTPIGFMDDIQNWTLKDIKKFHSLYYQPKNAIILVVGDVNSQKVFELSKKHFES
EECCEECCCCCHHHHHCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHH
LKNLDGKAIPTPYMKEPKQDGARTAVVHKDGVHLEWVALGYKVPAFKHKDQVALDALSKL
HHCCCCCCCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECEECCCCCCCHHHHHHHHHHH
LGEGKSSWLQSELVDKKRLASQAFSHNMQLQDESVFLFIAGGNPNVKAEALQKEIVALLE
HCCCHHHHHHHHHHHHHHHHHHHHHCCCEEECCEEEEEEECCCCCCHHHHHHHHHHHHHH
KLKKGEITQAELDKLKINQKADFISNLESSSDVAGLFADYLVQNDIQGLTDYQQQFLDLK
HHHCCCCCHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
VSDLVRVANEYFKDTQSTTVFLKP
HHHHHHHHHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Endopeptidases of unknown catalytic mechanism [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]