Click here to switch to the map view.

The map label for this gene is dxs [C]

Identifier: 187934753

GI number: 187934753

Start: 3734761

End: 3735687

Strand: Reverse

Name: dxs [C]

Synonym: CLL_A3528

Alternate gene names: 187934753

Gene position: 3735687-3734761 (Counterclockwise)

Preceding gene: 187933476

Following gene: 187935514

Centisome position: 98.3

GC content: 32.47

Gene sequence:

>927_bases
ATGAAAAGAGCAACTAGAGAATCATATGGAGCAACTTTAGCTCAATTAGGAAATGAAAATAAAAATATAGTAGTATTAGA
TGCGGACCTTTCAAAAGCTACTAAATCAGAAATGTTTGCAAAAGCACATCCAGATAGATTTATTAATGTTGGTATAGCTG
AACAAAACATGATTGGTATGGCAGCAGGTCTTGCAAGTGGTGGAAAAATACCTTTTGCTACTACTTTTGCAGTTTTTGCA
GCAGGTAGAGCATTTGAAGTAATAAGAAATTCAGTATGTTATCCAAATGTTAATGTTAAAATAGCTGCAACTCATGCAGG
AATAACAGTAGGTCCAGATGGTGGATCACATCAAGCAATAGAAGATATCGCACTTATGGCATCATTACCTAATATGGTAG
TTTTATCACCAGCTGATGATATTGAAGCTTGTAAATGTATTAAAGCAGCAGCTGAAATTAAATCTCCTGTTTATATAAGA
TTAGGAAGAATTGCATTAGAAGATATATATACAGAAGATTATGATTTTGAGATAGGAAAAGGAAGTACTTTAGTTGAAGG
AAATGATGTAACAATAGTTGCAACTGGAATAATGGTTCATAAAGCATTAAAAGCTTCTGAAGAACTTAAAGCAGAGGGCA
TAAATGCAAGAGTCATAAATATTGCAACTATTAAACCAATAGATGAAGAAATAATAATAAAAGCAGCTAAAGAAACAAAA
GGAATTGTGACAGTTGAAGAACATTCAATAATTGGTGGGTTAGGTGATAGAGTAGCAAGCGTAGTTTGTGATAACCATCC
AACTATGGTTAAGAAAATAGGGGTTAATGATGTATTTGGAGAATCAGGGGATCCAGATGGATTATTAGAAAAGTATGGAT
TAACTGTTGAAAACATTAAGAAAGTATCTAAAGAATTAGTTAAATAG

Upstream 100 bases:

>100_bases
TTTATGGAAGACAATGTTGCATGGCATGGTATGGCTCCATCAAAAGAACAAAAAGAACAAGCTGTAATTGAATTAAGTAA
ATAGTAGGAGGAGAAAGCAC

Downstream 100 bases:

>100_bases
TTACTAAAAATGTATGGATACTATAATCTTGAGTTGTCTTTTAAATAATAAAGTAGCTTCCAACATAATAGAAATCTATG
TAGATATCTAAGGGGGGAAA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MKRATRESYGATLAQLGNENKNIVVLDADLSKATKSEMFAKAHPDRFINVGIAEQNMIGMAAGLASGGKIPFATTFAVFA
AGRAFEVIRNSVCYPNVNVKIAATHAGITVGPDGGSHQAIEDIALMASLPNMVVLSPADDIEACKCIKAAAEIKSPVYIR
LGRIALEDIYTEDYDFEIGKGSTLVEGNDVTIVATGIMVHKALKASEELKAEGINARVINIATIKPIDEEIIIKAAKETK
GIVTVEEHSIIGGLGDRVASVVCDNHPTMVKKIGVNDVFGESGDPDGLLEKYGLTVENIKKVSKELVK

Sequences:

>Translated_308_residues
MKRATRESYGATLAQLGNENKNIVVLDADLSKATKSEMFAKAHPDRFINVGIAEQNMIGMAAGLASGGKIPFATTFAVFA
AGRAFEVIRNSVCYPNVNVKIAATHAGITVGPDGGSHQAIEDIALMASLPNMVVLSPADDIEACKCIKAAAEIKSPVYIR
LGRIALEDIYTEDYDFEIGKGSTLVEGNDVTIVATGIMVHKALKASEELKAEGINARVINIATIKPIDEEIIIKAAKETK
GIVTVEEHSIIGGLGDRVASVVCDNHPTMVKKIGVNDVFGESGDPDGLLEKYGLTVENIKKVSKELVK
>Mature_308_residues
MKRATRESYGATLAQLGNENKNIVVLDADLSKATKSEMFAKAHPDRFINVGIAEQNMIGMAAGLASGGKIPFATTFAVFA
AGRAFEVIRNSVCYPNVNVKIAATHAGITVGPDGGSHQAIEDIALMASLPNMVVLSPADDIEACKCIKAAAEIKSPVYIR
LGRIALEDIYTEDYDFEIGKGSTLVEGNDVTIVATGIMVHKALKASEELKAEGINARVINIATIKPIDEEIIIKAAKETK
GIVTVEEHSIIGGLGDRVASVVCDNHPTMVKKIGVNDVFGESGDPDGLLEKYGLTVENIKKVSKELVK

Specific function: Catalyzes The Acyloin Condensation Reaction Between C Atoms 2 And 3 Of Pyruvate And Glyceraldehyde 3-Phosphate To Yield 1-Deoxy-D-Xylulose-5-Phosphate (Dxp). [C]

COG id: COG3958

COG function: function code G; Transketolase, C-terminal subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=310, Percent_Identity=39.3548387096774, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI4507521, Length=310, Percent_Identity=39.3548387096774, Blast_Score=218, Evalue=5e-57,
Organism=Homo sapiens, GI225637461, Length=303, Percent_Identity=40.2640264026403, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI225637463, Length=303, Percent_Identity=40.2640264026403, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI225637459, Length=303, Percent_Identity=40.2640264026403, Blast_Score=199, Evalue=3e-51,
Organism=Homo sapiens, GI133778974, Length=301, Percent_Identity=37.2093023255814, Blast_Score=185, Evalue=4e-47,
Organism=Homo sapiens, GI4557353, Length=230, Percent_Identity=25.6521739130435, Blast_Score=66, Evalue=4e-11,
Organism=Homo sapiens, GI34101272, Length=230, Percent_Identity=25.6521739130435, Blast_Score=66, Evalue=4e-11,
Organism=Escherichia coli, GI1786622, Length=291, Percent_Identity=29.2096219931272, Blast_Score=125, Evalue=4e-30,
Organism=Escherichia coli, GI48994911, Length=277, Percent_Identity=27.7978339350181, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788808, Length=321, Percent_Identity=28.3489096573209, Blast_Score=87, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI17539652, Length=302, Percent_Identity=37.4172185430464, Blast_Score=199, Evalue=2e-51,
Organism=Caenorhabditis elegans, GI17506935, Length=104, Percent_Identity=38.4615384615385, Blast_Score=74, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI17538422, Length=249, Percent_Identity=27.3092369477912, Blast_Score=71, Evalue=7e-13,
Organism=Saccharomyces cerevisiae, GI6325331, Length=271, Percent_Identity=28.4132841328413, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6319698, Length=283, Percent_Identity=24.3816254416961, Blast_Score=70, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6319593, Length=191, Percent_Identity=28.2722513089005, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI24666278, Length=310, Percent_Identity=34.1935483870968, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24645119, Length=309, Percent_Identity=33.6569579288026, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI45551847, Length=309, Percent_Identity=33.6569579288026, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI45550715, Length=309, Percent_Identity=33.6569579288026, Blast_Score=175, Evalue=3e-44,
Organism=Drosophila melanogaster, GI21358145, Length=247, Percent_Identity=27.1255060728745, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24650940, Length=247, Percent_Identity=27.1255060728745, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI160714832, Length=234, Percent_Identity=25.2136752136752, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI160714828, Length=234, Percent_Identity=25.2136752136752, Blast_Score=67, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 32720; Mature: 32720

Theoretical pI: Translated: 5.45; Mature: 5.45

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRATRESYGATLAQLGNENKNIVVLDADLSKATKSEMFAKAHPDRFINVGIAEQNMIGM
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHH
AAGLASGGKIPFATTFAVFAAGRAFEVIRNSVCYPNVNVKIAATHAGITVGPDGGSHQAI
HHCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEECCEEECCCCCCHHHH
EDIALMASLPNMVVLSPADDIEACKCIKAAAEIKSPVYIRLGRIALEDIYTEDYDFEIGK
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCEEECC
GSTLVEGNDVTIVATGIMVHKALKASEELKAEGINARVINIATIKPIDEEIIIKAAKETK
CCEEEECCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHEEECCCCC
GIVTVEEHSIIGGLGDRVASVVCDNHPTMVKKIGVNDVFGESGDPDGLLEKYGLTVENIK
CEEEEECCCEECCHHHHHHHHHCCCCCCEEEECCCCHHCCCCCCCCHHHHHHCCCHHHHH
KVSKELVK
HHHHHHCC
>Mature Secondary Structure
MKRATRESYGATLAQLGNENKNIVVLDADLSKATKSEMFAKAHPDRFINVGIAEQNMIGM
CCCCCHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHCCCCCEEEEEECCCCHHHH
AAGLASGGKIPFATTFAVFAAGRAFEVIRNSVCYPNVNVKIAATHAGITVGPDGGSHQAI
HHCCCCCCCCCHHHHHHHHHCCHHHHHHHCCCCCCCCCEEEEEEECCEEECCCCCCHHHH
EDIALMASLPNMVVLSPADDIEACKCIKAAAEIKSPVYIRLGRIALEDIYTEDYDFEIGK
HHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCCCEEEEECHHHHHHHHCCCCCEEECC
GSTLVEGNDVTIVATGIMVHKALKASEELKAEGINARVINIATIKPIDEEIIIKAAKETK
CCEEEECCCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHEEECCCCC
GIVTVEEHSIIGGLGDRVASVVCDNHPTMVKKIGVNDVFGESGDPDGLLEKYGLTVENIK
CEEEEECCCEECCHHHHHHHHHCCCCCCEEEECCCCHHCCCCCCCCHHHHHHCCCHHHHH
KVSKELVK
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]