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The map label for this gene is rnr [H]

Identifier: 187934548

GI number: 187934548

Start: 3151182

End: 3153422

Strand: Reverse

Name: rnr [H]

Synonym: CLL_A3051

Alternate gene names: 187934548

Gene position: 3153422-3151182 (Counterclockwise)

Preceding gene: 187935138

Following gene: 187934027

Centisome position: 82.98

GC content: 28.11

Gene sequence:

>2241_bases
ATGACAATAAAAGAAACATTATTAAGTTTTATGAAAGAACCTGCTTATAGTCCAATGACTATTGAAGAGTTGGCTCTTGT
TTTTGATATAAAATCACATGAATATGGTGATTTCAAAAAGATGTTAAAAATTATGGGGAATGAAGGATTGATTTCAACTA
CTGAAAAGAACAAATACTTTATAACCGAAAATGCATCAGTAATAGAAGAGCGTGTAGGCTTAATTACTGGAAGACTTCAA
GCACATCCAAAGGGATTTGGATTTTTAATACCAGATGTAGAAGGCGAAAGTGATGTATTTATTCCAGGTTCATGCATGAA
CGGAGCAATAAATGGAGATAAAATACAAGTTGAAATAACAAGAGAAAATTCTAATACTAAAAAAAGAGAAGGCGAAGTTT
ATAAAATCCTTGAAAGAAATACAACTAAAATAGTAGGTATATATGAAGACAATAAAAACTTTGGATTTGTTGTTTCAGAA
GATACAAGAATTACTCAAGATATTTTTATTTCTAAAAAGGATAGAAATGGAGCAGAAAATGGTGATGTAGTTATAGTAGA
AATAACTAAATGGCCTGATAGAAAAAGAAGTCCAGAAGGATTAATAAAAGAAGTATTAGGTAAAAAAGGCGATAAAGGTA
TTGATATTTTAACAATTATAAGAAAGTTTGGTTTACCAGAAGAATTCAGTAAAAAAGTTTTAAAATTTGCAGAACAAATT
CCAGAAACTATAAAGCCTGAAGAATATAAGAGAAGAGTAGATTTAAGAGATCTTAGAATGGTAACTATAGATGGTGAAGA
TGCTAAGGATTTAGATGATGCTGTATCTATAGAAAAATTGGAAGATGGAAACTTTAAATTAGGAGTTCACATTGCAGATG
TTACTCATTATGTTAGAGAAAATAATATATTAGATAAGGAAGCATTGAAAAGAGCTACATCTGTTTATTTAATAGATAGA
GTTATTCCTATGCTACCTAAACAATTATCTAATGGTATATGTTCATTAAATCCAAAAGTTGATAGATTAGCATTAAGTTG
CTTTATGGTAATAAACAATAAAGGAACAGTCGTAGATCATGAGATAATGGAAAGTGTTATTAAAACAAGTGAAAGAATGA
CATATACTGATGTTACTAAGATATTAAGAGATAACGATGAAGAATTAATAAAAAAATATGATTATCTTTGTGATGATTTT
AAGTTAATGGAAGAACTTTGCTTAATATTAAGAAGTAAGAGAATGAAAAGAGGAGCCATTGACTTCGACTTTGAAGAATC
AAAGATAATCTTAGATGAAATGGGAAAGCCAATAGATATAAAACCATATGAACGTGAAATAGCTAATAAAATTATAGAAG
AATTTATGCTAATTTGTAATGAAACAGTTGCTGAGCATATGTTCTGGAGCAAACTTCCTTTTGTATACAGAGTTCATGAA
ACTCCAGATGAAGAAAAGTTAGTTAAATTTAAAGAATTTATATATAATTTAGGATATAAAATTAATTGGAGTGAAGATGT
AAATCCAAAAACTTTACAAAGTATATTAGAACAAGTTAAAGGAAAAAAAGAAGAGACAATAGTAAGTACATTATTATTAA
GATCAATGATGCAAGCACGTTATGCACCAGAATGTGTAGGTCACTTTGGATTAGCTGCACAGTATTATTGTCACTTTACA
TCTCCAATAAGAAGATATCCTGACTTACAAATTCATAGAATAATAAAAGAACATCTTAATGGAGAAATTGATGATGCAAG
ATTTAAAAAATTAGTACCAATAGTTGATGTAGCATCAAAACAATCATCTGAAAAAGAAAGAGTAGCTCAAGAAGCTGAAA
GAGAAGTTGATGATTTAAAGAAAGCTGAATATATGCTTGATAAAATAGGAGAAGAATTTGATGGAATGATATCTTCTGTT
ACATCTTTTGGTATGTTTGTTGAGTTACCAAATACTATTGAAGGATTAGTTCATGTTACTGAATTAGACGATGATTACTA
TATATTTGATGAAGCACATTTAGCGTTAATTGGTGAAAAGACAAAGAACATGCATAAACTTGGAGATGAAGTAAAAGTAA
AATGTGTTAAGGTTGATATAGATAATAGAGAAATTTATTTTAAACTAGTTTCAACAAAAATAGATGAAGATAATGAAGAT
AAAGAGAATAATGAAGAAAAAACCAGTAAAGAAATTATAAATGAACTTTTATCTTCAGAAGAAGATACCATTCTTAATTA
A

