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The map label for this gene is putP [H]

Identifier: 187932981

GI number: 187932981

Start: 3259869

End: 3261341

Strand: Reverse

Name: putP [H]

Synonym: CLL_A3148

Alternate gene names: 187932981

Gene position: 3261341-3259869 (Counterclockwise)

Preceding gene: 187934642

Following gene: 187932465

Centisome position: 85.82

GC content: 30.14

Gene sequence:

>1473_bases
ATGAATGAAAAAATAATAATTGGAGGTACATTTGCATTATACTTGGTAGTAATGTTATGTATAGGCCTACATTTTTATTA
TCGAACTAATAATTTATCAGATTATACATTAGGAGGAAGAAAGCTTGGATATTGGGGTAGCTCTATAAGTGCACAAGCTT
CAGATATGAGTGGATGGCTATTATTAGGTCTTCCAGGAGCGGCTTTTTTAACAGGTTTATCTGGATCTGTATGGATGGCT
TTAGGATTAGCTATTGGAACATATTTAAATTGGAAAATAGTTGCCAAAAGGCTTAGAGTAGATACTCAAAAATATTCAGA
TTCAATAACAGTACCATCTTATTTAGAAAACAGATTTAATGATAAATCAAAAACATTAAAATTAATTTCGTCATTATTCA
TACTAGTATTCTTTATACCATATACTGCTTCAGGATTTGTTTCAGGAGGAAAGCTATTTACAACAGTTTTTGGTACACCA
TATATAATTTCTGTTATTATATGTGGCATAGTCGTTGTAAGTTATACTTTTTTAGGTGGATTTATGGCTGTATGTTATAC
AGATATAATTCAAGGGTTATTAATGTTTTTTACATTACTTGTATTGCCTATAATAGTTATAGTAGAAGCTGGTGGAGTAG
GAAATATATTATCAACTTTTGATTCATCACTTTTAAATCCATTAGATATTGGTTTTATAACTGGATCAAGTAGTGGAACA
GTAGGTATGGCAGTTATAGGAATTATTTCATCTCTTGCATGGGGGCTTGGATATTTTGGACAACCTCATATTATTACAAA
GTTTATGGCTATAGAAAATCCAGAGGAAATTAAAATTTCAAGGAGAATAGCTACGGTTTGGGTCATAATAACACTTTTAG
CTTCAACTGCTATAGGTCTTGTTGGACATTATTATTTTCCAAACTTAACGGGTGCTGATTCTGAAACTATATTTATTTTA
TTAGTTCATAAATGTGTTCCATTAATATTTATTGGAGTATTATTATCATCAATATTAGCTGCAATAATGAGTACTGCTGA
TTCACAACTTTTAGTTATATCTTCTACAATTTCAGAAGATATTTATAGGTCTATTATAAAACCTAAAGCTTCAGATAAAG
AACTTATAGGAATTAGTAGATTATCAGTATTAGTTGTAGCACTTATAGCATTTTGTATTTCACTTAATCCAGATAGCTCC
GTATTGAAACTCGTATCCTATGCATGGGCAGGATTTGGTTGTGCTTTTGGACCAGTAATTTTATTATCACTATTCTGGGA
AAAAATGACTAGAAATGGTGCCGTTGCAGGTATGTTAATAGGTGGATTTACATCAGCTACTTGGCCAATATTTAAAAACT
ATTTTTCATCACAAATATTTAATCTTTATGAAATTGTACCAGGATTTTTATTGGCGTTAATTGCAATATACGTTGTTAGT
AATTTGGATATAAAAAAGCATAAAGTAAAATAG

Upstream 100 bases:

>100_bases
AGTTCATTTTAACTTAAGAAAATTGAATTTATACGGATTTTCTGTTAAAATCGTTACATTACGTACAAAATTGTTACTTA
TATTTAGGAGGTTTATATAA

Downstream 100 bases:

>100_bases
TACATATAAGAATTCTCAAAGTCCAATTGCATTACCACGTTACCTATTACATATATCAACATATATTTAAAACATAGCTA
AATTCTAAGACAGTATTTTA

Product: sodium/proline symporter

Products: NA

Alternate protein names: Sodium/proline symporter [H]

Number of amino acids: Translated: 490; Mature: 490

Protein sequence:

>490_residues
MNEKIIIGGTFALYLVVMLCIGLHFYYRTNNLSDYTLGGRKLGYWGSSISAQASDMSGWLLLGLPGAAFLTGLSGSVWMA
LGLAIGTYLNWKIVAKRLRVDTQKYSDSITVPSYLENRFNDKSKTLKLISSLFILVFFIPYTASGFVSGGKLFTTVFGTP
YIISVIICGIVVVSYTFLGGFMAVCYTDIIQGLLMFFTLLVLPIIVIVEAGGVGNILSTFDSSLLNPLDIGFITGSSSGT
VGMAVIGIISSLAWGLGYFGQPHIITKFMAIENPEEIKISRRIATVWVIITLLASTAIGLVGHYYFPNLTGADSETIFIL
LVHKCVPLIFIGVLLSSILAAIMSTADSQLLVISSTISEDIYRSIIKPKASDKELIGISRLSVLVVALIAFCISLNPDSS
VLKLVSYAWAGFGCAFGPVILLSLFWEKMTRNGAVAGMLIGGFTSATWPIFKNYFSSQIFNLYEIVPGFLLALIAIYVVS
NLDIKKHKVK

Sequences:

>Translated_490_residues
MNEKIIIGGTFALYLVVMLCIGLHFYYRTNNLSDYTLGGRKLGYWGSSISAQASDMSGWLLLGLPGAAFLTGLSGSVWMA
LGLAIGTYLNWKIVAKRLRVDTQKYSDSITVPSYLENRFNDKSKTLKLISSLFILVFFIPYTASGFVSGGKLFTTVFGTP
YIISVIICGIVVVSYTFLGGFMAVCYTDIIQGLLMFFTLLVLPIIVIVEAGGVGNILSTFDSSLLNPLDIGFITGSSSGT
VGMAVIGIISSLAWGLGYFGQPHIITKFMAIENPEEIKISRRIATVWVIITLLASTAIGLVGHYYFPNLTGADSETIFIL
LVHKCVPLIFIGVLLSSILAAIMSTADSQLLVISSTISEDIYRSIIKPKASDKELIGISRLSVLVVALIAFCISLNPDSS
VLKLVSYAWAGFGCAFGPVILLSLFWEKMTRNGAVAGMLIGGFTSATWPIFKNYFSSQIFNLYEIVPGFLLALIAIYVVS
NLDIKKHKVK
>Mature_490_residues
MNEKIIIGGTFALYLVVMLCIGLHFYYRTNNLSDYTLGGRKLGYWGSSISAQASDMSGWLLLGLPGAAFLTGLSGSVWMA
LGLAIGTYLNWKIVAKRLRVDTQKYSDSITVPSYLENRFNDKSKTLKLISSLFILVFFIPYTASGFVSGGKLFTTVFGTP
YIISVIICGIVVVSYTFLGGFMAVCYTDIIQGLLMFFTLLVLPIIVIVEAGGVGNILSTFDSSLLNPLDIGFITGSSSGT
VGMAVIGIISSLAWGLGYFGQPHIITKFMAIENPEEIKISRRIATVWVIITLLASTAIGLVGHYYFPNLTGADSETIFIL
LVHKCVPLIFIGVLLSSILAAIMSTADSQLLVISSTISEDIYRSIIKPKASDKELIGISRLSVLVVALIAFCISLNPDSS
VLKLVSYAWAGFGCAFGPVILLSLFWEKMTRNGAVAGMLIGGFTSATWPIFKNYFSSQIFNLYEIVPGFLLALIAIYVVS
NLDIKKHKVK

Specific function: Catalyzes the sodium-dependent uptake of extracellular proline [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=490, Percent_Identity=44.0816326530612, Blast_Score=386, Evalue=1e-107,
Organism=Homo sapiens, GI110835708, Length=528, Percent_Identity=23.6742424242424, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI14140236, Length=468, Percent_Identity=20.0854700854701, Blast_Score=69, Evalue=1e-11,
Organism=Homo sapiens, GI109659836, Length=377, Percent_Identity=23.0769230769231, Blast_Score=65, Evalue=1e-10,
Organism=Escherichia coli, GI1787251, Length=477, Percent_Identity=46.5408805031447, Blast_Score=403, Evalue=1e-113,
Organism=Escherichia coli, GI87082237, Length=441, Percent_Identity=29.0249433106576, Blast_Score=140, Evalue=2e-34,
Organism=Escherichia coli, GI1790503, Length=453, Percent_Identity=25.8278145695364, Blast_Score=114, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17539284, Length=454, Percent_Identity=23.568281938326, Blast_Score=72, Evalue=8e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011851
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 53142; Mature: 53142

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNEKIIIGGTFALYLVVMLCIGLHFYYRTNNLSDYTLGGRKLGYWGSSISAQASDMSGWL
CCCCEEECCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCCCCCCCCCCCCEE
LLGLPGAAFLTGLSGSVWMALGLAIGTYLNWKIVAKRLRVDTQKYSDSITVPSYLENRFN
EEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
DKSKTLKLISSLFILVFFIPYTASGFVSGGKLFTTVFGTPYIISVIICGIVVVSYTFLGG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
FMAVCYTDIIQGLLMFFTLLVLPIIVIVEAGGVGNILSTFDSSLLNPLDIGFITGSSSGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCC
VGMAVIGIISSLAWGLGYFGQPHIITKFMAIENPEEIKISRRIATVWVIITLLASTAIGL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGHYYFPNLTGADSETIFILLVHKCVPLIFIGVLLSSILAAIMSTADSQLLVISSTISED
HHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
IYRSIIKPKASDKELIGISRLSVLVVALIAFCISLNPDSSVLKLVSYAWAGFGCAFGPVI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
LLSLFWEKMTRNGAVAGMLIGGFTSATWPIFKNYFSSQIFNLYEIVPGFLLALIAIYVVS
HHHHHHHHHHCCCCEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLDIKKHKVK
CCCCHHCCCC
>Mature Secondary Structure
MNEKIIIGGTFALYLVVMLCIGLHFYYRTNNLSDYTLGGRKLGYWGSSISAQASDMSGWL
CCCCEEECCHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCEECCCCCCCCCCCCCCCCEE
LLGLPGAAFLTGLSGSVWMALGLAIGTYLNWKIVAKRLRVDTQKYSDSITVPSYLENRFN
EEECCHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCC
DKSKTLKLISSLFILVFFIPYTASGFVSGGKLFTTVFGTPYIISVIICGIVVVSYTFLGG
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHH
FMAVCYTDIIQGLLMFFTLLVLPIIVIVEAGGVGNILSTFDSSLLNPLDIGFITGSSSGT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCHHEEEEECCCCCC
VGMAVIGIISSLAWGLGYFGQPHIITKFMAIENPEEIKISRRIATVWVIITLLASTAIGL
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
VGHYYFPNLTGADSETIFILLVHKCVPLIFIGVLLSSILAAIMSTADSQLLVISSTISED
HHHHHCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEHHHHHH
IYRSIIKPKASDKELIGISRLSVLVVALIAFCISLNPDSSVLKLVSYAWAGFGCAFGPVI
HHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCHHHHHHH
LLSLFWEKMTRNGAVAGMLIGGFTSATWPIFKNYFSSQIFNLYEIVPGFLLALIAIYVVS
HHHHHHHHHHCCCCEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLDIKKHKVK
CCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8969499; 9384377 [H]