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The map label for this gene is hcpD [H]

Identifier: 188526965

GI number: 188526965

Start: 153874

End: 154791

Strand: Direct

Name: hcpD [H]

Synonym: HPSH_00810

Alternate gene names: 188526965

Gene position: 153874-154791 (Clockwise)

Preceding gene: 188526963

Following gene: 188526979

Centisome position: 9.57

GC content: 40.74

Gene sequence:

>918_bases
ATGATAAAGAGTTGGACTAAAAAATGGGTTTTTATTTGGTTGGTGGTGGCGGGCTGTTTCAGTCATTTGATGGCTACAAC
CGGTGAGACATATTTTAAAATGGCTACTCAAGCCTTTAAGAGAGGGGATTACCATAAAGCGGTGGCTTTTTATAAGAGGA
GCTGTAATTTAAGAGTGGGGGTGAGTTGCACGAGTTTAGGCTCTATGTATGAAGATGGCGATGGCGTGGATCAGAATATT
CCAAAAGCCGTTTTTTATTACAGAAGAGGGTGCAATTTAAGGAATCATTTGGCTTGCGCGAGTTTAGGCTCTATGTATGA
AGATGGCGATGGCGTTCAAAAAAACCTTCCAAAGGCTATCTATTATTACAGGAGAGGGTGCCACTTAAAGGGTGGGGTGA
GTTGCGGGAGTTTAGGTTTTATGTATTTTAATGGTACGGGCGTTAAGCAAAATTATGCCAAAGCCCTTTCTCTTTCTAAA
TACGCTTGCAGTTTGAATTACGGCATTAGTTGTAACTTTACAGGGTATATGTATAGGAATGCAAAAGGCACGGAGAAGGA
TTTGAAAAAAGCCCTTACGCATTTTAAAAGAGGGTGCCATTTAAAAGACGGAGCGAGTTGTGTGAGTTTAGGCTATATGT
ATGAAGCCGGTCTTTATGTCAGACAAAGTGAAGGGCAAGCCTTGAATCTTTATAAAAAGGGTTGTTCTTTAAAAGAAGGG
AGCGGTTGTCATAATGTGGCGGTGATGTATTACACGGGTAAGGGCGCTCCAAAGGATTTGGATAAAGCCACTTCATATTA
TAAGAAAGGTTGCACTTTAGGCTTTAGTGGTAGTTGTAAAGTATTAGAAATGGTTGGCAAGAATTCTGATAATTTGCAAG
ATGACGCGCAAAACGACACGCAAGATGATACGCAATAG

Upstream 100 bases:

>100_bases
GAATTTATTTTTTTGAATATTATACTATAATAACCAATTAGATTGGGGTTTTACTGATTTTTCTTTGTGTGAGCTTTGGC
TTAGTTTTGTAAGGAATGAG

Downstream 100 bases:

>100_bases
GCCAGAGTTTAGGGGCTATGATTAAAACTATAGAAATCTTTCCACTTTCGTGCTATCAAATGGGGATTGAGTGCCTCTAT
TGATGGGTATTGAGATTAAA

Product: hypothetical protein

Products: NA

Alternate protein names: Cysteine-rich protein D; Penicillin-binding protein 4; PBP 4 [H]

Number of amino acids: Translated: 305; Mature: 305

Protein sequence:

>305_residues
MIKSWTKKWVFIWLVVAGCFSHLMATTGETYFKMATQAFKRGDYHKAVAFYKRSCNLRVGVSCTSLGSMYEDGDGVDQNI
PKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSK
YACSLNYGISCNFTGYMYRNAKGTEKDLKKALTHFKRGCHLKDGASCVSLGYMYEAGLYVRQSEGQALNLYKKGCSLKEG
SGCHNVAVMYYTGKGAPKDLDKATSYYKKGCTLGFSGSCKVLEMVGKNSDNLQDDAQNDTQDDTQ

Sequences:

>Translated_305_residues
MIKSWTKKWVFIWLVVAGCFSHLMATTGETYFKMATQAFKRGDYHKAVAFYKRSCNLRVGVSCTSLGSMYEDGDGVDQNI
PKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSK
YACSLNYGISCNFTGYMYRNAKGTEKDLKKALTHFKRGCHLKDGASCVSLGYMYEAGLYVRQSEGQALNLYKKGCSLKEG
SGCHNVAVMYYTGKGAPKDLDKATSYYKKGCTLGFSGSCKVLEMVGKNSDNLQDDAQNDTQDDTQ
>Mature_305_residues
MIKSWTKKWVFIWLVVAGCFSHLMATTGETYFKMATQAFKRGDYHKAVAFYKRSCNLRVGVSCTSLGSMYEDGDGVDQNI
PKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAIYYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSK
YACSLNYGISCNFTGYMYRNAKGTEKDLKKALTHFKRGCHLKDGASCVSLGYMYEAGLYVRQSEGQALNLYKKGCSLKEG
SGCHNVAVMYYTGKGAPKDLDKATSYYKKGCTLGFSGSCKVLEMVGKNSDNLQDDAQNDTQDDTQ

Specific function: May hydrolyze 6-aminopenicillinic acid and 7- aminocephalosporanic acid (ACA) derivatives. Binds to penicillin [H]

COG id: COG0790

COG function: function code R; FOG: TPR repeat, SEL1 subfamily

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 4 TPR repeats [H]

Homologues:

Organism=Homo sapiens, GI151301150, Length=226, Percent_Identity=28.7610619469027, Blast_Score=70, Evalue=2e-12,
Organism=Homo sapiens, GI19923669, Length=165, Percent_Identity=30.9090909090909, Blast_Score=68, Evalue=1e-11,
Organism=Escherichia coli, GI87081769, Length=242, Percent_Identity=28.099173553719, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537799, Length=204, Percent_Identity=26.4705882352941, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006597
- InterPro:   IPR011990 [H]

Pfam domain/function: PF08238 Sel1 [H]

EC number: =3.5.2.6 [H]

Molecular weight: Translated: 33813; Mature: 33813

Theoretical pI: Translated: 9.22; Mature: 9.22

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.9 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
8.2 %Cys+Met (Translated Protein)
4.9 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
8.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKSWTKKWVFIWLVVAGCFSHLMATTGETYFKMATQAFKRGDYHKAVAFYKRSCNLRVG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEE
VSCTSLGSMYEDGDGVDQNIPKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAI
CCHHHHCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCHHH
YYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSKYACSLNYGISCNFTGYMYRN
HHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEECCCEEECEEEEEEEC
AKGTEKDLKKALTHFKRGCHLKDGASCVSLGYMYEAGLYVRQSEGQALNLYKKGCSLKEG
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEHHHHCCCCCCCC
SGCHNVAVMYYTGKGAPKDLDKATSYYKKGCTLGFSGSCKVLEMVGKNSDNLQDDAQNDT
CCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
QDDTQ
CCCCC
>Mature Secondary Structure
MIKSWTKKWVFIWLVVAGCFSHLMATTGETYFKMATQAFKRGDYHKAVAFYKRSCNLRVG
CCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCHHHHHHHHHHCCCEEEE
VSCTSLGSMYEDGDGVDQNIPKAVFYYRRGCNLRNHLACASLGSMYEDGDGVQKNLPKAI
CCHHHHCCHHCCCCCCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCHHHHCCHHH
YYYRRGCHLKGGVSCGSLGFMYFNGTGVKQNYAKALSLSKYACSLNYGISCNFTGYMYRN
HHHHCCCCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHHEEEECCCEEECEEEEEEEC
AKGTEKDLKKALTHFKRGCHLKDGASCVSLGYMYEAGLYVRQSEGQALNLYKKGCSLKEG
CCCCHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCEEEECCCCCEEHHHHCCCCCCCC
SGCHNVAVMYYTGKGAPKDLDKATSYYKKGCTLGFSGSCKVLEMVGKNSDNLQDDAQNDT
CCCCEEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCC
QDDTQ
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9252185; 10438788 [H]