Upstream 100 bases:

>100_bases
ATAATTATAAAAAATATATATTATAAAATGTTATTGTGGTAGTATATACTTAATATAATAGAAATATTTGCTATCAGTTA
AGATAACAGGAGGACGTGTT

Downstream 100 bases:

>100_bases
ACATCTATTAATTGATTAAAAATATTAGTTATATTATAATTTTTATATGAAAGTTAATATGAAACCTAAATTATACAGTA
GGCTGTATTTTAAATATGTG

Product: ribonuclease R

Products: NA

Alternate protein names: RNase R; VacB protein homolog [H]

Number of amino acids: Translated: 746; Mature: 745

Protein sequence:

>746_residues
MTIKETLLSFMKEPAYSPMTIEELALVFDIKSHEYGDFKKMLKIMGNEGLISTTEKNKYFITENASVIEERVGLITGRLQ
AHPKGFGFLIPDVEGESDVFIPGSCMNGAINGDKIQVEITRENSNTKKREGEVYKILERNTTKIVGIYEDNKNFGFVVSE
DTRITQDIFISKKDRNGAENGDVVIVEITKWPDRKRSPEGLIKEVLGKKGDKGIDILTIIRKFGLPEEFSKKVLKFAEQI
PETIKPEEYKRRVDLRDLRMVTIDGEDAKDLDDAVSIEKLEDGNFKLGVHIADVTHYVRENNILDKEALKRATSVYLIDR
VIPMLPKQLSNGICSLNPKVDRLALSCFMVINNKGTVVDHEIMESVIKTSERMTYTDVTKILRDNDEELIKKYDYLCDDF
KLMEELCLILRSKRMKRGAIDFDFEESKIILDEMGKPIDIKPYEREIANKIIEEFMLICNETVAEHMFWSKLPFVYRVHE
TPDEEKLVKFKEFIYNLGYKINWSEDVNPKTLQSILEQVKGKKEETIVSTLLLRSMMQARYAPECVGHFGLAAQYYCHFT
SPIRRYPDLQIHRIIKEHLNGEIDDARFKKLVPIVDVASKQSSEKERVAQEAEREVDDLKKAEYMLDKIGEEFDGMISSV
TSFGMFVELPNTIEGLVHVTELDDDYYIFDEAHLALIGEKTKNMHKLGDEVKVKCVKVDIDNREIYFKLVSTKIDEDNED
KENNEEKTSKEIINELLSSEEDTILN

Sequences:

>Translated_746_residues
MTIKETLLSFMKEPAYSPMTIEELALVFDIKSHEYGDFKKMLKIMGNEGLISTTEKNKYFITENASVIEERVGLITGRLQ
AHPKGFGFLIPDVEGESDVFIPGSCMNGAINGDKIQVEITRENSNTKKREGEVYKILERNTTKIVGIYEDNKNFGFVVSE
DTRITQDIFISKKDRNGAENGDVVIVEITKWPDRKRSPEGLIKEVLGKKGDKGIDILTIIRKFGLPEEFSKKVLKFAEQI
PETIKPEEYKRRVDLRDLRMVTIDGEDAKDLDDAVSIEKLEDGNFKLGVHIADVTHYVRENNILDKEALKRATSVYLIDR
VIPMLPKQLSNGICSLNPKVDRLALSCFMVINNKGTVVDHEIMESVIKTSERMTYTDVTKILRDNDEELIKKYDYLCDDF
KLMEELCLILRSKRMKRGAIDFDFEESKIILDEMGKPIDIKPYEREIANKIIEEFMLICNETVAEHMFWSKLPFVYRVHE
TPDEEKLVKFKEFIYNLGYKINWSEDVNPKTLQSILEQVKGKKEETIVSTLLLRSMMQARYAPECVGHFGLAAQYYCHFT
SPIRRYPDLQIHRIIKEHLNGEIDDARFKKLVPIVDVASKQSSEKERVAQEAEREVDDLKKAEYMLDKIGEEFDGMISSV
TSFGMFVELPNTIEGLVHVTELDDDYYIFDEAHLALIGEKTKNMHKLGDEVKVKCVKVDIDNREIYFKLVSTKIDEDNED
KENNEEKTSKEIINELLSSEEDTILN
>Mature_745_residues
TIKETLLSFMKEPAYSPMTIEELALVFDIKSHEYGDFKKMLKIMGNEGLISTTEKNKYFITENASVIEERVGLITGRLQA
HPKGFGFLIPDVEGESDVFIPGSCMNGAINGDKIQVEITRENSNTKKREGEVYKILERNTTKIVGIYEDNKNFGFVVSED
TRITQDIFISKKDRNGAENGDVVIVEITKWPDRKRSPEGLIKEVLGKKGDKGIDILTIIRKFGLPEEFSKKVLKFAEQIP
ETIKPEEYKRRVDLRDLRMVTIDGEDAKDLDDAVSIEKLEDGNFKLGVHIADVTHYVRENNILDKEALKRATSVYLIDRV
IPMLPKQLSNGICSLNPKVDRLALSCFMVINNKGTVVDHEIMESVIKTSERMTYTDVTKILRDNDEELIKKYDYLCDDFK
LMEELCLILRSKRMKRGAIDFDFEESKIILDEMGKPIDIKPYEREIANKIIEEFMLICNETVAEHMFWSKLPFVYRVHET
PDEEKLVKFKEFIYNLGYKINWSEDVNPKTLQSILEQVKGKKEETIVSTLLLRSMMQARYAPECVGHFGLAAQYYCHFTS
PIRRYPDLQIHRIIKEHLNGEIDDARFKKLVPIVDVASKQSSEKERVAQEAEREVDDLKKAEYMLDKIGEEFDGMISSVT
SFGMFVELPNTIEGLVHVTELDDDYYIFDEAHLALIGEKTKNMHKLGDEVKVKCVKVDIDNREIYFKLVSTKIDEDNEDK
ENNEEKTSKEIINELLSSEEDTILN

Specific function: 3'-5'exoribonuclease that participates in an essential cell function. Acts nonspecifically on poly(A), poly(U) and ribosomal RNAs [H]

COG id: COG0557

COG function: function code K; Exoribonuclease R

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain [H]

Homologues:

Organism=Homo sapiens, GI190014623, Length=612, Percent_Identity=30.3921568627451, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI190014625, Length=612, Percent_Identity=30.3921568627451, Blast_Score=228, Evalue=2e-59,
Organism=Homo sapiens, GI134288890, Length=493, Percent_Identity=30.6288032454361, Blast_Score=213, Evalue=5e-55,
Organism=Homo sapiens, GI19115966, Length=653, Percent_Identity=27.4119448698315, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI219521928, Length=653, Percent_Identity=27.4119448698315, Blast_Score=175, Evalue=1e-43,
Organism=Homo sapiens, GI156105695, Length=212, Percent_Identity=27.8301886792453, Blast_Score=88, Evalue=4e-17,
Organism=Homo sapiens, GI156105693, Length=204, Percent_Identity=28.4313725490196, Blast_Score=84, Evalue=5e-16,
Organism=Escherichia coli, GI87082383, Length=728, Percent_Identity=37.7747252747253, Blast_Score=465, Evalue=1e-132,
Organism=Escherichia coli, GI1787542, Length=654, Percent_Identity=26.605504587156, Blast_Score=178, Evalue=9e-46,
Organism=Caenorhabditis elegans, GI212645896, Length=619, Percent_Identity=27.4636510500808, Blast_Score=187, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17553506, Length=506, Percent_Identity=29.0513833992095, Blast_Score=181, Evalue=1e-45,
Organism=Saccharomyces cerevisiae, GI6324552, Length=633, Percent_Identity=28.436018957346, Blast_Score=185, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320499, Length=462, Percent_Identity=24.025974025974, Blast_Score=102, Evalue=2e-22,
Organism=Saccharomyces cerevisiae, GI6323943, Length=472, Percent_Identity=25, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24649634, Length=480, Percent_Identity=32.9166666666667, Blast_Score=239, Evalue=7e-63,
Organism=Drosophila melanogaster, GI19922976, Length=409, Percent_Identity=33.0073349633252, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24654597, Length=409, Percent_Identity=33.0073349633252, Blast_Score=196, Evalue=3e-50,
Organism=Drosophila melanogaster, GI24654592, Length=409, Percent_Identity=33.0073349633252, Blast_Score=196, Evalue=4e-50,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011129
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- InterPro:   IPR013223
- InterPro:   IPR001900
- InterPro:   IPR022966
- InterPro:   IPR004476
- InterPro:   IPR011805 [H]

Pfam domain/function: PF08206 OB_RNB; PF00773 RNB; PF00575 S1 [H]

EC number: 3.1.-.- [C]

