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The map label for this gene is ddl [H]

Identifier: 187934805

GI number: 187934805

Start: 3181381

End: 3182286

Strand: Reverse

Name: ddl [H]

Synonym: CLL_A3075

Alternate gene names: 187934805

Gene position: 3182286-3181381 (Counterclockwise)

Preceding gene: 187935458

Following gene: 187932476

Centisome position: 83.74

GC content: 30.46

Gene sequence:

>906_bases
ATGAAAGTTGGAGTAATAATGGGAGGTATTTCATCAGAAAGAGAAATATCTTTAAAAAGTGGTAAATCAATAGTTGATAG
TATAAATAAAAATAAATATGAAGTGGTTTCTATAGTTATTGATGAAAAAGAAGATATAATAAATAAAGTTAAAGGCATTG
ATTTTGCACTTTTAGCATTGCATGGTCAATTTGGAGAAGATGGAACAGTTCAATCAGTTCTTCAAACACTTGAGATACCA
TATTCAGGATGTGGTCCGTTAAGTAGCTCTATGTGCATGGATAAGGACATAAGTAAATGCATATTAAAGGCTGCTAATAT
AAGAACAGCACCTTGGATAAATTTAAGAAGAAATGATAAAATAAATTATGAAAAAATAGAAGGAATGGGATATCCGGTAG
TAGTAAAACCAACCCATGGGGGGTCAAGTGTTGCTACATTTATAATAAAAGAAGAAAAAGATATAAAAAATGCTGTTACA
GAAGCCTTTAAATGGGACAGCGAAGTTATTATAGAAAAATTTATAAAAGGTGATGAAATAACTTGTCCTGTATTTGGCGA
TAAGATGTTACCAGTTGTAGCAATAAAGCCAAAAGCTGAATTTTTTGATTTCACTGCAAAATATGCAGATGGAGGATCGG
ATGAATTTGTAACAGAACTTCCAAAAGAATTACATGAAGAAGTAGAAGAAATGGCTTTAGCAACATACAAAGCATTAAAG
TGTGAAGTTTATTCAAGAGTTGATATGATAGTAACTGAAGATAAAGTTCCATACATTTTAGAAGTTAATACTTTACCTGG
AATGACTCCAAATAGTTTAATTCCTAAGAGTGCAGCAGGAGTTAATATATCATTTTCAGAACTTATAGATATGATAATTG
ATGAATCTATAAAGGTCATTAGATAG

Upstream 100 bases:

>100_bases
ATTCAATTATAAAGTTGTTTCTCCGAGCTCAAATATAAACACATATTAAAAAATAGCATAATATAAAATAATTATTGAAC
TAAGATATTGGAGGTAACTA

Downstream 100 bases:

>100_bases
AATATAGTGGTTTTGAATAAAAACTTTAACTAAATTTTAACCATTATAAAATAATAATCATATAACATAGAGATAAGCGT
CTGTATAAATGCTTATCTCT

Product: D-alanine--D-alanine ligase

Products: NA

Alternate protein names: D-Ala-D-Ala ligase; D-alanylalanine synthetase [H]

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MKVGVIMGGISSEREISLKSGKSIVDSINKNKYEVVSIVIDEKEDIINKVKGIDFALLALHGQFGEDGTVQSVLQTLEIP
YSGCGPLSSSMCMDKDISKCILKAANIRTAPWINLRRNDKINYEKIEGMGYPVVVKPTHGGSSVATFIIKEEKDIKNAVT
EAFKWDSEVIIEKFIKGDEITCPVFGDKMLPVVAIKPKAEFFDFTAKYADGGSDEFVTELPKELHEEVEEMALATYKALK
CEVYSRVDMIVTEDKVPYILEVNTLPGMTPNSLIPKSAAGVNISFSELIDMIIDESIKVIR

Sequences:

>Translated_301_residues
MKVGVIMGGISSEREISLKSGKSIVDSINKNKYEVVSIVIDEKEDIINKVKGIDFALLALHGQFGEDGTVQSVLQTLEIP
YSGCGPLSSSMCMDKDISKCILKAANIRTAPWINLRRNDKINYEKIEGMGYPVVVKPTHGGSSVATFIIKEEKDIKNAVT
EAFKWDSEVIIEKFIKGDEITCPVFGDKMLPVVAIKPKAEFFDFTAKYADGGSDEFVTELPKELHEEVEEMALATYKALK
CEVYSRVDMIVTEDKVPYILEVNTLPGMTPNSLIPKSAAGVNISFSELIDMIIDESIKVIR
>Mature_301_residues
MKVGVIMGGISSEREISLKSGKSIVDSINKNKYEVVSIVIDEKEDIINKVKGIDFALLALHGQFGEDGTVQSVLQTLEIP
YSGCGPLSSSMCMDKDISKCILKAANIRTAPWINLRRNDKINYEKIEGMGYPVVVKPTHGGSSVATFIIKEEKDIKNAVT
EAFKWDSEVIIEKFIKGDEITCPVFGDKMLPVVAIKPKAEFFDFTAKYADGGSDEFVTELPKELHEEVEEMALATYKALK
CEVYSRVDMIVTEDKVPYILEVNTLPGMTPNSLIPKSAAGVNISFSELIDMIIDESIKVIR

Specific function: Cell wall formation [H]

COG id: COG1181

COG function: function code M; D-alanine-D-alanine ligase and related ATP-grasp enzymes

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-grasp domain [H]

Homologues:

Organism=Escherichia coli, GI1786280, Length=306, Percent_Identity=35.6209150326797, Blast_Score=207, Evalue=7e-55,
Organism=Escherichia coli, GI1786579, Length=349, Percent_Identity=30.0859598853868, Blast_Score=171, Evalue=5e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR000291
- InterPro:   IPR005905
- InterPro:   IPR011095
- InterPro:   IPR011127
- InterPro:   IPR013817
- InterPro:   IPR016185 [H]

Pfam domain/function: PF07478 Dala_Dala_lig_C; PF01820 Dala_Dala_lig_N [H]

EC number: =6.3.2.4 [H]

Molecular weight: Translated: 33268; Mature: 33268

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: PS50975 ATP_GRASP ; PS00843 DALA_DALA_LIGASE_1 ; PS00844 DALA_DALA_LIGASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVGVIMGGISSEREISLKSGKSIVDSINKNKYEVVSIVIDEKEDIINKVKGIDFALLAL
CEEEEEECCCCCCCEEEHHCCHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCEEEEEE
HGQFGEDGTVQSVLQTLEIPYSGCGPLSSSMCMDKDISKCILKAANIRTAPWINLRRNDK
ECCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
INYEKIEGMGYPVVVKPTHGGSSVATFIIKEEKDIKNAVTEAFKWDSEVIIEKFIKGDEI
CCHHHHCCCCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHCCCCE
TCPVFGDKMLPVVAIKPKAEFFDFTAKYADGGSDEFVTELPKELHEEVEEMALATYKALK
EEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CEVYSRVDMIVTEDKVPYILEVNTLPGMTPNSLIPKSAAGVNISFSELIDMIIDESIKVI
HHHHHHEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHC
R
C
>Mature Secondary Structure
MKVGVIMGGISSEREISLKSGKSIVDSINKNKYEVVSIVIDEKEDIINKVKGIDFALLAL
CEEEEEECCCCCCCEEEHHCCHHHHHHCCCCCEEEEEEEECCHHHHHHHHCCCCEEEEEE
HGQFGEDGTVQSVLQTLEIPYSGCGPLSSSMCMDKDISKCILKAANIRTAPWINLRRNDK
ECCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCC
INYEKIEGMGYPVVVKPTHGGSSVATFIIKEEKDIKNAVTEAFKWDSEVIIEKFIKGDEI
CCHHHHCCCCCCEEEEECCCCCCEEEEEEECCHHHHHHHHHHHCCCHHHHHHHHHCCCCE
TCPVFGDKMLPVVAIKPKAEFFDFTAKYADGGSDEFVTELPKELHEEVEEMALATYKALK
EEEECCCCCCEEEEECCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
CEVYSRVDMIVTEDKVPYILEVNTLPGMTPNSLIPKSAAGVNISFSELIDMIIDESIKVI
HHHHHHEEEEEECCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCHHHHC
R
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA