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The map label for this gene is panB

Identifier: 188527199

GI number: 188527199

Start: 386037

End: 386849

Strand: Reverse

Name: panB

Synonym: HPSH_02030

Alternate gene names: 188527199

Gene position: 386849-386037 (Counterclockwise)

Preceding gene: 188527214

Following gene: 188527198

Centisome position: 24.05

GC content: 41.33

Gene sequence:

>813_bases
ATGAGCATGCAAACCGCCCCAATTAAAAAAATCACTCTCAACCACCTCCAAGCTAAAAAAAATCAAGAAAAAATCATCGC
TATCACCGCTTATGATGCGCTATTCGCTCAAATATTTGATCCGCTAGTGGATGTGATTTTAGTGGGCGATAGTTTGAATA
TGAGTTTTTTCAATCAAAACGACACTTTAAATGCGAGTGTGGGAATGATGCTCTATCACACCAAAGCCGTGTGCGCGGGC
GCTAAAATTCCTTTTATCATCACAGACATGCCCTTTGGAAGCTATAAAGATGAAAAAACAGCCCTAAAAAACGCCATTAG
AGTTTATAAAGAAACCCAAGCGAGCGCGATCAAATTGGAGGGAGGGAAAGAAAAAGCGAAACTGGTTAAAACGCTCACTG
ATGAGGGCGTTATCGTGGTAGGGCATATCGGCTTAATGCCCCAATTCGTGCGTCTTGATGGAGGTTATAAGATCAAGGGT
AAAAATGAAGAGCAACAAAAAAAGCTTTTAGAAGACGCCTTGAGTTTAGAAGAAGCCGGTGCGGGTTTGTTGGTTTTAGA
GGGTATAACCACCCCCATCGCTCAAAAAATCACGCAAACAATCAAAATCCCCACGATCGGCATAGGGAGCGGTAAAGATT
GCGACGGGCAGATTTTAGTGTGGAGCGATATGTTAGGCTTTTTTGATAGTTTTAAGCCTAAATTCGTGCGAGAATACCTT
AAGGGGAAAGAATTGGTTCAAAACGCTATCAAGCAATACGCTGATGATGTGAAAAAGGGAAACTTTCCTAACGAATTAGA
AAGTTATCATTAA

Upstream 100 bases:

>100_bases
ACTAAAATAATTAAAATGACCGGTTAAAATTGAGTGAAATTTTACCCACCCCAATAAAGTCATGCTACAATGCCACTATA
TTTAACACTTAGGATTTTTA

Downstream 100 bases:

>100_bases
ATGAAAGAACGGATAGTCAATTTAGAAACTTTGGATTTTGAAACTTCTCAAGAAGCGAGTTTGCGCCCTAATCTTTGGGA
AGATTATATCGGTCAAGAAA

Product: 3-methyl-2-oxobutanoate hydroxymethyltransferase

Products: NA

Alternate protein names: Ketopantoate hydroxymethyltransferase; KPHMT [H]

Number of amino acids: Translated: 270; Mature: 269

Protein sequence:

>270_residues
MSMQTAPIKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQNDTLNASVGMMLYHTKAVCAG
AKIPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLEGGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKG
KNEEQQKKLLEDALSLEEAGAGLLVLEGITTPIAQKITQTIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYL
KGKELVQNAIKQYADDVKKGNFPNELESYH

Sequences:

>Translated_270_residues
MSMQTAPIKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQNDTLNASVGMMLYHTKAVCAG
AKIPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLEGGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKG
KNEEQQKKLLEDALSLEEAGAGLLVLEGITTPIAQKITQTIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYL
KGKELVQNAIKQYADDVKKGNFPNELESYH
>Mature_269_residues
SMQTAPIKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQNDTLNASVGMMLYHTKAVCAGA
KIPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLEGGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKGK
NEEQQKKLLEDALSLEEAGAGLLVLEGITTPIAQKITQTIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYLK
GKELVQNAIKQYADDVKKGNFPNELESYH

Specific function: Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate [H]

COG id: COG0413

COG function: function code H; Ketopantoate hydroxymethyltransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the panB family [H]

Homologues:

Organism=Escherichia coli, GI1786326, Length=265, Percent_Identity=41.8867924528302, Blast_Score=202, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6319653, Length=244, Percent_Identity=35.2459016393443, Blast_Score=148, Evalue=1e-36,

Paralogues:

None

Copy number: 1080 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003700
- InterPro:   IPR015813 [H]

Pfam domain/function: PF02548 Pantoate_transf [H]

EC number: =2.1.2.11 [H]

Molecular weight: Translated: 29819; Mature: 29688

Theoretical pI: Translated: 8.59; Mature: 8.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSMQTAPIKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQN
CCCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHEEECCCCCEEEECCC
DTLNASVGMMLYHTKAVCAGAKIPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLE
CCCCCHHHHHHEEHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEC
GGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKGKNEEQQKKLLEDALSLEEAG
CCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCC
AGLLVLEGITTPIAQKITQTIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYL
CCEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEEHHHHHHHHHCCCHHHHHHHH
KGKELVQNAIKQYADDVKKGNFPNELESYH
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCC
>Mature Secondary Structure 
SMQTAPIKKITLNHLQAKKNQEKIIAITAYDALFAQIFDPLVDVILVGDSLNMSFFNQN
CCCCCCHHHHHHHHHHHCCCCCEEEEEEHHHHHHHHHHHHHHHHEEECCCCCEEEECCC
DTLNASVGMMLYHTKAVCAGAKIPFIITDMPFGSYKDEKTALKNAIRVYKETQASAIKLE
CCCCCHHHHHHEEHHHHHCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEC
GGKEKAKLVKTLTDEGVIVVGHIGLMPQFVRLDGGYKIKGKNEEQQKKLLEDALSLEEAG
CCHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCEEECCCCHHHHHHHHHHHHHHHHCC
AGLLVLEGITTPIAQKITQTIKIPTIGIGSGKDCDGQILVWSDMLGFFDSFKPKFVREYL
CCEEEECCCCHHHHHHHHHHHCCCEEECCCCCCCCCCEEEHHHHHHHHHCCCHHHHHHHH
KGKELVQNAIKQYADDVKKGNFPNELESYH
HHHHHHHHHHHHHHHHHHCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA