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The map label for this gene is moeA [H]

Identifier: 188526976

GI number: 188526976

Start: 163515

End: 164690

Strand: Reverse

Name: moeA [H]

Synonym: HPSH_00865

Alternate gene names: 188526976

Gene position: 164690-163515 (Counterclockwise)

Preceding gene: 188526977

Following gene: 188526975

Centisome position: 10.24

GC content: 37.41

Gene sequence:

>1176_bases
ATGGTTAGTTTTAAAGAAGCTCTAAAAATCCATTCTAGCATTCCCCTAGAACCCTTAGAAATAGAGATTATTTCTTTGTT
TGAAAGCATAGGGCGCATTTTGGCAGAGGATATTATTTGCATTCACGCCTTGCCTAAATTCAATCAAAGTGCAATGGATG
GCTATGGGTTTAAAATGCAAGATTTAGGCAAAAAAACTCAAGTCATTCAGCGCATCTTTGCCGGAGATGATGTGAGCGCT
TTAGAAGTTAAAGAAAATGAATGCGTTAAAATCATGACTGGAGCGATGGTGCCAAAGGGAATAGAAACGATTGTCCCTAT
AGAATGCATGCTAGAAAGCCATACAAATTTCGCCCTAGCTCCCAAAGATTTTAAAATAAACGCCAATATCCGTCAAAAGG
GCGAAAACGCTTCTTTAAACAGCGTGTTAGTCCCTAAAAATACCCGTTTGAATTACGGGCATATCGCGCTCATTGCCTCT
CAAGGGTTAAAAGAAATCAAAGCGTTCAGGAAATTAAAAATCGCTTTATTCAGTAGCGGCGATGAATTAGTGCCTTTAGG
GCAAAACGCCCTAGAATGCCAAGTTTATGATGTTAATTCAGTGGGTATTTTTAACATGCTTAAAAACTACAACACGCATT
TTTTAGGGGTTTTAAAAGATAATAAAGATTTACAGCTTAAACCACTTGAATCACAAGACTATGATGTCATCCTTTCAAGT
GCAGGGGTGAGTGTGGGGGATAAAGACTTTTTTAAAGACGCTTTGAAAGAAAAAAACGCCCTTTTTTATTATGAAAAAGT
CAATCTCAAACCTGGAAAACCGGTAACTTTAGCCAAACTCAATCAAAGCATTATTATAGGCTTACCGGGTAATCCTTTAA
GCTGCTTATTGGTTTTACGAGTTTTGATTCTACCCTTATTGGAGCGCTTATCTTTAAATAAAGATTTTAAACTAAAACCC
TTTAAGGCTCAAATCAATGCCCCTTTAAAGCTTAAAGGCGAACGAGCGCATTTAATTTTAGGCAACTATTCAAACAACCA
ATTCATTCCTTACAACGACAACCGCTATGAATCAGGAGCGATTCAAGCCCTTGCGCAAGTTGATTCTATCGCTTTGATTG
ATGAAGGGGTGGGATTAGTTCAGGGCGAAATTGAAATTTTAAGGTTTGAAAATTAA

Upstream 100 bases:

>100_bases
TGTGGGCATTATCTTAATCATTTCAGCTATCATGGGGCGTTTTAAAGAAGAAATCAGCCTGGCCTTTAGCACCATTAGCA
AAATCTTTTAAAGGATCAAT

Downstream 100 bases:

>100_bases
AATGGCTTTTAACAATGCTATAATGGCAAGTTTAAAACCCCACTCATAAAGGTTCTGTTTGTGGATAACTACACCTATAG
CGAATTGTTAAAAAGCTTGC

Product: molybdopterin biosynthesis protein (moeA)

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 391; Mature: 391

Protein sequence:

>391_residues
MVSFKEALKIHSSIPLEPLEIEIISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQDLGKKTQVIQRIFAGDDVSA
LEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDNKDLQLKPLESQDYDVILSS
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNNQFIPYNDNRYESGAIQALAQVDSIALIDEGVGLVQGEIEILRFEN

Sequences:

>Translated_391_residues
MVSFKEALKIHSSIPLEPLEIEIISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQDLGKKTQVIQRIFAGDDVSA
LEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDNKDLQLKPLESQDYDVILSS
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNNQFIPYNDNRYESGAIQALAQVDSIALIDEGVGLVQGEIEILRFEN
>Mature_391_residues
MVSFKEALKIHSSIPLEPLEIEIISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQDLGKKTQVIQRIFAGDDVSA
LEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALAPKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIAS
QGLKEIKAFRKLKIALFSSGDELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDNKDLQLKPLESQDYDVILSS
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLLVLRVLILPLLERLSLNKDFKLKP
FKAQINAPLKLKGERAHLILGNYSNNQFIPYNDNRYESGAIQALAQVDSIALIDEGVGLVQGEIEILRFEN

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=350, Percent_Identity=27.1428571428571, Blast_Score=129, Evalue=4e-30,
Organism=Homo sapiens, GI10880983, Length=350, Percent_Identity=27.1428571428571, Blast_Score=129, Evalue=5e-30,
Organism=Escherichia coli, GI1787049, Length=317, Percent_Identity=36.5930599369085, Blast_Score=196, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI25147659, Length=354, Percent_Identity=25.7062146892655, Blast_Score=120, Evalue=2e-27,
Organism=Caenorhabditis elegans, GI17562606, Length=322, Percent_Identity=24.5341614906832, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI17136978, Length=280, Percent_Identity=30, Blast_Score=111, Evalue=7e-25,
Organism=Drosophila melanogaster, GI24638841, Length=280, Percent_Identity=30, Blast_Score=111, Evalue=7e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 43410; Mature: 43410

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS01079 MOCF_BIOSYNTHESIS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVSFKEALKIHSSIPLEPLEIEIISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHH
DLGKKTQVIQRIFAGDDVSALEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALA
HCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCEECHHHEECCCCCEEEC
PKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGLKEIKAFRKLKIALFSSG
CCCEEEECCHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCC
DELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDNKDLQLKPLESQDYDVILSS
CCEEECCCCCEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCEEEEEC
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLLVLR
CCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VLILPLLERLSLNKDFKLKPFKAQINAPLKLKGERAHLILGNYSNNQFIPYNDNRYESGA
HHHHHHHHHHCCCCCCEECCHHHCCCCCEEECCCEEEEEEEECCCCCEECCCCCCCCHHH
IQALAQVDSIALIDEGVGLVQGEIEILRFEN
HHHHHHHCCEEEEECCCCEEECCEEEEEECC
>Mature Secondary Structure
MVSFKEALKIHSSIPLEPLEIEIISLFESIGRILAEDIICIHALPKFNQSAMDGYGFKMQ
CCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCHH
DLGKKTQVIQRIFAGDDVSALEVKENECVKIMTGAMVPKGIETIVPIECMLESHTNFALA
HCCHHHHHHHHHHCCCCCEEEEECCCCCEEEEECCCCCCCCCCEECHHHEECCCCCEEEC
PKDFKINANIRQKGENASLNSVLVPKNTRLNYGHIALIASQGLKEIKAFRKLKIALFSSG
CCCEEEECCHHCCCCCCCCCEEECCCCCCCCCCEEEEEECCCHHHHHHHHHEEEEEECCC
DELVPLGQNALECQVYDVNSVGIFNMLKNYNTHFLGVLKDNKDLQLKPLESQDYDVILSS
CCEEECCCCCEEEEEEECCCCHHHHHHHCCCCEEEEEEECCCCCEEEECCCCCCEEEEEC
AGVSVGDKDFFKDALKEKNALFYYEKVNLKPGKPVTLAKLNQSIIIGLPGNPLSCLLVLR
CCCCCCCHHHHHHHHHCCCEEEEEEEECCCCCCCEEEEECCCEEEEEECCCHHHHHHHHH
VLILPLLERLSLNKDFKLKPFKAQINAPLKLKGERAHLILGNYSNNQFIPYNDNRYESGA
HHHHHHHHHHCCCCCCEECCHHHCCCCCEEECCCEEEEEEEECCCCCEECCCCCCCCHHH
IQALAQVDSIALIDEGVGLVQGEIEILRFEN
HHHHHHHCCEEEEECCCCEEECCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]