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The map label for this gene is hemL [H]

Identifier: 187932607

GI number: 187932607

Start: 2984069

End: 2985352

Strand: Reverse

Name: hemL [H]

Synonym: CLL_A2904

Alternate gene names: 187932607

Gene position: 2985352-2984069 (Counterclockwise)

Preceding gene: 187935456

Following gene: 187933473

Centisome position: 78.56

GC content: 30.84

Gene sequence:

>1284_bases
GTGAATAATTTAGAAATATTCGAAGAATCAAAGAAATATATGCCAGGTGGAGTAAATAGTCCTGTTAGATGTTTTAAAGA
GATGGGAATGAATCCTCCAGTTATAAAGTCAGGAAAAGGTGTAATTATTAAAGATGAAGATGGAAAAGAATATATAGATT
TTGTCTTAGCATGGGGACCATTACTTTTAGGACATTGTGATGAAGATGTGGTAAAAGCAATAAAAGAAACAAGTGAAAAT
GCATTAGCTTTTGGAGCACCAACTAAGTTAGAATTAGAACTAAGTAAATTTATGTGTGAAAATTTAGATAATGTAGACAT
GATAAGAATGGTTAATTCAGGTACAGAAGCTACTATGAGTGCTGTAAAGCTTGCAAGAGGATATACAGGAAAGAGCAAGA
TAGTTAAATTTGCAGGATGCTATCATGGACATTTCGATGGATTTTTAATAGAAGCAGGTTCAGGAGTACTTACAGAAGGA
ATTCCAGGATCCCTTGGAGTACCAAAGGAAAGTGTAGAAAACACATTAATAGGACTATATAATGATAAAACTCAAATAAA
AGAACTTTTTAAAAAGCAAGGAAATGAAATTGCTGCTGTTATCATAGAGCCAGTTGCAGGAAATATGGGTGTTATAAAGG
CCAATGAAGATTTTATTAAGGAATTAAGATCTTTATGTGATGAATATGGTGCATTACTTATATTTGATGAAGTAATGACA
GGATTCAGAGTAGCATTTAAAGGAGCACAAACATTATTTGATATTAAGCCTGATTTAATTACATATGCTAAAATAATGGG
TGGCGGTCTTCCATGTGGAGCATATGCTGGTAAAAAAGAAATAATGGAAAAGTTATCGCCATGCGGAGGAGTTTACCAAG
CAGGTACAATGTCAGGTAATCCTGTTGTAATGTCAGCAGGACTTGCTACATTAACTAAATTGAAAAATAATATAGAATTA
TATGATCATGTTGAAAAAATAGGTGAAAAACTTCAAGAAGGTCTTATAAAAATATCAAAAGAAAATGATGTACCATTAAT
AATAAATAGAGTTGGTGGAATGTTAACATTATTCTTTACAGAATTAGAAAAAGTAAACACTTATGAAGATGTGAAAACTT
GTGATAATGAAAGATTTAAGAGATACTTTAAACATATGTTAAATGAAGGATTTAATATCGCTCCATCACAATTTGAAGCT
ATGTTTTTAAGTGTAAAGCATACAGAAGAACATATTGATAAATTCTTAGATGCATTTAAGAGGTTTGCTATAAATGAAAA
ATAA

Upstream 100 bases:

>100_bases
AATAATAACTTATCATGCATTAGAAGCAGCAAAAATTTTAAATAAATAGTATCTGTTCTTTATTTAAGTATTTACAGGAA
GTATACAGGGAGTGAACATA

Downstream 100 bases:

>100_bases
TAAAGCTATTATATTAGTTAGTTTTGGTACGTCAAATATCGAGGCTATAAAAAAATGTATAGATCCAATAGAAAATGAGA
TAAGAGCAGTTTATGGACGT

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MNNLEIFEESKKYMPGGVNSPVRCFKEMGMNPPVIKSGKGVIIKDEDGKEYIDFVLAWGPLLLGHCDEDVVKAIKETSEN
ALAFGAPTKLELELSKFMCENLDNVDMIRMVNSGTEATMSAVKLARGYTGKSKIVKFAGCYHGHFDGFLIEAGSGVLTEG
IPGSLGVPKESVENTLIGLYNDKTQIKELFKKQGNEIAAVIIEPVAGNMGVIKANEDFIKELRSLCDEYGALLIFDEVMT
GFRVAFKGAQTLFDIKPDLITYAKIMGGGLPCGAYAGKKEIMEKLSPCGGVYQAGTMSGNPVVMSAGLATLTKLKNNIEL
YDHVEKIGEKLQEGLIKISKENDVPLIINRVGGMLTLFFTELEKVNTYEDVKTCDNERFKRYFKHMLNEGFNIAPSQFEA
MFLSVKHTEEHIDKFLDAFKRFAINEK

Sequences:

>Translated_427_residues
MNNLEIFEESKKYMPGGVNSPVRCFKEMGMNPPVIKSGKGVIIKDEDGKEYIDFVLAWGPLLLGHCDEDVVKAIKETSEN
ALAFGAPTKLELELSKFMCENLDNVDMIRMVNSGTEATMSAVKLARGYTGKSKIVKFAGCYHGHFDGFLIEAGSGVLTEG
IPGSLGVPKESVENTLIGLYNDKTQIKELFKKQGNEIAAVIIEPVAGNMGVIKANEDFIKELRSLCDEYGALLIFDEVMT
GFRVAFKGAQTLFDIKPDLITYAKIMGGGLPCGAYAGKKEIMEKLSPCGGVYQAGTMSGNPVVMSAGLATLTKLKNNIEL
YDHVEKIGEKLQEGLIKISKENDVPLIINRVGGMLTLFFTELEKVNTYEDVKTCDNERFKRYFKHMLNEGFNIAPSQFEA
MFLSVKHTEEHIDKFLDAFKRFAINEK
>Mature_427_residues
MNNLEIFEESKKYMPGGVNSPVRCFKEMGMNPPVIKSGKGVIIKDEDGKEYIDFVLAWGPLLLGHCDEDVVKAIKETSEN
ALAFGAPTKLELELSKFMCENLDNVDMIRMVNSGTEATMSAVKLARGYTGKSKIVKFAGCYHGHFDGFLIEAGSGVLTEG
IPGSLGVPKESVENTLIGLYNDKTQIKELFKKQGNEIAAVIIEPVAGNMGVIKANEDFIKELRSLCDEYGALLIFDEVMT
GFRVAFKGAQTLFDIKPDLITYAKIMGGGLPCGAYAGKKEIMEKLSPCGGVYQAGTMSGNPVVMSAGLATLTKLKNNIEL
YDHVEKIGEKLQEGLIKISKENDVPLIINRVGGMLTLFFTELEKVNTYEDVKTCDNERFKRYFKHMLNEGFNIAPSQFEA
MFLSVKHTEEHIDKFLDAFKRFAINEK

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI13994255, Length=359, Percent_Identity=27.5766016713092, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4557809, Length=359, Percent_Identity=25.9052924791086, Blast_Score=100, Evalue=4e-21,
Organism=Homo sapiens, GI24119277, Length=337, Percent_Identity=26.7062314540059, Blast_Score=92, Evalue=9e-19,
Organism=Homo sapiens, GI37574042, Length=323, Percent_Identity=28.1733746130031, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI226442709, Length=305, Percent_Identity=28.1967213114754, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI226442705, Length=263, Percent_Identity=28.8973384030418, Blast_Score=81, Evalue=2e-15,
Organism=Homo sapiens, GI284507298, Length=278, Percent_Identity=26.6187050359712, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1786349, Length=416, Percent_Identity=49.0384615384615, Blast_Score=446, Evalue=1e-127,
Organism=Escherichia coli, GI1789016, Length=378, Percent_Identity=30.1587301587302, Blast_Score=142, Evalue=3e-35,
Organism=Escherichia coli, GI1789759, Length=335, Percent_Identity=29.8507462686567, Blast_Score=126, Evalue=2e-30,
Organism=Escherichia coli, GI1787560, Length=379, Percent_Identity=28.7598944591029, Blast_Score=125, Evalue=6e-30,
Organism=Escherichia coli, GI145693181, Length=324, Percent_Identity=30.8641975308642, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788044, Length=323, Percent_Identity=31.8885448916409, Blast_Score=117, Evalue=2e-27,
Organism=Escherichia coli, GI1786991, Length=318, Percent_Identity=25.7861635220126, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992977, Length=351, Percent_Identity=28.2051282051282, Blast_Score=102, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI25144271, Length=360, Percent_Identity=25.5555555555556, Blast_Score=95, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6323470, Length=372, Percent_Identity=26.3440860215054, Blast_Score=106, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6324432, Length=325, Percent_Identity=27.6923076923077, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324386, Length=422, Percent_Identity=22.7488151658768, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI21357415, Length=319, Percent_Identity=26.9592476489028, Blast_Score=90, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 47203; Mature: 47203

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNLEIFEESKKYMPGGVNSPVRCFKEMGMNPPVIKSGKGVIIKDEDGKEYIDFVLAWGP
CCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHH
LLLGHCDEDVVKAIKETSENALAFGAPTKLELELSKFMCENLDNVDMIRMVNSGTEATMS
HHHCCCCHHHHHHHHHCCCCCEEECCCCEEEHHHHHHHHCCCCCCHHHHHHCCCHHHHHH
AVKLARGYTGKSKIVKFAGCYHGHFDGFLIEAGSGVLTEGIPGSLGVPKESVENTLIGLY
HHHHHHCCCCHHHHEEHHCEECCCCCCEEEECCCCEECCCCCCCCCCCHHHHCCCEEEEE
NDKTQIKELFKKQGNEIAAVIIEPVAGNMGVIKANEDFIKELRSLCDEYGALLIFDEVMT
CCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCEEEHHHHHH
GFRVAFKGAQTLFDIKPDLITYAKIMGGGLPCGAYAGKKEIMEKLSPCGGVYQAGTMSGN
HHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
PVVMSAGLATLTKLKNNIELYDHVEKIGEKLQEGLIKISKENDVPLIINRVGGMLTLFFT
CEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEHHHHHHHHHHHHH
ELEKVNTYEDVKTCDNERFKRYFKHMLNEGFNIAPSQFEAMFLSVKHTEEHIDKFLDAFK
HHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFAINEK
HHHCCCC
>Mature Secondary Structure
MNNLEIFEESKKYMPGGVNSPVRCFKEMGMNPPVIKSGKGVIIKDEDGKEYIDFVLAWGP
CCCCHHHHHHHHCCCCCCCHHHHHHHHCCCCCCEEECCCEEEEECCCCHHHHHHHHHHHH
LLLGHCDEDVVKAIKETSENALAFGAPTKLELELSKFMCENLDNVDMIRMVNSGTEATMS
HHHCCCCHHHHHHHHHCCCCCEEECCCCEEEHHHHHHHHCCCCCCHHHHHHCCCHHHHHH
AVKLARGYTGKSKIVKFAGCYHGHFDGFLIEAGSGVLTEGIPGSLGVPKESVENTLIGLY
HHHHHHCCCCHHHHEEHHCEECCCCCCEEEECCCCEECCCCCCCCCCCHHHHCCCEEEEE
NDKTQIKELFKKQGNEIAAVIIEPVAGNMGVIKANEDFIKELRSLCDEYGALLIFDEVMT
CCHHHHHHHHHHCCCEEEEEEEEECCCCCEEEECCHHHHHHHHHHHHHHCCEEEHHHHHH
GFRVAFKGAQTLFDIKPDLITYAKIMGGGLPCGAYAGKKEIMEKLSPCGGVYQAGTMSGN
HHHHHHHCCHHHHCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCC
PVVMSAGLATLTKLKNNIELYDHVEKIGEKLQEGLIKISKENDVPLIINRVGGMLTLFFT
CEEEECHHHHHHHHHCCCHHHHHHHHHHHHHHHHHEEECCCCCCCEEHHHHHHHHHHHHH
ELEKVNTYEDVKTCDNERFKRYFKHMLNEGFNIAPSQFEAMFLSVKHTEEHIDKFLDAFK
HHHHCCCHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RFAINEK
HHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA