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The map label for this gene is ppiC [C]

Identifier: 188526979

GI number: 188526979

Start: 166669

End: 167568

Strand: Direct

Name: ppiC [C]

Synonym: HPSH_00880

Alternate gene names: 188526979

Gene position: 166669-167568 (Clockwise)

Preceding gene: 188526965

Following gene: 188526980

Centisome position: 10.36

GC content: 39.22

Gene sequence:

>900_bases
ATGAAAAAAAATATCTTGAATTTAGCGTTAGTGGGTGCGTTGAGCGTATCGTTTTTGATGGCCAAGCCGGCTCATAACGC
AAATAACGCTACGCATAACACGAAAAAAACGGCTGATTCTTCAGCAGGCGTGTTAGCGACAGTGGATGGCAGGCCTATCA
CTAAAAGCGATTTTGATATGATTAAGCAACGAAATCCTAATTTTGATTTTGACAAGCTTAAAGAGAAAGAGAAAGAAGCC
TTGATTGAGCAAGCCATTCGCACCGCGCTTGTAGAAAATGAAGCTAAAACAGAAAAGCTCAATCAGACTCCAGAATTTAA
AGCGATGATGGAAGCGGTTAAAAAACAGGCTTTAGTGGAATTTTGGGCTAAAAAACAGGCTGAAGAAGTGAAAAAAATCC
AAATCCCAGAAAAGGAAATGCAAGATTTTTACAACGCTAATAAAGATCAGCTTTTCGTCAAGCAAGAAGCCCATGCTAGG
CATATTTTAGTGAAAACCGAAGATGAGGCTAAACGGATTATTTCTGAGATTGACAAACAGCCAAAGGCTAAAAAAGAAGC
CAAATTCATTGAGTTAGCCAATCGCGATACGATTGATCCTAACAGCAAGAACGCGCAAAATGGTGGCGATTTAGGGAAAT
TCCAAAAAAACCAAATGGCTCCGGATTTTTCTAAAGCCGCTTTCGCTCTAACTCCTGGGGATTACACTAAAACCCCTGTT
AAAACGGAGTTTGGTTATCATATCATCTATTTGATTTCTAAAGATAGCCCTGTAACTTACACTTATGATCAGGCTAAACC
CACCATTAAGGGGATGTTACAAGAAAAGCTTTTCCAAGAACGCATGAATCAACGCATTGAGGAACTAAGAAAGCGTGCTA
AAATTGTTATCAACAAGTAA

Upstream 100 bases:

>100_bases
TTTAATGTGAGTTTTCTATAATCATGATAGATGATTTTGTTTTAAATTTGCTATAATGTGAATTTAATGATGAAAATTAG
TTTAGAGTGGAGAACACACA

Downstream 100 bases:

>100_bases
TTGATGAGGTGTTATCATGTTAGTTAAAGGCAATGAAATCTTACTGAAGGCCCATAAAGAAGGCTATGGGGTAGGGGCGT
TTAATTTCGTGAATTTTGAA

Product: putative peptidyl-prolyl cis-trans isomerase

Products: peptidylproline (omega=0) [C]

Alternate protein names: NA

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MKKNILNLALVGALSVSFLMAKPAHNANNATHNTKKTADSSAGVLATVDGRPITKSDFDMIKQRNPNFDFDKLKEKEKEA
LIEQAIRTALVENEAKTEKLNQTPEFKAMMEAVKKQALVEFWAKKQAEEVKKIQIPEKEMQDFYNANKDQLFVKQEAHAR
HILVKTEDEAKRIISEIDKQPKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
KTEFGYHIIYLISKDSPVTYTYDQAKPTIKGMLQEKLFQERMNQRIEELRKRAKIVINK

Sequences:

>Translated_299_residues
MKKNILNLALVGALSVSFLMAKPAHNANNATHNTKKTADSSAGVLATVDGRPITKSDFDMIKQRNPNFDFDKLKEKEKEA
LIEQAIRTALVENEAKTEKLNQTPEFKAMMEAVKKQALVEFWAKKQAEEVKKIQIPEKEMQDFYNANKDQLFVKQEAHAR
HILVKTEDEAKRIISEIDKQPKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
KTEFGYHIIYLISKDSPVTYTYDQAKPTIKGMLQEKLFQERMNQRIEELRKRAKIVINK
>Mature_299_residues
MKKNILNLALVGALSVSFLMAKPAHNANNATHNTKKTADSSAGVLATVDGRPITKSDFDMIKQRNPNFDFDKLKEKEKEA
LIEQAIRTALVENEAKTEKLNQTPEFKAMMEAVKKQALVEFWAKKQAEEVKKIQIPEKEMQDFYNANKDQLFVKQEAHAR
HILVKTEDEAKRIISEIDKQPKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
KTEFGYHIIYLISKDSPVTYTYDQAKPTIKGMLQEKLFQERMNQRIEELRKRAKIVINK

Specific function: Ppiases Accelerate The Folding Of Proteins. It Prefers Amino Acid Residues With Hydrophobic Side Chains Like Leucine And Phenylalanine In The P1 Position Of The Peptides Substrates. [C]

COG id: COG0760

COG function: function code O; Parvulin-like peptidyl-prolyl isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PpiC domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000297
- InterPro:   IPR023058 [H]

Pfam domain/function: PF00639 Rotamase [H]

EC number: 5.2.1.8 [C]

Molecular weight: Translated: 34073; Mature: 34073

Theoretical pI: Translated: 10.09; Mature: 10.09

Prosite motif: PS01096 PPIC_PPIASE_1 ; PS50198 PPIC_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKNILNLALVGALSVSFLMAKPAHNANNATHNTKKTADSSAGVLATVDGRPITKSDFDM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCEEEEECCCCCCHHHHHH
IKQRNPNFDFDKLKEKEKEALIEQAIRTALVENEAKTEKLNQTPEFKAMMEAVKKQALVE
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHH
FWAKKQAEEVKKIQIPEKEMQDFYNANKDQLFVKQEAHARHILVKTEDEAKRIISEIDKQ
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCC
PKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCEEEECCCCCCCCCC
KTEFGYHIIYLISKDSPVTYTYDQAKPTIKGMLQEKLFQERMNQRIEELRKRAKIVINK
CCCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKKNILNLALVGALSVSFLMAKPAHNANNATHNTKKTADSSAGVLATVDGRPITKSDFDM
CCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHCCCCCCCEEEEECCCCCCHHHHHH
IKQRNPNFDFDKLKEKEKEALIEQAIRTALVENEAKTEKLNQTPEFKAMMEAVKKQALVE
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHCCCHHHHHHHHHHHHHHHHH
FWAKKQAEEVKKIQIPEKEMQDFYNANKDQLFVKQEAHARHILVKTEDEAKRIISEIDKQ
HHHHHHHHHHHHCCCCHHHHHHHHCCCCCEEEEEECCCCCEEEEECCHHHHHHHHHHHCC
PKAKKEAKFIELANRDTIDPNSKNAQNGGDLGKFQKNQMAPDFSKAAFALTPGDYTKTPV
CCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHCCEEEECCCCCCCCCC
KTEFGYHIIYLISKDSPVTYTYDQAKPTIKGMLQEKLFQERMNQRIEELRKRAKIVINK
CCCCCEEEEEEEECCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Peptidoproline (omega=180) [C]

Specific reaction: Peptidoproline (omega=180) = peptidylproline (omega=0) [C]

General reaction: Rotation (Single bond) [C]

Inhibitor: cyclosporins [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]