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The map label for this gene is purR [H]

Identifier: 187933813

GI number: 187933813

Start: 3060615

End: 3061634

Strand: Reverse

Name: purR [H]

Synonym: CLL_A2975

Alternate gene names: 187933813

Gene position: 3061634-3060615 (Counterclockwise)

Preceding gene: 187935229

Following gene: 187933525

Centisome position: 80.56

GC content: 28.04

Gene sequence:

>1020_bases
ATGGGGGCCACGATAAATGATATTGCTAAAATAGCAGATGTATCATCTACAACAGTTTCAAGGGTATTAAACGATTCAGG
TTATGTAAAAGAAGAGACTAGACAAAAAGTTTTAAATGTTATAAAAGAAATGAATTATACTCCAAGTGCTATTGCTAGAA
GCCTTTCTAAAAGTGAAACCAACACAATTGGAATTATTGTTCCAGACATAACTAATAATTACTTTGGAGAAATAATAAAA
GGAATAAGTGAAATTGCAGAAGACAAAAATTTAAATATAGTTTTATTTAATACAGATAATTCTTTAGAAAAGGAGTTAAA
GGCTTTAAAGTCTGCAAAAGCTCAAAGAATAAAAGGAATAATAATGACACCAGCTTTTGGAGATGGTAATTTTAAAACTA
AGTATACTACTTTAATAGAACAGTTAAATATACCAGTTGTTTTGGTATCAGCGGATATAAAATATAGCAATTTAAGTGGA
GTTTTTGTGGACAACGTAAAATGTGGAGCAGATGCCACTAATTTATTAATAAAAGAAGGTCATGAAAAAATAGGAATAAT
GACAGGGAATATAGATTCTGACGCAACTATGGACATGCTTTCTGGATATAAAAAAGTACTTAATGAAAATAATATTGATA
TTATTGATAAATATATTTTCAATGCAGATTTCAAAGCAGAAATAGCTTATAAATTAACTAATAATATATTAAAAATGGAA
GATAAACCAACAGCATTAGTTATTTGTAGCAATATGATGACTATGGGAGCAATAAGGGCACTTATAGATTCGAAAAAGAA
AACACCAGAGGATATATCTATTGTAGGAATTAATAGAGTTGATTTTTTAGATATAGTAGGATTACAAGTTACATATATAG
AGGATTCACCGATAAAACTTGGAAAGAGTTCTATGAATATGCTTTGGGAAATAATAAATGATAAAAATAATAAATCTGTA
AGGAGAACAATAATGGCTCCTAGAATAATATGTAATGGTTCAGAGAAAAGGATATATTGA

Upstream 100 bases:

>100_bases
AATTAAAAAATAATATTAATTTTTCAATGTTTTAATTAATCGTTTACAAAACGATAAAAACAGTTTGAGTAGTTATGTGA
AAAAATTAAGGAGGATTCAT

Downstream 100 bases:

>100_bases
AATGAATAGTATATATGTTAATTGCTAAAATTATTATAGTGAATAACTTAAAATTAATTTTTAAATAAAGTTAAATCTAC
ATAATATACTAAATTAATTT

Product: transcriptional regulator

Products: NA

Alternate protein names: Pur regulon repressor; Purine nucleotide synthesis repressor [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MGATINDIAKIADVSSTTVSRVLNDSGYVKEETRQKVLNVIKEMNYTPSAIARSLSKSETNTIGIIVPDITNNYFGEIIK
GISEIAEDKNLNIVLFNTDNSLEKELKALKSAKAQRIKGIIMTPAFGDGNFKTKYTTLIEQLNIPVVLVSADIKYSNLSG
VFVDNVKCGADATNLLIKEGHEKIGIMTGNIDSDATMDMLSGYKKVLNENNIDIIDKYIFNADFKAEIAYKLTNNILKME
DKPTALVICSNMMTMGAIRALIDSKKKTPEDISIVGINRVDFLDIVGLQVTYIEDSPIKLGKSSMNMLWEIINDKNNKSV
RRTIMAPRIICNGSEKRIY

Sequences:

>Translated_339_residues
MGATINDIAKIADVSSTTVSRVLNDSGYVKEETRQKVLNVIKEMNYTPSAIARSLSKSETNTIGIIVPDITNNYFGEIIK
GISEIAEDKNLNIVLFNTDNSLEKELKALKSAKAQRIKGIIMTPAFGDGNFKTKYTTLIEQLNIPVVLVSADIKYSNLSG
VFVDNVKCGADATNLLIKEGHEKIGIMTGNIDSDATMDMLSGYKKVLNENNIDIIDKYIFNADFKAEIAYKLTNNILKME
DKPTALVICSNMMTMGAIRALIDSKKKTPEDISIVGINRVDFLDIVGLQVTYIEDSPIKLGKSSMNMLWEIINDKNNKSV
RRTIMAPRIICNGSEKRIY
>Mature_338_residues
GATINDIAKIADVSSTTVSRVLNDSGYVKEETRQKVLNVIKEMNYTPSAIARSLSKSETNTIGIIVPDITNNYFGEIIKG
ISEIAEDKNLNIVLFNTDNSLEKELKALKSAKAQRIKGIIMTPAFGDGNFKTKYTTLIEQLNIPVVLVSADIKYSNLSGV
FVDNVKCGADATNLLIKEGHEKIGIMTGNIDSDATMDMLSGYKKVLNENNIDIIDKYIFNADFKAEIAYKLTNNILKMED
KPTALVICSNMMTMGAIRALIDSKKKTPEDISIVGINRVDFLDIVGLQVTYIEDSPIKLGKSSMNMLWEIINDKNNKSVR
RTIMAPRIICNGSEKRIY

Specific function: Is the main repressor of the genes involved in the de novo synthesis of purine nucleotides, regulating purB, purC, purEK, purF, purHD, purL, purMN and guaBA expression. PurR is allosterically activated to bind its cognate DNA by binding the purine corepre

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787948, Length=330, Percent_Identity=30.9090909090909, Blast_Score=176, Evalue=3e-45,
Organism=Escherichia coli, GI1790369, Length=338, Percent_Identity=27.810650887574, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1790194, Length=333, Percent_Identity=26.7267267267267, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1787580, Length=321, Percent_Identity=29.595015576324, Blast_Score=150, Evalue=8e-38,
Organism=Escherichia coli, GI1789068, Length=280, Percent_Identity=29.2857142857143, Blast_Score=143, Evalue=2e-35,
Organism=Escherichia coli, GI1788474, Length=295, Percent_Identity=27.7966101694915, Blast_Score=113, Evalue=1e-26,
Organism=Escherichia coli, GI1786540, Length=336, Percent_Identity=25.8928571428571, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1789202, Length=282, Percent_Identity=26.9503546099291, Blast_Score=109, Evalue=3e-25,
Organism=Escherichia coli, GI1787906, Length=276, Percent_Identity=23.1884057971014, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1786268, Length=295, Percent_Identity=20.6779661016949, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI1789456, Length=337, Percent_Identity=26.4094955489614, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI48994940, Length=284, Percent_Identity=24.6478873239437, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1790715, Length=321, Percent_Identity=22.4299065420561, Blast_Score=75, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 37551; Mature: 37420

Theoretical pI: Translated: 7.99; Mature: 7.99

Prosite motif: PS00356 HTH_LACI_1 ; PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGATINDIAKIADVSSTTVSRVLNDSGYVKEETRQKVLNVIKEMNYTPSAIARSLSKSET
CCCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
NTIGIIVPDITNNYFGEIIKGISEIAEDKNLNIVLFNTDNSLEKELKALKSAKAQRIKGI
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCEE
IMTPAFGDGNFKTKYTTLIEQLNIPVVLVSADIKYSNLSGVFVDNVKCGADATNLLIKEG
EEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCEECCCCEEEEECEECCCCHHHHHHHCC
HEKIGIMTGNIDSDATMDMLSGYKKVLNENNIDIIDKYIFNADFKAEIAYKLTNNILKME
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCHHEEHHHHHCCEEEEC
DKPTALVICSNMMTMGAIRALIDSKKKTPEDISIVGINRVDFLDIVGLQVTYIEDSPIKL
CCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECEEEEEEECCCCCC
GKSSMNMLWEIINDKNNKSVRRTIMAPRIICNGSEKRIY
CHHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCCCCC
>Mature Secondary Structure 
GATINDIAKIADVSSTTVSRVLNDSGYVKEETRQKVLNVIKEMNYTPSAIARSLSKSET
CCCHHHHHHHHCCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCC
NTIGIIVPDITNNYFGEIIKGISEIAEDKNLNIVLFNTDNSLEKELKALKSAKAQRIKGI
CEEEEEECCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHCEE
IMTPAFGDGNFKTKYTTLIEQLNIPVVLVSADIKYSNLSGVFVDNVKCGADATNLLIKEG
EEECCCCCCCCCHHHHHHHHHCCCCEEEEEECCEECCCCEEEEECEECCCCHHHHHHHCC
HEKIGIMTGNIDSDATMDMLSGYKKVLNENNIDIIDKYIFNADFKAEIAYKLTNNILKME
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCEEEHHHHHCCCCHHEEHHHHHCCEEEEC
DKPTALVICSNMMTMGAIRALIDSKKKTPEDISIVGINRVDFLDIVGLQVTYIEDSPIKL
CCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCEEEEECEEEEEEECCCCCC
GKSSMNMLWEIINDKNNKSVRRTIMAPRIICNGSEKRIY
CHHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA