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The map label for this gene is tktB [C]

Identifier: 187933476

GI number: 187933476

Start: 3735704

End: 3736516

Strand: Reverse

Name: tktB [C]

Synonym: CLL_A3529

Alternate gene names: 187933476

Gene position: 3736516-3735704 (Counterclockwise)

Preceding gene: 187932714

Following gene: 187934753

Centisome position: 98.32

GC content: 31.73

Gene sequence:

>813_bases
ATGAACAAGCAACATTTAGAAAATATATCAAAAGAATTAAGAAAAGATATTATTGAAATGATTTATGAATCAGGTTCAGG
ACATCCAGGTGGATCTTTATCAATAATAGATGTAGTTACATATTTATATTTCGAAAAGATGAACATAGATCCTAAAAACC
CTAAGTTAGAAGGTAGAGATAGATTTATATTAAGCAAAGGTCATGCAGCACCAGCACAATATTCAGCTCTGGCTAAAAGA
GGATTTTTTGAAAGAGAAGAATTAAAGAATTTAAGAAAATTAGGATCATTTTTACAAGGACATCCTGATGCAAAGAAATG
TCCAGGCGTTGAAATTTCTACAGGATCTTTAGGCCAAGGATTTTCAAATAGTTGTGGATTAGCTTTAGCATCTAAAATGG
ATAATAAAAGTGAAAATATTTATGTTGTCTTAGGTGATGGAGAAATACAAGAAGGAATAGTTTGGGAAACAGCTATGGCA
GCAGCTAAATTTAAATTAGATAACTTAGTTGCTATTGTTGATAAAAATGGGATTCAACTAGATGGAAGAACATCAGAAAT
AATGGGTGTAGATCCATTAGGCGATAGATGGAAAAGTTTTGGCTGGAATGTTATAGAATGTGATGGTCACAATTTTGATG
AAATAGATGAAGCATTTAATAAAGCAGGACAAGTTGAAGGAAAGCCTACAGTAATAATAGCTCATACAATCAAAGGAAAA
GGTATATCTTTTATGGAAGACAATGTTGCATGGCATGGTATGGCTCCATCAAAAGAACAAAAAGAACAAGCTGTAATTGA
ATTAAGTAAATAG

Upstream 100 bases:

>100_bases
AAGCAAGAAAAAAGAAGCATAAAAAATAATAAATATATAATAAAAAAATGAGGAATTTAATTCCTCATTTTTTCAAATAT
AAAATTGGAGGTAACAATCT

Downstream 100 bases:

>100_bases
TAGGAGGAGAAAGCACATGAAAAGAGCAACTAGAGAATCATATGGAGCAACTTTAGCTCAATTAGGAAATGAAAATAAAA
ATATAGTAGTATTAGATGCG

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 270; Mature: 270

Protein sequence:

>270_residues
MNKQHLENISKELRKDIIEMIYESGSGHPGGSLSIIDVVTYLYFEKMNIDPKNPKLEGRDRFILSKGHAAPAQYSALAKR
GFFEREELKNLRKLGSFLQGHPDAKKCPGVEISTGSLGQGFSNSCGLALASKMDNKSENIYVVLGDGEIQEGIVWETAMA
AAKFKLDNLVAIVDKNGIQLDGRTSEIMGVDPLGDRWKSFGWNVIECDGHNFDEIDEAFNKAGQVEGKPTVIIAHTIKGK
GISFMEDNVAWHGMAPSKEQKEQAVIELSK

Sequences:

>Translated_270_residues
MNKQHLENISKELRKDIIEMIYESGSGHPGGSLSIIDVVTYLYFEKMNIDPKNPKLEGRDRFILSKGHAAPAQYSALAKR
GFFEREELKNLRKLGSFLQGHPDAKKCPGVEISTGSLGQGFSNSCGLALASKMDNKSENIYVVLGDGEIQEGIVWETAMA
AAKFKLDNLVAIVDKNGIQLDGRTSEIMGVDPLGDRWKSFGWNVIECDGHNFDEIDEAFNKAGQVEGKPTVIIAHTIKGK
GISFMEDNVAWHGMAPSKEQKEQAVIELSK
>Mature_270_residues
MNKQHLENISKELRKDIIEMIYESGSGHPGGSLSIIDVVTYLYFEKMNIDPKNPKLEGRDRFILSKGHAAPAQYSALAKR
GFFEREELKNLRKLGSFLQGHPDAKKCPGVEISTGSLGQGFSNSCGLALASKMDNKSENIYVVLGDGEIQEGIVWETAMA
AAKFKLDNLVAIVDKNGIQLDGRTSEIMGVDPLGDRWKSFGWNVIECDGHNFDEIDEAFNKAGQVEGKPTVIIAHTIKGK
GISFMEDNVAWHGMAPSKEQKEQAVIELSK

