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The map label for this gene is cls [H]

Identifier: 187932465

GI number: 187932465

Start: 3258232

End: 3259665

Strand: Reverse

Name: cls [H]

Synonym: CLL_A3147

Alternate gene names: 187932465

Gene position: 3259665-3258232 (Counterclockwise)

Preceding gene: 187932981

Following gene: 187934416

Centisome position: 85.77

GC content: 27.2

Gene sequence:

>1434_bases
ATGAATATATTATTAGGAATAGGTATGTTAGTTTTAATATTAAATATATTCTTTTCATTATCATTAATATTTATAGAAAG
AAAAGATCCAACAACAACATGGGCATGGCTTTTAATATTAATTATTTTACCGGGATTTGGTTTTGTATTATATCTTCTAT
TTGGACAAAACTTAAGTAGGCAAAAGATTTTTAAAGAAAAAACACAAATTGATGAAATAAAGAGAAGAAATTTAAGTAGT
AGATATGGTAATAGGAGTAATTGTCATGATGGAGGAGATAAATTTTTTGATTTAAGAAAAATGAATTATAATCATTCGGG
TTCTCAATATACAACTAACAATGATCTTGATGTGTATGTTAATGGAGAAGATAAGTTTAGACAATTAATTGAAGATATAA
AGAATGCAAAGGAATATATACATATAGAATATTATATTTTTCGTAATGATTGTTTAGGAAAAGAAATAATAGCAGAATTA
ACAAAAAAGGCAGCAAGTGGAGTTGAAGTAAGACTTTTAGCAGACAGTATGGGTTCTTATACATTAACCAAAGGTGCATT
AAAGAATTATTTAAAATCAGGAGGAAAATTTGCAATATTTTTCCCAGGAATATTACCACACATAAATACACGTATAAATT
ATAGAAATCATAGAAAAATAGTAGTAATAGATGGAGAATATGGGTATGTTGGTGGATTTAATGTTGGTAAGGAATATATA
AATAGAGATCCTAAGGTTGGATTTTGGAGAGATACTCACGTTAGAATAAGAGGCGGGGCAGTAAATGATTTAAATGAAAG
ATTCTTATTAGATTGGTGTTATGCATCAGAAGAGGTAATAAGTGATTATAATAAATATTTATCAGATAAAAATGAAGAAG
TGGGCGATGTTGGTATACAAATAGTTACTAGTGGACCTGATCATGAAGAAGAATATATTAGAAATGCTTATATTAAACTT
ATAAACAATGCTAAAAATAATTTATATTTAGAAACGCCTTATTTAGTACCAGATTTACCTATATTAGAAGCTTTAAAAAT
ATCAGCATTATCAGGTGTTGACGTTAGAATAATAATTCCAGGAAATCCAGATCACTTTTTTATGCAATGGGCAGCTAGTT
CTTATATAGGTGAACTTTTAAATGCTGGAATAAAAATATATTATTATAAAAATGGATTTATCCATGCTAAGGCTATGGTT
GCAGATAGCACTGTAGTATCTATAGGAACAGCTAACATGGATATAAGAAGTTTCAAATTAAATTTTGAAGTTAATGCTTT
TATATTTGATGATAGAGTAGCTATTGATTATGAGAAACAATTCATGGAAGATATTGAATTTTCTGAAGAAATAACAATAG
AATCGCATGCTAATAGAAGTACGTCTATTAAGATAAAAGAATCTTTAGCAAGATTAGTTTCACCAATACTTTAA

Upstream 100 bases:

>100_bases
AACATGATAAAATATTAAATATAGCATATAAATTGAATGAAGAATTATAATAGAATGATTTAATTTTAAATAATAACCTA
AACGAAGGAAGTGAGAAAAT

Downstream 100 bases:

>100_bases
TAATTATAAATTATGGATTATGTATAAAAATTATTTTTTACTTTAACTTGGAATAAATCCTTAAATAAAATAATAAGATG
TGAAAAGAGGAATGAATCAT

Product: cardiolipin synthetase

Products: NA

Alternate protein names: CL synthase [H]

Number of amino acids: Translated: 477; Mature: 477

Protein sequence:

>477_residues
MNILLGIGMLVLILNIFFSLSLIFIERKDPTTTWAWLLILIILPGFGFVLYLLFGQNLSRQKIFKEKTQIDEIKRRNLSS
RYGNRSNCHDGGDKFFDLRKMNYNHSGSQYTTNNDLDVYVNGEDKFRQLIEDIKNAKEYIHIEYYIFRNDCLGKEIIAEL
TKKAASGVEVRLLADSMGSYTLTKGALKNYLKSGGKFAIFFPGILPHINTRINYRNHRKIVVIDGEYGYVGGFNVGKEYI
NRDPKVGFWRDTHVRIRGGAVNDLNERFLLDWCYASEEVISDYNKYLSDKNEEVGDVGIQIVTSGPDHEEEYIRNAYIKL
INNAKNNLYLETPYLVPDLPILEALKISALSGVDVRIIIPGNPDHFFMQWAASSYIGELLNAGIKIYYYKNGFIHAKAMV
ADSTVVSIGTANMDIRSFKLNFEVNAFIFDDRVAIDYEKQFMEDIEFSEEITIESHANRSTSIKIKESLARLVSPIL

Sequences:

>Translated_477_residues
MNILLGIGMLVLILNIFFSLSLIFIERKDPTTTWAWLLILIILPGFGFVLYLLFGQNLSRQKIFKEKTQIDEIKRRNLSS
RYGNRSNCHDGGDKFFDLRKMNYNHSGSQYTTNNDLDVYVNGEDKFRQLIEDIKNAKEYIHIEYYIFRNDCLGKEIIAEL
TKKAASGVEVRLLADSMGSYTLTKGALKNYLKSGGKFAIFFPGILPHINTRINYRNHRKIVVIDGEYGYVGGFNVGKEYI
NRDPKVGFWRDTHVRIRGGAVNDLNERFLLDWCYASEEVISDYNKYLSDKNEEVGDVGIQIVTSGPDHEEEYIRNAYIKL
INNAKNNLYLETPYLVPDLPILEALKISALSGVDVRIIIPGNPDHFFMQWAASSYIGELLNAGIKIYYYKNGFIHAKAMV
ADSTVVSIGTANMDIRSFKLNFEVNAFIFDDRVAIDYEKQFMEDIEFSEEITIESHANRSTSIKIKESLARLVSPIL
>Mature_477_residues
MNILLGIGMLVLILNIFFSLSLIFIERKDPTTTWAWLLILIILPGFGFVLYLLFGQNLSRQKIFKEKTQIDEIKRRNLSS
RYGNRSNCHDGGDKFFDLRKMNYNHSGSQYTTNNDLDVYVNGEDKFRQLIEDIKNAKEYIHIEYYIFRNDCLGKEIIAEL
TKKAASGVEVRLLADSMGSYTLTKGALKNYLKSGGKFAIFFPGILPHINTRINYRNHRKIVVIDGEYGYVGGFNVGKEYI
NRDPKVGFWRDTHVRIRGGAVNDLNERFLLDWCYASEEVISDYNKYLSDKNEEVGDVGIQIVTSGPDHEEEYIRNAYIKL
INNAKNNLYLETPYLVPDLPILEALKISALSGVDVRIIIPGNPDHFFMQWAASSYIGELLNAGIKIYYYKNGFIHAKAMV
ADSTVVSIGTANMDIRSFKLNFEVNAFIFDDRVAIDYEKQFMEDIEFSEEITIESHANRSTSIKIKESLARLVSPIL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=463, Percent_Identity=26.7818574514039, Blast_Score=184, Evalue=8e-48,
Organism=Escherichia coli, GI1787007, Length=323, Percent_Identity=26.9349845201238, Blast_Score=124, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 54638; Mature: 54638

Theoretical pI: Translated: 6.69; Mature: 6.69

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNILLGIGMLVLILNIFFSLSLIFIERKDPTTTWAWLLILIILPGFGFVLYLLFGQNLSR
CCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QKIFKEKTQIDEIKRRNLSSRYGNRSNCHDGGDKFFDLRKMNYNHSGSQYTTNNDLDVYV
HHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCEEEEE
NGEDKFRQLIEDIKNAKEYIHIEYYIFRNDCLGKEIIAELTKKAASGVEVRLLADSMGSY
CCHHHHHHHHHHHHCCHHEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCE
TLTKGALKNYLKSGGKFAIFFPGILPHINTRINYRNHRKIVVIDGEYGYVGGFNVGKEYI
EECHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCEEEEEECCCCEECCCHHHHHHH
NRDPKVGFWRDTHVRIRGGAVNDLNERFLLDWCYASEEVISDYNKYLSDKNEEVGDVGIQ
CCCCCCCEEECCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCCCCCCCCCEE
IVTSGPDHEEEYIRNAYIKLINNAKNNLYLETPYLVPDLPILEALKISALSGVDVRIIIP
EEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEC
GNPDHFFMQWAASSYIGELLNAGIKIYYYKNGFIHAKAMVADSTVVSIGTANMDIRSFKL
CCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEEEEEECCEEEEEECCCCEEEEEEE
NFEVNAFIFDDRVAIDYEKQFMEDIEFSEEITIESHANRSTSIKIKESLARLVSPIL
EEEEEEEEEECEEEECHHHHHHHHCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCC
>Mature Secondary Structure
MNILLGIGMLVLILNIFFSLSLIFIERKDPTTTWAWLLILIILPGFGFVLYLLFGQNLSR
CCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCH
QKIFKEKTQIDEIKRRNLSSRYGNRSNCHDGGDKFFDLRKMNYNHSGSQYTTNNDLDVYV
HHHHHHHHHHHHHHHHCHHHHCCCCCCCCCCCCCEEEEEECCCCCCCCEEECCCCEEEEE
NGEDKFRQLIEDIKNAKEYIHIEYYIFRNDCLGKEIIAELTKKAASGVEVRLLADSMGSY
CCHHHHHHHHHHHHCCHHEEEEEEEEEECCCCCHHHHHHHHHHHHCCCEEEEEECCCCCE
TLTKGALKNYLKSGGKFAIFFPGILPHINTRINYRNHRKIVVIDGEYGYVGGFNVGKEYI
EECHHHHHHHHHCCCCEEEECCCCCCCCCCEEEECCCCEEEEEECCCCEECCCHHHHHHH
NRDPKVGFWRDTHVRIRGGAVNDLNERFLLDWCYASEEVISDYNKYLSDKNEEVGDVGIQ
CCCCCCCEEECCEEEEECCCCCCCCCCEEEEEHHCCHHHHHHHHHHHCCCCCCCCCCCEE
IVTSGPDHEEEYIRNAYIKLINNAKNNLYLETPYLVPDLPILEALKISALSGVDVRIIIP
EEECCCCHHHHHHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHCCCCEEEEEEC
GNPDHFFMQWAASSYIGELLNAGIKIYYYKNGFIHAKAMVADSTVVSIGTANMDIRSFKL
CCCCHHHHHHHHHHHHHHHHHCCEEEEEEECCEEEEEEEEECCEEEEEECCCCEEEEEEE
NFEVNAFIFDDRVAIDYEKQFMEDIEFSEEITIESHANRSTSIKIKESLARLVSPIL
EEEEEEEEEECEEEECHHHHHHHHCCCCCEEEEECCCCCCCEEEHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10585141 [H]