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The map label for this gene is vanR [H]

Identifier: 187932476

GI number: 187932476

Start: 3180357

End: 3181067

Strand: Reverse

Name: vanR [H]

Synonym: CLL_A3074

Alternate gene names: 187932476

Gene position: 3181067-3180357 (Counterclockwise)

Preceding gene: 187934805

Following gene: 187934998

Centisome position: 83.71

GC content: 26.58

Gene sequence:

>711_bases
ATGATAGGCAATAAAACTATTTTAATAGTTGATGATGAAAAAGAAATTAGAGATCTAGTTGAAATATATTTAAAAAGTGA
AGGGTATGCTACAGTAAAGGCATGCAATGGCGAAGAAGCATTAAATATAATTAGAGAACAAAATATAGATTTAGTAATAT
TAGACGTTATGATGCCTAAATTAAATGGTATAGATACATGTTTGAAAATAAGAGAAGAAAGAGAAATGCCAATAATAATG
TTATCAGCTAAAAGCGAAGGCATAGATAAGATACTGGGACTTAATATGGGGGCTGATGATTATATAACAAAACCTTTTAA
TCCATTAGAATTAGTAGCTAGAGTAAAATCACAATTAAGAAGATTTTATAAGTTTAATACTAAGCACATGGAAGATGAAA
AAGAAGAAGAGAGTATAATAGAAATTGATGAACTAATAATAAATTTAGAAACACATGAAGTAATATTAAGTAATAATTTA
GTGAAATTAACGCCTACTGAATTTGATATATTGTTATTGCTTTCTAAGAATAGAGGAAAAGTTTTTTCAATAGAAAATAT
ATATGAAAGTGTTTGGAATCAGGAATTTATGTCTTCAGATAATACTGTAATGGTACATATAAGAAAAATAAGAGAAAAAA
TAGAAAGTGATCCAAGAACCCCTAAATTTATAAAGACCGTATGGGGAGTTGGGTATAAAATTGAAAAATAA

Upstream 100 bases:

>100_bases
TAGAAAATCTTAAGAAGTTTACAGAGGTTTTTTTTAGAAATTTAAGTTAAAATATAGTTAAGGAAAATTATGTTTACTTT
ACAATAAAAGGGGGATGAAT

Downstream 100 bases:

>100_bases
AGAAAAATTAAAAAACCTTTATGAACAATATAATGAAAAATTAGTTGCTTTAAAGGTTTATAAGTTTTTTCGTAGCGTAT
GTTTAAAATTAAGAATAAAT

Product: regulatory protein VanR

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 236

Protein sequence:

>236_residues
MIGNKTILIVDDEKEIRDLVEIYLKSEGYATVKACNGEEALNIIREQNIDLVILDVMMPKLNGIDTCLKIREEREMPIIM
LSAKSEGIDKILGLNMGADDYITKPFNPLELVARVKSQLRRFYKFNTKHMEDEKEEESIIEIDELIINLETHEVILSNNL
VKLTPTEFDILLLLSKNRGKVFSIENIYESVWNQEFMSSDNTVMVHIRKIREKIESDPRTPKFIKTVWGVGYKIEK

Sequences:

>Translated_236_residues
MIGNKTILIVDDEKEIRDLVEIYLKSEGYATVKACNGEEALNIIREQNIDLVILDVMMPKLNGIDTCLKIREEREMPIIM
LSAKSEGIDKILGLNMGADDYITKPFNPLELVARVKSQLRRFYKFNTKHMEDEKEEESIIEIDELIINLETHEVILSNNL
VKLTPTEFDILLLLSKNRGKVFSIENIYESVWNQEFMSSDNTVMVHIRKIREKIESDPRTPKFIKTVWGVGYKIEK
>Mature_236_residues
MIGNKTILIVDDEKEIRDLVEIYLKSEGYATVKACNGEEALNIIREQNIDLVILDVMMPKLNGIDTCLKIREEREMPIIM
LSAKSEGIDKILGLNMGADDYITKPFNPLELVARVKSQLRRFYKFNTKHMEDEKEEESIIEIDELIINLETHEVILSNNL
VKLTPTEFDILLLLSKNRGKVFSIENIYESVWNQEFMSSDNTVMVHIRKIREKIESDPRTPKFIKTVWGVGYKIEK

Specific function: Member of the two-component regulatory system vanS/vanR. Activates the transcription of vanH, vanA and vanX in response to vancomycin which results in vancomycin resistance [H]

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=35.2173913043478, Blast_Score=162, Evalue=1e-41,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=37.9912663755458, Blast_Score=161, Evalue=3e-41,
Organism=Escherichia coli, GI1786599, Length=233, Percent_Identity=35.1931330472103, Blast_Score=150, Evalue=6e-38,
Organism=Escherichia coli, GI2367329, Length=226, Percent_Identity=35.8407079646018, Blast_Score=147, Evalue=5e-37,
Organism=Escherichia coli, GI1790863, Length=228, Percent_Identity=36.8421052631579, Blast_Score=139, Evalue=1e-34,
Organism=Escherichia coli, GI1790860, Length=232, Percent_Identity=33.6206896551724, Blast_Score=135, Evalue=2e-33,
Organism=Escherichia coli, GI87082012, Length=228, Percent_Identity=32.8947368421053, Blast_Score=134, Evalue=5e-33,
Organism=Escherichia coli, GI1786784, Length=230, Percent_Identity=34.3478260869565, Blast_Score=130, Evalue=6e-32,
Organism=Escherichia coli, GI1786911, Length=228, Percent_Identity=31.140350877193, Blast_Score=129, Evalue=1e-31,
Organism=Escherichia coli, GI1787229, Length=227, Percent_Identity=30.3964757709251, Blast_Score=114, Evalue=5e-27,
Organism=Escherichia coli, GI1790552, Length=229, Percent_Identity=30.5676855895196, Blast_Score=107, Evalue=5e-25,
Organism=Escherichia coli, GI1789402, Length=232, Percent_Identity=31.0344827586207, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787375, Length=231, Percent_Identity=27.2727272727273, Blast_Score=97, Evalue=1e-21,
Organism=Escherichia coli, GI145693140, Length=229, Percent_Identity=28.82096069869, Blast_Score=90, Evalue=1e-19,
Organism=Escherichia coli, GI1788550, Length=121, Percent_Identity=33.8842975206612, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1787487, Length=132, Percent_Identity=31.0606060606061, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1790299, Length=117, Percent_Identity=29.0598290598291, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1790437, Length=126, Percent_Identity=30.952380952381, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788905, Length=144, Percent_Identity=28.4722222222222, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27377; Mature: 27377

Theoretical pI: Translated: 4.82; Mature: 4.82

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGNKTILIVDDEKEIRDLVEIYLKSEGYATVKACNGEEALNIIREQNIDLVILDVMMPK
CCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCC
LNGIDTCLKIREEREMPIIMLSAKSEGIDKILGLNMGADDYITKPFNPLELVARVKSQLR
CCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RFYKFNTKHMEDEKEEESIIEIDELIINLETHEVILSNNLVKLTPTEFDILLLLSKNRGK
HHHHCCCCCCCCCHHHHHHHHHHHHHEECCHHEEEECCCEEEECCCCEEEEEEEECCCCC
VFSIENIYESVWNQEFMSSDNTVMVHIRKIREKIESDPRTPKFIKTVWGVGYKIEK
EEEHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHCCCEEECC
>Mature Secondary Structure
MIGNKTILIVDDEKEIRDLVEIYLKSEGYATVKACNGEEALNIIREQNIDLVILDVMMPK
CCCCEEEEEEECHHHHHHHHHHHHCCCCCEEEEECCCHHHHHHHHHCCCCEEEEEECCCC
LNGIDTCLKIREEREMPIIMLSAKSEGIDKILGLNMGADDYITKPFNPLELVARVKSQLR
CCCHHHHHHHHHCCCCCEEEEECCCCCHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHH
RFYKFNTKHMEDEKEEESIIEIDELIINLETHEVILSNNLVKLTPTEFDILLLLSKNRGK
HHHHCCCCCCCCCHHHHHHHHHHHHHEECCHHEEEECCCEEEECCCCEEEEEEEECCCCC
VFSIENIYESVWNQEFMSSDNTVMVHIRKIREKIESDPRTPKFIKTVWGVGYKIEK
EEEHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHCCCCCHHHHHHHHCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8380148; 1556077; 1320585 [H]