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The map label for this gene is degP [H]

Identifier: 188527237

GI number: 188527237

Start: 421520

End: 422950

Strand: Reverse

Name: degP [H]

Synonym: HPSH_02220

Alternate gene names: 188527237

Gene position: 422950-421520 (Counterclockwise)

Preceding gene: 188527238

Following gene: 188527236

Centisome position: 26.29

GC content: 40.39

Gene sequence:

>1431_bases
ATGATGAAAAAAACCCTTTTTATCTCTTTGGCTTTAGCGTTAAGCTTGAATGCGGGCAATATCCAAATCCAAAGCATGCC
CAAAGTTAAAGAGCGAGTGAGTGTCCCCTCTAAAGACGATACGATCTATTCTTACCACGATTCTATTAAGGATTCGATTA
AAGCGGTGGTGAATATCTCTACTGAAAAGAAGATTAAAAATAGCTTTATAGGTGGCGGTGTGTTTAATGACCCCTTTTTC
CAACAATTTTTTGGGGATTTGGGCGGCATGATCCCTAAAGAAAGAATGGAAAGGGCTTTAGGCAGCGGCGTAATCATTTC
TAAAGATGGCTATATTGTAACTAATAACCATGTGATTGATGGTGCAGATAAGATTAAAGTTACCATTCCAGGGAGCAATA
AAGAATATTCCGCTACTTTAGTAGGCACGGACTCTGAAAGCGATTTAGCGGTGATTCGCATCACTAAAGACAATCTGCCC
ACGATCAAATTCTCTGATTCTAATGATATTTCAGTGGGCGATTTGGTTTTTGCGATTGGTAACCCTTTTGGCGTTGGTGA
AAGCGTTACGCAAGGCATTGTTTCAGCGCTCAATAAAAGCGGGATTGGGATCAACAGCTATGAGAATTTCATTCAAACAG
ACGCTTCCATTAATCCTGGAAATTCCGGCGGCGCTTTAATTGATAGCCGTGGAGGGTTAGTGGGGATTAATACCGCTATT
ATCTCTAAAACTGGGGGCAACCACGGCATTGGCTTTGCCATCCCCTCTAACATGGTTAAAGATATTGTAACCCAACTCAT
CAAAACCGGTAAGATTGAGAGAGGTTACTTGGGCGTGGGCTTGCAAGATTTGAGTGGCGATTTGCAAAATTCTTATGACA
ATAAAGAAGGGGCGGTAGTCATTAGCGTAGAAAAAGACTCTCCGGCTAAAAAAGCAGGGATTTTGGTGTGGGATTTGATC
ACCGAAGTCAATGGGAAAAAAGTTAAAAACACGAACGAATTGAGAAATCTAATCGGATCTATGCTACCCAATCAAAGAGT
AACCTTAAAAGTCATTAGAGATAAAAAAGAACGCACCTTCACTCTCACTCTTGCCGAAAGGAAAAACCCTAACAAAAAAG
AAACAATTTCTGCTCAAAACGGTGCGCAAGGCCAATTGAACGGGCTTCAAGTAGAAGATTTAACCCAAAAAACCAAAAGG
TCTATGCGTTTGAGCGATGATGTTCAAGGGGTTTTAGTTTCTCAAGTGAATGAAAATTCCCCAGCAGAGCAAGCCGGATT
TAGGCAAGGCAACATTATCACAAAAATTGAAGAGGTTGAAGTTAAAAGCGTTGCGGATTTTAACCATGCTTTAGAAAAGT
ATAAAGGCAAACCCAAACGATTCTTAGTTTTAGACTTGAATCAAGGTTATAGGATCATTTTGGTGAAATGA

Upstream 100 bases:

>100_bases
TTGGATACTATTTTACACAAAAAGCTAATGAAAATAACAAAAAAGATTTGATATAATCTTTTCTTAATTTTGAAGTTTAG
CAAATTTTAAGGAAGTAACC

Downstream 100 bases:

>100_bases
TAGAGGTGGGTTGTTGGTCGCATGTCTTTGATTAGAGTGAATGGGGAAGCTTTTAAACTCTCTTTAGAAAGTTTGGAAGA
AGACCCTTTTGAAAATAAAG

Product: protease DO

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MMKKTLFISLALALSLNAGNIQIQSMPKVKERVSVPSKDDTIYSYHDSIKDSIKAVVNISTEKKIKNSFIGGGVFNDPFF
QQFFGDLGGMIPKERMERALGSGVIISKDGYIVTNNHVIDGADKIKVTIPGSNKEYSATLVGTDSESDLAVIRITKDNLP
TIKFSDSNDISVGDLVFAIGNPFGVGESVTQGIVSALNKSGIGINSYENFIQTDASINPGNSGGALIDSRGGLVGINTAI
ISKTGGNHGIGFAIPSNMVKDIVTQLIKTGKIERGYLGVGLQDLSGDLQNSYDNKEGAVVISVEKDSPAKKAGILVWDLI
TEVNGKKVKNTNELRNLIGSMLPNQRVTLKVIRDKKERTFTLTLAERKNPNKKETISAQNGAQGQLNGLQVEDLTQKTKR
SMRLSDDVQGVLVSQVNENSPAEQAGFRQGNIITKIEEVEVKSVADFNHALEKYKGKPKRFLVLDLNQGYRIILVK

Sequences:

>Translated_476_residues
MMKKTLFISLALALSLNAGNIQIQSMPKVKERVSVPSKDDTIYSYHDSIKDSIKAVVNISTEKKIKNSFIGGGVFNDPFF
QQFFGDLGGMIPKERMERALGSGVIISKDGYIVTNNHVIDGADKIKVTIPGSNKEYSATLVGTDSESDLAVIRITKDNLP
TIKFSDSNDISVGDLVFAIGNPFGVGESVTQGIVSALNKSGIGINSYENFIQTDASINPGNSGGALIDSRGGLVGINTAI
ISKTGGNHGIGFAIPSNMVKDIVTQLIKTGKIERGYLGVGLQDLSGDLQNSYDNKEGAVVISVEKDSPAKKAGILVWDLI
TEVNGKKVKNTNELRNLIGSMLPNQRVTLKVIRDKKERTFTLTLAERKNPNKKETISAQNGAQGQLNGLQVEDLTQKTKR
SMRLSDDVQGVLVSQVNENSPAEQAGFRQGNIITKIEEVEVKSVADFNHALEKYKGKPKRFLVLDLNQGYRIILVK
>Mature_476_residues
MMKKTLFISLALALSLNAGNIQIQSMPKVKERVSVPSKDDTIYSYHDSIKDSIKAVVNISTEKKIKNSFIGGGVFNDPFF
QQFFGDLGGMIPKERMERALGSGVIISKDGYIVTNNHVIDGADKIKVTIPGSNKEYSATLVGTDSESDLAVIRITKDNLP
TIKFSDSNDISVGDLVFAIGNPFGVGESVTQGIVSALNKSGIGINSYENFIQTDASINPGNSGGALIDSRGGLVGINTAI
ISKTGGNHGIGFAIPSNMVKDIVTQLIKTGKIERGYLGVGLQDLSGDLQNSYDNKEGAVVISVEKDSPAKKAGILVWDLI
TEVNGKKVKNTNELRNLIGSMLPNQRVTLKVIRDKKERTFTLTLAERKNPNKKETISAQNGAQGQLNGLQVEDLTQKTKR
SMRLSDDVQGVLVSQVNENSPAEQAGFRQGNIITKIEEVEVKSVADFNHALEKYKGKPKRFLVLDLNQGYRIILVK

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasmic Protein [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=263, Percent_Identity=34.9809885931559, Blast_Score=134, Evalue=1e-31,
Organism=Homo sapiens, GI22129776, Length=285, Percent_Identity=32.9824561403509, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI24308541, Length=279, Percent_Identity=31.8996415770609, Blast_Score=119, Evalue=5e-27,
Organism=Homo sapiens, GI7019477, Length=281, Percent_Identity=30.6049822064057, Blast_Score=115, Evalue=8e-26,
Organism=Escherichia coli, GI1786356, Length=381, Percent_Identity=43.0446194225722, Blast_Score=271, Evalue=9e-74,
Organism=Escherichia coli, GI1789629, Length=466, Percent_Identity=36.6952789699571, Blast_Score=252, Evalue=4e-68,
Organism=Escherichia coli, GI1789630, Length=381, Percent_Identity=36.745406824147, Blast_Score=207, Evalue=1e-54,
Organism=Drosophila melanogaster, GI24646839, Length=285, Percent_Identity=29.8245614035088, Blast_Score=121, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.-

Molecular weight: Translated: 51558; Mature: 51558

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKTLFISLALALSLNAGNIQIQSMPKVKERVSVPSKDDTIYSYHDSIKDSIKAVVNIS
CCCHHEEEEEEEEEEECCCCEEEECCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHEEECC
TEKKIKNSFIGGGVFNDPFFQQFFGDLGGMIPKERMERALGSGVIISKDGYIVTNNHVID
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCEEEECCEEEC
GADKIKVTIPGSNKEYSATLVGTDSESDLAVIRITKDNLPTIKFSDSNDISVGDLVFAIG
CCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEECCCCCCCHHHEEEEEC
NPFGVGESVTQGIVSALNKSGIGINSYENFIQTDASINPGNSGGALIDSRGGLVGINTAI
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEEEE
ISKTGGNHGIGFAIPSNMVKDIVTQLIKTGKIERGYLGVGLQDLSGDLQNSYDNKEGAVV
EEECCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCHHHHCCCCCCCEEE
ISVEKDSPAKKAGILVWDLITEVNGKKVKNTNELRNLIGSMLPNQRVTLKVIRDKKERTF
EEECCCCCCHHHCEEEEEEHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
TLTLAERKNPNKKETISAQNGAQGQLNGLQVEDLTQKTKRSMRLSDDVQGVLVSQVNENS
EEEEECCCCCCHHHEECCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
PAEQAGFRQGNIITKIEEVEVKSVADFNHALEKYKGKPKRFLVLDLNQGYRIILVK
CHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEC
>Mature Secondary Structure
MMKKTLFISLALALSLNAGNIQIQSMPKVKERVSVPSKDDTIYSYHDSIKDSIKAVVNIS
CCCHHEEEEEEEEEEECCCCEEEECCCCHHHHCCCCCCCCEEEEHHHHHHHHHHHEEECC
TEKKIKNSFIGGGVFNDPFFQQFFGDLGGMIPKERMERALGSGVIISKDGYIVTNNHVID
HHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHCCCEEEECCCEEEECCEEEC
GADKIKVTIPGSNKEYSATLVGTDSESDLAVIRITKDNLPTIKFSDSNDISVGDLVFAIG
CCCEEEEEECCCCCCEEEEEEECCCCCCEEEEEEECCCCCEEEECCCCCCCHHHEEEEEC
NPFGVGESVTQGIVSALNKSGIGINSYENFIQTDASINPGNSGGALIDSRGGLVGINTAI
CCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCCEEEECCCCEEEEEEEE
ISKTGGNHGIGFAIPSNMVKDIVTQLIKTGKIERGYLGVGLQDLSGDLQNSYDNKEGAVV
EEECCCCCCEEEECCHHHHHHHHHHHHHHCCCCCCEEECCHHHHCCHHHHCCCCCCCEEE
ISVEKDSPAKKAGILVWDLITEVNGKKVKNTNELRNLIGSMLPNQRVTLKVIRDKKERTF
EEECCCCCCHHHCEEEEEEHHCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCEEE
TLTLAERKNPNKKETISAQNGAQGQLNGLQVEDLTQKTKRSMRLSDDVQGVLVSQVNENS
EEEEECCCCCCHHHEECCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCEEECCCCCC
PAEQAGFRQGNIITKIEEVEVKSVADFNHALEKYKGKPKRFLVLDLNQGYRIILVK
CHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10684935 [H]