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The map label for this gene is hemB [H]

Identifier: 187935456

GI number: 187935456

Start: 2985404

End: 2986369

Strand: Reverse

Name: hemB [H]

Synonym: CLL_A2905

Alternate gene names: 187935456

Gene position: 2986369-2985404 (Counterclockwise)

Preceding gene: 187934684

Following gene: 187932607

Centisome position: 78.58

GC content: 31.88

Gene sequence:

>966_bases
ATGATAAAAAGAGGCAGAAGATTAAGAGCAACATCTGCTATTAGAGATATGATAAGAGAGACTACACTAAATACTAAGGA
TTTTATATATCCTATATTTGTTGTAGAAGGAGAAAATATAAAGAATGAAATTTCTTCTTTACCAGACAATTATCATTATT
CAATAGATAGATTACATGAAGTAATTGCAGAAGTTGAAAAAGCTAACATTGCAGGAGTTCTTTTATTTGGTATTCCAGAA
CATAAAGATGCTTGTGGAAGTGAAGCATATAATGACAATGGAATTGTTCAACAAGCTGTAAGAAAGATTAAGGAATTAAA
TAAGGAACTACTTGTTATAACAGATGTTTGCATGTGTGAATACACATCTCATGGACATTGTGGAATAATTCATGAATCTG
ATGTAGATAATGATGAGACGCTTGAATACTTAAGTAAAATTGCAGTTTCTCATGCAAAAGCAGGAGCTGATATGGTAGCG
CCTTCAGATATGATGGATGGCAGAATTGGATTTATGAGAAAAGCATTAGATGATAATGGATTTAAAAAAGTGAGTATAAT
GAGTTATTCTGCAAAATATTGCTCAGCATTTTATGGACCATTTAGGGAGGCCGCTGGATCAGCACCCGAATTTGGAAATA
GAAAAACATATCAAATGGATCCAGCTAATAGATTAGAAGCATTAAGAGAAACAGAAAAAGACATAGAAGAAGGTTGTGAT
ATTATAATGGTTAAGCCGGCATTACCTTATTTAGATGTAATAAGAGAATGCAGACAAAACTTTAATATGCCTCTTGCAGC
TTATAATGTAAGTGGTGAATATGCAATGGTTAAGGCAGCAGGAAAACAAGGACTTATAGATGAAGAAAGAATAATAATGG
AAATTTTAACTTCAATAAAGAGAGCTGGGGCAGATATAATAATAACTTATCATGCATTAGAAGCAGCAAAAATTTTAAAT
AAATAG

Upstream 100 bases:

>100_bases
TTGAAGAACTAGGCATAAAGGCATATATTTGCAAGGAGCATTCACAAGACGGATTCTTAAATGAAATTGAATCATTTGTA
AAAGATATGGAGGCGTAATT

Downstream 100 bases:

>100_bases
TATCTGTTCTTTATTTAAGTATTTACAGGAAGTATACAGGGAGTGAACATAGTGAATAATTTAGAAATATTCGAAGAATC
AAAGAAATATATGCCAGGTG

Product: delta-aminolevulinic acid dehydratase

Products: NA

Alternate protein names: ALAD; ALADH; Porphobilinogen synthase [H]

Number of amino acids: Translated: 321; Mature: 321

Protein sequence:

>321_residues
MIKRGRRLRATSAIRDMIRETTLNTKDFIYPIFVVEGENIKNEISSLPDNYHYSIDRLHEVIAEVEKANIAGVLLFGIPE
HKDACGSEAYNDNGIVQQAVRKIKELNKELLVITDVCMCEYTSHGHCGIIHESDVDNDETLEYLSKIAVSHAKAGADMVA
PSDMMDGRIGFMRKALDDNGFKKVSIMSYSAKYCSAFYGPFREAAGSAPEFGNRKTYQMDPANRLEALRETEKDIEEGCD
IIMVKPALPYLDVIRECRQNFNMPLAAYNVSGEYAMVKAAGKQGLIDEERIIMEILTSIKRAGADIIITYHALEAAKILN
K

Sequences:

>Translated_321_residues
MIKRGRRLRATSAIRDMIRETTLNTKDFIYPIFVVEGENIKNEISSLPDNYHYSIDRLHEVIAEVEKANIAGVLLFGIPE
HKDACGSEAYNDNGIVQQAVRKIKELNKELLVITDVCMCEYTSHGHCGIIHESDVDNDETLEYLSKIAVSHAKAGADMVA
PSDMMDGRIGFMRKALDDNGFKKVSIMSYSAKYCSAFYGPFREAAGSAPEFGNRKTYQMDPANRLEALRETEKDIEEGCD
IIMVKPALPYLDVIRECRQNFNMPLAAYNVSGEYAMVKAAGKQGLIDEERIIMEILTSIKRAGADIIITYHALEAAKILN
K
>Mature_321_residues
MIKRGRRLRATSAIRDMIRETTLNTKDFIYPIFVVEGENIKNEISSLPDNYHYSIDRLHEVIAEVEKANIAGVLLFGIPE
HKDACGSEAYNDNGIVQQAVRKIKELNKELLVITDVCMCEYTSHGHCGIIHESDVDNDETLEYLSKIAVSHAKAGADMVA
PSDMMDGRIGFMRKALDDNGFKKVSIMSYSAKYCSAFYGPFREAAGSAPEFGNRKTYQMDPANRLEALRETEKDIEEGCD
IIMVKPALPYLDVIRECRQNFNMPLAAYNVSGEYAMVKAAGKQGLIDEERIIMEILTSIKRAGADIIITYHALEAAKILN
K

Specific function: Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen [H]

COG id: COG0113

COG function: function code H; Delta-aminolevulinic acid dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ALADH family [H]

Homologues:

Organism=Homo sapiens, GI189083849, Length=306, Percent_Identity=43.4640522875817, Blast_Score=272, Evalue=2e-73,
Organism=Escherichia coli, GI87081728, Length=317, Percent_Identity=50.1577287066246, Blast_Score=309, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6321398, Length=314, Percent_Identity=41.7197452229299, Blast_Score=239, Evalue=5e-64,
Organism=Drosophila melanogaster, GI21358291, Length=298, Percent_Identity=41.2751677852349, Blast_Score=256, Evalue=1e-68,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001731
- InterPro:   IPR013785 [H]

Pfam domain/function: PF00490 ALAD [H]

EC number: =4.2.1.24 [H]

Molecular weight: Translated: 35944; Mature: 35944

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS00169 D_ALA_DEHYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKRGRRLRATSAIRDMIRETTLNTKDFIYPIFVVEGENIKNEISSLPDNYHYSIDRLHE
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCHHHHHH
VIAEVEKANIAGVLLFGIPEHKDACGSEAYNDNGIVQQAVRKIKELNKELLVITDVCMCE
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHH
YTSHGHCGIIHESDVDNDETLEYLSKIAVSHAKAGADMVAPSDMMDGRIGFMRKALDDNG
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHCCCC
FKKVSIMSYSAKYCSAFYGPFREAAGSAPEFGNRKTYQMDPANRLEALRETEKDIEEGCD
CEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCC
IIMVKPALPYLDVIRECRQNFNMPLAAYNVSGEYAMVKAAGKQGLIDEERIIMEILTSIK
EEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RAGADIIITYHALEAAKILNK
HCCCCEEEEEHHHHHHHHHCC
>Mature Secondary Structure
MIKRGRRLRATSAIRDMIRETTLNTKDFIYPIFVVEGENIKNEISSLPDNYHYSIDRLHE
CCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHCCCCCCCCCHHHHHH
VIAEVEKANIAGVLLFGIPEHKDACGSEAYNDNGIVQQAVRKIKELNKELLVITDVCMCE
HHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCEEEEEHHHHHH
YTSHGHCGIIHESDVDNDETLEYLSKIAVSHAKAGADMVAPSDMMDGRIGFMRKALDDNG
CCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCHHHHHHHHHCCCC
FKKVSIMSYSAKYCSAFYGPFREAAGSAPEFGNRKTYQMDPANRLEALRETEKDIEEGCD
CEEEEEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHCCCC
IIMVKPALPYLDVIRECRQNFNMPLAAYNVSGEYAMVKAAGKQGLIDEERIIMEILTSIK
EEEECCCCCHHHHHHHHHHCCCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHHHHHHH
RAGADIIITYHALEAAKILNK
HCCCCEEEEEHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1672867; 9384377 [H]