Specific function: Unknown

COG id: COG3959

COG function: function code G; Transketolase, N-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=266, Percent_Identity=41.3533834586466, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI4507521, Length=266, Percent_Identity=41.3533834586466, Blast_Score=205, Evalue=3e-53,
Organism=Homo sapiens, GI133778974, Length=266, Percent_Identity=39.8496240601504, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI225637459, Length=266, Percent_Identity=29.6992481203008, Blast_Score=130, Evalue=9e-31,
Organism=Homo sapiens, GI225637461, Length=166, Percent_Identity=36.7469879518072, Blast_Score=117, Evalue=1e-26,
Organism=Homo sapiens, GI225637463, Length=166, Percent_Identity=36.7469879518072, Blast_Score=117, Evalue=1e-26,
Organism=Escherichia coli, GI1788808, Length=276, Percent_Identity=36.5942028985507, Blast_Score=158, Evalue=4e-40,
Organism=Escherichia coli, GI48994911, Length=252, Percent_Identity=36.1111111111111, Blast_Score=152, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17539652, Length=252, Percent_Identity=42.4603174603175, Blast_Score=201, Evalue=4e-52,
Organism=Saccharomyces cerevisiae, GI6325331, Length=242, Percent_Identity=39.6694214876033, Blast_Score=147, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6319593, Length=256, Percent_Identity=34.375, Blast_Score=140, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551847, Length=251, Percent_Identity=41.0358565737052, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI45550715, Length=251, Percent_Identity=41.0358565737052, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24666278, Length=266, Percent_Identity=38.7218045112782, Blast_Score=186, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24645119, Length=216, Percent_Identity=42.1296296296296, Blast_Score=171, Evalue=5e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005474 [H]

Pfam domain/function: PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 29756; Mature: 29756

Theoretical pI: Translated: 5.93; Mature: 5.93

Prosite motif: PS00801 TRANSKETOLASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKQHLENISKELRKDIIEMIYESGSGHPGGSLSIIDVVTYLYFEKMNIDPKNPKLEGRD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
RFILSKGHAAPAQYSALAKRGFFEREELKNLRKLGSFLQGHPDAKKCPGVEISTGSLGQG
EEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCC
FSNSCGLALASKMDNKSENIYVVLGDGEIQEGIVWETAMAAAKFKLDNLVAIVDKNGIQL
CCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEE
DGRTSEIMGVDPLGDRWKSFGWNVIECDGHNFDEIDEAFNKAGQVEGKPTVIIAHTIKGK
CCCCCCEEECCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCC
GISFMEDNVAWHGMAPSKEQKEQAVIELSK
CCEEEECCCEECCCCCCHHHHHHHHEEECC
>Mature Secondary Structure
MNKQHLENISKELRKDIIEMIYESGSGHPGGSLSIIDVVTYLYFEKMNIDPKNPKLEGRD
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCC
RFILSKGHAAPAQYSALAKRGFFEREELKNLRKLGSFLQGHPDAKKCPGVEISTGSLGQG
EEEEECCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHCCCCEEECCCCCCC
FSNSCGLALASKMDNKSENIYVVLGDGEIQEGIVWETAMAAAKFKLDNLVAIVDKNGIQL
CCCCCCHHHHHHCCCCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHCCEEEEEECCCEEE
DGRTSEIMGVDPLGDRWKSFGWNVIECDGHNFDEIDEAFNKAGQVEGKPTVIIAHTIKGK
CCCCCCEEECCCCHHHHHHCCCEEEEECCCCHHHHHHHHHHCCCCCCCCEEEEEEEECCC
GISFMEDNVAWHGMAPSKEQKEQAVIELSK
CCEEEECCCEECCCCCCHHHHHHHHEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]