Molecular weight: Translated: 85965; Mature: 85834

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTIKETLLSFMKEPAYSPMTIEELALVFDIKSHEYGDFKKMLKIMGNEGLISTTEKNKYF
CCHHHHHHHHHHCCCCCCCCHHHHHHHEEECCCCCCHHHHHHHHHCCCCCEEECCCCEEE
ITENASVIEERVGLITGRLQAHPKGFGFLIPDVEGESDVFIPGSCMNGAINGDKIQVEIT
EECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEECCHHCCCCCCCCEEEEEEE
RENSNTKKREGEVYKILERNTTKIVGIYEDNKNFGFVVSEDTRITQDIFISKKDRNGAEN
ECCCCCCHHCCHHHHHHHCCCEEEEEEEECCCCEEEEEECCCEECHHHEEEECCCCCCCC
GDVVIVEITKWPDRKRSPEGLIKEVLGKKGDKGIDILTIIRKFGLPEEFSKKVLKFAEQI
CCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHC
PETIKPEEYKRRVDLRDLRMVTIDGEDAKDLDDAVSIEKLEDGNFKLGVHIADVTHYVRE
HHCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHEECCCCEEEEEEHHHHHHHHHH
NNILDKEALKRATSVYLIDRVIPMLPKQLSNGICSLNPKVDRLALSCFMVINNKGTVVDH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHEEEEEECCCCCEECH
EIMESVIKTSERMTYTDVTKILRDNDEELIKKYDYLCDDFKLMEELCLILRSKRMKRGAI
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFDFEESKIILDEMGKPIDIKPYEREIANKIIEEFMLICNETVAEHMFWSKLPFVYRVHE
CCCCCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
TPDEEKLVKFKEFIYNLGYKINWSEDVNPKTLQSILEQVKGKKEETIVSTLLLRSMMQAR
CCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YAPECVGHFGLAAQYYCHFTSPIRRYPDLQIHRIIKEHLNGEIDDARFKKLVPIVDVASK
CCHHHHHHHHHHHHHHEEECCHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
QSSEKERVAQEAEREVDDLKKAEYMLDKIGEEFDGMISSVTSFGMFVELPNTIEGLVHVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEECCCHHHHHEEEE
ELDDDYYIFDEAHLALIGEKTKNMHKLGDEVKVKCVKVDIDNREIYFKLVSTKIDEDNED
ECCCCEEEECCCEEEEECHHHHHHHHCCCCEEEEEEEEEECCCEEEEEEEECCCCCCCCC
KENNEEKTSKEIINELLSSEEDTILN
CCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
TIKETLLSFMKEPAYSPMTIEELALVFDIKSHEYGDFKKMLKIMGNEGLISTTEKNKYF
CHHHHHHHHHHCCCCCCCCHHHHHHHEEECCCCCCHHHHHHHHHCCCCCEEECCCCEEE
ITENASVIEERVGLITGRLQAHPKGFGFLIPDVEGESDVFIPGSCMNGAINGDKIQVEIT
EECCHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCEEECCHHCCCCCCCCEEEEEEE
RENSNTKKREGEVYKILERNTTKIVGIYEDNKNFGFVVSEDTRITQDIFISKKDRNGAEN
ECCCCCCHHCCHHHHHHHCCCEEEEEEEECCCCEEEEEECCCEECHHHEEEECCCCCCCC
GDVVIVEITKWPDRKRSPEGLIKEVLGKKGDKGIDILTIIRKFGLPEEFSKKVLKFAEQI
CCEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHC
PETIKPEEYKRRVDLRDLRMVTIDGEDAKDLDDAVSIEKLEDGNFKLGVHIADVTHYVRE
HHCCCCHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHEECCCCEEEEEEHHHHHHHHHH
NNILDKEALKRATSVYLIDRVIPMLPKQLSNGICSLNPKVDRLALSCFMVINNKGTVVDH
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCEECCCCHHHHHHEEEEEECCCCCEECH
EIMESVIKTSERMTYTDVTKILRDNDEELIKKYDYLCDDFKLMEELCLILRSKRMKRGAI
HHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
DFDFEESKIILDEMGKPIDIKPYEREIANKIIEEFMLICNETVAEHMFWSKLPFVYRVHE
CCCCCCCEEHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
TPDEEKLVKFKEFIYNLGYKINWSEDVNPKTLQSILEQVKGKKEETIVSTLLLRSMMQAR
CCCHHHHHHHHHHHHHCCCEEECCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
YAPECVGHFGLAAQYYCHFTSPIRRYPDLQIHRIIKEHLNGEIDDARFKKLVPIVDVASK
CCHHHHHHHHHHHHHHEEECCHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCC
QSSEKERVAQEAEREVDDLKKAEYMLDKIGEEFDGMISSVTSFGMFVELPNTIEGLVHVT
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHCCEEEECCCHHHHHEEEE
ELDDDYYIFDEAHLALIGEKTKNMHKLGDEVKVKCVKVDIDNREIYFKLVSTKIDEDNED
ECCCCEEEECCCEEEEECHHHHHHHHCCCCEEEEEEEEEECCCEEEEEEEECCCCCCCCC
KENNEEKTSKEIINELLSSEEDTILN
CCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]